scholarly journals Prevalence of hyperuricemia in cerebrovascular accidents and its correlation with their outcome

2021 ◽  
Vol 9 (4) ◽  
pp. 269-273
Author(s):  
Dr. Preeti Kori ◽  
◽  
Dr. Mahendra Chouhan ◽  
Dr. Sohan Singh Mandloi ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Vascular System ◽  
High Serum ◽  
Uric Acid Concentration ◽  
Stroke Patients ◽  
Cerebrovascular Accidents ◽  
Serum Uric Acid Concentration ◽  
Significant Difference ◽  
Male Patients

Introduction: Cerebrovascular accident or stroke is a disease of the vascular system of the brain.According to ICD 11, stroke is classified as a neurological disease and not under the circulatorysystem. It is the second leading cause of death worldwide. It cannot be said that high Serum UricAcid [SUA] amongst patients with cerebrovascular accidents is directly correlated with theiroutcome. The present study planned to estimate uric acid levels and their association in acute strokepatients, both ischemic and hemorrhagic. Method: A total of 100 stroke patients admitted under theneurology department were included in the study. Brain imaging (CT/MRI) was performed. Theserum uric acid was estimated. Results: Out of a total of 100 patients, 74 were males, and 26 werefemales. Nine patients were less than 45 years old and 91 patients were 45 and above. Thirty-ninepatients had ischemic, and 61 patients had a hemorrhagic stroke, respectively. Out of 100 patients,23 patients had normal uric acid levels (<7mg/dl). Seventy-seven patients were with high uric acidlevels. The mean serum uric acid concentration in male patients was 8.48±2.7and 9.20±2.7 infemales. Among the total 100 cases, 69 survived, and the remaining 31 were among the non-survivor group at the time of discharge. Mean serum uric acid in stroke survivors was 8.5±2.6mg/dl, while in non-survivors, it was 8.6±2.2 mg/dl. There was no significant difference between thelevels of uric acid among survivors and non-survivors. Conclusions: The prevalence ofhyperuricemia (>9mg/dl) amongst stroke patients was 77% in the present study. The values ofserum uric acid were significantly elevated in the patients aged > 45 years. The serum uric acidvalues were high among the group of hyperglycemic and hypertensive patients at the time ofadmission. There was no significant difference between the levels of uric acid among survivors andnon-survivors.

High serum uric acid concentration predicts poor survival in patients with breast cancer

2017 ◽  
Vol 473 ◽  
pp. 160-165 ◽  
Author(s):  
Cai-Feng Yue ◽  
Pin-Ning Feng ◽  
Zhen-Rong Yao ◽  
Xue-Gao Yu ◽  
Wen-bin Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
High Serum ◽  
Uric Acid Concentration ◽  
Poor Survival ◽  
Serum Uric Acid Concentration

Serum Uric Acid Concentrations Can Predict Hypertension: A Longitudinal Population-Based Epidemiological Study

2017 ◽  
Vol 49 (11) ◽  
pp. 873-879 ◽  
Author(s):  
Rongjiong Zheng ◽  
Tianmeng Yang ◽  
Qingmei Chen ◽  
Changxi Chen ◽  
Yushan Mao
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Chinese Population ◽  
Cox Regression ◽  
Elevated Serum ◽  
Population Based ◽  
High Serum ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration ◽  
Hypertension Development

AbstractAn elevated serum uric acid concentration may be associated with hypertension, which is the leading cause of death worldwide. However, whether the elevation is causal or a consequence of hypertension among the Chinese population remains unclear. This study was designed to investigate the longitudinal relationship between the serum uric acid concentrations and hypertension among Chinese individuals. This study included 5105 subjects, initially without hypertension, who were followed up for 9 years. The subjects were divided into four groups based on the serum uric acid quartile. Cox proportional hazard models were used to analyse the risk factors for hypertension development. Over the 9 years, 2259 of the subjects developed hypertension. The overall 9-year cumulative incidence of hypertension was 44.3%, ranging from 36.3% in quartile 1 to 42.4%, 44.1%, and 54.5% in quartiles 2, 3, and 4, respectively (p for trend<0.001). The Cox regression analyses indicated that the serum uric acid concentrations were independently and positively associated with the risk of incident hypertension. This longitudinal study demonstrated that high serum uric acid concentrations increase the risk of hypertension among the Chinese population.

scholarly journals Independent Association of High Serum Uric Acid Concentration with Angiographically Defined Coronary Artery Disease

2007 ◽  
Vol 211 (4) ◽  
pp. 369-377 ◽  
Author(s):  
Zorana Jelic-Ivanovic ◽  
Lidija Memon ◽  
Vesna Spasojevic-Kalimanovska ◽  
Nataša Bogavac-Stanojevic ◽  
Slavica Spasic
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
High Serum ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration ◽  
Artery Disease ◽  
Independent Association

scholarly journals Sex Difference in the Association Between Eating Away From Home and the Risk of High Serum Uric Acid in South China

2021 ◽  
Vol 8 ◽  
Author(s):  
Shao-wei Chen ◽  
Ping Wang ◽  
Gui-yuan Ji ◽  
Qi Jiang ◽  
Xiao-min Hong ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
South China ◽  
Odds Ratio ◽  
Red Meat ◽  
High Serum ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration ◽  
Generalized Linear Mixed Effects ◽  
The Relationship

Background: The prevalence of high serum uric acid is increasingly rising in recent years, and diet behavior is perceived to be associated with it. This study aimed to explore the relationship between eating away from home (EAFH) and the risk of high serum uric acid in adults in South China.Methods: The data utilized in this study were from Guangdong Nutrition and Health Survey (NHS) 2015. Serum uric acid concentration was detected. EAFH in the past week was investigated. We defined EAFH as food consumption away from home. Dietary data were collected by 24-h recalls on 3 consecutive days. A generalized linear mixed-effects model was applied to compute the odds ratio (OR) and its corresponding 95% CI.Results: A total of 3,489 individuals were included in this study. A 1.27-fold OR (95% CI: 1.05–1.52, P = 0.012) of high serum uric acid was identified in adults with EAFH in comparison with those without EAFH. With respect to men, a 1.66-fold OR (95% CI: 1.3–2.1, P &lt; 0.001) of high serum uric acid was observed. We also observed that men with EAFH had higher intakes of red meat, poultry, vegetable, carbohydrate, protein, fat, and total energy, while a lower grain intake than those without EAFH. However, there was a lack of significant association between EAFH and the odds ratio of high serum uric acid in women. Women with EAFH did not have higher consumptions of red meat, vegetable, fish, fat, and water than those without EAFH.Conclusions: This study found that EAFH was associated with an increased odds ratio of high serum uric acid in men, but not in women.

Effect and Mechanism of Total Saponin of Dioscorea on Animal Experimental Hyperuricemia

2006 ◽  
Vol 34 (01) ◽  
pp. 77-85 ◽  
Author(s):  
Guang-Liang Chen ◽  
Wei Wei ◽  
Shu-Yun Xu
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Serum Uric Acid Level ◽  
Urate Oxidase ◽  
Uric Acid Concentration ◽  
Total Saponin ◽  
Test Kit ◽  
Serum Uric Acid Concentration ◽  
Potassium Oxonate

In this study, we investigated the effects and mechanisms of Total Saponin of Dioscorea (TSD) on animal experimental hyperuricemia. Mouse and rat hyperuricemic models were made by orally administering yeast extract paste once a day (30 and 20 g/kg, respectively), for 7 days. Yeast would disturb normal purine metabolism by increasing xanthine oxidase (XOD) activity and generating large quantities of uric acid. This model is similar to human hyperuricemia, which is induced by high-protein diets, due to a purine and nucleic acid metabolic disturbance. Another mouse hyperuricemia model was generated by intraperitoneal injection once with uric acid 250 mg/kg or potassium oxonate 300 mg/kg. Potassium oxonate, a urate oxidase inhibitor, can raise the serum uric acid level by inhibiting the decomposition of uric acid. Likewise, injecting uric acid can also increase serum uric acid concentration. The concentration of uric acid in serum or urine was detected by the phosphotungstic acid method, and the activity of XOD was assayed by a test kit. The results showed that TSD (240, 120 and 60 mg/kg, ig) could significantly lower the level of serum uric acid in hyperuricemic mice. TSD (120 and 60 mg/kg, ig) could also lower the level of serum uric acid in hyperuricemic rats, reduce the activity of XOD in the serum and liver of hyperuricemic rats, and increase the level of urine uric acid concentration as well as 24-hour total uric acid excretion. In conclusion, TSD possesses a potent anti-hyperuricemic effect on hyperuricemic animals, and the mechanism may be relevant in accelerating the excretion and decreasing the production of uric acid.

scholarly journals Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid Concentrations and Lipid Parameters Among King Abdulaziz University Hospital Patients

2021 ◽  
Author(s):  
Ranya A. Ghamri ◽  
Tala A. Qalai ◽  
Raghad A. Ismail ◽  
Joud M. Aljehani ◽  
Dina S. Alotaibi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lipid Profile ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Density Lipoprotein ◽  
University Hospital ◽  
Uric Acid Concentration ◽  
Serum Uric Acid Concentration ◽  
King Abdulaziz University ◽  
The Relationship

Abstract Background: Hyperuricemia is a metabolic defect caused by high purine consumption, overproduction of uric acid, or reduced uric acid excretion. Hyperuricemia is the second most common metabolic disease after diabetes mellitus and can mediate proinflammatory endocrine imbalance in adipose tissue, which contributed to dyslipidemia. Furthermore, several studies have associated uric acid with dyslipidemia. However, no previous studies have examined patients without chronic illness. Thus, we aimed to assess the relationship between serum uric acid concentration and lipid profile parameters and to estimate the prevalence of hyperuricemia in the city of Jeddah. Methods: A retrospective study was conducted among 1206 patients without chronic illness after applying the exclusion criteria. Patients had undergone laboratory blood testing over a 3-year period (2018–2020) at King Abdulaziz University Hospital, which was ethically approved. We used a predesigned checklist to collect data from electronic hospital records using Google Forms. Bivariate analysis, tables, and graphs were used to represent and identify the relationships between variables. A P-value of <0.05 was considered significant.Results: Our study revealed a prevalence of 12% for hyperuricemia in the study population. Males were more frequently affected than females (8.13% vs. 3.73%, respectively). There was no association between serum uric acid concentration and lipid profile parameters, including total cholesterol (P = 0.92), triglyceride (P = 0.42), high-density lipoprotein (P = 0.47), and low-density lipoprotein (P = 0.66). There was a strong association between serum uric acid concentration and high body mass index (P < 0.001), older age (P = 0.002), male sex (P < 0.001), and nationality (P < 0.001). Furthermore, there was an association between sex and mean erythrocyte sedimentation rate (P = 0.02) and mean triglyceride concentration (P = 0.02).Conclusion: We observed a low prevalence of hyperuricemia, and our results indicate no association between serum uric acid concentration and lipid profile parameters.

scholarly journals Serum uric acid concentration (SUAC): A useful tool to assess extent and severity of chronic plaque psoriasis in Pakistani population.

2019 ◽  
Vol 26 (11) ◽  
pp. 1825-1828
Author(s):  
Hafiz Bashir Ahmed ◽  
Deepa Mohan Lal ◽  
Muhammad Suleman Pirzado ◽  
Ajmal Rashid ◽  
Irfan Anwar ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Plaque Psoriasis ◽  
Critical Role ◽  
Elevated Serum ◽  
Control Group ◽  
Uric Acid Concentration ◽  
Chronic Plaque Psoriasis ◽  
Serum Uric Acid Concentration

Objectives: Psoriasis is a systemic chronic inflammatory autoimmune disease. Psoriasis can lead to multiple complications and co-morbidities. It has also been observed that raised serum uric acid levels predispose to gouty arthritis and also thought to be a risk factor for cardiovascular mortality and morbidity. The basic aim of this study was to ascertain level of serum uric acid in patients with chronic plaque psoriasis and control cases which might be a useful tool for assessing the extent and severity of chronic plaque psoriasis. Study Design: Case control study. Setting: At Outpatient’s Department (OPD) of Department of Dermatology, PNS Shifa, Karachi. Period: From January 2013 to December 2016. Material & Methods: One hundred and ninety four (194) patients were taken in this study and 97 patients were biopsy proven cases of psoriasis and 97 other participants included as control cases reporting to OPD with other complaint like acne, hair fall and fungal infections. After written and informed consent, 5ml of venous blood was drawn in sterile syringe and using gel sample tube to see the serum uric acid levels. On the basis of laboratory reports the elevated serum uric acid level in psoriatic versus normal controls was recorded on a pre-designed proforma. Results: There were 54.6% (106/194) male and 45.4% (88/194) female. Elevated serum uric level was 4.5 times (Approximate of 4.46) more common in cases than control group (OR: 4.46 95%CI: 1.83 to 10.91). Conclusion: Raised levels of serum Uric acid have been seen frequently in psoriatic patients. Early treatment for higher levels of serum uric acid might play a critical role in the better treatment of psoriatic patients. These results revealed that serum uric acid concentration (SUAC) of psoriasis may play a vital role in assessing the complex multifactorial etiology of the psoriasis, severity and other possible metabolic factors.

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