scholarly journals Tissue lipid metabolism and hepatic metabolomic profiling in response to supplementation of fermented cottonseed meal in the diets of broiler chickens

2015 ◽  
Vol 16 (6) ◽  
pp. 447-455 ◽  
Author(s):  
Cun-xi Nie ◽  
Wen-ju Zhang ◽  
Yong-qiang Wang ◽  
Yan-feng Liu ◽  
Wen-xia Ge ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Cottonseed Meal ◽  
Broiler Chickens ◽  
Tissue Lipid ◽  
Metabolomic Profiling ◽  
Fermented Cottonseed Meal

scholarly journals Molecular analysis of intestinal bacterial microbiota of broiler chickens fed diets containing fermented cottonseed meal

2013 ◽  
Vol 92 (2) ◽  
pp. 392-401 ◽  
Author(s):  
H. Sun ◽  
J.W. Tang ◽  
C.L. Fang ◽  
X.H. Yao ◽  
Y.F. Wu ◽  
...  
Keyword(s):  
Cottonseed Meal ◽  
Molecular Analysis ◽  
Broiler Chickens ◽  
Bacterial Microbiota ◽  
Fermented Cottonseed Meal

Impacts of Dietary Protein from Fermented Cottonseed Meal on Lipid Metabolism and Metabolomic Profiling in the Serum of Broilers

2020 ◽  
Vol 21 (8) ◽  
pp. 812-820
Author(s):  
Cunxi Nie ◽  
Yongqiang Wang ◽  
Yanfeng Liu ◽  
Jiancheng Liu ◽  
Wenxia Ge ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Cottonseed Meal ◽  
Dietary Protein ◽  
Fatty Acid Synthase ◽  
Hormone Sensitive Lipase ◽  
Control Group ◽  
Essential Information ◽  
Fermented Cottonseed Meal

Dietary protein from fermented cottonseed meal (FCSM), widely used in poultry diets in China, had regulating effects on lipid metabolism. To understand the effects of FCSM on lipid metabolism in broilers, we analyzed the biochemical indexes, enzyme activity, hormone level and metabolites in serum responses to FCSM intake. One hundred and eighty 21-d-old Chinese yellow feathered broilers (536.07±4.43 g) were randomly divided into 3 groups with 6 replicates and 3 diets with 6 % supplementation of unfermented CSM (control group), FCSM by C. Tropicalis (Ct CSM) or C. tropicalis plus S. Cerevisae (Ct-Sc CSM). Result showed that: (1) FCSM intake decreased significantly the content of triglyceride (TAG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (P<0.05) in serum; (2) FCSM intake could significantly increase enzyme activity of acetyl CoA carboxylase (ACC), lipoprotein lipase (LPL), fatty acid synthase (FAS) and hormone sensitive lipase (HSL) (P<0.05); (3) Ct-Sc CSM intake increased significantly the levels of adiponectin (ADP) (P<0.05); (4) FCSM intake caused significant metabolic changes involving glycolysis, TCA cycle, synthesis of fatty acid and glycogen, and metabolism of glycerolipid, vitamins B group and amino acids. Our results strongly suggested that FCSM intake could significantly affect lipid metabolism via multiple pathways. These findings provided new essential information about the effect of FCSM on broilers and demonstrated the great potential of nutrimetabolomics, through which the research complex nutrients are included in animal diet.

scholarly journals Effect of Fermented Cottonseed Meal on the Lipid-Related Indices and Serum Metabolic Profiles in Broiler Chickens

Animals ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 930 ◽  
Author(s):  
Jun-Li Niu ◽  
Jun Zhang ◽  
Lian-Qing Wei ◽  
Wen-Ju Zhang ◽  
Cun-Xi Nie
Keyword(s):  
Cottonseed Meal ◽  
Broiler Chickens ◽  
Acid Metabolism ◽  
Control Diet ◽  
Subcutaneous Fat ◽  
Abdominal Fat ◽  
Hormone Sensitive Lipase ◽  
Fat Tissue ◽  
Hormone Sensitive ◽  
Fermented Cottonseed Meal

This study aimed to investigate the changes of lipid-related gene and serum metabolites in broiler chickens fed with fermented cottonseed meal (FCSM) diet, through quantitative real-time PCR and metabolomics analysis. Totally, 180 1-day-old Cobb broilers were randomly assigned to two groups with six replicates of 15 birds in each. The two diets consisted of a control diet supplemented with 0% FCSM (CON group) and an experimental diet with 6% FCSM (fermented by Candida tropicalis) replacing the soybean meal (FCSM group). The results showed that both abdominal fat content and subcutaneous fat thickness significantly reduced (p < 0.05) in response to dietary FCSM supplementation at the age of 21 d. Serum concentrations of glucose, triglyceride, and low-density lipoprotein cholesterol decreased (p < 0.05) in FCSM fed broilers compared with CON fed broilers, while the levels of epinephrine and growth hormone in serum, liver and abdominal fat tissue were higher (p < 0.05) in FCSM than in CON fed broilers. The activity of hormone-sensitive esterase and lipoprotein lipase (LPL) in the liver and abdominal fat were higher (p < 0.05) in FCSM than CON group. Additionally, compared with the CON group (p < 0.05), the expression of peroxisome proliferator-activated receptor alpha and LPL genes were upregulated in the livers of FCSM group broilers. Gene expressions of hormone-sensitive lipase and LPL in the abdominal fat tissue were also upregulated (p < 0.05) with the broilers fed with FCSM diets. A total of 20 significantly different metabolites were obtained in the serum of different dietary FCSM supplemented fed broilers. The mainly altered pathways were clustered into organic acid metabolism, fatty acid metabolism, and amino acid metabolism. These results not only provide a better understanding of broilers’ lipid metabolism with FCSM but also can be helpful in further improvement of the broilers’ healthy production and utilization of FCSM.

scholarly journals Glucagon Receptor Signaling and Glucagon Resistance

2019 ◽  
Vol 20 (13) ◽  
pp. 3314 ◽  
Author(s):  
Janah ◽  
Kjeldsen ◽  
Galsgaard ◽  
Winther-Sørensen ◽  
Stojanovska ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Metabolic Diseases ◽  
Physiological Role ◽  
Glucagon Receptor ◽  
Metabolomic Profiling ◽  
Hepatic Fat

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas). The suggested key role of glucagon in the development of diabetes has been termed the bihormonal hypothesis. However, studying tissue-specific knockout of the glucagon receptor has revealed that the physiological role of glucagon may extend beyond blood-glucose regulation. Decades ago, animal and human studies reported an important role of glucagon in amino acid metabolism through ureagenesis. Using modern technologies such as metabolomic profiling, knowledge about the effects of glucagon on amino acid metabolism has been expanded and the mechanisms involved further delineated. Glucagon receptor antagonists have indirectly put focus on glucagon’s potential role in lipid metabolism, as individuals treated with these antagonists showed dyslipidemia and increased hepatic fat. One emerging field in glucagon biology now seems to include the concept of hepatic glucagon resistance. Here, we discuss the roles of glucagon in glucose homeostasis, amino acid metabolism, and lipid metabolism and present speculations on the molecular pathways causing and associating with postulated hepatic glucagon resistance.

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