Functional Abnormalities in the Neural Circuitry of Reading in Men with Nonsyndromic Clefts of the Lip or Palate

2006 ◽  
Vol 43 (6) ◽  
pp. 683-690 ◽  
Author(s):  
Grant Goldsberry ◽  
Dan O'Leary ◽  
Rich Hichwa ◽  
Peg Nopoulos
Keyword(s):  
Blood Flow ◽  
Language Processing ◽  
Oral Reading ◽  
Neural Circuit ◽  
Occipital Lobe ◽  
Neural Circuitry ◽  
Brain Regions ◽  
Healthy Controls ◽  
Positron Emission ◽  
Increased Blood Flow

Objective: The current study was designed to evaluate the neurobiology of reading in a group of men with nonsyndromic clefts of the lip or palate (NSCLP) compared with healthy controls by positron emission tomography. Design: Subjects included eight men with NSCLP compared with six healthy control men. By using radioactively labeled water (O15), regional brain blood flow was obtained during the performance of three simple reading tasks: reading unrelated words, reading unrelated sentences, and reading a story. Results: During each of the reading conditions, NSCLP subjects compared with healthy controls showed increased blood flow in areas previously reported to be involved in language processing and reading (inferior frontal lobe, cerebellum, and occipital lobe). The increased blood flow suggests a possible neural inefficiency. In contrast, when analyzing the brain regions involved in more complex language functioning (reading stories compared with reading only words), control subjects showed an increase in blood flow in a distributed neural circuit, whereas the NSCLP subjects showed a decrease in flow in these regions. Additionally, the NSCLP subjects had activation of several regions not activated in the healthy controls, suggesting a compensatory circuit used for this more complex reading task. Conclusions: These results indicate that subjects with NSCLP show abnormalities in the function of the distributed neural circuitry used for oral reading.

Oral reading in bilingual aphasia: Evidence from Mongolian and Chinese

2007 ◽  
Vol 10 (2) ◽  
pp. 201-210 ◽  
Author(s):  
BRENDAN STUART WEEKES ◽  
I FAN SU ◽  
WENGANG YIN ◽  
XIHONG ZHANG
Keyword(s):  
Language Processing ◽  
Oral Reading ◽  
Word Processing ◽  
Brain Regions ◽  
Writing Systems ◽  
Word Comprehension ◽  
Bilingual Aphasia ◽  
Written Word ◽  
Cognitive Neuropsychological ◽  
The Brain

Cognitive neuropsychological studies of bilingual patients with aphasia have contributed to our understanding of how the brain processes different languages. The question we asked is whether differences in script have any impact on language processing in bilingual aphasic patients who speak languages with different writing systems: Chinese and Mongolian. We observed a pattern of greater impairment to written word comprehension and oral reading in L2 (Chinese) than in L1 (Mongolian) for two patients. We argue that differences in script have only a minimal effect on written word processing in bilingual aphasia when the age of acquisition, word frequency and imageability of lexical items is controlled. Our conclusion is that reading of familiar words in Mongolian and Chinese might not require independent cognitive systems or brain regions.

Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla 1H-MRS

Cephalalgia ◽  
2014 ◽  
Vol 34 (12) ◽  
pp. 959-967 ◽  
Author(s):  
R Zielman ◽  
WM Teeuwisse ◽  
F Bakels ◽  
J Van der Grond ◽  
A Webb ◽  
...  
Keyword(s):  
Occipital Lobe ◽  
Brain Regions ◽  
Biochemical Changes ◽  
High Spectral Resolution ◽  
7 Tesla ◽  
Healthy Controls ◽  
Hemiplegic Migraine ◽  
1H Mrs ◽  
Total N ◽  
The Brain

Aim The aim of this study was to assess biochemical changes in the brain of patients with hemiplegic migraine in between attacks. Methods Eighteen patients with hemiplegic migraine (M:F, 7:11; age 38 ± 14 years) of whom eight had a known familial hemiplegic migraine (FHM) mutation (five in the CACNA1A gene (FHM1), three in the ATP1A2 gene (FHM2)) and 19 age- and sex-matched healthy controls (M:F, 7:12; mean age 38 ±  12 years) were studied. We used single-voxel 7 tesla 1H-MRS (STEAM, TR/TM/TE = 2000/19/21 ms) to investigate four brain regions in between attacks: cerebellum, hypothalamus, occipital lobe, and pons. Results Patients with hemiplegic migraine showed a significantly lower total N-acetylaspartate/total creatine ratio (tNAA/tCre) in the cerebellum (median 0.73, range 0.59–1.03) than healthy controls (median 0.79, range (0.67–0.95); p = 0.02). In FHM1 patients with a CACNA1A mutation, the tNAA/tCre was lowest. Discussion We found a decreased cerebellar tNAA/tCre ratio that might serve as an early biomarker for neuronal dysfunction and/or loss. This is the first high-spectral resolution 7 tesla 1H-MRS study of interictal biochemical brain changes in hemiplegic migraine patients.

Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans

2008 ◽  
Vol 104 (1) ◽  
pp. 212-217 ◽  
Author(s):  
Andrew P. Binks ◽  
Vincent J. Cunningham ◽  
Lewis Adams ◽  
Robert B. Banzett
Keyword(s):  
Blood Flow ◽  
Nucleus Accumbens ◽  
Positron Emission Tomography Imaging ◽  
Occipital Lobe ◽  
Brain Regions ◽  
Functional Brain Imaging ◽  
Regions Of Interest ◽  
Breath Hold ◽  
Obstructive Sleep ◽  
The Brain

Hypoxia increases cerebral blood flow (CBF), but it is unknown whether this increase is uniform across all brain regions. We used H215O positron emission tomography imaging to measure absolute blood flow in 50 regions of interest across the human brain ( n = 5) during normoxia and moderate hypoxia. Pco2 was kept constant (∼44 Torr) throughout the study to avoid decreases in CBF associated with the hypocapnia that normally occurs with hypoxia. Breathing was controlled by mechanical ventilation. During hypoxia (inspired Po2 = 70 Torr), mean end-tidal Po2 fell to 45 ± 6.3 Torr (means ± SD). Mean global CBF increased from normoxic levels of 0.39 ± 0.13 to 0.45 ± 0.13 ml/g during hypoxia. Increases in regional CBF were not uniform and ranged from 9.9 ± 8.6% in the occipital lobe to 28.9 ± 10.3% in the nucleus accumbens. Regions of interest that were better perfused during normoxia generally showed a greater regional CBF response. Phylogenetically older regions of the brain tended to show larger vascular responses to hypoxia than evolutionary younger regions, e.g., the putamen, brain stem, thalamus, caudate nucleus, nucleus accumbens, and pallidum received greater than average increases in blood flow, while cortical regions generally received below average increases. The heterogeneous blood flow distribution during hypoxia may serve to protect regions of the brain with essential homeostatic roles. This may be relevant to conditions such as altitude, breath-hold diving, and obstructive sleep apnea, and may have implications for functional brain imaging studies that involve hypoxia.

scholarly journals The diagnostic value of 3D-ASL in vertebral artery stenosis among individuals at risk of stroke

2019 ◽  
Author(s):  
DanDan Xu ◽  
XinMing Huang ◽  
GuoEn Cai ◽  
XiaoXia Yang ◽  
YingQing Wang ◽  
...  
Keyword(s):  
At Risk ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Vertebral Artery ◽  
Occipital Lobe ◽  
Brain Regions ◽  
Artery Stenosis ◽  
Vertebral Artery Stenosis ◽  
Left And Right ◽  
The Difference

Abstract Background: This study explored the predictive value of 3D-ASL for vertebral artery stenosis (VAS) in individuals at risk of stroke. Methods: A total of 43 participants at risk of stroke were enrolled in our study. All participants underwent 3D-ASL and carotid artery computed tomography angiography (CTA) or cervical vascular ultrasound. Cerebral blood flow (CBF) was measured in the left and right frontal lobes, temporal lobes, parietal lobes, occipital lobes, basal ganglia, thalamus, cerebellum, and hippocampus. Calculate the CBF BI (CBF BI means: The absolute value of the difference in cerebral blood flow in the corresponding brain regions on the left and right sides of the enrolled personnel) of the corresponding brain regions of the left and right between the VAS group and the non-VAS group respectively. To evaluate the predictive value of 3D-ASL for vascular stenosis in participants at risk of stroke, we used two-sample t-tests to determine if there were significant differences in BI. Results: Among 43 participants at risk of stroke we recruited, 20 participants with vertebral artery stenosis (the VAS group) and 23 without vertebral artery stenosis (the non-VAS group). There were significant differences in BI of the occipital lobe between the VAS group and the non-VAS group (p < 0.05). According to the occipital lobe BI value, the receiver operating characteristic curve (ROC) demonstrated best diagnostic limits of 10.46 ml/(100g×min). Conclusion: Using 3D-ASL to detect cerebral blood flow and calculate the difference of bilateral occipital cerebral blood flow which can help to diagnose vertebral artery stenosis in high risk population of stroke.

scholarly journals Subcortical Hypermetabolism Associated With Cortical Hypometabolism Is a Common Metabolic Pattern in Patients With Anti-Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaobin Zhao ◽  
Shaokun Zhao ◽  
Yaojing Chen ◽  
Zhanjun Zhang ◽  
Xiaotong Li ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Parietal Lobe ◽  
Statistical Parametric Mapping ◽  
Occipital Lobe ◽  
Healthy Controls ◽  
Metabolic Pattern ◽  
Individual Level ◽  
Positron Emission ◽  
Neurologic Disability ◽  
The Individual

PurposeBrain 18F-fluorodeoxyglucose positron emission tomography (FDG PET) is a sensitive technique for assisting in the diagnosis of patients with anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis. However, the common pattern of this disorder assessed by FDG PET remains unknown. The present study aimed to explore the glucose metabolic patterns of this disorder based on PET voxel analysis.MethodsThis retrospective study enrolled 25 patients with anti-LGI1 encephalitis, who were admitted in Beijing Tiantan Hospital between September 2014 and July 2019. The glucose metabolic pattern was compared between the included patients and 44 age- and gender-matched healthy controls using Statistical Parametric Mapping. Then, the correlation between the metabolic pattern and scaled activities of daily living (ADLs) of the patients was assessed.ResultsThe median time from symptom onset to PET scans was 9 w (range:2-53w). The groupwise analysis revealed that patients with anti-LGI1 encephalitis had left hippocampal hypermetabolism and hypometabolism in almost all neocortical regions. The individual-level results showed most patients presented a decreased metabolism in neocortical regions, as well as an increase in metabolism in the hippocampus and basal ganglia. Furthermore, the metabolic gradient between hippocampus and neocortical regions was positively associated with the ADLs (frontal lobe, r=0.529, P=0.008; parietal lobe, r=0.474, P=0.019; occipital lobe, r=0.413, P=0.045; temporal lobe, r=0.490, P=0.015), respectively. In addition, the patients with facio-brachial dystonic seizures (FBDS) presented bilateral putamen hypermetabolism, when compared to patients without FBDS and healthy controls.ConclusionSubcortical hypermetabolism associated with cortical hypometabolism presented with a common metabolic pattern in patients with anti-LGI1 encephalitis in the present study. The resolution of the metabolic gradient of the hippocampal hypermetabolism and neocortical hypometabolism may bring about improved clinical neurologic disability.

Brain Activation During Craving for Alcohol Measured by Positron Emission Tomography

2006 ◽  
Vol 40 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Hans M. Olbrich ◽  
Gabriele Valerius ◽  
Christine Paris ◽  
Friedemann Hagenbuch ◽  
Dieter Ebert ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Alcohol Dependence ◽  
Brain Regions ◽  
Emission Tomography ◽  
Alcoholic Beverages ◽  
Alcohol Craving ◽  
Positron Emission ◽  
Dorsolateral Prefrontal

Objective: Craving for alcohol is probably involved in acquisition and maintenance of alcohol dependence to a substantial degree. However, the brain substrates and mechanisms that underlie alcohol craving await more detailed elucidation. Method: Positron emission tomography was used to map regional cerebral blood flow (CBF) in 21 detoxified patients with alcohol dependence during exposure to alcoholic and non-alcoholic beverages. Results: During the alcohol condition compared with the control condition, significantly increased CBF was found in the ventral putamen. Additionally, activated areas included insula, dorsolateral prefrontal cortex and cerebellum. Cerebral blood flow increase in these regions was related to self-reports of craving assessed in the alcoholic patients. Conclusions: In this investigation, cue-induced alcohol craving was associated with activation of brain regions particularly involved in brain reward mechanisms, memory and attentional processes. These results are consistent with studies on craving for other addictive substances and may offer strategies for more elaborate studies on the neurobiology of addiction.

scholarly journals Deep-learning-based attenuation correction in dynamic [15O]H2O studies using PET/MRI in healthy volunteers

2021 ◽  
pp. 0271678X2110291
Author(s):  
Oriol Puig ◽  
Otto M Henriksen ◽  
Flemming L Andersen ◽  
Ulrich Lindberg ◽  
Liselotte Højgaard ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Activity Concentration ◽  
Reference Method ◽  
Occipital Lobe ◽  
Brain Regions ◽  
Regions Of Interest ◽  
Whole Brain ◽  
Ultrashort Echo Time ◽  
Positron Emission ◽  
Static Images

Quantitative [15O]H2O positron emission tomography (PET) is the accepted reference method for regional cerebral blood flow (rCBF) quantification. To perform reliable quantitative [15O]H2O-PET studies in PET/MRI scanners, MRI-based attenuation-correction (MRAC) is required. Our aim was to compare two MRAC methods (RESOLUTE and DeepUTE) based on ultrashort echo-time with computed tomography-based reference standard AC (CTAC) in dynamic and static [15O]H2O-PET. We compared rCBF from quantitative perfusion maps and activity concentration distribution from static images between AC methods in 25 resting [15O]H2O-PET scans from 14 healthy men at whole-brain, regions of interest and voxel-wise levels. Average whole-brain CBF was 39.9 ± 6.0, 39.0 ± 5.8 and 40.0 ± 5.6 ml/100 g/min for CTAC, RESOLUTE and DeepUTE corrected studies respectively. RESOLUTE underestimated whole-brain CBF by 2.1 ± 1.50% and rCBF in all regions of interest (range −2.4%– −1%) compared to CTAC. DeepUTE showed significant rCBF overestimation only in the occipital lobe (0.6 ± 1.1%). Both MRAC methods showed excellent correlation on rCBF and activity concentration with CTAC, with slopes of linear regression lines between 0.97 and 1.01 and R2 over 0.99. In conclusion, RESOLUTE and DeepUTE provide AC information comparable to CTAC in dynamic [15O]H2O-PET but RESOLUTE is associated with a small but systematic underestimation.

scholarly journals Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Virginia E Hawkins ◽  
Ana C Takakura ◽  
Ashley Trinh ◽  
Milene R Malheiros-Lima ◽  
Colin M Cleary ◽  
...  
Keyword(s):  
Blood Flow ◽  
Vascular Tone ◽  
Purinergic Signaling ◽  
Brain Regions ◽  
Neural Function ◽  
Retrotrapezoid Nucleus ◽  
Highly Sensitive ◽  
And Behavior ◽  
Increased Blood Flow ◽  
Regulation Of Vascular Tone

Cerebral blood flow is highly sensitive to changes in CO2/H+ where an increase in CO2/H+ causes vasodilation and increased blood flow. Tissue CO2/H+ also functions as the main stimulus for breathing by activating chemosensitive neurons that control respiratory output. Considering that CO2/H+-induced vasodilation would accelerate removal of CO2/H+ and potentially counteract the drive to breathe, we hypothesize that chemosensitive brain regions have adapted a means of preventing vascular CO2/H+-reactivity. Here, we show in rat that purinergic signaling, possibly through P2Y2/4 receptors, in the retrotrapezoid nucleus (RTN) maintains arteriole tone during high CO2/H+ and disruption of this mechanism decreases the CO2ventilatory response. Our discovery that CO2/H+-dependent regulation of vascular tone in the RTN is the opposite to the rest of the cerebral vascular tree is novel and fundamentally important for understanding how regulation of vascular tone is tailored to support neural function and behavior, in this case the drive to breathe.

Flexible neural circuitry in word processing

1999 ◽  
Vol 22 (2) ◽  
pp. 299-300 ◽  
Author(s):  
Michael I. Posner ◽  
Gregory J. DiGirolamo
Keyword(s):  
Blood Flow ◽  
Language Processing ◽  
Word Processing ◽  
Time Course ◽  
Right Hemisphere ◽  
Neural Circuitry ◽  
Task Demands ◽  
Language Areas

ERP studies have shown modulation of activation in left frontal and posterior cortical language areas, as well as recruitment of right hemisphere homologues, based on task demands. Furthermore, blood-flow studies have demonstrated changes in the neural circuitry of word processing based on experience. The neural areas and time course of language processing are plastic depending on task demands and experience.

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