Abstract
Background: We analyzed the effects of hemorrhage control methods on the mortality of patients with hemodynamic instability due to pelvic fracture and investigated independent risk factors for mortality in these patients.Methods : A total of 97 pelvic bone fracture patients with hemodynamic instability who visited the emergency departments of two university hospitals from January 2013 to October 2017 were enrolled. These patients were divided into the survival and non-survival groups based on 28-day mortality and acute hemorrhage mortality. Clinical data including laboratory test results, trauma severity scores, and hemorrhage control modalities were collected and statistically analyzed. Furthermore, the effects of each hemorrhagic control modality on mortality were analyzed. Multivariate logistic regression was performed to determine independent risk factors for mortality.Results: Overall mortality was 41.24% (40 patients), 28-day mortality was 38.14% (37 patients), and acute hemorrhage mortality was 28.86% (28 patients). With respect to hemorrhage control modalities, 47 patients (48.5%) underwent pelvic angiography, 45 patients (46.4%) underwent pre-peritoneal pelvic packing, and 19 patients (19.6%) underwent external fixation. Differences in hemorrhage control methods had no significant effects on mortality. However, there was a significant difference in mortality between the groups with and without any hemorrhage control methods. A multivariate logistic regression analysis revealed that patient age, trauma and injury severity score (TRISS; probability of survival), and transfusion amount within 24 hours were independent factors for 28-day mortality. Using the same statistical analysis, patient age, transfusion amount within 24 hours, Glasgow coma scale (GCS) score, and systolic blood pressure (SBP) were independent factors for mortality due to acute hemorrhage.Conclusions: Hemorrhage control methods can aid in reducing acute hemorrhage mortality in hemodynamically unstable patients with pelvic fractures; nevertheless, no significant difference in mortality according to different hemorrhage control methods was found. Older age, higher transfusion requirements, low TRISS scores, GCS scores, and SBP are independent risk factors for mortality in pelvic fracture patients with hemodynamic instability.