scholarly journals Development of a Novel Monoclonal Antibody Recognizing Basal Cells of Human Squamous Epithelia.

2002 ◽  
Vol 65 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Jiro HITOMI ◽  
Fumio ISHIZAKI ◽  
Eiji KIMURA ◽  
Nobuyuki SATO
Keyword(s):  
Monoclonal Antibody ◽  
Basal Cells ◽  
Squamous Epithelia

Evidence for a role of the monoclonal antibody E48 defined antigen in cell-cell adhesion in squamous epithelia and head and neck squamous cell carcinoma

1991 ◽  
Vol 196 (2) ◽  
pp. 264-269 ◽  
Author(s):  
Ad H.G.J. Schrijvers ◽  
Martijn Gerretsen ◽  
Jan M. Fritz ◽  
Marijke van Walsum ◽  
Jasper J. Quak ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Squamous Epithelia ◽  
Cell Cell

scholarly journals A Murine Monoclonal Antibody (VM-1) Against Human Basal Cells Inhibits the Growth of Human Keratinocytes in Culture

1985 ◽  
Vol 84 (4) ◽  
pp. 257-261 ◽  
Author(s):  
Allan R. Oseroff ◽  
Eva A. Pfendt ◽  
Linda DiCicco ◽  
Vera B. Morhenn
Keyword(s):  
Monoclonal Antibody ◽  
Human Keratinocytes ◽  
Murine Monoclonal Antibody ◽  
Basal Cells

Expression of protein p27 in various forms of seborrheic keratosis

2016 ◽  
Vol 19 (5) ◽  
pp. 283-286
Author(s):  
Alexandra K. Aleksandrova ◽  
G. I Sukolin ◽  
V. A Smolynnikova
Keyword(s):  
Cell Cycle ◽  
Monoclonal Antibody ◽  
Kinase Inhibitor ◽  
Research Unit ◽  
Basal Cells ◽  
Seborrheic Keratosis ◽  
Histological Types ◽  
Characteristic Features ◽  
Definition Of ◽  
P27 Kip1

The significant role in the pathogenesis of seborrheic keratosis (SK) plays the violation of the cell cycle regulation. According to the research unit the cell proliferation in acanthotic and irritated histological types of SK is regulated by p27 (Kip1), cyclin-dependent kinase inhibitor. Considering the variety of histological types of SK, definition of p27 expression will reveal the characteristic features of the cell cycle disorders and proliferation for each type of tumor. Material and Methods. Of the 102 tumors from patients with SK, according to the results of histological examination, were selected 10 specimens of each histological types of SK: acanthotic, hyperkeratotic, adenoid, irritated, and clonal. We assessed all specimens for p27 (Kip1) expression using immunohistochemistry (monoclonal antibody p27 at a dilution of 1:20 (Novocastra Laboratories Ltd.). Three skin biopsy samples of healthy individuals were included. Results. Severe diffuse nuclear expression of p27 was present in all cases of adenoid, irritated, and 4 cases of clonal histological types of SK. In other tumor types positive reaction with monoclonal antibody to p27 was reduced as compared with healthy skin were recorded single positively stained nuclei of basal cells. Conclusions. Thus, we have found a violation of p27 protein expression in all types of seborrheic keratosis as with the excess (adenoid, irritated, clonal SK type) and in p27 protein deficiency (acanthotic, hyperkeratotic) normal course of cell cycle phases is broken. This leads to the disappearance of control over the cell proliferative activity and apoptosis, facilitating a slow, uncontrolled growth of SK cells.

scholarly journals A monoclonal antibody against basal cells of human epidermis. Potential use in the diagnosis of cervical neoplasia.

1985 ◽  
Vol 76 (5) ◽  
pp. 1978-1983 ◽  
Author(s):  
V B Morhenn ◽  
A B Schreiber ◽  
O Soriero ◽  
W McMillan ◽  
A C Allison
Keyword(s):  
Monoclonal Antibody ◽  
Cervical Neoplasia ◽  
Human Epidermis ◽  
Basal Cells ◽  
Potential Use

A new monoclonal antibody against hemidesmosomes of human epidermal basal cells

1990 ◽  
Vol 1 (5) ◽  
pp. 387
Author(s):  
Xiao-Min Zhang ◽  
Yuji Horiguchi ◽  
Sadao Imamura
Keyword(s):  
Monoclonal Antibody ◽  
Basal Cells

scholarly journals Detection of illegal estrogen administration through immunohistochemical markers in the bovine prostate

1999 ◽  
Vol 19 (3-4) ◽  
pp. 133-138
Author(s):  
Patricia Elena Fernández ◽  
Héctor Ramón Sanguinetti ◽  
Enrique Leo Portiansky ◽  
Claudio Gustavo Barbeito ◽  
Eduardo Juan Gimeno
Keyword(s):  
Monoclonal Antibody ◽  
Antigen Retrieval ◽  
Basal Cells ◽  
Epithelial Hyperplasia ◽  
Cell Markers ◽  
Immunohistochemical Markers ◽  
Metaplastic Epithelium ◽  
Definition Of ◽  
Induced Changes ◽  
Estrogen Administration

The immunodetection of diverse cell markers was evaluated in prostatic samples from bullocks, and bullocks showing epithelial hyperplasia-metaplasia, with oestrogen-induced changes, and in experimental samples from bullocks inoculated with dietylstilbestrol (DES). Antigen-retrieval procedures allowed the use of tissues that had been fixed in formalin for long periods. Three tissue markers were chosen for the study: cytokeratins 13 and 16, vimentin and desmin. Monoclonal antibody K8.12 (specific for cytokeratins 13 and 16) stained basal cells and hyperplastic-metaplastic epithelium; monoclonal antivimentin, and desmin, allowed the definition of fibromuscular changes.

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