scholarly journals Involvement of the central nervous system in dengue fever: three serologically confirmed cases from Fortaleza, Ceará, Brazil

1998 ◽  
Vol 40 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Pedro F. C. VASCONCELOS ◽  
Amélia P. A. TRAVASSOS DA ROSA ◽  
Ivo C. B. COELHO ◽  
Dalgimar B. MENEZES ◽  
Elizabeth S. TRAVASSOS DA ROSA ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Blood Sample ◽  
Dengue Fever ◽  
Fatal Outcome ◽  
Hemorrhagic Fever ◽  
Nuchal Rigidity ◽  
First Case ◽  
Igm Elisa ◽  
The Central Nervous System

Three cases of dengue fever involving the central nervous system (CNS) are reported. All occurred in 1994 during a dengue (DEN) epidemic caused by serotypes DEN-1 and DEN-2. The first case examined was a 17-year-old girl who complained of fever, nuchal rigidity and genital bleeding. Three blood samples were positive by anti-dengue IgM ELISA and showed hemagglutination-inhibition (HI) test titers <FONT FACE="Symbol">³</font> 1,280. The second case concerned a 86-year-old woman with fever, muscle and joint pains, altered consciousness, syncope, nuchal rigidity and meningismus. Her blood sample showed an HI titer of 1:320 for flaviviruses, and an IgM ELISA positive for dengue. The third case was a 67-year-old woman with fever, abnormal behaviour, seizures, tremor of extremities, thrombocytopenia, increased hematocrit and leukopenia. The patient suffered a typical case of dengue hemorrhagic fever with ensuing shock and a fatal outcome. A single blood sample showed HI antibodies of <FONT FACE="Symbol">³</font> 1,280 and an IgM ELISA positive for dengue. No virus could be isolated from any patient by inoculation of blood into C6/36 cells and suckling mice. No other agent of disease was encountered in the patient.

scholarly journals Extensive systemic metastases from primary central nervous system haemangiopericytoma

2020 ◽  
Vol 6 (2) ◽  
pp. 20190081
Author(s):  
Chi Long Ho ◽  
Jeremy JH Lam ◽  
Robert Chun Chen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Fatal Outcome ◽  
Imaging Features ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Meningeal Tumour ◽  
Local Tumour ◽  
The Central Nervous System ◽  
Extracranial Metastases

Primary intracranial tumours rarely metastasise outside of the central nervous system (CNS). This report describes a rare case of recurrent meningeal haemangiopericytoma with extensive systemic metastases, which eventually resulted in a fatal outcome. We discuss some prevailing theories as to the rarity of extracranial metastases from primary CNS haemangiopericytoma, and elucidate the epidemiology, imaging features, differential diagnosis, treatment, and prognosis of this unusual but surprisingly aggressive meningeal tumour. Besides aggressive treatment for local tumour control, patients with primary CNS haemangiopericytoma require long-term post-treatment surveillance to detect systemic metastases.

Isolated Central Nervous System Hemophagocytic Lymphohistiocytosis: Case Report

Neurosurgery ◽  
2005 ◽  
Vol 56 (1) ◽  
pp. E187-E190 ◽  
Author(s):  
Jun Shinoda ◽  
Satoru Murase ◽  
Katsunobu Takenaka ◽  
Noboru Sakai
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Complete Resolution ◽  
Pathological Examination ◽  
Magnetic Resonance Imaging Scan ◽  
Corticosteroid Administration ◽  
Surgical Specimen ◽  
First Case ◽  
The Central Nervous System

Abstract OBJECTIVE AND IMPORTANCE: The first case of histologically proven hemophagocytic lymphohistiocytosis (HLH) isolated to the central nervous system (CNS) is reported. HLH affecting the CNS mimics several neurological disorders and may be misdiagnosed. The diagnostic and therapeutic problems of this disease are discussed. CLINICAL PRESENTATION: We report a case of a 5-year-old girl with a 2-month history of right hemiparesis. The initial magnetic resonance imaging scan mimicked the appearance of malignant glioma or cerebral infarction. By use of neuroimaging alone, it was extremely difficult to reach an appropriate diagnosis. INTERVENTION: Pathological examination of a surgical specimen of the lesion revealed histological characteristics typical of HLH. Because of the absence of both physical and blood chemical findings of systemic HLH, the patient was diagnosed as having HLH isolated in the CNS without systemic HLH. Radiotherapy with corticosteroid administration led to complete resolution of the CNS lesions, but the duration of remission was only 3 months. The patient died secondary to refractory progression of the CNS lesion. CONCLUSION: Radiotherapy with corticosteroid administration led to a complete resolution of the lesions, although for only a transitory remission. Although HLH is extremely rare, the existence of this disease isolated in the CNS should be documented, and further case accumulation and therapeutic investigations are needed to clarify the pathophysiological characteristics of this disease.

scholarly journals Solitary tentorial sarcoid granuloma associated with Propionibacterium acnes infection: case report

2017 ◽  
Vol 127 (3) ◽  
pp. 687-690 ◽  
Author(s):  
Jiro Akimoto ◽  
Kenta Nagai ◽  
Daisuke Ogasawara ◽  
Yujiro Tanaka ◽  
Hitoshi Izawa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Immune Response ◽  
Nervous System ◽  
Case Report ◽  
Propionibacterium Acnes ◽  
Granulomatous Disease ◽  
Tentorium Cerebelli ◽  
First Case ◽  
Sarcoid Granuloma ◽  
The Central Nervous System

Sarcoidosis is a systemic granulomatous disease with unknown cause, which very rarely occurs exclusively in the central nervous system. The authors performed biopsy sampling of a mass that developed in the left tentorium cerebelli that appeared to be a malignant tumor. The mass was diagnosed as a sarcoid granuloma, which was confirmed with the onset of antibody reaction product against Propionibacterium acnes. Findings suggesting sarcoidosis to be an immune response to P. acnes infection have recently been reported, and they give insight for diagnosis and treatment of this disease. The authors report the possible first case that was confirmed with P. acnes infection in a meningeal lesion in solitary neurosarcoidosis.

SUBPIAL HEMANGIOPERICYTOMA WITH MARKED EXTRAMEDULLARY GROWTH

Neurosurgery ◽  
2007 ◽  
Vol 61 (6) ◽  
pp. E1336-E1337 ◽  
Author(s):  
Daina Kashiwazaki ◽  
Kazutoshi Hida ◽  
Shunsuke Yano ◽  
Toshitaka Seki ◽  
Yoshinobu Iwasaki
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Thoracic Spine ◽  
Vascular Tumors ◽  
First Case ◽  
Intradural Tumor ◽  
The Central Nervous System ◽  
Fibrous Tumor ◽  
Brain And Spinal Cord

Abstract OBJECTIVE Hemangiopericytomas, vascular tumors arising in soft tissue, are relatively rare in the central nervous system; they comprise less than 1% of all hemangiopericytomas. Central nervous system hemangiopericytomas occur primarily in the epidural space of the brain and spinal cord. There are no previous reports of subpial, extramedullary growing central nervous system hemangiopericytomas. CLINICAL PRESENTATION We document the first case of a subpial hemangiopericytoma with extramedullary growth in the thoracic spine. The patient was a 31-year-old man who developed progressively worsening left lower limb numbness that was followed by gait disturbance over the course of 4 months. INTERVENTION Magnetic resonance imaging revealed an intradural tumor at the T4–T6 level of the thoracic spine. Because the patient's symptoms progressed, he underwent resection of the tumor, which had arisen in the spinal cord subpially without attachment to the dura mater. CONCLUSION The pathological diagnosis was hemangiopericytoma. Differential diagnoses include hemangioblastoma, meningioma, schwannoma, and solitary fibrous tumor, the clinical course and prognosis of which are different from hemangiopericytoma. Our experience indicates that hemangiopericytomas can occur as intradural tumors arising from the subpial portion.

scholarly journals Meningitis in a Pregnant Woman Caused by Streptococcus dysgalactiae subspecies equisimilis

2013 ◽  
Vol 62 (2) ◽  
pp. 217-219 ◽  
Author(s):  
ROBERT WALTEREIT ◽  
ULRICH HERRLINGER ◽  
MAIK STARK ◽  
STEFAN BORGMANN
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnant Woman ◽  
Immunocompromised Patients ◽  
Streptococcus Dysgalactiae ◽  
Pathogenic Potential ◽  
First Case ◽  
The Central Nervous System ◽  
Streptococcus Dysgalactiae Subspecies Equisimilis ◽  
The Brain

Infection of the central nervous system by streptococci is known to result in severe bacterial meningitis, however some strains have low pathogenic potential and affect the brain only in immunocompromised patients. Here we report the first case of an otherwise healthy non immunocompromised young adult woman who developed meningitis caused by Streptococcus dysgalactiae subspecies equisimilis. The patient was in the 17th week of her 3rd pregnancy. The course of the disease was quickly remittent under antibiotic treatment.

Regression of intracranial Rosai–Dorfman disease following corticosteroid therapy

2006 ◽  
Vol 104 (5) ◽  
pp. 840-844 ◽  
Author(s):  
Christopher M. McPherson ◽  
Justin Brown ◽  
Angela W. Kim ◽  
Franco Demonte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Corticosteroid Therapy ◽  
Histopathological Analysis ◽  
Extranodal Involvement ◽  
First Case ◽  
Rosai Dorfman Disease ◽  
Effective Option ◽  
The Central Nervous System ◽  
Skull Base Lesions

✓ Rosai–Dorfman disease (RDD) is an idiopathic histioproliferative disorder usually presenting with massive, painless lymphadenopathy. Extranodal involvement has been reported including at least 50 cases affecting the central nervous system (CNS). The treatment of CNS RDD as reported in the literature has primarily involved a surgical technique. The authors report on the case of a 53-year-old man presenting with multiple skull base lesions mimicking meningiomas. The patient suffered visual deterioration and underwent a right orbitopterional craniotomy as well as optic nerve decompression. Histopathological analysis revealed histiocytic cells and emperipolesis consistent with RDD. Following surgery, corticosteroid agents were administered, leading to marked resolution of both the remaining surgically untreated lesions and the balance of the patient's symptoms. This report represents the first case of the resolution of intracranial RDD following corticosteroid therapy. Corticosteroid agents should be considered an effective option in the treatment of CNS RDD.

scholarly journals Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Yi Sun ◽  
Bin Guo ◽  
Hao Yan ◽  
Ai Lan Wu ◽  
Wen Wu Yao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Laboratory Tests ◽  
Hemorrhagic Fever ◽  
Activated Partial Thromboplastin Time ◽  
Zhejiang Province ◽  
Case Presentation ◽  
First Case ◽  
Severe Fever ◽  
Elevated Lactate

Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017. Case presentation A 64-year-old man was admitted to hospital after 4 days of fever. SFTSV was detected 1 day after the patient was admitted to hospital. The patient presented with CNS disturbance and died 4 days after admission. Detailed clinical and epidemiological investigations and laboratory tests were conducted. Reduced platelet, white blood cell, lymphocyte, and neutrophil counts, elevated lactate dehydrogenase, creatine kinase, aspartate aminotransferaseand alanine aminotransferase concentrations, and an increased activated partial thromboplastin time were observed. In a phylogenetic analysis, the isolate clustered close to a strain derived from South Korea. Conclusions: This is the first case of SFTSV infection with CNS disturbance in Dongyang, Zhejiang Province, China. The surveillance of suspected cases of SFTS is important in SFTSV endemic regions.

scholarly journals Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children

2016 ◽  
Author(s):  
Russell Clive Dale
Keyword(s):  
Decision Making ◽  
Central Nervous System ◽  
Nervous System ◽  
Fatal Outcome ◽  
Decision Making Process ◽  
Therapeutic Decision ◽  
Inflammatory Disorders ◽  
Sydenham Chorea ◽  
The Central Nervous System ◽  
Therapeutic Decision Making

Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to improve outcomes. However, the therapeutic decision-making process is complex. The clinician has to balance the risk of disease, with the risk of treatment side effects. To achieve this balance, it is important to understand the natural history of disease, the risk of residual disability, the risk of relapse, and risk of a fatal outcome. It is also important to have some understanding of the pathological processes, as some of the entities have more reversible processes, whereas others have destructive processes. This review will assess the dynamic nature of this decision-making process, and compare some of the more severe diseases such as neuromyelitis optica, anti-N-methyl-D-aspartate receptor encephalitis and opsoclonus myoclonus ataxia syndrome, with disorders with more favourable outcomes such as Sydenham chorea and post-infectious cerebellar ataxia. 

scholarly journals Simultaneous trigonal and spinal meningioma with varied histology: A rare case report

2021 ◽  
Vol 12 ◽  
pp. 611
Author(s):  
H. R. Darshan ◽  
Biren Khimji Patel ◽  
Ajit Singh ◽  
Prakash Nair ◽  
Rajalakshmi Poyuran ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rare Case ◽  
Case Description ◽  
Spinal Meningioma ◽  
Multiple Meningiomas ◽  
First Case ◽  
Rare Case Report ◽  
The Central Nervous System ◽  
Spinal Meningiomas

Background: Meningioma is one of the most common neoplasms of the central nervous system. Multiple meningiomas without neurofibromatosis are not a usual occurrence. Intraventricular meningioma with spinal meningioma is rare and not been reported in the literature. Case Description: We report a case of a 63-year-old male with the left trigonal and spinal meningioma. Both the meningiomas were resected in different settings. The histological examination of tumors revealed to be of varied histology, that is, meningothelial and atypical meningioma, respectively. Conclusion: Although various cases with multiple cranial and spinal meningiomas are described, this is the first case of an intraventricular and spinal meningioma. With varied histology, the case also reaffirms the theory of polyclonal origin of multiple meningiomas.

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