scholarly journals Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni

1986 ◽  
Vol 19 (1) ◽  
pp. 39-42
Author(s):  
Fausto Edmundo Lima Pereira ◽  
Pedro Raso ◽  
Paulo Marcos Zech Coelho
Keyword(s):  
Weight Gain ◽  
Schistosoma Mansoni ◽  
Infected Group ◽  
Sarcoma 180 ◽  
Ascites Tumor ◽  
Tumor Inoculation ◽  
Transplantable Tumor ◽  
Tumoricidal Activity ◽  
Tumor Implantation ◽  
Ascites Formation

Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected mice the weight gain (ascites formation) started later and was shorter than in uninfected Controls. Also, the number of tumor cells into the peritoneal cavity 72h after tumor implantation was shorter in infected group than incontrols. This in creased resistance against a transplantable tumor probably is related to the effect of endotoxin on tumoricidal activity of macrophages activated by the infection. The immunodepression induced by Schistosoma mansoni infection enhances the proliferation of endogenous bacteria increasing the amount of endotoxin absorbed from the gut.

scholarly journals Evolution of sarcoma 180 in mice infected with Trypanosoma cruzi

1983 ◽  
Vol 78 (3) ◽  
pp. 237-244
Author(s):  
Fausto Edmundo Lima Pereira ◽  
William Assad Sassine ◽  
Dimith Chequer Bouhabib ◽  
Elton de Almeida Lucas
Keyword(s):  
Weight Gain ◽  
Trypanosoma Cruzi ◽  
Tumor Cells ◽  
Ascitic Fluid ◽  
Tumor Development ◽  
Sarcoma 180 ◽  
Tumor Inoculation ◽  
Time Intervals ◽  
Tumor Challenge ◽  
Ascites Formation

Mice infected with Trypanosoma cruzi were challenged with 2x10[raised to the power of 6] cells of sarcoma 180 (ascite tumor) by i.p. route, on day seven post infection. Tumor development was followed by evaluation of weight gain, by measurement of ascitic fluid produced and enumeration of tumor cells in ascitic fluid. Infected mice were more resitant to tumor development as demonstrated by reduction in ascites formation and by reduction in the number of tumor cells in ascitic fluid, at different time intervals after tumor challenge. The number of peritoneal cells exsudated after tumor inoculation was greater in infected mice than in controls. This increased resitance of mice infected with T. cruzi to tumor development could be due to the action of macrophages activated by the infection and by the action of endotoxins absorbed from the gut or produced by the own parasite.

scholarly journals Evolution of sarcoma 180 in mice treated with hyperchlorinated water

1983 ◽  
Vol 78 (2) ◽  
pp. 209-214
Author(s):  
Fausto Edmundo Lima Pereira ◽  
Fabio Benezath Chaves
Keyword(s):  
Weight Gain ◽  
Tumor Cells ◽  
Peritoneal Cavity ◽  
Tap Water ◽  
Bactericidal Effect ◽  
Peritoneal Macrophages ◽  
Tumor Evolution ◽  
Sarcoma 180 ◽  
Tumor Implantation ◽  
Effect Of Chlorine

Mice treated with hyperchlorinated water (50 ppm of chlorine) and control mice, drinking tap water (1-3 ppm of chlorine) were inoculated with 2.5 x 10 [raised to the power of 6] sarcoma 180 cells, by intraperitoneal route. Tumor evolution was measured by enumeration of tumor cells in peritoneal cavity and by evaluation of weight gain at different time intervals after tumor implantation. In mice treated with excessive amounts of chlorine there was enhancement of tumor growth demonstrated by: (a) shorter incubation period and increased weight gain (ascites formation) after tumor implantation; (b) increased number of tumor cells in the peritoneal cavity 2, 3 and 4 days after tumor challenge. The number of peritoneal cells exsudated after tumor implantation was lower in mice treated with hyperchlorinated water than in controls. The tumor enhancement observed after excessive chlorine ingestion would be due to: (a) reduction of the number of peritoneal macrophages that migrate to the peritoneal cavity and (b) reduction of the tumoricidal capacity of peritonela macrophages induced by the direct effect of chlorine or by the reduction of the amount of endogenous endotoxins due to the bactericidal effect of chlorine.

Yersinia enterocolitica enteritis affects rabbit intestinal longitudinal smooth muscle function

1992 ◽  
Vol 262 (2) ◽  
pp. G278-G284 ◽  
Author(s):  
R. B. Scott ◽  
D. T. Tan
Keyword(s):  
Smooth Muscle ◽  
Weight Gain ◽  
Food Intake ◽  
Yersinia Enterocolitica ◽  
Biomechanical Properties ◽  
Isometric Tension ◽  
Infected Group ◽  
Tension Development ◽  
Longitudinal Smooth Muscle ◽  
Tension Curves

To determine whether Yersinia enterocolitica (YE) enteritis has an effect on the biomechanical properties of intestinal smooth muscle, New Zealand White rabbits (600-900 g) were divided into an infected group (n = 9) and sham-infected animals fed ad libitum (n = 9), or pair fed with the infected group (n = 9). Animals were inoculated with 10(10) organisms of YE in 10 ml NaHCO3 (infected group) or 10 ml NaHCO3 (sham-infected control and pair-fed groups) at time 0. Daily food intake, weight gain, and YE excretion were noted. Six days later animals were killed and longitudinal smooth muscle strips prepared from proximal (P), medial (M), and distal (D) segments of intestine in each treatment group. Isometric tension was recorded in tissue baths perfused with oxygenated Krebs solution and 10(-6) M tetrodotoxin. Basal and active (the response to 10(-5) M carbachol) length-tension curves were generated. Then, with the muscle strips stretched to their optimum length for tension development, the dose response to carbachol and to graded depolarization with KCl was determined. Infected animals had a significantly reduced food intake and weight gain compared with controls. The development of basal tension with stretch was not significantly different in infected compared with control or pair-fed tissues from the same site.(ABSTRACT TRUNCATED AT 250 WORDS)

Antitumor Activity of Fermented Colostrum and Milk

1983 ◽  
Vol 46 (5) ◽  
pp. 385-386 ◽  
Author(s):  
K. M. SHAHANI ◽  
B. A. FRIEND ◽  
P. J. BAILEY
Keyword(s):  
Lactobacillus Acidophilus ◽  
Streptococcus Thermophilus ◽  
Lactobacillus Bulgaricus ◽  
Ehrlich Ascites Tumor Cells ◽  
Ascites Tumor ◽  
Tumor Implantation ◽  
Cell Counts ◽  
Ehrlich Ascites ◽  
Whole Milk ◽  
Ad Libitum

Male Swiss mice, implanted with Ehrlich ascites tumor cells, were fed each of the following test materials: fresh bovine colostrum, colostrum cultured with Lactobacillus acidophilus, colostrum cultured with Lactobacillus bulgaricus, colostrum cultured with L. bulgaricus and Streptococcus thermophilus, milk cultured with L. acidophilus and milk cultured with L. bulgaricus. Fresh colostrum had no significant effect when fed ad libitum for 7 consecutive days after tumor implantation. Colostrum fermented with L. acidophilus, L. bulgaricus or yogurt culture significantly (P< 0.05) inhibited tumor cell proliferation as indicated by a 16 to 40% decrease in cell counts and a 13 to 35% decrease in DNA synthesis. Similar effects were noted for whole milk fermented with either L. acidophilus or L. bulgaricus.

β-lapachone enhancement of lipid peroxidation and superoxide anion and hydrogen peroxide formation by Sarcoma 180 ascites tumor cells

1979 ◽  
Vol 28 (6) ◽  
pp. 723-728 ◽  
Author(s):  
Roberto Docampo ◽  
Fernando S. Cruz ◽  
Alberto Boveris ◽  
Ramiro P.A. Muniz ◽  
Darci M.S. Esquivel
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Tumor Cells ◽  
Superoxide Anion ◽  
Sarcoma 180 ◽  
Ascites Tumor ◽  
Peroxide Formation ◽  
Hydrogen Peroxide Formation

A study of subclinical worm infestation in sheep: Part II. The ‘tolerance’ level of infestation

1957 ◽  
Vol 49 (2) ◽  
pp. 223-228 ◽  
Author(s):  
C. R. W. Spedding ◽  
T. H. Brown
Keyword(s):  
Weight Gain ◽  
Live Weight ◽  
Infected Group ◽  
High Rate ◽  
Live Weight Gain ◽  
Tolerance Level ◽  
Worm Infestation ◽  
Weight Gains ◽  
Nematode Eggs ◽  
Different Levels

1. The live-weight gain of lambs initially infected at five different levels was compared with that of similar but worm-free animals, under conditions of set-stocking at a high rate per acre.2. Over a period of 9 months the worm-free controls gained 67·7% more weight than the total infected group, but the live-weight gains of the five levels did not appear to be related to their original infection or to their egg counts.3. Although a few nematode eggs were detected in the faeces of some control lambs, reinfection was negligible under the conditions of this experiment.4. It was concluded that a marked depression of productivity may be associated with an egg count as low as 114 e.p.g. in sheep 4–7 months of age.

AUTORADIOGRAPHIC STUDIES OF THE DISTRIBUTION OF 1-AMINOCYCLOPENTANE CARBOXYLIC ACID IN NORMAL AND CANCEROUS MICE

1962 ◽  
Vol 40 (1) ◽  
pp. 1111-1114 ◽  
Author(s):  
L. Berlinguet ◽  
Nicole Bégin ◽  
L. M. Babineau
Keyword(s):  
Bone Marrow ◽  
Amino Acid ◽  
Carboxylic Acid ◽  
Tumor Cells ◽  
Ehrlich Ascites Tumor ◽  
Sarcoma 180 ◽  
Ascites Tumor ◽  
Ehrlich Ascites

Normal and cancerous mice were injected with 1-aminocyclopentane C14-carboxylic acid and the distribution of the drug in the animals was studied by autoradiography. In normal mice, the amino acid is concentrated selectively by the pancreas and the bone marrow. In cancerous mice (Ehrlich ascites tumor and sarcoma-180), the tumor cells also intensively accumulate the amino acid.

Cytoskeletal proteins associated with cell surface envelopes from Sarcoma 180 ascites tumor cells

1976 ◽  
Vol 72 (1) ◽  
pp. 288-294 ◽  
Author(s):  
Pamela B. Moore ◽  
Darrell R. Anderson ◽  
John W. Huggins ◽  
Kermit L. Carraway
Keyword(s):  
Cell Surface ◽  
Tumor Cells ◽  
Cytoskeletal Proteins ◽  
Sarcoma 180 ◽  
Ascites Tumor
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