Eradicate Coronavirus by blocking replication, counteracting its defense system

10.31237/osf.io/y4cbt ◽

2020 ◽

Author(s):

Kira Smith

Keyword(s):

Defense Mechanism ◽

P53 Protein ◽

Sirtuin 1 ◽

Defense System ◽

Down Regulation ◽

Virus Growth ◽

Self Defense ◽

System P ◽

Lysosomotropic Agent ◽

Regulation Of Growth

SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.

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Eradicate Coronavirus by blocking replication, counteracting its defense system

10.31219/osf.io/psz35 ◽

2020 ◽

Author(s):

Kira Smith

Keyword(s):

Target Genes ◽

Defense Mechanism ◽

P53 Protein ◽

Sirtuin 1 ◽

Defense System ◽

Virus Growth ◽

Self Defense ◽

System P ◽

Lysosomotropic Agent ◽

Regulation Of Growth

SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as HIF-1α with the target genes and cytokines. Autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.

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Halting Coronavirus Replication

Epidemiology - Open Journal ◽

10.17140/epoj-5-119 ◽

2020 ◽

Vol 5 (1) ◽

pp. 13-15

Author(s):

Kira Smith ◽

Keyword(s):

Small Molecules ◽

Defense Mechanism ◽

P53 Protein ◽

Sirtuin 1 ◽

Down Regulation ◽

Virus Growth ◽

Viral Growth ◽

Self Defense

Sirtuin 1 (SIRT1) inhibitors can reduce replication of many viruses with certain characteristics similar to those of coronaviruses, while the p53 protein is another important factor in the down-regulation of viral growth. Tenovin is a class of small molecules that inhibit Sirtuin 1 and 2, in addition to activating the p53 protein, by means of regulating the interactions used by coronaviruses as a self-defense mechanism. By blocking virus growth and continuous replication, with already tested antiviral medicines, the promise of coronavirus disease 2019 (COVID-19) eradication exists.

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Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system

10.31219/osf.io/g9uas ◽

2020 ◽

Author(s):

Kira Smith

Keyword(s):

Small Molecule ◽

Ubiquitin Ligase ◽

P53 Protein ◽

E3 Ubiquitin Ligase ◽

Sirtuin 1 ◽

Defense System ◽

System P ◽

Unique Domain

How Treatment works: Coronaviruses reduce p53 protein as defese mechanism, by means an interaction between Sars-unique domain (SUD) and papain-like protease (PLPRO) via E3 ubiquitin ligase RCHY1. P53 is an important factor in downregulation of coronavirus replication, with reduction of Sirtuin 1 SIRT1. Tenovin-1 is a small molecule that inhibits SIRT1 and 2, and activates p53, protecting it against MDM-2 mediated degradation, which involves ubiquitination.

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The Quick Defense Personal Self-Defense System

Protection, Security, and Safeguards ◽

10.1201/9781420041897-26 ◽

2000 ◽

pp. 301-310

Keyword(s):

Defense System ◽

Self Defense

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UJI AKTIVITAS ANTIBAKTERI DAN ANTI-UV Phyllidiella nigra DAN BAKTERI SIMBIOTIKNYA DARI PERAIRAN TANJUNG MANDOLANG

JURNAL PESISIR DAN LAUT TROPIS ◽

10.35800/jplt.8.2.2020.29768 ◽

2020 ◽

Vol 8 (2) ◽

pp. 61

Author(s):

Tessalonica Dajoh ◽

Robert A Bara ◽

Esther Angkouw ◽

Medy Ompi ◽

Rosita A Lintang ◽

...

Keyword(s):

Escherichia Coli ◽

Antibacterial Activity ◽

Secondary Metabolites ◽

Bacillus Megaterium ◽

Absorption Maximum ◽

Chemical Compounds ◽

Inhibition Zone ◽

Defense System ◽

E Coli ◽

Self Defense

Phyllidiella nigra is an organism that is suspected to have secondary metabolites because their ability to develop its self defense system by camouflage and using chemical compounds derived from their nature diet as deterrent against their predators. The purpose of this study was to isolate symbiotic bacterial derived from P. nigra, extracted and followed by, the antibacterial assays against Escherichia coli and Bacillus megaterium as well as the anti-UV assay. The results showed that the five isolates tested had an antibacterial activity with the highest average inhibition zone against E. coli DSM 498 bacteria, isolate 1 (14.67 mm), isolate 5 (14 mm), and against B. Megaterium DSM 32T bacteria, isolate 3 (13.33 mm). The three isolates which had the highest inhibition zone and P. nigra extract were tested for anti-UV assay using a UV-Vis Spectrophotometer. The results obtained isolate 3 has absorption of UV-A with the UV absorbtion maximum at λ 340 nm and P. nigra extract has absorption on UV-B radiation with UV absorption maximum at λ 290 nm. Key words: Nudibranchia, Bacteria, Anti-bacteial, Anti-UV Phyllidiella nigra merupakan organisme yang diduga memiliki metabolit sekunder karena mampu mengembangkan sistem pertahanan dirinya dengan cara kamuflase dan menggunakan senyawa kimia sebagai racun yang didapat dari makanannya. Tujuan dari penelitian ini yaitu mendapatkan isolat bakteri yang bersimbiosis dengan P. nigra, mendapatkan ekstrak dari baktri simbion, dan menguji antibakteri dan anti-UV ekstrak etil aseta bakteri simbion dengan metode difusi agar terhadap bakteri Escherichia coli dan Bacillus megaterium. Hasil penelitian didapatkan kelima isolat yang diuji memiliki aktivitas antibakteri dengan rerata zona hambat tertinggi terhadap bakteri E. coli DSM 498 yaitu isolat 1 (14,67 mm), isolat 5 (14 mm), dan terhadap baktri B. megaterium DSM 32T yaitu isolat 3 (13,33 mm). Ketiga isolat yang memiliki zona hambat tertinggi dan ekstrak P. nigra diujikan anti-UV menggunakan alat UV-Vis Spektrofotometer. Hasil yang didapat isolat 3 memiliki serapan terhadap radiasi sinar UV-A dengan puncak tertinggi pada λ 340 nm dan ekstrak P. nigra memiliki serapan terhadap radiasi sinar UV-B dengan puncak tertinggi berada pada λ 290 nm. Kata kunci: Nudibranchia, Bacteria, Anti-bacteial, Anti-UV

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Down-Regulation of Growth Signaling Pathways Linked to a Reduced Cotyledonary Vascularity in Placentomes of Over-Nourished, Obese Pregnant Ewes

Placenta ◽

10.1016/j.placenta.2009.02.001 ◽

2009 ◽

Vol 30 (5) ◽

pp. 405-410 ◽

Cited By ~ 34

Author(s):

M.J. Zhu ◽

M. Du ◽

M.J. Nijland ◽

P.W. Nathanielsz ◽

B.W. Hess ◽

...

Keyword(s):

Signaling Pathways ◽

Down Regulation ◽

Regulation Of Growth

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Age-specific different immune responses due to capabilities of secreting primal immunoglobulins responding to unexperienced antigens

10.21203/rs.3.rs-841907/v1 ◽

2021 ◽

Author(s):

JANGHO LEE ◽

Kyoungshik Cho ◽

Hyejin Kook ◽

Suman Kang ◽

Yunsung Lee ◽

...

Keyword(s):

Stem Cells ◽

Immune System ◽

Defense Mechanism ◽

Ex Vivo ◽

Binding Capacity ◽

Culture Conditions ◽

Fetal Stem Cells ◽

Self Defense ◽

Wide Range ◽

Ex Vivo Culture

Abstract Among numerous studies on COVID-19, we noted that the infection and mortality rates of SARS-CoV-2 increased with age and that fetuses known to be particularly susceptible to infection were better protected despite various mutations. Hence, we established the hypothesis that a new immune system exists that forms before birth and decreases with aging. To prove this, we analyzed the components from early pregnancy fetal stem cells cultivated in various ex-vivo culture conditions simulating the environment during pregnancy. Resultingly, we confirmed that IgM, a natural antibody produced only in early B-1 cells, immunoglobulins including IgG3, which has a wide range of antigen-binding capacity and affinity, complement proteins, and antiviral proteins are induced. Our results suggest that fetal stem cells can form an independent immune system responding to unlearned antigens as a self-defense mechanism before establishing mature immune systems. Moreover, we propose the possibility of new solutions to cope with various infectious diseases based on the factors therein.

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Demilitarizing Palestine

The Global Community Yearbook of International Law and Jurisprudence 2018 ◽

10.1093/oso/9780190072506.003.0009 ◽

2019 ◽

pp. 191-206

Author(s):

Louis René Beres

Keyword(s):

International Law ◽

Prime Minister ◽

World System ◽

Legal Order ◽

Self Defense ◽

System P ◽

The World ◽

National Leaders

In principle, at least, Israeli Prime Minister Benjamin Netanyahu has made his country’s acceptance of Palestinian statehood contingent upon prior Palestinian “demilitarization.” This expressed contingency, however, is potentially contrary to pertinent international law, especially those norms regarding any sovereign state’s peremptory rights to self-defense. It follows, as this article will clarify, that potentially a new Palestinian state could permissibly abrogate any pre-independence commitments it had once made to remain demilitarized, and that reciprocally Israel ought never base its related security expectations upon any such mutable diplomatic promises. Ultimately most important, as the article concludes, is that national leaders all over the world finally begin to take seriously the organic “oneness” of our world legal order, and accordingly look toward identifying some promisingly coherent replacements for our time-dishonored Realpolitik or “Westphalian” world system.

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