Nonwoven polypropylene prosthesis in large abdominal wall defects in rats

PURPOSE: To evaluate, in large abdominal wall defects surgically shaped in rats, if a synthetic polypropylene nonwoven prosthesis could be used as a therapeutic option to conventional polypropylene mesh. METHODS: Twenty four (24) Wistar rats were enrolled into three groups. Group 1 (Simulation group) with an abdominal wall defect of 3 X 3 left untreated and Groups 2 and 3, respectively treated with a conventional polypropylene mesh and a polypropylene nonwoven (NWV) prosthesis to cover the breach. At the 45th postoperatively day, adhesion (area and strength) and vascularization of Groups 2 and 3 were evaluated. The histological preparations with Hematoxylin-Eosin, Tricromium of Masson, Pricrosirius red and polarization with birefringence, and also the structural analysis of the prostheses carried on by Thermogravimetry and Differential Scanning Calorimetry were also assessed. RESULTS: There were no significant differences between the Groups 2 and 3. CONCLUSION: In rats, the polypropylene nonwoven prosthesis showed to be safe and has to be considered as an alternative to conventional mesh manufactured by weaving in the treatment of great defects of the abdominal wall.

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Preparation of poly(l-lactic acid)-modified polypropylene mesh and its antiadhesion in experimental abdominal wall defect repair

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.32947 ◽

2013 ◽

Vol 102 (1) ◽

pp. 12-21 ◽

Cited By ~ 24

Author(s):

Zhigang Zhang ◽

Tianzhu Zhang ◽

Junsheng Li ◽

Zhenling Ji ◽

Hemei Zhou ◽

...

Keyword(s):

Lactic Acid ◽

Abdominal Wall ◽

Polypropylene Mesh ◽

Abdominal Wall Defect ◽

Wall Defect ◽

Defect Repair

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Left-Sided Gastroschisis

The American Surgeon ◽

10.1177/000313480607200713 ◽

2006 ◽

Vol 72 (7) ◽

pp. 637-640 ◽

Cited By ~ 2

Author(s):

Kenneth W. Gow ◽

Amina Bhatia ◽

Daniel F. Saad ◽

Mark L. Wulkan ◽

Kurt F. Heiss

Keyword(s):

Abdominal Wall ◽

Clinical Course ◽

Abdominal Wall Defect ◽

Abdominal Wall Defects ◽

Wall Defect ◽

The Right

Gastroschisis is a periumbilical, abdominal wall defect arising to the right of the umbilicus. We describe the clinical course of a left-sided gastroschisis in a term female born at 39 weeks’ gestation. To our knowledge, there have been only 14 left-sided abdominal wall defects reported in the literature. We discuss our case and review the literature to try to determine if there is any clinic difference between right- versus left-sided lesions to make recommendations as to management.

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How safe is the use of prosthetic materials in the repair of abdominal-wall defects in malnourished subjects?

Open Medicine ◽

10.2478/s11536-009-0029-2 ◽

2009 ◽

Vol 4 (3) ◽

pp. 331-336 ◽

Cited By ~ 1

Author(s):

Mehmet Karahan ◽

Hakan Kulacoglu ◽

Duray Seker ◽

Zafer Ergul ◽

Aysel Kiziltay ◽

...

Keyword(s):

Wound Healing ◽

Abdominal Wall ◽

Polypropylene Mesh ◽

Histopathological Examination ◽

Abdominal Wall Defect ◽

Infectious Complications ◽

Abdominal Wall Defects ◽

Tissue Samples ◽

Significant Difference ◽

Histopathological Studies

AbstractIncisional hernias and abdominal-wall defects consume large amounts of healthcare resources. Use of mesh is effective in treatment of these disorders and can decrease the rate of recurrence. This experimental study focused on the safety of mesh use in the setting of malnutrition, a condition that impairs wound healing. Rats were divided into two groups: normally fed and food-restricted. An abdominal-wall defect, 2 by 2 cm, was covered with polypropylene mesh, 2.5 by 2.5 cm. After sacrifice of the rats at the 21st and 60th days, tissue samples were sent for tensiometric and histopathological studies. No significant difference in infectious complications was observed between the two groups. Tensiometry revealed no significant differences between the groups. On histopathological examination, the only difference noted was in the vascularization scores of normally fed rats. For malnourished subjects that survived after surgery, the use of polypropylene mesh appeared safe in the closure of abdominal-wall defects, with no increase in infection rate and satisfactory wound healing.

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The Oscar Ramirez Procedure, a Solution for Treating Incisional Hernias with Big Abdominal Wall Defect

Acta Medica Marisiensis ◽

10.2478/amma-2014-0026 ◽

2014 ◽

Vol 60 (3) ◽

pp. 122-124

Author(s):

M. Gherghinescu ◽

D. Popa ◽

A. Panțiru ◽

C. Russu ◽

C. Roșca ◽

...

Keyword(s):

Abdominal Wall ◽

Abdominal Wall Defect ◽

Postoperative Recovery ◽

Oblique Muscle ◽

Abdominal Wall Defects ◽

Hernia Sac ◽

Wall Defect ◽

External Edge ◽

Incisional Hernias ◽

Bowel Movements

Abstract Background: Incisional hernias are important complications of abdominal surgery. Normally they are followed by the growth of the hernia sac and an increase of the abdominal wall defect with loss of domain of the herniated organs. Case report: We report a case of a 51 year old female, admitted in the 1st Surgical Clinic of the County Emergency Clinical Hospital of Tîrgu Mureș with a large median reducible incisional hernia and a wall defect of 10/12 cm. The abdominoplasty was performed using the Oscar Ramirez technique, which consists of a longitudinal incision along the aponeurosis of the external oblique muscle, at approximately 1-2 cm from the external edge of the rectus abdominis. This procedure allows the abdominal wall closure. This case is part of a lot of 4 patients who received this treatment using the aforementioned procedure in the past 2 months. Postoperative recovery was favorable, bowel movements were present on the second day after the surgery, the subcutaneous drains were shortened on the fifth day and removed on the sixth. There were no immediate postoperative complications or up to a month after the surgery. The patient was discharged on the seventh day. Conclusions: This technique can be used alone in case of large abdominal wall defects, or prequeling an on-lay mesh procedure addressed to a weak abdominal wall, case in which the functional result is superior to a substitutional mesh.

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Rectus Abdominis Muscle Malignant Fibrous Histiocytoma Causing a Large Abdominal Wall Defect: Reconstruction with Biological Mesh

Case Reports in Surgery ◽

10.1155/2014/723851 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3

Author(s):

Evangelos Falidas ◽

Stavros Gourgiotis ◽

Christina Goudeli ◽

Stavros Mathioulakis ◽

Konstantinos Vlachos ◽

...

Keyword(s):

Soft Tissue ◽

Abdominal Wall ◽

Malignant Fibrous Histiocytoma ◽

Fibrous Histiocytoma ◽

Abdominal Wall Defect ◽

Biological Mesh ◽

Rectus Abdominis ◽

Abdominal Wall Defects ◽

Rectus Abdominis Muscle ◽

Wall Defect

Malignant fibrous histiocytoma (MFH) is a common soft tissue sarcoma usually involving limbs and retroperitoneum. MFH of the rectus abdominis muscle is extremely rare. Surgery in similar cases leads to large abdominal wall defects needing reconstruction. Biological and synthetic laminar absorbable prostheses are available for the repair of hernia defects in the abdominal wall. They share the important feature of being gradually degraded in the host, resulting the formation of a neotissue. We herein report the case of an 84-year-old man with MFH of the rectus abdominis muscle which was resected and the large abdominal wall defect was successfully repaired with a biological mesh.

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One of Curious Congenital Midline Abdominal Defects In Newborn: A Giant Omphalozele In A 3 Years-Old Boy

Journal of Regenerative Biology and Medicine ◽

10.37191/mapsci-2582-385x-3(4)-073 ◽

2021 ◽

Author(s):

Stefan Bittmann

Keyword(s):

Abdominal Wall ◽

Abdominal Wall Defect ◽

Abdominal Wall Defects ◽

Wall Defect ◽

Lateral Abdominal Wall ◽

The Third ◽

Abdominal Organs ◽

Wall Components ◽

Congenital Abdominal Wall Defects

Omphalocele is one of the congenital abdominal wall defects and specifically refers to an umbilical ring defect in which the abdominal organs protrude in front of the abdominal wall in a thin sac or membrane. Such an abdominal wall defect develops around the third week of pregnancy due to the failure of adhesion between the embryonic lateral abdominal wall components.

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Assembled anti-adhesion polypropylene mesh with self-fixable and degradable in situ mussel-inspired hydrogel coating for abdominal wall defect repair

Biomaterials Science ◽

10.1039/c8bm00824h ◽

2018 ◽

Vol 6 (11) ◽

pp. 3030-3041 ◽

Cited By ~ 11

Author(s):

Wanjun Hu ◽

Zhigang Zhang ◽

Shenglin Lu ◽

Tianzhu Zhang ◽

Naizhen Zhou ◽

...

Keyword(s):

Abdominal Wall ◽

Polypropylene Mesh ◽

Abdominal Wall Defect ◽

Wall Defect ◽

Defect Repair ◽

Hydrogel Coating

Construction of assembled anti-adhesion polypropylene mesh through in situ coating with self-fixable and degradable hydrogels.

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Use of alloplastic meshes in abdominal wounds of rats with induced peritonitis

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/s0102-67202014000100007 ◽

2014 ◽

Vol 27 (1) ◽

pp. 26-29 ◽

Cited By ~ 3

Author(s):

Rafael Calvão BARBUTO ◽

Ivana DUVAL-ARAUJO ◽

Sumara Marques BARRAL ◽

Raphael Grossi ROCHA ◽

Cristiane de Souza BECHARA ◽

...

Keyword(s):

Tensile Strength ◽

Abdominal Wall ◽

Granulation Tissue ◽

Abdominal Wall Defect ◽

Test Group ◽

Microscopic Analysis ◽

Female Rats ◽

Control Group ◽

Abdominal Wall Defects ◽

Wall Defect

Background : The use of alloplastic meshes has been historically contra-indicated in patients with infection. Aim : To evaluate the use of polypropylene meshes in the treatment of abdominal wall defects in rats with peritonitis. Methods : Twenty Wistar female rats were divided into two groups: induction of peritonitis (test group) and without peritonitis (control group). An abdominal wall defect was created in all animals, and polypropylene mesh was applied. The evaluation of the tensile strength of the mesh was carried out using tensiometer and microscopic analysis of the healing area was done. Results : More adhesion of the mesh to the rat abdominal wall was observed in test group. The histopathological analyses showed prevalence of moderate to accentuated granulation tissue in both groups, without significant differences. Conclusion : The use of the mesh coverage on abdominal wall defects of rats with induced peritonitis did not show worse results than its use in healthy animals, nor was its integration to the resident tissue any worse.

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Abdominal wall repair with human acellular dermal autograft

Surgical Techniques Development ◽

10.4081/std.2012.e6 ◽

2011 ◽

Vol 2 (1) ◽

pp. 6

Author(s):

Roel E. Genders ◽

Paul P.G.M. Kouwenberg ◽

Rob P. Bleichrodt

Keyword(s):

Abdominal Wall ◽

Abdominal Wall Defect ◽

Operative Procedure ◽

Abdominal Wall Defects ◽

Dermal Matrix ◽

Wall Defect ◽

Mortality And Morbidity ◽

Acellular Dermis ◽

Number Of Patients ◽

Acellular Dermal

Repair of abdominal wall defects in the presence of contamination or infection is a significant problem. The loss of tissue warrants enforcement of the abdominal wall, preferably by autologous material. However, autologous repair often requires extensive surgery. This paper presents a review of available literature of placement of an acellular human dermis to repair an abdominal fascia defect, in contaminated as well as in non-contaminated surgical fields. It is illustrated with a case report that describes the successful reconstruction of an infected abdominal wall defect with a human acellular dermis allograft. A systematic literature review was undertaken with searches performed in the Pubmed and Cochrane databases for the period up till March 2009, using the search terms Alloderm [Substance Name], Hernia [Mesh] and the key words acellular dermis, acellular dermal matrix, human acellular dermal allograft and abdominal wall defect. To assess methodological quality, each article was subjected to a modification of the methodological index for non-randomized studies (MINORS) according to Slim et al. Two items from the original index were not included because none of the studies selected had an unbiased assessment of the study end points and in none of the studies was a prospective calculation of the study size performed. Seventeen studies were included in the review. Data were extracted regarding study design, number of patients, surgical technique, followup period, contaminated or non-contaminated area of the fascia defect, mortality and morbidity (hemorrhage, seroma, wound dehiscence, infection) of the operative procedure, the longterm results (removal of the graft, reherniation and bulging) and level of evidencey. A total of 169 short-term complications and 151 longterm complications occurred after 643 surgical procedures reconstructing both contaminated and clean abdominal wall defects by implantation of an HADA. Human acellular dermal allograft seems to be a good alternative for autologous repair of contaminated or infected abdominal wall defects.

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