Ontogeny and secretory patterns of plasma insulin-like growth factor-I concentrations in meat-type chickens

1990 ◽  
Vol 124 (1) ◽  
pp. 81-87 ◽  
Author(s):  
R. J. Johnson ◽  
J. P. McMurtry ◽  
F. J. Ballard
Keyword(s):  
Plasma Concentration ◽  
Broiler Chickens ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Blood Samples ◽  
Factor I ◽  
Igf I ◽  
Plasma Gh ◽  
Secretory Pattern ◽  
Meat Type

ABSTRACT The ontogeny and secretory pattern of plasma insulin-like growth factor-I (IGF-I) in relation to GH secretion were studied in meat-type (broiler) poultry during prepubertal and post-pubertal growth. Male and female broiler chickens of two commercial strains (strains A and B) were reared from 1 to 198 days of age. From 1 to 49 days of age birds were reared in raised-wire cages and thereafter in deep-litter pens, with food available ad libitum. Blood samples were taken at regular intervals during growth, and at 29 and 43 days of age representative birds were cannulated and serial blood samples taken at 10-min intervals for 5 to 7 h. Plasma concentrations of GH and IGF-I were measured by radioimmunoassay. Birds of strain A were heavier (P<0·05) than those of strain B from 12 to 35 days of age. In general, male birds were heavier (P<0·01) than females from 12 to 35 days of age. Plasma GH concentrations were significantly higher (P<0·05) from 12 to 35 days of age, while plasma IGF-I concentrations were lower (P<0·05) from 6 to 21 days of age in male compared with female birds. Plasma IGF-I concentration increased with age, reaching a plateau at 28 days of age, while plasma GH concentration declined over the same period. Plasma IGF-I concentrations declined in a linear manner from 49 to 198 days of age, and there was no evidence of a pubertal increase. There were no differences between strains in the plasma concentrations of GH or IGF-I. Serial blood sampling at 29 and 43 days of age showed that there was no relationship between GH and IGF-I, despite a highly pulsatile GH secretory pattern which existed at 29 days of age. These results show that as the plasma concentration of GH declines that of IGF-I increases. Plasma concentration of both GH and IGF-I in broiler chickens was sexually dimorphic, especially during the early growth phase to about 35 days of age. Journal of Endocrinology (1990) 124, 81–87

Plasma concentrations of insulin-like growth factor-I and insulin in the infant calf: ontogeny and influence of altered nutrition

1988 ◽  
Vol 119 (1) ◽  
pp. 43-50 ◽  
Author(s):  
B. H. Breier ◽  
P. D. Gluckman ◽  
J. J. Bass
Keyword(s):  
Birth Weight ◽  
Growth Factor ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Factor I ◽  
Igf I ◽  
Group 3 ◽  
Group 2 ◽  
Milk Feeding ◽  
Group 1

ABSTRACT The developmental pattern of plasma insulin-like growth factor-I (IGF-I) and insulin in calves subject to different patterns of weaning was investigated from birth until the age of 6 months. Fifteen male Friesian calves were fed on whole milk (10% of body weight per day) for the first 8 weeks after birth, then allocated into three balanced groups. Group 1 was weaned at 8 weeks; group 2 was weaned at 8 weeks, returned to milk-feeding at 13 weeks to be weaned again at the age of 16 weeks; group 3 was weaned at 12 weeks. After weaning the calves were fed on concentrates and lucerne hay. At birth, circulating concentrations of IGF-I correlated with birth weight (r = 0·78, P< 0·001). There was a significant (P<0·001) fall in plasma IGF-I from birth (40·3 ± 2·5 μg/l) until 5 weeks (23·8± 1·3 μg/l), and then a gradual (P<0·01) rise until week 8 (35·0 ± 2·2 μg/l). Weaning (groups 1 and 2 after week 8) caused a significant (P<0·01) decrease in plasma IGF-I (20·5 ± 1·9 μg/l); thereafter plasma levels of IGF-I rose gradually (P<0·01) in animals fed on concentrates. The milk-fed calves (group 3) showed a progressive increase in plasma IGF-I with age until they were weaned at 12 weeks (51·0 ± 3·4 μg/l); IGF-I levels then decreased to be similar to group 1 (32·5 ± 2·1 μg/l). When group 2 was returned to milk-feeding, plasma IGF-I concentrations increased to 58·2 ±3·8 μg/l within 4 days and then continued to rise gradually until decreasing upon weaning. The age-related increase in the plasma concentration of IGF-I after 6 weeks was parallel in milk- and concentrate-fed calves. Binding of 125I-labelled bovine GH to hepatic membranes of neonatal calves was low at birth (specific binding; 1·56 ±0·29% n=3). Somatotrophic binding was apparent at 6 weeks (6·43 ±0·42%, n = 3) and increased (9·2± 1·1%, n=3) at the age of 12 weeks. Thus the early postnatal changes in plasma IGF-I may reflect the transition from GH-independent to GH-dependent IGF-I secretion. Plasma concentrations of insulin at birth correlated with IGF-I (r = 0·54, P<0·05). However, regression analysis suggested no effect of insulin on birth weight independent of IGF-I. Plasma insulin levels rose gradually until weaning and thereafter were significantly (P<0·01) higher in the milk- than concentratefed calves. Major changes in plasma concentrations of IGF-I related to monogastric (milk feeding) or ruminant (concentrate feeding) nutrition of the young calf are demonstrated. They may be mediated through changing plasma insulin concentrations. An age-dependent prepubertal rise in plasma IGF-I apparently independent of nutritional factors commenced with the appearance of functional somatotrophic receptors in the liver. J. Endocr. (1988) 119, 43–50

Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs

1988 ◽  
Vol 118 (1) ◽  
pp. 105-108 ◽  
Author(s):  
J. Eugen Eigenmann ◽  
Adel Amador ◽  
Donald F. Patterson
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Growth Factor ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
The Mean ◽  
Growth Factor I

Abstract. Plasma insulin-like growth factor I concentrations from proportionate, chondrodystrophic and giant breeds were evaluated and compared with body size. IGF-I plasma concentrations were 91.2 ± 10.9 μg/l in Keeshounds (proportionate dog), 122.6 ± 25.4 μg/l in Bassethounds (chondrodystrophic dog) and 280 ± 22.8 μg/l in German Shepherds (proportionate dog). The highest IGF-I level (389.6 ± 24.2 μg/l) was found in the New Foundland, a giant breed (mean ± sem). The mean body weight was 11.8 ±0.4 kg in Keeshounds, 15.4 ± 1.4 kg in Bassethounds, 32 ± 1.5 kg in German Shepherds, and 45.6 ± 1.7 kg in New Foundlands (mean ± sem). Body weight and plasma IGF-I concentration were significantly correlated (y (IGF-I) = −7.43 + 8.7 × (body weight); P < 0.0001.

Long [R3] insulin-like growth factor-I reduces growth, plasma growth hormone, IGF binding protein-3 and endogenous IGF-I concentrations in pigs

1997 ◽  
Vol 155 (3) ◽  
pp. 559-565 ◽  
Author(s):  
V Dunaiski ◽  
FR Dunshea ◽  
PE Walton ◽  
C Goddard
Keyword(s):  
Growth Hormone ◽  
Growth Performance ◽  
Plasma Insulin ◽  
Average Daily Gain ◽  
Factor I ◽  
Igf I ◽  
Igf Binding ◽  
Plasma Gh ◽  
Daily Gain ◽  
Igfbp 3

Growth hormone (GH) improves growth performance in the pig. Analogues of insulin-like growth factor-I (IGF-I) that bind poorly to IGF binding proteins (IGFBP) stimulate growth in the rat but, in contrast, inhibit growth in the pig. This study was designed to determine the effect of IGF peptides alone or in combination with porcine GH (pGH) on growth characteristics and plasma hormone concentrations in finisher pigs. A four-day infusion of Long [R3] IGF-I (LR3IGF-I; 180 micrograms/kg/day) decreased the average daily gain, food intake, and plasma IGFBP-3, IGF-I and insulin concentrations. The mean plasma GH concentration was decreased by 23% and the area under the GH peaks was reduced by 60%. Co-administration of pGH (30 micrograms/kg/day) with LR3IGF-I had no interactive effect on growth performance, and plasma insulin, IGFBP-3 and IGF-I concentrations remained suppressed. The area under the GH peaks was not restored with this combination treatment although mean plasma GH concentrations were elevated in all animals receiving pGH. Infusion of IGF-I (180 micrograms/kg/day) decreased plasma insulin and mean GH concentrations but had no significant effect on IGFBP-3 concentrations. Average daily gain and feed intake were not changed by IGF-I treatment. A combination of IGF-I and pGH injection (30 micrograms/kg/day) increased plasma IGFBP-3 concentrations but plasma insulin levels remained suppressed. Plasma glucose levels were unaffected by any treatment. The study demonstrates that both IGF-I and LR3IGF-I suppress plasma GH concentrations in finisher pigs. This, in turn, may be responsible for the reduction in the plasma concentration of IGF-I, IGFBP-3 and insulin seen in LR3IGF-I-treated animals. The decrease in these parameters may contribute to the inhibitory effect of LR3IGF-I on growth performance in the pig.

Low-level arginine supplementation (0.1%) of wheat-based diets in pregnancy increases the total and live-born litter sizes in gilts

2017 ◽  
Vol 57 (6) ◽  
pp. 1091 ◽  
Author(s):  
P. Guo ◽  
Z. Y. Jiang ◽  
K. G. Gao ◽  
L. Wang ◽  
X. F. Yang ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Reproductive Performance ◽  
Plasma Concentrations ◽  
Dietary Supplementation ◽  
Commercial Production ◽  
Blood Samples ◽  
Low Level ◽  
Igf I ◽  
Arginine Supplementation ◽  
In Pregnancy

The present study was conducted to test the effects of l-arginine supplementation of wheat-based diets on the pregnancy outcome of gilts. Pregnant gilts (Yorkshire × Landrace, n = 113) were assigned randomly into two groups representing dietary supplementation with 0.1% l-arginine as l-arginine-HCl or 0.17% l-alanine (isonitrogenous control) between Days 30 and 110 of pregnancy. Blood samples were obtained from the ear vein on Days 30, 70 and 90 of pregnancy. Compared with the control, arginine supplementation increased the total number of piglets born by 1.10 per litter and the number of live-born piglets by 1.10 per litter (P < 0.05). Plasma concentration of spermine was higher in gilts fed arginine diets than in those fed control diets at Day 90 of pregnancy (P < 0.05). Dietary arginine supplementation increased plasma concentration of IGF-I of gilts at Day 90 of pregnancy (P < 0.01) and plasma concentrations of arginine, proline and ornithine at Days 70 and 90 of pregnancy (P < 0.05). These results indicated that low-level supplementation (0.1%) of l-arginine–HCl of wheat-based diets beneficially enhances the reproductive performance of gilts and is feasible for use in commercial production.

RELATIONSHIP BETWEEN LAMB BIRTH WEIGHTS AND FETAL PLASMA GROWTH HORMONE AND INSULIN CONCENTRATIONS

1986 ◽  
Vol 66 (4) ◽  
pp. 995-1001
Author(s):  
G. J. MEARS
Keyword(s):  
Growth Hormone ◽  
Fetal Growth ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Metabolic Clearance ◽  
Plasma Growth Hormone ◽  
Fetal Plasma ◽  
Plasma Gh ◽  
Ovine Fetal

Plasma concentrations of growth hormone (GH) and insulin were monitored in 11 chronically cannulated ovine fetuses and their mothers during the last month of gestation to obtain information on the role that these hormones have in determining fetal growth rate. Maternal plasma GH and insulin concentrations were independent of stage of gestation and lamb birth weights. Fetal plasma insulin concentrations were episodic in nature, independent of stage of gestation, and tended to be higher in fetuses that were heavier at birth. Fetal plasma GH concentrations were only slightly episodic in nature, were tenfold higher than maternal levels at 116–124 d gestation and increased by approximately another 25% prior to parturition. Fetal plasma GH concentrations were negtively correlated with lamb birth weights. In twin preparations, fetal plasma GH concentrations were significantly lower in the twin that was heaviest at birth. The lower GH concentrations found in faster growing fetuses are suggestive of a more rapid metabolic clearance of GH by the tissues of these animals. The results indicate that circulating fetal GH and, possibly, insulin are involved in determining the rate of ovine-fetal growth. Key words: Ovine birth weights, fetal GH, fetal insulin, fetal growth

Blood Plasma Concentrations of Insulin-like Growth Factor-I (IGF-I) in Resting Standardbred Horses

2002 ◽  
Vol 163 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Z.J. Champion ◽  
B.H. Breier ◽  
W.E. Ewen ◽  
T.T. Tobin ◽  
P.J. Casey
Keyword(s):  
Growth Factor ◽  
Blood Plasma ◽  
Plasma Concentrations ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Influence of nutritional status on growth hormone-dependent circulating somatomedin-C activity in mature sheep

1991 ◽  
Vol 130 (2) ◽  
pp. 313-320 ◽  
Author(s):  
P. C. Wynn ◽  
M. C. Stuart ◽  
A. L. C. Wallace ◽  
A. C. Kirby ◽  
E. F. Annison
Keyword(s):  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Maximum Level ◽  
Daily Injection ◽  
Gh Treatment ◽  
Somatomedin C ◽  
Merino Sheep ◽  
The Third ◽  
Plasma Gh ◽  
Circulating Levels

ABSTRACT The effect of daily administration of ovine GH for a period of 4 weeks on somatomedin-C biological activity in plasma was investigated in mature Merino sheep fed a maintenance energy intake (low plane; LP) or 1·6 times this amount (high plane; HP). The GH treatment resulted in a significant (P < 0·05) increase in plasma GH levels in blood samples collected 23·5 h after each daily injection in both LP and HP groups. Plasma concentrations of somatomedin-C activity and insulin were significantly stimulated to a maximum level by the third GH injection and remained at this level for 7 days. Subsequently, circulating levels of both hormones fell to 40–50% of the peak response to GH and returned to basal levels within 48 h of the cessation of GH injections. In the HP group the response of plasma insulin and somatomedin-C activity to GH injection was greater than in the LP group. Journal of Endocrinology (1991) 130, 313–320

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