Double Trouble: an observational study of thyroid dysfunction in South Indian subjects with type 2 diabetes

Abstract Background This study aimed to explore predictive factors of time below target glucose range (TBR) ≥ 1% among patients’ characteristics and glycemic variability (GV) indices using continuous glucose monitoring data in elderly patients with type 2 diabetes. Methods We conducted a prospective observational study on 179 (71 female) Japanese outpatients with type 2 diabetes aged ≥ 65 years. The characteristics of the participants with TBR ≥ 1% were evaluated by multivariate logistic regression analysis. Receiver-operating characteristic (ROC) curve analyses of GV indices, comprising coefficient of variation (CV), standard deviation, and mean amplitude of glycemic excursions, were performed to identify the optimal index for the identification of patients with TBR ≥ 1%. Results In the multivariate logistic regression analysis, none of the clinical characteristics, including HbA1c and C-peptide index, were independent markers for TBR ≥ 1%, while all three GV indices showed significant associations with TBR ≥ 1%. Among the three GV indices, CV showed the best performance based on the area under the curve in the ROC curve analyses. Conclusions Among elderly patients with type 2 diabetes, CV reflected TBR ≥ 1% most appropriately among the GV indices examined. Trial registration UMIN-CTR: UMIN000029993. Registered 16 November 2017

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Effects of sedentary behavior and daily walking steps on body mass index and body composition: Prospective observational study using outpatient clinical data of Japanese patients with type 2 diabetes

Journal of Diabetes Investigation ◽

10.1111/jdi.13527 ◽

2021 ◽

Author(s):

Shuhei Nakanishi ◽

Masashi Shimoda ◽

Fuminori Tatsumi ◽

Kenji Kohara ◽

Atsushi Obata ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Mass Index ◽

Body Composition ◽

Observational Study ◽

Sedentary Behavior ◽

Body Mass ◽

Clinical Data ◽

Prospective Observational Study ◽

Japanese Patients

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Association of genetic polymorphisms in vitamin D receptor (ApaI, TaqI and FokI) with vitamin D and glycemic status in type 2 diabetes patients from Southern India

Drug Metabolism and Personalized Therapy ◽

10.1515/dmpt-2020-0178 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Sandhiya Selvarajan ◽

Akila Srinivasan ◽

Deepanjali Surendran ◽

Jayanthi Mathaiyan ◽

Sadishkumar Kamalanathan

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Southern India ◽

Glycemic Status ◽

Genotype Frequencies ◽

South Indian ◽

Vitamin D Levels ◽

Vdr Polymorphisms ◽

Diabetes Patients

Abstract Objectives To evaluate the association of VDR polymorphisms (FokI, TaqI and ApaI) with vitamin D levels and glycemic status in type 2 diabetes patients from Southern India. Methods In this observational study, genotype frequencies and vitamin D levels of 200 cases (type 2 diabetes patients) were compared with 300 controls (unrelated anonymised stored samples of healthy volunteers) from south India. Serum 25 (OH) D levels were measured by immunoassay technique, glycated hemoglobin (HbA1c) was measured using HPLC and genotyping of VDR polymorphisms were carried out using Real time Polymerase Chain Reaction (RT PCR). Results About 69.2% of type 2 diabetes patients were found to have vitamin D deficiency. FokI polymorphism showed variations in serum 25 (OH) D levels, with AA and AG genotypes having significantly lower serum 25 (OH) D levels as compared to GG [13.24 (8.4) ng/ml, 15.02 (7.07) ng/ml and 20.67 (13.64) ng/ml respectively]. There was no difference in HbA1c levels with respect to the vitamin D levels and VDR polymorphisms. Conclusions AA and AG genotypes of FokI polymorphisms are associated with low serum 25 (OH) D levels. However there was no association between VDR polymorphisms and glycemic status in south Indian type 2 diabetes patients.

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