scholarly journals Parasite Community of Cichla kelberi (Perciformes, Cichlidae) in the Três Marias Reservoir, Minas Gerais, Brazil

2014 ◽  
Vol 23 (3) ◽  
pp. 367-374 ◽  
Author(s):  
Michelle Daniele Santos-Clapp ◽  
Marilia Carvalho Brasil-Sato
Keyword(s):  
Parasite Community ◽  
Minas Gerais ◽  
Ecological Requirements ◽  
Biogeographical Distribution ◽  
Positive Correlations ◽  
Associated Species ◽  
First Time ◽  
Peacock Bass ◽  
Três Marias Reservoir

A total of 112 specimens of yellow peacock bass, Cichla kelberi, were collected in the Três Marias Reservoir, upper São Francisco River, State of Minas Gerais, between 2004 and 2005. Twelve species of parasites were collected: two species of ectoparasites (the monogenetic Gussevia sp. and the copepod Ergasilus sp.); and ten species of endoparasites, including four species of adult endoparasites: the cestodes Proteocephalus macrophallus and P. microscopicus, and the nematodes: Capillostrongyloides sentinosa and Rhabdochona acuminata, and six species of larval endoparasites: the metacercariae of Austrodiplostomum compactum and the nematodes: Hysterothylacium sp., Contracaecum sp. Type 1, Procamallanus (Spirocamallanus) inopinatus, Spiroxys sp., and Goezia sp.. A significant positive correlation in the abundance of the two adult endoparasites species, P. macrophallus and P. microscopicus, may indicate that such associated species had the same ecological requirements. The positive correlations between the prevalence of the larval endoparasites, Hysterothylacium sp. and A. compactum, may indicate that there was opportunism for the two generalists species. Ergasilus sp., C. sentinosa, R. acuminata and Hysterothylacium sp. were recorded for the first time in C. kelberi, and this increased their list of known hosts. In addition, both proteocephalid species and C. sentinosa can extend their known biogeographical distribution to the Três Marias Reservoir.

scholarly journals Central precocious puberty in a girl with LEGIUS syndrome: an accidental association?

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Valentina Orlandi ◽  
Paolo Cavarzere ◽  
Laura Palma ◽  
Rossella Gaudino ◽  
Franco Antoniazzi
Keyword(s):  
Genetic Analysis ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Neurofibromatosis Type ◽  
Case Presentation ◽  
New Variant ◽  
Legius Syndrome ◽  
Timing Of Puberty ◽  
First Time

Abstract Background Central precocious puberty is a condition characterized by precocious activation of the hypothalamic-pituitary-gonadal axis. It may be idiopathic or secondary to organic causes, including syndromes such as Neurofibromatosis type 1 (NF1). Case presentation We presented a girl of 6 years and 10 months with almost 11 café-au-lait skin macules, without other clinical or radiological signs typical of NF1, and with a central precocious puberty. Genetic analysis evidenced the new variant NM-152594.2:c.304delAp. (Thr102Argfs*19) in SPRED1 gene, which allowed to diagnose Legius syndrome. Conclusions We report for the first time a case of central precocious puberty in a girl with Legius syndrome. The presence of central precocious puberty in a child with characteristic café-au-lait macules should suggest pediatricians to perform genetic analysis in order to reach a definitive diagnosis. Further studies on timing of puberty in patients with RASopathies are needed to better elucidate if this clinical association is casual or secondary to their clinical condition.

scholarly journals EXPRESS: Pulmonary Hypertension Associated With Neurofibromatosis Type 2

2021 ◽  
pp. 204589402110295
Author(s):  
Hirohisa Taniguchi ◽  
Tomoya Takashima ◽  
Ly Tu ◽  
Raphaël Thuillet ◽  
Asuka Furukawa ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Neurofibromatosis Type ◽  
Pulmonary Vascular Remodeling ◽  
Life Threatening ◽  
History Of ◽  
Pulmonary Arterial ◽  
First Time

Although precapillary pulmonary hypertension (PH) is a rare but severe complication of patients with neurofibromatosis type 1 (NF1), its association with NF2 remains unknown. Herein, we report a case of a 44-year-old woman who was initially diagnosed with idiopathic pulmonary arterial hypertension (IPAH) and treated with PAH-specific combination therapy. However, a careful assessment for a relevant family history of the disease and genetic testing reveal that this patient had a mutation in the NF2 gene. Using immunofluorescence and Western blotting, we demonstrated a decrease in endothelial NF2 protein in lungs from IPAH patients compared to control lungs, suggesting a potential role of NF2 in PAH development. To our knowledge, this is the first time that precapillary PH has been described in a patient with NF2. The altered endothelial NF2 expression pattern in PAH lungs should stimulate work to better understand how NF2 is contributing to the pulmonary vascular remodeling associated to these severe life-threatening conditions.

Continuous Ketone Monitoring: A New Paradigm for Physiologic Monitoring

2021 ◽  
pp. 193229682110098
Author(s):  
Jennifer Y. Zhang ◽  
Trisha Shang ◽  
Suneil K. Koliwad ◽  
David C. Klonoff
Keyword(s):  
Interstitial Fluid ◽  
Good Accuracy ◽  
Physiologic Monitoring ◽  
New Paradigm ◽  
Continuous Glucose Monitor ◽  
Sensor Platform ◽  
Wired Enzyme ◽  
First Time

In this issue of JDST, Alva and colleagues present for the first time, development of a continuous ketone monitor (CKM) tested both in vitro and in humans. Their sensor measured betahydroxybutyrate (BHB) in interstitial fluid (ISF). The sensor was based on wired enzyme electrochemistry technology using BHB dehydrogenase. The sensor required only a single retrospective calibration without a need for further adjustments over 14 days. The device produced a linear response over the 0-8 mM range with good accuracy. This novel CKM could provide a new dimension of useful automatically collected information for managing diabetes. Passively collected ISF ketone information would be useful for predicting and managing ketoacidosis in patients with type 1 diabetes, as well as other states of abnormal ketonemia. Although additional studies of this CKM will be required to assess performance in intended patient populations and prospective factory calibration will be required to support real time measurements, this novel monitor has the potential to greatly improve outcomes for people with diabetes. In the future, a CKM might be integrated with a continuous glucose monitor in the same sensor platform.

Découverte d’une nouvelle population de Rhithrogena delphinensis Sowa & Degrange, 1987, dans le massif des Arves, et compléments à la description de la larve (Ephemeroptera, Heptageniidae)

2021 ◽  
Vol 126 (4) ◽  
pp. 401-420
Author(s):  
Bertrand Launay ◽  
Julien Barnasson ◽  
Juliette Becquet ◽  
Michel Brulin ◽  
Sophie Cauvy-Fraunie ◽  
...  
Keyword(s):  
Drainage Basin ◽  
Morphological Characteristics ◽  
Western Alps ◽  
Coi Gene ◽  
Morphological Description ◽  
Base Pairs ◽  
Northern Flank ◽  
Ecological Requirements ◽  
First Time ◽  
Existing Data

Discovery of a new population of Rhithrogena delphinensis Sowa & Degrange, 1987, in the Arves Massif, and additions to the morphological description of the larva (Ephemeroptera, Heptageniidae). Rhithrogena delphinensis, described originally on the basis of four larvae from the Western Alps, south of the Arves Massif and from the northern flank of the Ecrins Massif, had not been captured again since 1986. Here, we report the discovery of a new population from river Arvan, whose drainage basin is located between the Grandes Rousses Massif and the northern flank of the Arves Massif. This newly discovered population seems abundant in numbers, and reveals the particular ecological requirements of the species as well as its dependence on glacier fed or nival streams. The morphological characteristics of the larvae are described in detail, and illustrated by photographs. The variability of some of the proposed identification criteria is discussed, and a key to the identification of the Rhithrogena species from the alpestris group of the Western Alps, to which R. delphinensis belongs, is provided. Finally, a portion of 658 base pairs of the COI gene of R. delphinensis is sequenced for the first time and compared to already existing data on the alpestris group in the Western Alps.

scholarly journals Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation-Dependent Cellular Translation Shutoff via PERK/GCN2

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuanzhi Liu ◽  
Anchun Cheng ◽  
Mingshu Wang ◽  
Sai Mao ◽  
Xumin Ou ◽  
...  
Keyword(s):  
Virus Type ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Translation Efficiency ◽  
Eif2α Phosphorylation ◽  
Duck Hepatitis ◽  
Cellular Translation ◽  
First Time

Duck hepatitis A virus type 1 (DHAV-1) is one of the most deadly pathogens that endanger the duck industry. Most viruses usually turn off host translation after infection to facilitate viral replication and translation. For the first time report to our knowledge, DHAV-1 can induce eIF2α phosphorylation and inhibit cellular translation in duck embryo fibroblasts (DEFs). Moreover, the activity of DHAV-1 in the cells caused obvious eIF2α phosphorylation, which has nothing to do with the viral protein. Subsequently, we screened two kinases (PERK and GCN2) that affect eIF2α phosphorylation through inhibitors and shRNA. Notably, the role of GCN2 in other picornaviruses has not been reported. In addition, when the phosphorylation of eIF2α induced by DHAV-1 is inhibited, the translation efficiency of DEFs restores to a normal level, indicating that DHAV-1 induced cellular translation shutoff is dependent on eIF2α phosphorylation.

scholarly journals Prévalence d’anticorps dirigés contre les virus de la fièvre catarrhale ovine, de l’herpèsvirus bovin de type 1 et de la diarrhée bovine/maladie des muqueuses chez le buffle d’eau dans l’Etat de Minas Gerais, Brésil

1996 ◽  
Vol 49 (3) ◽  
pp. 195-197
Author(s):  
A.P. Lage ◽  
R.S. Castro ◽  
M.I.V. Melo ◽  
P.H.P. Aguiar ◽  
J.B. Barreto Filho ◽  
...  
Keyword(s):  
Minas Gerais

Une étude sérologique visant à identifier les buffles porteurs d'anticorps dirigés contre les virus de la fièvre catarrhale ovine (BTV), de l'herpèsvirus de type 1 (BHV 1) et de la maladie des muqueuses (BVD) a été réalisée dans l'Etat de Minas Gerais, au Brésil. Dans 54,4 % des sérums testés, des anticorps précipitants anti-BTV ont été mis en évidence par immunodiffusion en gelose. Le test de séroneutralisation sur microplaque a montré que 14,7 % et 52,7 % des buffles présentaient respectivement des anticorps anti-BHV 1 et anti-BVD. La prévalence d'anticorps dirigés contre BTV était, de manière significative, inférieure chez les buffles d'eau âgés de moins de deux ans à celle observée chez les adultes.

Too many floristic inventories? New records in seasonal semi-deciduous forest in the Serra da Mantiqueira in Minas Gerais state answer this question

Rodriguésia ◽  
2021 ◽  
Vol 72 ◽  
Author(s):  
Daniel Elias Ferreira Barbosa ◽  
Geicilaine Alves Basilio ◽  
Luciana Carvalho Pereira ◽  
Diego Rafael Gonzaga ◽  
Alain Chautems ◽  
...  
Keyword(s):  
New Records ◽  
Deciduous Forest ◽  
Minas Gerais ◽  
The State ◽  
Primary Data ◽  
Minas Gerais State ◽  
Great Relevance ◽  
Brazilian Flora ◽  
Floristic Data ◽  
First Time

Abstract The importance of continuously conducting botanical inventories has been questioned in recent decades, generating a lack of investment and interest in this area. However, several applied studies are only possible after obtaining the primary data from such surveys. Despite having the greatest richness of plants known in Brazil, several areas with knowledge gaps remain in Minas Gerais (MG) state. This is the case for the Serra da Mantiqueira, an important area for biodiversity conservation in the country. In this scenario, the phytophysiognomy of Seasonal Semi-deciduous Forest (SSF) deserves attention, as it is broadly distributed and has great relevance in the state, although subsampled. Therefore, this study aimed to present records of species for the flora of MG and discuss the need for floristic surveys in Brazil. These species were recorded in three of 10 studied remnants along expeditions performed between the years of 2012 and 2019 as part of a wide study performed in SSF remnants in the Serra da Mantiqueira which have a deficit of floristic data. Three species are recorded for the first time in MG, one species was rediscovered after more than two centuries from the last collection (which represents its nomenclatural type), in addition to nine other species which must be considered rare in the state. This study contributed to filling gaps in knowledge on Brazilian flora and also demonstrated the relevance of continuing new collections, mainly in specific subsampled areas in the interior of the country such as in SSF remnants.

scholarly journals Cloning, expression and enzyme activity delineation of two novel CANT1 mutations: the disappearance of dimerization may indicate the change of protein conformation and even function

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Hong-Dan Wang ◽  
Liang-Jie Guo ◽  
Zhan-Qi Feng ◽  
Da-Wei Zhang ◽  
Meng-Ting Zhang ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Cloning And Expression ◽  
Expression Vectors ◽  
Extracellular Secretion ◽  
Chinese Origin ◽  
Desbuquois Dysplasia ◽  
Pathogenic Change ◽  
First Time

Abstract Background Desbuquois dysplasia (DBQD) was a rare autosomal recessive skeletal dysplasia. Calcium activated nucleotidase 1 (CANT1) mutation was identified as a common pathogenic change for DBQD type 1 and Kim variant but not for DBQD type 2. To our knowledge, all patients with DBQD type 1 currently found could be explained by mutations in the CANT1 gene, but mutations in the CANT1 gene might not be directly diagnosed as DBQD type 1. Results We have identified two novel CANT1 mutations (mut1: c.594G > A [p.Trp198*], mut2: c.734C > T [p.Pro245Leu]) in three children from a family of Chinese origin for the first time. Two of the three children could be diagnosed as typical DBQD type 1 and one child could not be diagnosed as DBQD type 1 based on the clinical data we had. To further clarify the effect of the two mutations of the CANT1 gene, we studied the CANT1 gene expression and detected the protein secretion and nucleotide enzyme activity through cDNA cloning and expression vectors construction for wild and mutant types. The mut1 was a nonsense mutation which could lead to premature termination and produced the truncated bodies; The CANT1 dimer of mut2 was significantly reduced and even undetectable. The extracellular secretion of mut1 was extremely high while mut2 was significantly reduced compared with the wild type. And mut1 and mut2 also could result in a significant reduction in the activity of CANT1 nucleotidease. From the results we could deduce that the two mutations of the CANT1 gene were the causes of the two cases in this study. Conclusions Regarding the particularity of the cases reported in this study, the pathogenesis of CANT1 might be more complicated. The genetic and phenotype of three children with the same genetic background need to be further studied. Larger cohort of patients was needed to establish genotype–phenotype correlations in DBQD.

scholarly journals On Brazilian Helobata Bergroth, 1888 (Coleoptera: Hydrophilidae) II: new distribution data

2018 ◽  
Vol 58 ◽  
pp. e20185835
Author(s):  
Bruno Clarkson ◽  
Lucia M. Almeida
Keyword(s):  
Minas Gerais ◽  
Distribution Data ◽  
Cerrado Biome ◽  
Brazilian Species ◽  
First Time ◽  
New Distribution

As an add-on to the work of Clarkson et al. (2016), new distributional data on species of Helobata Bergroth, 1888 (Hydrophilidae: Acidocerinae) from Brazil is provided. Helobata amazonensis Clarkson, Santos & Ferreira‑Jr., 2016, is recorded for the first time for Roraima State and its female is recorded for the first time. Helobata quatipuru Fernández & Bachmann, 1987 and H. larvalis (Horn, 1873) are recorded for the first time for Minas Gerais, Cerrado Biome area. The genus is recorded for the first time for Goiás State. Additions and modifications in the previously published key to Brazilian species are provided.

On the spider genus Cryptachaea from Peru, Bolivia and cave environments in Brazil: a new species, additional descriptions and new records (Araneae, Theridiidae)

Zootaxa ◽  
2019 ◽  
Vol 4646 (2) ◽  
pp. 271-292
Author(s):  
MANOELA SANTANNA ◽  
EVERTON NEI LOPES RODRIGUES ◽  
IGOR CIZAUSKAS ◽  
ANTONIO DOMINGOS BRESCOVIT
Keyword(s):  
New Species ◽  
New Records ◽  
Minas Gerais ◽  
Sao Paulo ◽  
São Paulo ◽  
Mato Grosso ◽  
Males And Females ◽  
First Time ◽  
Mato Grosso Do Sul ◽  
A New Species

In this paper a new species of Cryptachaea Archer, 1946 based on males and females is described from Brazilian caves: Cryptachaea pilar Santanna & Rodrigues, new species from the states of Minas Gerais and São Paulo. The females of Cryptachaea parana (Levi, 1963) and C. schneirlai (Levi, 1959) are described and illustrated for the first time. Cryptachaea uviana (Levi, 1963) is synonymized with C. migrans (Keyserling, 1884). The species Cryptachaea alacris (Keyserling, 1884), C. benivia Rodrigues & Poeta, 2015, C. parana (Levi, 1963) and C. schneirlai (Levi, 1959) are recorded for the first from Brazil; and C. migrans for the first time from Bolivia. Additionally, new records from Brazilian caves are provided for Cryptachaea parana, from the states of Tocantins, Goiás, Minas Gerais, Mato Grosso do Sul and São Paulo; C. schneirlai and C. alacris from the state of Pará; C. dea (Buckup & Marques, 2006) and C. rioensis (Levi, 1963) from Pará and Minas Gerais, C. jequirituba (Levi, 1963) from Minas Gerais and C. benivia from São Paulo. 

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