Lab analysis Protocol - Impact of vitamin A, riboflavin, pyridoxal, and vitamin B12 nutritional status on plasma homocysteine and docosahexaenoic fatty acid in Brazilian children and adolescents v1 (protocols.io.vd4e28w)

protocols.io ◽  
2018 ◽  
Author(s):  
Maria Ol ◽  
Ane Cristina ◽  
F bio ◽  
Mariana Giaretta ◽  
Carolina de ◽  
...  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Carlos Alessandro Fuzo ◽  
Fábio da Veiga Ued ◽  
Sofia Moco ◽  
Ornella Cominetti ◽  
Sylviane Métairon ◽  
...  

AbstractPolymorphisms in genes related to the metabolism of vitamin B12 haven’t been examined in a Brazilian population. To (a) determine the correlation between the local genetic ancestry components and vitamin B12 levels using ninety B12-related genes; (b) determine associations between these genes and their SNPs with vitamin B12 levels; (c) determine a polygenic risk score (PRS) using significant variants. This cross-sectional study included 168 children and adolescents, aged 9–13 years old. Total cobalamin was measured in plasma. Genotyping arrays and whole exome data were combined to yield ~ 7000 SNPs in 90 genes related to vitamin B12. The Efficient Local Ancestry Inference was used to estimate local ancestry for African (AFR), Native American, and European (EUR). The association between the genotypes and vitamin B12 levels were determined with generalized estimating equation. Vitamin B12 levels were driven by positive (EUR) and negative (AFR, AMR) correlations with genetic ancestry. A set of 36 variants were used to create a PRS that explained 42% of vitamin level variation. Vitamin B12 levels are influenced by genetic ancestry and a PRS explained almost 50% of the variation in plasma cobalamin in Brazilian children and adolescents.


2018 ◽  
Author(s):  
Windu Merdekawati

Pemanfaatan rumput laut sebagai bahan pangan telah dilakukan sejak jaman dahulu bahkan rumput laut disinyalir telah dikonsumsi sejak jaman manusia purba. Rumput laut umumnya bersifat edible (dapat dimakan). Tumbuhan laut ini kaya akan polisakarida, mineral esensial, vitamin serta protein, rendah kalori dan rendah lemak. Kadar polisakarida dalam rumput laut mencapai 4-76% dari berat keringnya. Terdapat sekitar 56 jenis mineral dan trace mineral dalam rumput laut. Kadar mineral dalam rumput laut 10-20 kali lebih tinggi daripada mineral dalam tumbuhan darat. Dalam rumput laut juga tersimpan vitamin A, B, C, dan D serta vitamin E. Rumput laut juga mengandung vitamin B12 yang umumnya ditemukan dalam hewan. Kadar protein pada rumput laut mencapai 10-40% sedangkan kadar lemak hanya berkisar 1-5% dari berat kering. Jenis lemak dalam rumput laut merupakan PUFA (polyunsaturated fatty acid) khususnya asam lemak omega-3 dan omega-6 yang terkonsentrasi dalam fraksi galaktolipid. Rumput laut telah dimanfaatkan secara tradisional oleh masyarakat Asia dalam pengobatan penyakit kanker, hati dan tiroid; meningkatkan fungsi imun tubuh; sebagai anti-bakteri serta anti-virus. Perlunya konsumsi rumput laut dalam menu sehari-hari cukup beralasan mengingat beragam substansi penting serta manfaatnya untuk menunjang dan melindungi kesehatan tubuh.


2021 ◽  
Vol 3 (9) ◽  
pp. 189-192
Author(s):  
Rui Wang ◽  
◽  
Huidi Zhang ◽  
Yi-chun Hu ◽  
Jing Chen ◽  
...  

2020 ◽  
Vol 20 (3) ◽  
pp. 667-679
Author(s):  
Dixis Figueroa Pedraza

Abstract Objectives: to examine the nutritional status of vitamin A in Brazilian children under 5 years old, delimiting their deficiency and associated factors. Methods: this is a systematic review of articles published between 2008 and 2018, using the SciELO, Bireme, and PubMed electronic databases. A validated instrument critically evaluated the studies. The summary measures were obtained by the random effect model, and their results are presented using the Forest Plot graph. The qualitative synthesis was based on the description of the main factors associated with Vitamin A Deficiency. Results: we included 14 cross-sectional studies with observations in basic health units, daycare centers, and households. The summary measure indicated Vitamin A Deficiency of 20% (CI95%= 17% - 23%), with high homogeneity according to the source of the sample. Lower age of the child, low birth weight, poor iron nutritional status, diarrhea, subclinical infection, inadequate basic sanitation conditions, younger mothers and less maternal educa-tion represented the main exposures associated with the outcome. Conclusion: the results show Vitamin A Deficiency as a public health problem in Brazilian children under 5 years old, especially when related to the development of infectious processes and maternal and child characteristics that show greater susceptibility.


Sign in / Sign up

Export Citation Format

Share Document