Macroparasite Population Dynamics Among Geographical Localities and Host Life Cycle Stages: Eugregarines inIschnura verticalis

2013 ◽  
Vol 99 (3) ◽  
pp. 403-409 ◽  
Author(s):  
Brittany E. Bunker ◽  
John Janovy ◽  
Elisabeth Tracey ◽  
Austin Barnes ◽  
Ayla Duba ◽  
...  
2020 ◽  
Vol 12 (12) ◽  
pp. 2403-2416
Author(s):  
Ignacio Miguel Durante ◽  
Anzhelika Butenko ◽  
Vendula Rašková ◽  
Arzuv Charyyeva ◽  
Michaela Svobodová ◽  
...  

Abstract Receptor adenylate cyclases (RACs) on the surface of trypanosomatids are important players in the host–parasite interface. They detect still unidentified environmental signals that affect the parasites’ responses to host immune challenge, coordination of social motility, and regulation of cell division. A lesser known class of oxygen-sensing adenylate cyclases (OACs) related to RACs has been lost in trypanosomes and expanded mostly in Leishmania species and related insect-dwelling trypanosomatids. In this work, we have undertaken a large-scale phylogenetic analysis of both classes of adenylate cyclases (ACs) in trypanosomatids and the free-living Bodo saltans. We observe that the expanded RAC repertoire in trypanosomatids with a two-host life cycle is not only associated with an extracellular lifestyle within the vertebrate host, but also with a complex path through the insect vector involving several life cycle stages. In Trypanosoma brucei, RACs are split into two major clades, which significantly differ in their expression profiles in the mammalian host and the insect vector. RACs of the closely related Trypanosoma congolense are intermingled within these two clades, supporting early RAC diversification. Subspecies of T. brucei that have lost the capacity to infect insects exhibit high numbers of pseudogenized RACs, suggesting many of these proteins have become redundant upon the acquisition of a single-host life cycle. OACs appear to be an innovation occurring after the expansion of RACs in trypanosomatids. Endosymbiont-harboring trypanosomatids exhibit a diversification of OACs, whereas these proteins are pseudogenized in Leishmania subgenus Viannia. This analysis sheds light on how ACs have evolved to allow diverse trypanosomatids to occupy multifarious niches and assume various lifestyles.


2019 ◽  
Vol 0 (3) ◽  
pp. 53-60 ◽  
Author(s):  
T.Yu. Altufyeva ◽  
◽  
P.A. Ivanov ◽  
G.R. Sakhapova ◽  
◽  
...  

2009 ◽  
Vol 66 (1) ◽  
Author(s):  
Susana Gómez-González ◽  
Lohengrin A Cavieres ◽  
Patricio Torres ◽  
Cristian Torres-Díaz

Energies ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3287
Author(s):  
Alireza Tabrizikahou ◽  
Piotr Nowotarski

For decades, among other industries, the construction sector has accounted for high energy consumption and emissions. As the energy crisis and climate change have become a growing concern, mitigating energy usage is a significant issue. The operational and end of life phases are all included in the building life cycle stages. Although the operation stage accounts for more energy consumption with higher carbon emissions, the embodied stage occurs in a time-intensive manner. In this paper, an attempt has been made to review the existing methods, aiming to lower the consumption of energy and carbon emission in the construction buildings through optimizing the construction processes, especially with the lean construction approach. First, the energy consumption and emissions for primary construction materials and processes are introduced. It is followed by a review of the structural optimization and lean techniques that seek to improve the construction processes. Then, the influence of these methods on the reduction of energy consumption is discussed. Based on these methods, a general algorithm is proposed with the purpose of improving the construction processes’ performance. It includes structural optimization and lean and life cycle assessments, which are expected to influence the possible reduction of energy consumption and carbon emissions during the execution of construction works.


Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 638
Author(s):  
Monika Mazur ◽  
Daria Wojciechowska ◽  
Ewa Sitkiewicz ◽  
Agata Malinowska ◽  
Bianka Świderska ◽  
...  

The slime mold Dictyostelium discoideum’s life cycle includes different unicellular and multicellular stages that provide a convenient model for research concerning intracellular and intercellular mechanisms influencing mitochondria’s structure and function. We aim to determine the differences between the mitochondria isolated from the slime mold regarding its early developmental stages induced by starvation, namely the unicellular (U), aggregation (A) and streams (S) stages, at the bioenergetic and proteome levels. We measured the oxygen consumption of intact cells using the Clarke electrode and observed a distinct decrease in mitochondrial coupling capacity for stage S cells and a decrease in mitochondrial coupling efficiency for stage A and S cells. We also found changes in spare respiratory capacity. We performed a wide comparative proteomic study. During the transition from the unicellular stage to the multicellular stage, important proteomic differences occurred in stages A and S relating to the proteins of the main mitochondrial functional groups, showing characteristic tendencies that could be associated with their ongoing adaptation to starvation following cell reprogramming during the switch to gluconeogenesis. We suggest that the main mitochondrial processes are downregulated during the early developmental stages, although this needs to be verified by extending analogous studies to the next slime mold life cycle stages.


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