scholarly journals Halting Coronavirus Replication

2020 ◽  
Vol 5 (1) ◽  
pp. 13-15
Author(s):  
Kira Smith ◽  
Keyword(s):  
Small Molecules ◽  
Defense Mechanism ◽  
P53 Protein ◽  
Sirtuin 1 ◽  
Down Regulation ◽  
Virus Growth ◽  
Viral Growth ◽  
Self Defense

Sirtuin 1 (SIRT1) inhibitors can reduce replication of many viruses with certain characteristics similar to those of coronaviruses, while the p53 protein is another important factor in the down-regulation of viral growth. Tenovin is a class of small molecules that inhibit Sirtuin 1 and 2, in addition to activating the p53 protein, by means of regulating the interactions used by coronaviruses as a self-defense mechanism. By blocking virus growth and continuous replication, with already tested antiviral medicines, the promise of coronavirus disease 2019 (COVID-19) eradication exists.

scholarly journals Eradicate Coronavirus by blocking replication, counteracting its defense system

2020 ◽  
Author(s):  
Kira Smith
Keyword(s):  
Defense Mechanism ◽  
P53 Protein ◽  
Sirtuin 1 ◽  
Defense System ◽  
Down Regulation ◽  
Virus Growth ◽  
Self Defense ◽  
System P ◽  
Lysosomotropic Agent ◽  
Regulation Of Growth

SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.

scholarly journals Eradicate Coronavirus by blocking replication, counteracting its defense system

2020 ◽  
Author(s):  
Kira Smith
Keyword(s):  
Defense Mechanism ◽  
P53 Protein ◽  
Sirtuin 1 ◽  
Defense System ◽  
Down Regulation ◽  
Virus Growth ◽  
Self Defense ◽  
System P ◽  
Lysosomotropic Agent ◽  
Regulation Of Growth

SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.

scholarly journals Eradicate Coronavirus by blocking replication, counteracting its defense system

2020 ◽  
Author(s):  
Kira Smith
Keyword(s):  
Target Genes ◽  
Defense Mechanism ◽  
P53 Protein ◽  
Sirtuin 1 ◽  
Defense System ◽  
Virus Growth ◽  
Self Defense ◽  
System P ◽  
Lysosomotropic Agent ◽  
Regulation Of Growth

SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as HIF-1α with the target genes and cytokines. Autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.

scholarly journals Small-Molecules Targeting Sirtuin 1: A Patent Review (2012-2015)

2016 ◽  
Vol 6 (6) ◽  
Author(s):  
Alessandra Graziadio ◽  
Alessandra Locatelli
Keyword(s):  
Small Molecules ◽  
Sirtuin 1 ◽  
Patent Review

Age-specific different immune responses due to capabilities of secreting primal immunoglobulins responding to unexperienced antigens

2021 ◽  
Author(s):  
JANGHO LEE ◽  
Kyoungshik Cho ◽  
Hyejin Kook ◽  
Suman Kang ◽  
Yunsung Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Immune System ◽  
Defense Mechanism ◽  
Ex Vivo ◽  
Binding Capacity ◽  
Culture Conditions ◽  
Fetal Stem Cells ◽  
Self Defense ◽  
Wide Range ◽  
Ex Vivo Culture

Abstract Among numerous studies on COVID-19, we noted that the infection and mortality rates of SARS-CoV-2 increased with age and that fetuses known to be particularly susceptible to infection were better protected despite various mutations. Hence, we established the hypothesis that a new immune system exists that forms before birth and decreases with aging. To prove this, we analyzed the components from early pregnancy fetal stem cells cultivated in various ex-vivo culture conditions simulating the environment during pregnancy. Resultingly, we confirmed that IgM, a natural antibody produced only in early B-1 cells, immunoglobulins including IgG3, which has a wide range of antigen-binding capacity and affinity, complement proteins, and antiviral proteins are induced. Our results suggest that fetal stem cells can form an independent immune system responding to unlearned antigens as a self-defense mechanism before establishing mature immune systems. Moreover, we propose the possibility of new solutions to cope with various infectious diseases based on the factors therein.

A Generalized and Robust Anti-Predatory Nature-Inspired Algorithm for Complex Problems

2019 ◽  
Vol 10 (1) ◽  
pp. 75-91 ◽  
Author(s):  
Rohit Kumar Sachan ◽  
Dharmender Singh Kushwaha
Keyword(s):  
Standard Deviation ◽  
Defense Mechanism ◽  
Mathematical Formulation ◽  
Predatory Behavior ◽  
Rank Test ◽  
Bee Colony ◽  
Self Defense ◽  
Nature Inspired Algorithm ◽  
Nature Inspired Algorithms ◽  
Result Analysis

This article describes how nature-inspired algorithms (NIAs) have evolved as efficient approaches for addressing the complexities inherent in the optimization of real-world applications. These algorithms are designed to imitate processes in nature that provide some ways of problem solving. Although various nature-inspired algorithms have been proposed by various researchers in the past, a robust and computationally simple NIA is still missing. A novel nature-inspired algorithm that adapts to the anti-predatory behavior of the frog is proposed. The algorithm mimics the self defense mechanism of a frog. Frogs use their reflexes as a means of protecting themselves from the predators. A mathematical formulation of these reflexes forms the core of the proposed approach. The robustness of the proposed algorithm is verified through performance evaluation on sixteen different unconstrained mathematical benchmark functions based on best and worst values as well as mean and standard deviation of the computed results. These functions are representative of different properties and characteristics of the problem domain. The strength and robustness of the proposed algorithm is established through a comparative result analysis with six well-known optimization algorithms, namely: genetic, particle swarm, differential evolution, artificial bee colony, teacher learning and Jaya. The Friedman rank test and the Holm-Sidak test have been used for statistical analysis of obtained results. The proposed algorithm ranks first in the case of mean result and scores second rank in the case of “standard deviation”. This proves the significance of the proposed algorithm.

A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

2020 ◽  
Vol 49 (19) ◽  
pp. 6995-7014 ◽  
Author(s):  
Jessica J. Miller ◽  
Christian Gaiddon ◽  
Tim Storr
Keyword(s):  
Small Molecules ◽  
Therapeutic Intervention ◽  
P53 Protein ◽  
P53 Pathway ◽  
Cancer Types

Small molecules targeting various aspects of the p53 protein pathway have shown significant promise in the treatment of a number of cancer types.

scholarly journals Uterine Deletion of Trp53 Compromises Antioxidant Responses in the Mouse Decidua

Endocrinology ◽  
2012 ◽  
Vol 153 (9) ◽  
pp. 4568-4579 ◽  
Author(s):  
Kristin E. Burnum ◽  
Yasushi Hirota ◽  
Erin S. Baker ◽  
Mikihiro Yoshie ◽  
Yehia M. Ibrahim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Preterm Birth ◽  
Global Health ◽  
P53 Protein ◽  
Terminal Differentiation ◽  
Down Regulation ◽  
Antioxidant Responses ◽  
Global Health Issue ◽  
Potential Factors

Preterm birth is a global health issue impacting millions of mothers and babies. However, the etiology of preterm birth is not clearly understood. Our recent finding that premature decidual senescence with terminal differentiation is a cause of preterm birth in mice with uterine Trp53 deletion, encoding p53 protein, led us to explore other potential factors that are related to preterm birth. Using proteomics approaches, here, we show that 183 candidate proteins show significant changes in deciduae with Trp53 deletion as compared with normal deciduae. Functional categorization of these proteins unveiled new pathways that are influenced by p53. In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53.

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