Synthesis and characterization of nanostructured ceramics powders for biomedical applications

Nanostructured materials have been largely studied in the last few years because they have a great potential to applications in different fields like physics, chemistry, biology, mechanic and medicine. Synthesis and characterization of nanostructured materials is a subject of great interest involving science, market, politicians, government and society. The nanostructured materials are in demand in biomedical area, mainly the bioceramics composed of calcium phosphates (Ca/P), which have an excellent biocompatibility and mineralogical characteristics similar to those of bones. The aim of this work was to optimize the method of powder synthesis of nanostructured calcium phosphate and of nanocomposites composed of calcium phosphate//SiO2n, containing 5, 10 and 15% (in volume) of nanometric silica (SiO2n). The results are expressed according to the method of synthesis, mineralogical and morphological characterization, and thermal behavior for the different compositions of the nanostructured powder synthesized.

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Synthesis and Characterization of Nanostructured Ceramic Powders of Calcium Phosphate and Hydroxyapatite for Dental Applications

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.396-398.619 ◽

2008 ◽

Vol 396-398 ◽

pp. 619-622 ◽

Cited By ~ 7

Author(s):

Nelson Heriberto A. Camargo ◽

S. de Lima ◽

Julio C.P. Souza ◽

Juliana F. de Aguiar ◽

E. Gemelli ◽

...

Keyword(s):

Calcium Phosphate ◽

Calcium Phosphates ◽

Bone Matrix ◽

Morphological Characterization ◽

Synthesis And Characterization ◽

Infrared Spectrometry ◽

X Ray Diffraction ◽

Nanostructured Ceramic ◽

Dental Applications

In the last decades many investigations have been oriented toward the development of nanostructured biomaterials such as calcium phosphate ceramics, particularly those composed of stoicheiometric hydroxyapatite (Ca10(PO4)6(OH)2) and a-and β- tricalcium phosphate (Ca3(PO4)2), which present chemical and crystallographic similarities with hard tissues (bones and teeth). Because of these characteristics, these materials can be used for reconstitution and regeneration of bone tissues. The odontological and biomedical applications are still limited due to their brittle behaviour. This study was focused in the synthesis and characterization of a bone matrix of calcium phosphate (β-TCP) and hydroxyapatite (HAP-101 e HAp-201). The results presented here are related to the morphological characterization of nanostructured powders from scanning electron microscopy viewpoint. X-ray diffraction was used to identifier the present phases in the powders and the infrared spectrometry (FTIR) was used to analyse OH bonds from hydroxyapatite and PO4 from calcium phosphates.

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Study and Characterization of Powders Nanocomposites Calcium Phosphate/Silica-Gel (SiO2n) Obtained from Attrition Milling: For Biomedical Applications

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.396-398.615 ◽

2008 ◽

Vol 396-398 ◽

pp. 615-618

Author(s):

Rodrigo Brandão ◽

Fernando Pupio ◽

Nelson Heriberto A. Camargo ◽

E. Gemelli

Keyword(s):

Calcium Phosphate ◽

Silica Gel ◽

Biomedical Applications ◽

Bone Matrix ◽

Synthesis And Characterization ◽

X Ray Diffraction ◽

X Ray ◽

Attrition Milling ◽

Bone Calcium

The bioceramics nanostructured have made important characteristics in biomedical applications, especially the calcium phosphate ceramics. The aim of this work is synthesis and characterization of calcium phosphate and nanocomposites powders, the method of dissolution of CaO in liquid medium, precipitation and formation of bone calcium phosphate matrix, and nanocomposites by adding the solution of phosphoric acid (H3PO4). The nanocomposites powders were synthesized using as strengthening silica gel nanometer (20nm) at concentrations of 1%, 2%, 3% and 5% by volume and subjected to heat treatment to 900°C for 2 hours, seeking obtained HA (Hydroxyapatite). Later the bone matrix of calcium phosphate and nanocomposites powders were subjected from process attrition milling for 2 hours, by way of comparison. The studies characterizations were conducted through the technique of X-ray diffraction, scanning electron microscopy (SEM) and dilatometric test.

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Synthesis and Characterization of Hydrated Calcium Phosphate: Precursors for Obtaining Biocements

Materials Science Forum ◽

10.4028/www.scientific.net/msf.798-799.443 ◽

2014 ◽

Vol 798-799 ◽

pp. 443-448

Author(s):

Priscila Ferraz Franczak ◽

Nelson Heriberto Almeida Camargo ◽

Pricyla Corrêa ◽

Enori Gemelli

Keyword(s):

Calcium Phosphate ◽

Biomedical Applications ◽

Fine Particles ◽

Calcium Phosphates ◽

Synthesis Method ◽

Synthesis Process ◽

Promising Alternative ◽

Hydrated Calcium ◽

Reactive Method

Calcium phosphates biocements are biomaterials that present crystallographic and mineralogical characteristics similar to human skeletal structure. This has led to the development of new calcium phosphates biomaterials for biomedical applications, especially biomaterials for repairing defects and bone reconstruction. Calcium phosphates biocements are a promising alternative in biomedical applications, for they are easy to mold, they have good wettability, hydration and hardening capacity during its application in biological means. This work aimed at the synthesis of hydrated calcium phosphates powder, through a simple reactive method, which will be the basis for the production of calcium phosphate biocimentos with self-setting reaction. Three calcium phosphates compositions were produced via CaCO3/phosphoric acid reactive method in the ratios Ca/P = 1,5; 1,6 e 1,67 molar. The presented results are associated to hydrated powder morphology and synthesis process control. Scanning Electron Microscopy (SEM) helped with the morphological characterization of the powders, the laser analysis method was used for determining particle size and the Fourier Transformed Infrared Spectroscopy (FTIR) gave support to the identification of H2O e PO43-grouping vibrational bands. The work showed that for the different powder compositions the hydrated calcium phosphate phase is formed by clustered fine particles. This demonstrated that the chosen synthesis method permits the obtention of hydrated calcium phosphates, precursors for later biocement production.

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Synthesis and Characterization of Nanostructured Calcium Phosphates: Colloidal Suspension Rheological Study

Materials Science Forum ◽

10.4028/www.scientific.net/msf.881.153 ◽

2016 ◽

Vol 881 ◽

pp. 153-158

Author(s):

Marli Baltazar Roesler Eckstein ◽

Nelson Heriberto Almeida Camargo ◽

Camila Thais Mamani ◽

Priscila Ferraz Franczak ◽

Daiara Floriano-Silva ◽

...

Keyword(s):

Shear Rate ◽

Calcium Phosphate ◽

Calcium Phosphates ◽

Broad Class ◽

Colloidal Suspension ◽

Chemical Characterization ◽

Morphological Characterization ◽

Living Tissues ◽

Synthesis Methodology

Calcium phosphates bioceramics are a broad class of biomaterials, known by properties like biocompatibility and bioactivity in living tissues. The aim of this paper was the synthesis by wet method and characterization of nanostructured calcium phosphate powders in the Ca/P ratio of 1.67molar and rheological evaluation of the colloidal suspension during the synthesis: suspension viscosity with variable shear rate. Morphological characterization was performed for the hydrated nanostructured calcium phosphate powder by scanning electron microscopy with field effect, crystallography by X-Ray diffractometry, chemical characterization by Fourier Transformed Infrared Spectroscopy. The results demonstrated that varying the shear rate has a direct influence on the viscosity values according to time. This result may contribute to the development of a synthesis methodology for nanostructured calcium phosphate powders.

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Synthesis and Characterization of Ceramic Modified with Niobium for Biomedical Applications

Materials Science Forum ◽

10.4028/www.scientific.net/msf.869.884 ◽

2016 ◽

Vol 869 ◽

pp. 884-889

Author(s):

Nadia Sueli Vieira Capanema ◽

Alexandra A.P. Mansur ◽

Herman Sander Mansur

Keyword(s):

Biomedical Applications ◽

Room Temperature ◽

Structural Changes ◽

Calcium Phosphates ◽

Synthesis And Characterization ◽

Body Parts ◽

New Materials ◽

X Ray Diffraction ◽

X Ray

The need for obtaining new materials to replace human body parts that were destroyed or damaged led scientists from different areas of research for developing new biomaterials. Thus, the aim of this work was the synthesis and characterization of niobium-modified apatite bioceramics. Calcium phosphates (CaP) were synthesized with niobium partially replacing calcium sites using aqueous precipitation route at room temperature. The bioceramics, with and without Nb incorporation, were characterized by scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD) as prepared and after heat treatments The results indicated that Nb was incorporated in the apatite structure promoting morphological and structural changes in the ceramic properties.

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Synthesis and Characterization of a Hydrated Calcium Phosphate Matrix and Biphasic Compositions with MgO and α-Al2O3

Materials Science Forum ◽

10.4028/www.scientific.net/msf.881.165 ◽

2016 ◽

Vol 881 ◽

pp. 165-170

Author(s):

Priscila Ferraz Franczak ◽

Nelson Heriberto Almeida Camargo ◽

Daiara Floriano-Silva ◽

Marli Baltazar Roesler Eckstein ◽

Maicon Douglas Possamai

Keyword(s):

Calcium Phosphate ◽

Synthesis Method ◽

Morphological Characterization ◽

Synthesis And Characterization ◽

Fourier Transformed Infrared Spectroscopy ◽

The Matrix ◽

Vibrational Bands ◽

Wet Synthesis ◽

Hydrated Calcium

The calcium phosphate bioceramics are characterized by chemical and crystallographic similarity with the human skeleton. The wet synthesis method was used in the preparation of hydrated calcium phosphate nanostructured powders and biphasic compositions of calcium phosphate matrix. This study aimed the synthesis and characterization of a hydrated calcium phosphate matrix in the ratio Ca/P 1.67 molar and two biphasic compositions of hydrated calcium phosphate matrix, with 1% MgO and 5% α-Al2O3. Scanning Electron Microscopy (SEM) helped with the powders morphological characterization, X-ray diffractometry (XRD) served for crystallographic characterization of powders and Fourier Transformed Infrared Spectroscopy (FTIR) gave support to the identification of H2O, CO32- and PO43- grouping vibrational bands. The work showed that the presence of 1% MgO inside the hydrated calcium phosphate matrix provided brushite formation and the presence of 5% α-Al2O3 in the matrix provided the hydrated calcium phosphate powder.

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Synthesis and characterization of Fe-containing biphasic calcium phosphate ceramics

Journal of the Australian Ceramic Society ◽

10.1007/s41779-018-0245-9 ◽

2018 ◽

Vol 55 (2) ◽

pp. 381-385 ◽

Cited By ~ 5

Author(s):

Omer Kaygili

Keyword(s):

Calcium Phosphate ◽

Biphasic Calcium Phosphate ◽

Synthesis And Characterization ◽

Calcium Phosphate Ceramics

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Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells

RSC Advances ◽

10.1039/d0ra08959a ◽

2021 ◽

Vol 11 (16) ◽

pp. 9076-9085

Author(s):

Kanchan Yadav ◽

Megha Das ◽

Nurul Hassan ◽

Archana Mishra ◽

Jayeeta Lahiri ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Cancer Cells ◽

Live Cell Imaging ◽

Biomedical Applications ◽

Breast Cancer Cells ◽

Cell Imaging ◽

Synthesis And Characterization ◽

Novel Protein

A novel nanodot-using protein has been synthesized for the live cell imaging and drug delivery of melatonin in breast cancer cells. Its unique properties hold potential for various biomedical applications in the field of bioimaging and drug delivery.

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