Protective Effects of Vitamin E on Diabetes-induced Oxidative Stress Status and Homocysteine in the Rat Heart

AbstractHIV/AIDS related mortality has been dramatically reduced by the advent of antiretroviral therapy (ART). However, ART presents with associated adverse effects. One of such adverse effects is hepatotoxicity observed with nevirapine (NVP) containing ART. Since previous studies showed that NVP hepatotoxicity may be due to oxidative stress via generation of oxidative radicals, this study sought to evaluate the protective effects of antioxidants in alleviating NVP induced hepatotoxicity. Rats were divided into 6 groups with 8 animals per group and received doses of the antioxidants jobelyn (10.7 mg/kg/day), vitamin C (8 mg/kg/day), vitamin E (5 mg/kg/day) and/or NVP (6 mg/kg/day) for 60 days. The animals were sacrificed on day 61 by cervical dislocation, blood samples were collected for biochemical and hematological examination. The liver of the sacrificed animals was weighed and subjected to histopathological examination. There was a statistically significant (p<0.05) elevation in MDA level observed in the NVP group as compared with control. The results further showed non-significant decreases in the levels of MDA in the NVP plus antioxidant groups, except vitamin C, when compared with the NVP alone group. Vitamin E and Vitamin E plus C treated groups showed significantly (p<0.05) higher levels of SOD, CAT and GSH. The results also showed statistically significantly (p<0.05) lower levels of ALT and AST in the antioxidant treated groups There was an observed significantly (p<0.05) higher level of TP and urea in the antioxidant treated rats. A significantly (p<0.05) higher white blood cell count was observed in the antioxidant groups. Histopathological assessment of the liver extracted from the rats showed no visible pathology across the groups. Observations from this study suggest a potentially positive modulatory effect of antioxidants and may be indicative for the inclusion of antioxidants in nevirapine containing ART.

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Effects of vitamin E supplementation on exercise-induced oxidative stress: a meta-analysis

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2013-0566 ◽

2014 ◽

Vol 39 (9) ◽

pp. 1029-1037 ◽

Cited By ~ 18

Author(s):

Vahan Stepanyan ◽

Melissa Crowe ◽

Nagaraja Haleagrahara ◽

Bruce Bowden

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Vitamin E ◽

Muscle Damage ◽

Meta Analysis ◽

Protective Effects ◽

Study Selection ◽

Exercise Induced ◽

Study Designs ◽

Selection Of

Tocopherols (commonly referred to as “vitamin E”) are frequently studied antioxidants in exercise research. However, the studies are highly heterogeneous, which has resulted in contradicting opinions. The aim of this review is to identify similar studies investigating the effects of tocopherol supplementation on exercise performance and oxidative stress and to perform minimally biased qualitative comparisons and meta-analysis. The literature search and study selection were performed according to Cochrane guidelines. A 2-dimensional study execution process was developed to enable selection of similar and comparable studies. Twenty relevant studies were identified. The high variability of study designs resulted in final selection of 6 maximally relevant studies. Markers of lipid peroxidation (malondialdehyde) and muscle damage (creatine kinase) were the 2 most frequently and similarly measured variables. Meta comparison showed that tocopherol supplementation did not result in significant protection against either exercise-induced lipid peroxidation or muscle damage. The complex antioxidant nature of tocopherols and low accumulation rates in muscle tissues could underlie an absence of protective effects.

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Protective effects of vitamin E and curcumin on l-thyroxine-induced rat testicular oxidative stress

Chemico-Biological Interactions ◽

10.1016/j.cbi.2008.07.009 ◽

2008 ◽

Vol 176 (2-3) ◽

pp. 121-128 ◽

Cited By ~ 64

Author(s):

Dipak Kumar Sahoo ◽

Anita Roy ◽

Gagan B.N. Chainy

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Protective Effects

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Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients

Advanced Biomedical Research ◽

10.4103/2277-9175.178780 ◽

2016 ◽

Vol 5 (1) ◽

pp. 36 ◽

Cited By ~ 19

Author(s):

Mohamad Najafi ◽

Jafar Mehvari ◽

FatanehGholami Motlagh ◽

MohammadReza Aghaye Ghazvini ◽

AmirmansourAlavi Naeini ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Seizure Frequency ◽

Oxidative Stress Status ◽

Epileptic Patients ◽

And Oxidative Stress

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Dendrobine attenuates isoniazid- and rifampicin-induced liver injury by inhibiting miR-295-5p

Human & Experimental Toxicology ◽

10.1177/0960327120937047 ◽

2020 ◽

Vol 39 (12) ◽

pp. 1671-1680

Author(s):

R Ci ◽

K Zhang ◽

A Zhu ◽

W Zang

Keyword(s):

Oxidative Stress ◽

Liver Injury ◽

Luciferase Reporter ◽

Protective Effects ◽

Histological Changes ◽

Stress Markers ◽

Oxidative Stress Status ◽

Protein Expressions ◽

Polymerase Chain ◽

Underlying Mechanisms

The present study aims to investigate the protective effects of Dendrobine and its underlying mechanisms on liver injury induced by isoniazid (INH) and rifampicin (RIF). A mouse model of liver injury was induced by intragastrically administration of 100 mg/kg INH and 100 mg/kg RIF for 14 days. The mice were intragastrically administrated with Dendrobine (50, 100, and 200 mg/kg) before the administration of INH and RIF. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Oxidative stress markers including glutathione, superoxide dismutase, and malondialdehyde in the liver were measured and liver histopathological examinations were performed. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot were applied to determine the mRNA and protein expressions, respectively. Luciferase reporter assay was used to evaluate the interactions between miR-295-5p and CYP1A2. Dendrobine significantly decreased serum ALT and AST and inhibited the liver index and ameliorated the liver histological changes induced by INH and RIF. Besides, Dendrobine also regulated oxidative stress status in the liver by the regulation of CYP1A2. Moreover, mmu-miR-295-5p was identified to target CYP1A2 and to regulate the expression of CYP1A2. In summary, Dendrobine ameliorated INH and RIF induced mouse liver injury by miR-295-5p-mediated CYP1A2 expression.

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Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart

Scientific Reports ◽

10.1038/s41598-019-43320-5 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 22

Author(s):

Pallavi Mishra ◽

Biswaranjan Paital ◽

Srikanta Jena ◽

Shasank S. Swain ◽

Sunil Kumar ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin E ◽

Thyroid Hormone ◽

Rat Heart ◽

Altered Thyroid

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Rhanterium suaveolens, Vitamin E and C Pretreatment Prevents Valproic Acid Induced Renal Oxidant Damage

The Natural Products Journal ◽

10.2174/2210315510999200629205136 ◽

2020 ◽

Vol 10 ◽

Author(s):

Amel Amrani ◽

Ouahiba Benaissa ◽

Nassima Boubekri ◽

Fadila Benayache ◽

Samir Benayache ◽

...

Keyword(s):

Oxidative Stress ◽

Valproic Acid ◽

Vitamin E ◽

Serum Creatinine ◽

Natural Antioxidants ◽

Control Group ◽

Protective Effects ◽

Butanol Extract ◽

Renal Tubular ◽

Vit C

Background: Long-term administration of valproic acid (VPA) is known to promote renal tubular injury mediated by increase in renal oxidative stress. Recent evidence indicates that natural antioxidants are alternative to attenuate oxidative stress and kidney damage. Objective: This study was performed to investigate the protective effects of n-butanol extract of Rhanterium suaveolens, vitamin E (Vit E) and vitamin C (Vit C) against VPA induced nephrotoxicity in mice. Methods: Mice were randomly divided into 6 groups (n: 8) and treated daily for 12 days. They received VPA (300 mg/kg intraperitoneally (ip)), buthanolic extract (100 mg/kg), Vit E (100 mg/kg), and Vit C (16.66 mg/kg) 1h prior to administration of VPA. On day 13, blood and Kidneys samples were analyzed for biomarker levels and histopathological changes. Kidneys homogenates were used for determination of oxidative stress parameters that include malondialdehyde (MDA), glutathione (GSH) level and glutathione peroxidase (GPx) activity. Result: Treatment with VPA showed a significant increase in the levels of serum creatinine, urea and malondialdehyde (MDA) and decreasing the enzymatic activity (GPx) as well as GSH levels in kidney with marked necrotic epithelial cells and infiltration in kidney sections as compared to the control group. Pretreatment with the n-butanol extract of R. suaveolens, Vit C or Vit E 1 h prior to administration of VPA showed a significant decrease in the levels of serum creatinine, urea, and MDA, as well as an improvement in the antioxidant elements and histological changes compared to those previously seen in the group treated with VPA alone. Conclusion: It is concluded that n-butanol extract of R. suaveolens, Vit C and Vit E pretreatment effectively improved renal function and tissue oxidative damage caused by VPA.

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