scholarly journals Subclinical naming errors in mild cognitive impairment: A semantic deficit?

2008 ◽  
Vol 2 (3) ◽  
pp. 217-222 ◽  
Author(s):  
Indra F. Willers ◽  
Mónica L. Feldman ◽  
Ricardo F. Allegri
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Semantic Processing ◽  
Critical Factor ◽  
Boston Naming Test ◽  
Confrontation Naming ◽  
Straightforward Method ◽  
Semantic Errors ◽  
Comprehensive Classification ◽  
Error Types

Abstract Mild cognitive impairment (MCI) is the transitional stage between normal aging and Alzheimer's disease (AD). Impairments in semantic memory have been demonstrated to be a critical factor in early AD. The Boston Naming Test (BNT) is a straightforward method of examining semantic or visuo-perceptual processing and therefore represents a potential diagnostic tool. The objective of this study was to examine naming ability and identify error types in patients with amnestic mild cognitive impairment (aMCI). Methods: Twenty aMCI patients, twenty AD patients and twenty-one normal controls, matched by age, sex and education level were evaluated. As part of a further neuropsychological evaluation, all subjects performed the BNT. A comprehensive classification of error types was devised in order to compare performance and ascertain semantic or perceptual origin of errors. Results: AD patients obtained significantly lower total scores on the BNT than aMCI patients and controls. aMCI patients did not obtain significant differences in total scores, but showed significantly higher semantic errors compared to controls. Conclusion: This study reveals that semantic processing is impaired during confrontation naming in aMCI.

Validation of the Thai version of the short Boston Naming Test (T-BNT) in patients with Alzheimer’s dementia and mild cognitive impairment: clinical and biomarker correlates.

2018 ◽  
Vol 23 (7) ◽  
pp. 840-850 ◽  
Author(s):  
Daruj Aniwattanapong ◽  
Sookjaroen Tangwongchai ◽  
Thitiporn Supasitthumrong ◽  
Solaphat Hemrunroj ◽  
Chavit Tunvirachaisakul ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer’S Dementia ◽  
Boston Naming Test ◽  
Alzheimer's Dementia ◽  
Naming Test

Prospective memory in amnestic mild cognitive impairment

2009 ◽  
Vol 15 (3) ◽  
pp. 407-415 ◽  
Author(s):  
STELLA KARANTZOULIS ◽  
ANGELA K. TROYER ◽  
JILL B. RICH
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Memory ◽  
Amnestic Mild Cognitive Impairment ◽  
Attention Switching ◽  
Memory For Intentions ◽  
Neuropsychological Evaluations ◽  
Event Based ◽  
Cue Detection ◽  
Error Types

AbstractIndividuals with amnestic mild cognitive impairment (aMCI) often complain of difficulty remembering to carry out intended actions, consistent with findings of impaired prospective memory (PM) in this population. In this study, individuals with aMCI (N = 27) performed worse than healthy controls (N = 27) on the Memory for Intentions Screening Test (Raskin, 2004), including on time- and event-based subscales, and recognition of the intentions. The aMCI participants made more errors overall, but the proportion of the various error types did not differ between the two groups. Across all error types, both groups made more retrospective than prospective errors, especially on event-based PM tasks. Overall, the findings suggest that PM impairment in aMCI is associated with deficient cue detection involving both automatic (as in event-based tasks) and more strategic detection (as in time-based tasks) processes. These difficulties are likely due to a combination of problematic retrospective episodic memory (e.g., reduced encoding and/or consolidation of cue–intention pairings) and executive functions (e.g., decreased self-initiation, attention switching, and/or inhibition on memory tasks). Formal assessment of PM may help characterize the nature of the memory impairment among individuals with aMCI in clinical neuropsychological evaluations. (JINS, 2009, 15, 407–415.)

scholarly journals Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment

2020 ◽  
pp. 1-8
Author(s):  
Jung-Min Pyun ◽  
Nayoung Ryoo ◽  
Young Ho Park ◽  
SangYun Kim
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Disease Progression ◽  
Vascular Risk Factors ◽  
Plasma Fibrinogen ◽  
Cognitive Test ◽  
Vascular Risk ◽  
Confrontation Naming

<b><i>Background:</i></b> Fibrinogen is considered a marker of vascular pathology, indicating a weakened blood-brain barrier, and has a causative role in neuroinflammation and neurodegeneration. Little is known about the relationship between fibrinogen levels and cognitive function in patients with mild cognitive impairment (MCI). We aimed to investigate differences in cognitive profiles according to plasma fibrinogen levels in patients with MCI and the influence of plasma fibrinogen levels on cognitive decline. <b><i>Methods:</i></b> This retrospective cohort study included 643 patients with MCI: 323 patients in the high fibrinogen (high fib) group and 320 patients in the low fibrinogen (low fib) group. A multiple linear regression model was performed to compare cognitive test performance between groups. The Cox proportional hazard model was used to analyze the hazard ratio of fibrinogen level for disease progression. <b><i>Results:</i></b> The high fib group demonstrated poorer performance in attention, executive function, and confrontation naming than the low fib group. After adjustment for <i>APOE</i> genotype, the high fib group was associated with poor attention and executive function. After adjustment for vascular risk factors including body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking history, the high fib group showed declined attention and confrontation naming ability. High fibrinogen levels did not predict disease progression to CDR 1. <b><i>Conclusion:</i></b> High plasma fibrinogen levels were associated with poor performance in attention in patients with MCI, regardless of <i>APOE</i> genotype or vascular risk factors.

scholarly journals Role of cognitive reserve in progression from mild cognitive impairment to dementia

2010 ◽  
Vol 4 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Ricardo F. Allegri ◽  
Fernando E. Taragano ◽  
Hugo Krupitzki ◽  
Cecilia M. Serrano ◽  
Carol Dillon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Reserve ◽  
Cognitive Strategies ◽  
Clinical Activity ◽  
First Year ◽  
Boston Naming Test ◽  
Dementia Risk ◽  
Degenerative Dementia

Abstract Cognitive reserve is the ability to optimize performance through differential recruitment of brain networks, which may reflect the use of alternative cognitive strategies. Objectives: To identify factors related to cognitive reserve associated with progression from mild cognitive impairment (MCI) to degenerative dementia. Methods: A cohort of 239 subjects with MCI (age: 72.2±8.1 years, 58% women, education: 12 years) was assessed and followed for five years (2001 to 2006). Results: In the first year, 13.7% of MCI converted to dementia and 34.7% converted within three years (78.3% converted to Alzheimer's dementia). Risk factors for those who converted were education less than 12 years, MMSE score less than 27, Boston naming test score less than 51, IQ (Intelligence Quotient) less than 111, age over 75 years, lack of occupation at retirement, and presence of intrusions in memory recall (all account for 56% of the variability of conversion). Conclusions: MCI patients are a population at high risk for dementia. The study of risk factors (e.g. IQ, education and occupation), particularly those related to cognitive reserve, can contribute important evidence to guide the decision-making process in routine clinical activity and public health policy.

Expanded Exploration of the Auditory Naming Test in Patients with Dementia

2021 ◽  
pp. 1-17
Author(s):  
Joseph A. Hirsch ◽  
George M. Cuesta ◽  
Pasquale Fonzetti ◽  
Joseph Comaty ◽  
Barry D. Jordan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Control Variable ◽  
Index Score ◽  
Diagnostic Utility ◽  
Boston Naming Test ◽  
Mean Response Time ◽  
Confrontation Naming ◽  
Normal Individuals ◽  
Increased Sensitivity ◽  
Naming Test

Background: Auditory naming tests are superior to visual confrontation naming tests in revealing word-finding difficulties in many neuropathological conditions. Objective: To delineate characteristics of auditory naming most likely to reveal anomia in patients with dementia, and possibly improve diagnostic utility, we evaluated a large sample of patients referred with memory impairment complaints. Methods: Patients with dementia (N = 733) or other cognitive impairments and normal individuals (N = 69) were evaluated for frequency of impairment on variables of the Auditory Naming Test (ANT) of Hamberger & Seidel versus the Boston Naming Test (BNT). Results: Naming impairment occurred more frequently using the ANT total score (φ= 0.41) or ANT tip-of-the tongue score (TOT; φ= 0.19) but not ANT mean response time compared to the BNT in patients with dementia (p <  0.001). Significantly more patients were impaired on ANT variables than on the BNT in Alzheimer’s disease (AD), vascular dementia (VaD), mixed AD/VaD, and multiple domain mild cognitive impairment (mMCI) but not in other dementias or amnestic MCI (aMCI). This differential performance of patients on auditory versus visual naming tasks was most pronounced in older, well-educated, male patients with the least cognitive impairment. Impaired verbal comprehension was not contributory. Inclusion of an ANT index score increased sensitivity in the dementia sample (92%). Poor specificity (41%) may be secondary to the inherent limitation of using the BNT as a control variable. Conclusion: The ANT index score adds diagnostic utility to the assessment of naming difficulties in patients with suspected dementia.

scholarly journals Textual Inference Comprehension in Mild Cognitive Impairment: The Influence of Semantic Processing and Verbal Episodic Memory

2021 ◽  
Vol 13 ◽  
Author(s):  
Maria Paula Maziero ◽  
Ariella Fornachari Ribeiro Belan ◽  
Marina von Zuben de Arruda Camargo ◽  
Marcela Lima Silagi ◽  
Orestes Vicente Forlenza ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Episodic Memory ◽  
Semantic Processing ◽  
Semantic Knowledge ◽  
Amnestic Mild Cognitive Impairment ◽  
Control Group ◽  
Inference Making ◽  
Healthy Elderly ◽  
Verbal Episodic Memory

Language complaints, especially in complex tasks, may occur in mild cognitive impairment (MCI). Various language measures have been studied as cognitive predictors of MCI conversion to Alzheimer's type dementia. Understanding textual inferences is considered a high-demanding task that recruits multiple cognitive functions and, therefore, could be sensitive to detect decline in the early stages of MCI. Thus, we aimed to compare the performance of subjects with MCI to healthy elderly in a textual inference comprehension task and to determine the best predictors of performance in this ability considering one verbal episodic memory and two semantic tasks. We studied 99 individuals divided into three groups: (1) 23 individuals with amnestic mild cognitive impairment (aMCI), (2) 42 individuals with non-amnestic mild cognitive impairment (naMCI), (3), and (4) 34 cognitively healthy individuals for the control group (CG). A reduced version of The Implicit Management Test was used to assess different types of inferential reasoning in text reading. MCI patients performed poorer than healthy elderly, and there were no differences between MCI subgroups (amnestic and non-amnestic). The best predictors for inference-making were verbal memory in the aMCI and semantic tasks in the naMCI group. The results confirmed that the failure to understand textual inferences can be present in MCI and showed that different cognitive skills like semantic knowledge and verbal episodic memory are necessary for inference-making.

scholarly journals Neural signatures of predictive language processing in parkinson’s disease with and without mild cognitive impairment

2020 ◽  
Author(s):  
Patricia León-Cabrera ◽  
Javier Pagonabarraga ◽  
Joaquín Morís ◽  
Saúl Martínez-Horta ◽  
Juan Marín-Lahoz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Language Processing ◽  
Semantic Processing ◽  
Sentence Comprehension ◽  
Event Related Potentials ◽  
Final Word ◽  
Related Potentials

ABSTRACTCognitive deficits are common in Parkinson’s disease (PD), with some PD patients meeting criteria for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is preserved in PD. This ability is nowadays deemed crucial in achieving fast and efficient comprehension, and it may be negatively impacted by cognitive deterioration. To fill this gap of knowledge, we used event-related potentials (ERPs) to evaluate mechanisms of linguistic prediction in a sample of PD patients (on dopamine compensation) with and without MCI. To this end, participants read sentence contexts that were predictive or not about a sentence-final word. The final word appeared after 1 second, matching or mismatching the prediction. The introduction of the interval allowed to capture neural responses both before and after sentence-final words, reflecting semantic anticipation and processing. PD patients with normal cognition (N = 58) showed ERP responses comparable to those of matched controls. Specifically, in predictive contexts, a slow negative potential developed prior to sentence-final words, reflecting semantic anticipation. Later, expected words elicited reduced N400 responses (compared to unexpected words), indicating facilitated semantic processing. Besides, PD patients with MCI (N = 20) showed a prolongation of the N400 congruency effect (compared to matched PD patients without MCI), indicating that further cognitive decline impacts semantic processing. Finally, lower verbal fluency scores correlated with prolonged N400 congruency effects and with reduced pre-word differences in all PD patients (N = 78). This relevantly points to a role of deficits in temporal-dependent mechanisms in PD, besides prototypical frontal dysfunction, in altered semantic anticipation and semantic processing during sentence comprehension.

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