Enhanced Prevalence of Ankyloglossia with Maternal Cocaine Use

1992 ◽  
Vol 29 (1) ◽  
pp. 72-76 ◽  
Author(s):  
Edward F. Harris ◽  
Gerald W. Friend ◽  
Elizabeth A. Tolley
Keyword(s):  
Drug Use ◽  
Multiple Regression ◽  
Case Control Study ◽  
Case Control ◽  
Regression Equations ◽  
Term Neonates ◽  
Cocaine Use ◽  
Control Study

A series of 500 term neonates was examined in a well-baby nursery, 68 of whom tested positive for maternal cocaine use. From logistic multiple regression equations, weight and crown-heel length were significantly smaller in the maternal cocaine-use subset of this case-control study. Partial ankyloglossia, with a prevalence of 4.4 percent in the overall series, was significantly more common in males than in females (6.0% versus 2.3%), while race (black or white) had no influence on trait frequency. Controlling for race and sex, ankyloglossia was 3.5 times more likely to occur in the drug-use series, perhaps as a function of diminished mitotic rates.

Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case–Control Study

2021 ◽  
Author(s):  
Shaimaa Reda Abdelmaksoud ◽  
Mostafa Abdel-Azim Mostafa ◽  
Rana Atef khashaba ◽  
Effat Assar
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Sepsis Group ◽  
Term Neonates ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts. Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) p = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = −0.616 and −0.596, respectively) p <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034–1.144)) for LOS in vitamin D-deficient neonates. Conclusion Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS. Key Points

scholarly journals A matched case-control study to assess the association between non-steroidal anti-inflammatory drug use and thrombotic microangiopathy

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202801
Author(s):  
Aiden R. Liu ◽  
Ainslie M. Hildebrand ◽  
Stephanie Dixon ◽  
Jessica M. Sontrop ◽  
William F. Clark ◽  
...  
Keyword(s):  
Drug Use ◽  
Thrombotic Microangiopathy ◽  
Case Control Study ◽  
Case Control ◽  
Inflammatory Drug ◽  
Matched Case ◽  
Anti Inflammatory ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case‐Control Study

2015 ◽  
Vol 29 (6) ◽  
pp. 1464-1472 ◽  
Author(s):  
J.L. Gookin ◽  
M.T. Correa ◽  
A. Peters ◽  
A. Malueg ◽  
K.G. Mathews ◽  
...  
Keyword(s):  
Drug Use ◽  
Case Control Study ◽  
Case Control ◽  
Histologic Diagnosis ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Syphilis associated with recreational drug use, depression and high-risk sexual behaviour in men who have sex with men: a case–control study in China

2019 ◽  
Vol 95 (4) ◽  
pp. 267-272
Author(s):  
Huichao Wu ◽  
Cuizhen Xiu ◽  
Xiaojing Fu ◽  
Menglong Li ◽  
Zhenhong Wang ◽  
...  
Keyword(s):  
High Risk ◽  
Drug Use ◽  
Case Control Study ◽  
Case Control ◽  
Multiple Drug ◽  
Recreational Drug ◽  
Syphilis Infection ◽  
Recreational Drug Use ◽  
Sex With Men ◽  
Control Study

ObjectiveWe investigated syphilis prevalence among men who have sex with men (MSM) in China, as well as potential risk factors. Our principal hypothesis was that syphilis would be associated with the use of recreational drugs such as methamphetamines.MethodsFrom April to October 2013, we used several methods to recruit MSM in Qingdao, collecting demographic/behavioural information via self-administrated questionnaires. Trained health workers collected blood for the Treponema pallidum particle assay (TPPA) with positives confirmed by a toluidine red unheated serum test. We used an unmatched case–control study to identify factors that might predict syphilis infection using multivariable logistic regression.ResultsWe recruited 447 MSM who agreed to participate and who completed syphilis testing. Of 71 (15.9%) syphilis-positive MSM, 44 (62.0%) used drugs. Of 376 (84.1%) syphilis-negative MSM, 186 (49.5%) used drugs. We found a positive association with syphilis for any recreational drug use (crude OR (cOR) 1.7, 95 % CI 1.0 to 2.8), frequent methamphetamine use (cOR 2.4, 95% CI 1.1 to 5.3) and multiple drug use (adjusted OR (aOR) 3.4, 95% CI 1.3 to 9.2). Syphilis-positive men were more likely to have a higher physical depression score (aOR 5.2, 95% CI 1.1 to 24.4), be > 30 years old (aOR 2.7, 95% CI 1.5 to 4.8), report a prior STI (aOR 4.1, 95% CI 2.3 to 7.3) and report a sex party experience (aOR 2.2, 95% CI 1.1 to 4.4).ConclusionsRecreational drug use, depression and high-risk sexual behaviours were associated with syphilis infection among MSM in China. Only a multifaceted approach is likely be effective in control of both syphilis and HIV .

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