Effect of Lycium Barbarum Polysaccharides (LBP) on the cognitive function of rats with type 2 diabetic encephalopathy

Abstract Purpose This study aimed to examining Synergistic effect of Vitamin D (VD) Supplement and mindfulness on insulin resistance and different aspects of cognitive function in VD Deficient Type 2 Diabetic women. Methods In this randomized-controlled trial, totally 225 women with T2DM and VD deficiency were randomly allocated to five groups: (1) mindfulness, (2) mindfulness and VD, (3) mindfulness and placebo, (4) VD, and (5) placebo. Mindfulness includes 12 sessions and VD patients received a daily 4000 IU oral dosage (two capsules) with 28,000 IU vitamin D weekly for 12 weeks. Sun exposure, anthropometric indices, dietary intake, physical activity, energy levels, laboratory analyses, were measured at the pre-test and after 12-week supplementation. dependent variables include cognitive function (Risky decision making, IQ and Trail Making Test) and insulin resistance. Results In baseline, measures were not different among the groups. At the end of treatment, cognitive function results showed improvement for all groups except the “placebo” group. About other groups, there was not any difference between VD and mindfulness groups (or combinations with placebo). but in “VITAMIN + MINDFULNESS” has a greater improvement rather than other groups (P < 0.05). This result exactly repeated for insulin resistance. However, there were not any significant difference among groups for IQ(P > 0.05). There was any difference among groups for sunlight exposure and BMI (P > 0.05). For FBS only in combined group (VD + Mindfulness) the FBS significantly reduced that is synergistic effects (P < 0.05). Conclusion Combining VD Supplement and mindfulness can reduce insulin resistance and improve different aspects of cognitive function in VD Deficient patients.

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Association between Visit-to-Visit Glucose Variability and Cognitive Function in Aged Type 2 Diabetic Patients: A Cross-Sectional Study

PLoS ONE ◽

10.1371/journal.pone.0132118 ◽

2015 ◽

Vol 10 (7) ◽

pp. e0132118 ◽

Cited By ~ 12

Author(s):

Chulho Kim ◽

Jong-Hee Sohn ◽

Min Uk Jang ◽

Sung-Hun Kim ◽

Moon-Gi Choi ◽

...

Keyword(s):

Cognitive Function ◽

Glucose Variability ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Sectional Study ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Type 2 Diabetic

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The effect of nutrition counseling on glycemic control and cognitive function in type 2 diabetic patients

Diabetes Research and Clinical Practice ◽

10.1016/s0168-8227(16)31315-8 ◽

2016 ◽

Vol 120 ◽

pp. S150-S151

Author(s):

Chia-Hsin Yu ◽

Po-Wen Yang ◽

Yu-Pei Sung ◽

Cheng-Hsueh Chien ◽

Lin-Hui Li ◽

...

Keyword(s):

Cognitive Function ◽

Glycemic Control ◽

Diabetic Patients ◽

Nutrition Counseling ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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Positive correlation between cognitive impairment and renal microangiopathy in patients with type 2 diabetic nephropathy: a multicenter retrospective study

Journal of International Medical Research ◽

10.1177/0300060518789299 ◽

2018 ◽

Vol 46 (12) ◽

pp. 5040-5051 ◽

Cited By ~ 2

Author(s):

Jinyu Li ◽

Jiamin Pan ◽

Bohan Li ◽

Huiyu Tian ◽

Ying Zhu ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Cognitive Impairment ◽

Cognitive Function ◽

Correlation Analysis ◽

Pearson Correlation ◽

Control Group ◽

Positive Correlation ◽

Pearson Correlation Analysis ◽

Type 2 Diabetic

Objective This study was performed to explore the correlation between cognitive impairment and renal microangiopathy in patients with type 2 diabetic nephropathy (T2DN) by detecting changes in cognitive function and cerebral metabolism in these patients with different stages of T2DN. Methods Prospectively maintained databases were reviewed from 2006 to 2017. Blood biochemical indexes and the urinary albumin excretion rate (UAER) were measured in all participants. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MoCA). Cognitive impairment was the primary endpoint. Renal microangiopathy was the secondary endpoint. Pearson correlation analysis was used to assess correlations. Results Two hundred sixteen patients with type 2 diabetes mellitus (T2DM) were divided into three groups according to their UAER: T2DM without nephropathy (n=72), early T2DM with nephropathy (n=74), and the clinical stage of early T2DM with nephropathy (n=70). Healthy participants were selected as the normal control group (n=70). Pearson correlation analysis demonstrated that the total MMSE and MoCA score was negatively correlated with the UAER (r=−0.327) and positively correlated with the estimated glomerular filtration rate (r=0.428) in patients with T2DN. Conclusions The present study showed a positive correlation between cognitive impairment and renal microangiopathy in patients with T2DN.

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The synergistic effect of vitamin D supplement and mindfulness on insulin resistance and different aspects of cognitive function in vitamin D deficient type 2 diabetic mellitus women: A pilot randomized clinical trial with placebo-controlled

10.21203/rs.3.rs-258673/v1 ◽

2021 ◽

Author(s):

mohammadreza davoudi ◽

Parnian Rezaie ◽

Seyed Mojtaba Ahmadi ◽

Farhang Djafari ◽

zeinab khosrojerdi

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Cognitive Function ◽

Synergistic Effect ◽

Controlled Trial ◽

Oral Dosage ◽

Risky Decision ◽

Significant Difference ◽

Type 2 Diabetic

Abstract Purpose This study aimed to examine the synergistic effect of Vitamin D (VD) supplement and mindfulness on insulin resistance and different aspects of cognitive function in VD deficient type 2 diabetic women. Methods In this randomized-controlled trial, totally 225 women with type 2 diabetes mellitus (T2DM) and VD deficiency were randomly allocated to five groups: (1) mindfulness, (2) mindfulness and VD, (3) mindfulness and placebo, (4) VD, and (5) placebo. Mindfulness includes 12 sessions and VD patients received a daily 4000 IU oral dosage (two capsules) with 28,000 IU vitamin D weekly for 12 weeks. Sun exposure, anthropometric indices, dietary intake, physical activity, energy levels, and laboratory analyses were measured at the pre-test and after 12-week supplementation. Dependent variables include cognitive function (Risky decision making, IQ and Trail Making Test) and insulin resistance. Results In baseline, measures were not different among the groups. At the end of the treatment, cognitive function results showed improvement for all groups except the “placebo” group. About other groups, there was not any differences between VD and mindfulness groups (or combinations with placebo). However, in “VITAMIN + MINDFULNESS” group, a greater improvement compared to other groups was observed (P < 0.05). This result exactly repeated for insulin resistance. Furthermore, there were not any significant difference among groups for IQ (as one aspect of cognitive function) (P > 0.05). Moreover, there was not any differences among groups for sunlight exposure and BMI (P > 0.05). Only in combined group (VD + Mindfulness) the fasting blood sugar (FBS) significantly reduced that shows the synergistic effect of VD supplementation and Mindfulness (P < 0.05). Conclusion Combining VD Supplementation and mindfulness can reduce insulin resistance and improve different aspects of cognitive function in VD Deficient patients.

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