scholarly journals Sleep-disordered breathing a neglected risk factor in primary open-angle glaucoma

2021 ◽  
Vol 6 (4) ◽  
pp. 76-84
Author(s):  
Dr. Mandeep Kaur ◽  
◽  
Dr. Inderjit Kaur ◽  
Dr. Jagdeepak Singh ◽  
◽  
...  
Keyword(s):  
Risk Factor ◽  
Sleep Disordered Breathing ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
P Value ◽  
Open Angle ◽  
Male Predominance ◽  
Associated Risk Factors ◽  
The Relationship ◽  
Disordered Breathing

Background: Sleep-disordered breathing (SDB) is accompanied by large swings in blood pressureand the repetitive hypoxic period during sleep, which may accelerate anoxic optic nerve damageseen in glaucoma. There are many associated risk factors in primary open-angle glaucoma (POAG),but recently, SDB, though a neglected one, is coming up as a risk factor. However, various studieshave reported controversial findings. Objective: To evaluate the relationship between SDB andPOAG. Design: A hospital-based case-control study. Methods: A total of 400 patients between 30–70 years were recruited from eye OPD between 2008- 2010. They were divided into two groups, 200cases with established POAG and 200 age and sex-matched healthy subjects with normal IOP in thecontrol group. Detailed history, complete ophthalmic and ENT examination was made along withBMI, blood pressure and neck girth measurement. Both groups were interviewed with aquestionnaire regarding SDB and were recorded on the Epworth sleepiness scale (ESS). Results:The mean age being 55.02 ± 8.66 in the POAG group and male predominance noted both in POAGand SDB patients with ESS> 10 was statistically significant (p < 0.05). Also, patients in the POAGgroup with ESS > 10 had more IOP and BMI, greater neck girth, high BP and more ENT problemswith p-value < 0,001, which is highly significant, thus showing the relationship between SDB andPOAG. Conclusions: Increased community awareness and earlier detection of glaucoma and itscorrelation with SDB results in decreased morbidity.

High prevalence of sleep-disordered breathing in patients with primary open-angle glaucoma

2000 ◽  
Vol 78 (6) ◽  
pp. 638-641 ◽  
Author(s):  
S. Hakki Onen ◽  
Frédéric Mouriaux ◽  
Lotfi Berramdane ◽  
Jean-Claude Dascotte ◽  
Jean-François Kulik ◽  
...  
Keyword(s):  
Sleep Disordered Breathing ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
High Prevalence ◽  
Disordered Breathing

scholarly journals The Association between Myopia and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Jian Wu ◽  
Jie Hao ◽  
Yifan Du ◽  
Kai Cao ◽  
Caixia Lin ◽  
...  
Keyword(s):  
Risk Factor ◽  
Random Effects ◽  
Protective Factor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Field Loss ◽  
Random Effects Model ◽  
Open Angle ◽  
Cross Sectional ◽  
The Relationship

Background: Previous studies identified myopia as a risk factor for primary open-angle glaucoma (POAG). However, recent studies have shown different results, the definitive relationship between myopia and POAG remains controversial. Objectives: To investigate the relationship between myopia and POAG. Methods: Published articles were searched from PubMed, Embase, and Scopus databases between 1970 and 2020. A pooled analysis of the ORs was performed using a random-effects model. Results: Data on the association between myopia and POAG, were obtained from 16 cross sectional studies, and the pooled OR was 2.26 (95% confidence interval [CI], 1.77 – 2.89, P < 0.001) in random effects model (I2 = 86%; P < 0.01). For the relationship of myopia and POAG progression, data from seven longitudinal cohort studies were included and the pooled OR was 0.85 (95% CI, 0.73 – 0.99, P = 0.042) in the random-effects model (I2 = 88%; P < 0.01). Conclusion: Our findings demonstrated that myopia may be a risk factor associated with POAG and a possible protective factor for POAG progression. It may due to myopia with the presence of a lamina cribrosa defect slow down the visual field loss also POAG progression, further research for underlying mechanisms is still needed.

Clinical Profile of Myopic Patients as a Risk Factor for Primary Open Angle Glaucoma - A Prospective Observational Study in Gorakhpur, Uttar Pradesh

2021 ◽  
Vol 8 (33) ◽  
pp. 3084-3089
Author(s):  
Ram Kumar Jaiswal ◽  
Ramyash Singh Yadav ◽  
Mridula Ranjan ◽  
Dipti Wahi ◽  
Chiranji Rai
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Observational Study ◽  
High Myopia ◽  
Central Corneal Thickness ◽  
Prospective Observational Study ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Open Angle

BACKGROUND Myopia is a complex trait including both genetic and environmental factors as well as gene-environment interactions. It has been recognized as a risk factor for development of glaucoma. Both Myopia and raised IOP are known to increase mechanical stress at optic nerve head leading to glaucomatous nerve damage. This study intends to evaluate the clinical profile of myopic subjects and its correlation with Primary open angle glaucoma (POAG). METHODS A prospective observational study done from November 2019 to December 2020 after taking proper informed consent and ethical clearance. 164 eyes of 96 patients studied were divided into three groups, Group 1: low myopia (< -3.00D), Group 2: moderate myopia (-3.00 D to -5.75 D), Group 3: high myopia (≥ -6.00 D). A complete ocular examination was performed. Intraocular pressure was measured using Goldmann applanation tonometer. Visual field analysis using Humphrey automated perimetry was done in patients with suspected primary open angle glaucoma (POAG). Angle parameters and central corneal thickness (CCT) were measured using anterior segment optical coherence tomography (AS-OCT). RESULTS 164 eyes of 96 Myopic subjects were studied with no dropout during study period. Mean age was 46.05 yr. (range: 25-75 yr.). The refraction ranged from -0.50 DS to -17.00 DS. There was no statistically significant difference between Intraocular pressure (IOP), Central corneal thickness (CCT), corrected IOP and Nasal and Temporal Trabecular-iris Angle (TIA) between male and female of same age group. Mean IOP and mean CCT were found to vary significantly with age and with higher degree of myopia. Corrected IOP, Nasal and Temporal TIA increase significantly with higher degree of myopia. Cup-disc ratio (CDR) was found to be significantly higher in patients with moderate to high degree of Myopia. CONCLUSIONS Myopia is an important risk factor for development of primary open angle glaucoma, with its incidence increasing in patients with moderate to high myopia. KEYWORDS Myopia, Primary Open Angle Glaucoma, Intraocular Pressure, Central Corneal Thickness, Trabecular Iris Angle

Genetic risk factor in primary open-angle glaucoma: a case-control study

1994 ◽  
Vol 1 (3) ◽  
pp. 131-138 ◽  
Author(s):  
Guy Charliat ◽  
Damien Jolly ◽  
François Blanchard
Keyword(s):  
Risk Factor ◽  
Genetic Risk ◽  
Case Control Study ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Case Control ◽  
Genetic Risk Factor ◽  
Open Angle ◽  
Control Study

Comparison of Risk Factor Profiles for Primary Open-Angle Glaucoma Subtypes Defined by Pattern of Visual Field Loss: True Risk Factors or Arbitrary Definition?

2015 ◽  
Vol 56 (11) ◽  
pp. 6531
Author(s):  
Gokulan Ratnarajan ◽  
Cornelia Hirn ◽  
Eduardo Normando ◽  
Muriel Poli ◽  
Andrew Scott ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Field Loss ◽  
Open Angle

Helicobacter pylori infection as an environmental familial clustering risk factor for primary open-angle glaucoma

2008 ◽  
Vol 36 (3) ◽  
pp. 296-297 ◽  
Author(s):  
Jannis Kountouras ◽  
Christos Zavos ◽  
Nikolaos Grigoriadis ◽  
Georgia Deretzi ◽  
Panagiotis Katsinelos ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Risk Factor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Helicobacter Pylori Infection ◽  
Open Angle ◽  
Familial Clustering

Is Primary Open-Angle Glaucoma a Risk Factor for Stroke? (P04.062)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P04.062-P04.062
Author(s):  
C. Zavanone ◽  
K. Vassilev ◽  
U. Serra ◽  
S. Dupont
Keyword(s):  
Risk Factor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

Severe Myopia as a Risk Factor for Progressive Visual Field Loss in Primary Open-Angle Glaucoma

1997 ◽  
Vol 211 (2) ◽  
pp. 66-71 ◽  
Author(s):  
Etsuo Chihara ◽  
X. NIL ◽  
Jin Dong ◽  
Yasuyuki Takashima ◽  
Masayuki Akimoto ◽  
...  
Keyword(s):  
Risk Factor ◽  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Field Loss ◽  
Open Angle
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