Genetics of diabetic nephropathy

The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.

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Features of Genetic Polymorphism in Population with Diabetic Nephropathia: Literature Review

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2019/v29i930123 ◽

2019 ◽

pp. 1-7

Author(s):

O. O. Jabborov

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Environmental Parameters ◽

High Morbidity ◽

Chronic Complications ◽

Genome Wide ◽

High Prevalence ◽

Prevalence Of Diabetes Mellitus ◽

Genome Wide Scan

The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In high prevalence of diabetes mellitus, DN is associated with high morbidity and mortality primarily due to cardiovascular diseases. Genetic factors play a significant role in the pathogenesis of DN and genetically susceptible individuals that can develop after being exposed to environmental parameters. DN is assumed to be a complex, polygenic disease. Genetic predisposition to diabetes is familial, and often with concomitant obesity. A number of detected polymorphisms in genes is a predisposing risk factor for the development of type 2 diabetes. Two main categories have been used to identify the genes associated with DN: (1) analysis of candidate genes, and (2) more recently genome-wide scan. A significant effort has been made to identify these main genes, whereas results are still inconsistent with different genes associated to a small effect in specific populations. A variety of genetic markers characteristic of different population groups confirms the special significance of the ethnic component for identifying hereditary risks, which determines the relevance and need for a detailed, comprehensive study of the genetic basis of type 2 diabetes.

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High Prevalence of Diabetes Mellitus among Adult Patients with Viral Hepatitis C than Hepatitis B

International Journal of Life-Sciences Scientific Research ◽

10.21276/ijlssr.2017.3.5.17 ◽

2017 ◽

Vol 3 (5) ◽

pp. 1365-1369

Author(s):

Golam Azam ◽

Shahinul Alam ◽

Abdullah Saeed Khan ◽

Rubayat Sheikh Giasuddin ◽

Mobin Khan

Keyword(s):

Diabetes Mellitus ◽

Hepatitis C ◽

Hepatitis B ◽

Viral Hepatitis ◽

Adult Patients ◽

Viral Hepatitis C ◽

High Prevalence ◽

Prevalence Of Diabetes Mellitus

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A high prevalence of diabetes mellitus in a municipality of rural Crete, Greece

Diabetic Medicine ◽

10.1046/j.1464-5491.2001.00526.x ◽

2001 ◽

Vol 18 (9) ◽

pp. 768-769 ◽

Cited By ~ 13

Author(s):

C. Lionis ◽

M. Bathianaki ◽

N. Antonakis ◽

S. Papavasiliou ◽

A. Philalithis

Keyword(s):

Diabetes Mellitus ◽

High Prevalence ◽

Prevalence Of Diabetes Mellitus

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The role of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 in diabetic nephropathy

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302011000900002 ◽

2011 ◽

Vol 55 (9) ◽

pp. 677-685 ◽

Cited By ~ 11

Author(s):

Denise Alves Sortica ◽

Daisy Crispim ◽

Guilherme Pozueco Zaffari ◽

Rogério Friedman ◽

Luis Henrique Canani

Keyword(s):

Insulin Resistance ◽

Diabetic Nephropathy ◽

Kinase Activity ◽

Familial Aggregation ◽

Cell Types ◽

Chronic Complications ◽

Nucleotide Pyrophosphatase ◽

Enpp1 Gene ◽

Prevalence Of Diabetes Mellitus

The increased prevalence of diabetes mellitus has caused a rise in the occurrence of its chronic complications, such as diabetic nephropathy (DN), which is associated with elevated morbidity and mortality. Familial aggregation studies have demonstrated that besides the known environmental risk factors, DN has a major genetic component. Therefore, it is necessary to identify genes associated with risk for or protection against DN. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is expressed in several tissues, including the kidneys. Increased levels of ENPP1 expression inhibit tyrosine-kinase activity of the insulin receptor in several cell types, leading to insulin resistance. K121Q polymorphism of the ENPP1 gene seems to be associated with insulin resistance and DN development. The elucidation of genetic factors and their associations will provide better understanding of the pathogenesis of DN and, may consequently, lead to a more effective approach to prevention and treatment.

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Diabetic Patients Who are Amateur Divers

Polish Hyperbaric Research ◽

10.2478/phr-2018-0017 ◽

2018 ◽

Vol 64 (3) ◽

pp. 39-44

Author(s):

Daria Ługowska ◽

Tomasz Ługowski ◽

Olga Krzywińska ◽

Mariusz Kozakiewicz ◽

Paweł Grzelakowski

Keyword(s):

Diabetes Mellitus ◽

Risk Assessment ◽

21St Century ◽

Diabetic Patients ◽

Sport Practice ◽

High Prevalence ◽

Prevalence Of Diabetes Mellitus

Abstract Diabetes is an “epidemic of the 21st century” and it is estimated that in 2011 6.7% of Poland’s population suffered from diabetes, one quarter of which was unaware of the disease. Such a high prevalence of diabetes mellitus results in an increasing number of physicians being confronted with the problem of qualifying patient with diabetes to partake in amateur sports, including diving. This publication presents the most important information concerning risk assessment, admission of diabetic patients to amateur diving and some proposed protocols of management before and during sport practice.

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Beliefs and practices in diabetes care

Duazary ◽

10.21676/2389783x.3222 ◽

2020 ◽

Vol 17 (1) ◽

pp. 74-86

Author(s):

Juan Pablo Álvarez-Najar ◽

Mery Luz Valderrama-Sanabria ◽

Amalia Priscila Peña-Pita

Keyword(s):

Diabetes Mellitus ◽

Health Beliefs ◽

Eating Habits ◽

Communicable Disease ◽

High Morbidity ◽

Economic Costs ◽

Beliefs And Practices ◽

Life Style Changes ◽

High Prevalence ◽

Non Communicable Disease

Diabetes mellitus is considered a chronic non-communicable disease with high morbidity, presents to its high prevalence, social, family, and economic costs. Interventions aimed at life-style changes are fundamental in managing; due to this, patients must receive education. The aim of the study was to identify the beliefs and practices of the persons with diabetes mellitus, to propose nurse care according to these precepts. This was a descriptive study of systematic literature review, searching for articles in databases, Springer Science, Elsevier, ProQuest, Science Direct, Index, Pubmed, SciELO, Medigraphic, and Medline during 2016 to 2018, published between 2001 and 2018, in Spanish, English, and Portuguese. A total of 49 studies were contributing to fulfilling the objective. Within the beliefs for the management of disease, is the use of herbs, some consider as cause "fright"; Others take into account risk factors such as heredity, obesity, poor eating habits. Various beliefs are presented in relation to insulin treatment. Spirituality is emphasized; seeking refuge in God and prayer. Is important to understand the person, from their values, beliefs, customs and feelings. Education is a fundamental tool to control the disease, but health beliefs must be taken into account in order to achieve favorable results.

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