Study on specific species of malaria in relation to haematological changes

Background: As malaria is a potential medical emergency, prompt and accurate diagnosis is criticalfor its effective management. Conventional microscopic examination of peripheral thick and thinblood smear examination remains the “gold standard” for malaria diagnosis. Material: A 2 yearprospective study from 2011 to 2013 was conducted at Navodaya Medical College Hospital andResearch Centre, Raichur. The study comprised of a total number of 150 cases positive for Malaria,collected from above mentioned centre and those referred from peripheral referral centres. Clinicalhistory regarding age, sex, nature and duration of illness were elicited. Blood sample forhaematological study was taken before starting anti-malarial drugs in all these cases. Result: Out oftotal cases, P. vivax infected cases (62%) were common than P. falciparum (34%) and mixedinfection cases [PV & PF] (4%). Most common presenting symptom of cases affected by PV, PF andmixed infection were fever and chills & rigors and least common symptom was cough. Mostimportant haematological changes observed were anaemia and thrombocytopenia (77.3% each) andleucopenia (31.3%). All the above mentioned changes in haematological parameters were speciesspecific and statistically significant, except for red cell indices, DLC and ESR. Conclusions: Inconclusion, changes in haematological profile can help in early diagnosis of specific species ofmalaria for timely and appropriate treatment that can reduce the severity and prevention ofadditional consequences.

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PROGNOSIS OF ACUTE FULMINANT HEPATIC FAILURE

The Professional Medical Journal ◽

10.29309/tpmj/2012.19.04.2266 ◽

2012 ◽

Vol 19 (04) ◽

pp. 496-500

Author(s):

JAVED AHMED PHULPOTO

Keyword(s):

Mortality Rate ◽

Fulminant Hepatic Failure ◽

Hepatic Failure ◽

Developed Countries ◽

Medical College Hospital ◽

Medical Emergency ◽

College Hospital ◽

Medical Unit ◽

Medical College ◽

Geographical Variations

Acute fulminant hepatic failure (ALF) is a medical emergency and associated with high mortality rate. Its etiology showsconsiderable geographical variations. The viral causes are the most common in our region, [whilst acetaminophen (Paracetamol) inducedhepatotoxicity forms the most common precipitant in many developed countries]. Objective: To assess the causes and prognosis of acutefulminant hepatic failure in patients attending medical unit I, Ghulam Mohammad Mahar Medical college hospital, Sukkur. Study Design: Across-sectional study. Place of Study: Medical Unit-I, Ghulam Mohammad Mahar Medical College Hospital, Sukkur. Duration of Study: FromJanuary 2010 to July 2011. Methodology: A total one hundred twenty (120) patients of ALF were studied during the study period to evaluate thecauses and prognosis. Those patients who were admitted during the study period were included in the study. The selected patients presentedwith jaundice and hepatic encephalopathy of varying grades. Results: Almost all the cases the causative agents were viruses. Among these,the hepatitis E virus (HEV) was the top most causative agent followed by hepatitis B Virus (HBV) in this study. Despite good effort ofconservative treatment, the mortality rate was 77.5%. The mortality rate was higher in grade-III and grade-IV encephalopathy patients,whereas the prognosis is better in grade-1 and grade-II encephalopathy patients.

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Immediate outcome and risk factors determining the outcome of status epilepticus in children attending tertiary care centre

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20172516 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1289

Author(s):

Murali Thandavarayan ◽

Sureshkumar Ramaswamy ◽

Priyadarsini Bose ◽

Sivaraman Thirumalaikumarasamy

Keyword(s):

Risk Factors ◽

Status Epilepticus ◽

Tertiary Care ◽

Medical Emergency ◽

Time Of Arrival ◽

Care Hospital ◽

Tertiary Care Centre ◽

College Hospital ◽

Medical College

Background: Status epilepticus (SE) is a paediatric and neurological medical emergency, continuous seizure lasting more than 30 min, or two or more seizures without full recovery of consciousness between any of them. Determination of immediate outcome of SE in children in a tertiary care hospital and to identify the risk factors influencing the outcome was the objectives of the present study.Methods: A study was conducted in Dept of Pediatrics, Tirunelveli Medical College Hospital among the children from 1 month to12 years of age, who had admitted for SE in hospital’s pediatric causality from October 2009 to October 2010 were selected for the study.Results: Out of 92 patients, total 87 patients completed the study and out of those 74 have recovered and 13 have died. The risk factors significantly affecting the outcome were hypoxia at the time of arrival, decompensated shock, respiratory failure requiring intubation and acidosis.Conclusions: Proper prehospital therapy, early referral, proper care while transporting, anticipitating risk factors involved, and protocol based approach uniformly at all hospital can reduce the mortality due to status epilepticus in children.

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Clinical Profile of Kerosene Poisoning in a Tertiary Level Hospital in Bangladesh

Bangladesh Journal of Child Health ◽

10.3329/bjch.v38i1.20021 ◽

2014 ◽

Vol 38 (1) ◽

pp. 11-14 ◽

Cited By ~ 2

Author(s):

S Anwar ◽

AKMN Rahman ◽

SK A Houqe ◽

AKMA Moshed ◽

L Yasmin ◽

...

Keyword(s):

Soft Drink ◽

Clinical Findings ◽

Summer Season ◽

Clinical Profile ◽

Medical Emergency ◽

College Hospital ◽

Economic Class ◽

Medical College ◽

Respiratory Complaints ◽

Level Hospital

Background: Accidental ingestion of kerosene continues to remain a common medical emergency among children in developing countries. The importance of this poisoning makes it imperative that parents should be aware about this poisoning. Objective: To see clinical profile of Kerosene poisoning in Bangladesh. Methodology: This retrospective study analyzed 56 children with acute kerosene poisoning admitted in Dhaka Medical College Hospital from January 2010 to June 2010 Result: Fifty six kerosene poisoning cases were admitted within 6 months period. Among the cases boys 29(51.8%), aged less than three years 52(93%), from a rural background 36(64%) and belonging to lower economic class 51 (91%) were found. Inappropriate container of kerosene like soft drink bottle 40 (71%) & summer season 40 (71%) were found major risk factor for kerosene ingestion. Cough 52 (92%) and dyspnea 51(91%) were the commonest clinical findings. Conclusion: Respiratory complaints are predominant clinical features of Kerosene poisoning. Toddler age, children from rural area, summer season were found major risk factors for kerosene ingestion and is mostly due to faulty packing & storage of kerosene. DOI: http://dx.doi.org/10.3329/bjch.v38i1.20021 Bangladesh J Child Health 2014; VOL 38 (1) : 11-14

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Outcome of Upper Gastro Intestinal Haemorrhage - a Hospital Based Prospective Study

Faridpur Medical College Journal ◽

10.3329/fmcj.v8i1.16891 ◽

2013 ◽

Vol 8 (1) ◽

pp. 15-17

Author(s):

Md Towhid Alam ◽

MM Shahin Ul Islam ◽

Md Yusuf Ali ◽

Md Anisur Rahman Howlader ◽

SK Abdul Fattah ◽

...

Keyword(s):

Duodenal Ulcer ◽

Gastrointestinal Haemorrhage ◽

Medical Emergency ◽

Oesophageal Varices ◽

Recurrent Bleeding ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Upper Gi ◽

Mortality Outcome

Upper GI bleeding is a common medical emergency with a significant mortality, outcome of which depends upon the cause, appropriate and early intervention in a specialized center. This study was carried out to see the outcome of patient with Upper GI haemorrhage. Fifty cases with episode of upper gastrointestinal haemorrhage, admitted into medicine units of Faridpur Medical College Hospital from January 2011 to December 2011, were studied. Duodenal ulcer was the commonest cause of haematemesis and melaena followed by oesophageal varices, gastric ulcer and erosive gastritis. The peak incidence was among 35 to 45 years of age. Over all male female ratio was 4.55:1 but in case of duodenal ulcer it was 9:1. During hospital stay recurrent bleeding was noted in 10% of patients and during subsequent follow up it was 10% of the total and 50% in case of variceal bleeding group. Over all hospital mortality was 4% . DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16891 Faridpur Med. Coll. J. 2013;8(1): 15-17

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Ultrasonographic Evaluation of Hepatic Metastases of Malignant Diseases with Cytopathological Correlation

Journal of Dhaka Medical College ◽

10.3329/jdmc.v23i2.25398 ◽

2015 ◽

Vol 23 (2) ◽

pp. 239-244 ◽

Cited By ~ 1

Author(s):

Farhana Sultana ◽

Salahuddin Al Azad ◽

Asifa Sattar ◽

Mohammed Zaid Hossain ◽

Zereen Sultana Deepa ◽

...

Keyword(s):

Hepatic Metastasis ◽

Predictive Value ◽

Abdominal Mass ◽

Hepatic Metastases ◽

Metastatic Lesion ◽

Common Symptom ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Imaging Department

Objective: A prospective study was carried out to evaluate the role of ultrasonography in the diagnosis of hepatic metastasis and also to preoperative determination of hepatic metastasis and its validity in diagnostic process.Methods: A total of 52 patients having hepatic metastasis were enrolled in this study taken from Department of Hepatology of two tertiary level medical institutions. After sonographic evaluation of the metastatic lesion, cytopathology was done in all these patients. With written informed consent they were taken care of from the admission up to diagnosis of the hepatic metastasis, and subsequent management in hepatology unit.Place and period of study: Department of Radiology & Imaging, Department of Pathology and Department of Hepatology of Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital and of Dhaka Medical College Hospital (DMCH), during the period between July 2006 and June 2007.Results: The mean age of the patients was 51.20±11.9 years, ranging from 21 to 69 years. The highest incidence was in 60-69 years age group. The male and female ratio was 3.7:1. The most common symptom was pain with upper abdominal mass (73.1%), and others were anorexia and nausea with weight loss (67.3%), jaundice (28.8%) and ascites (23.1%). Only the right lobe of the liver was involved in 51.9% cases, left lobe in 28.8% and in 19.2% both lobes of the liver were affected. Hepatic metastasis was found as unifocal lesion in 7.7% and multifocal lesions in 92.3% cases. The echopattern was found 57.7% hyperechoic, 28.8% hypoechoic, and rest 13.5% mixed pattern. All cases were metastasis in sonography findings whereas 90.4% cases were metastasis and 9.6% other lesions in cytopathological findings. The validity of ultrasonography were determined by calculating sensitivity, specificity, accuracy, positive predictive value and negative predictive value which were 93.6%, 80.0%, 92.3%, 97.8% and 57.1% respectively.J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 239-244

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Outcome of External Ventricular Drainage in Spontaneous Intracerebral Haemorrhage with Ventricular Extension in different GCS Score

Journal of Clinical & Experimental Immunology ◽

10.33140/jcei.04.03.05 ◽

2019 ◽

Vol 4 (3) ◽

Keyword(s):

Intracerebral Haemorrhage ◽

Glasgow Outcome Scale ◽

External Ventricular Drainage ◽

Medical Emergency ◽

Ventricular Drainage ◽

Scoring Method ◽

College Hospital ◽

Medical College ◽

Gcs Score ◽

Spontaneous Intracerebral Haemorrhage

Background: Intracerebral Haemorrhage (ICH) is a medical emergency of the highest degree with frequent early neurological deterioration or death. External ventricular drainage (EVD) is the procedure of choice for the treatment of spontaneous intracerebral haemorrhage with ventricular extension or blood within the ventricles, acute hydrocephalus and increased intracranial pressure in patients of intracerebral haemorrhage and subarachnoid haemorrhage (SAH) with hydrocephalus and its sequelae. Objective: The aim and objective of this study was to predict the outcome of pre operative GCS following external ventricular drainage in spontaneous intracerebral haemorrhage with ventricular extension. Method: In this was prospective observational studies, a total number of 60 cases were taken purposively for a period of July, 2015- March, 2017 diagnosed by CT scan of brain at Department of Neurosurgery, Dhaka Medical College Hospital. All the patients, fulfilling the inclusion and exclusion criteria, were enrolled for the study. For assessing outcome of EVD in post operative patients and evaluating the efficacy of EVD surgery in follow ups. Glasgow Coma Scale and Glasgow Outcome Scale scoring method for patient assessment were used for outcome of EVD surgery. Result: A total of 60 patients were included in this study, age range was 45 to 86 years. Majority patients, 24 (40.0%) were from 61-70 years of age. The mean age was found 62.0±20. It was observed that 24 (40.00%) patients had GCS 5. GCS 6 was observed in 14(23.33%) patients. GCS 5 and 6 were not found post operatively in any cases. GCS 7 was observed in 14 (23.33%) cases. Whereas, GCS 8, 9, 10 were found in 11 (18.33%), 13 (21.66%), 10(16.66%) cases respectively and 4 cases were died on first post operative day. In most cases GCS level rose to 2 points. GOS at 7th POD died total 12 (20.00%) cases. It was observed that 48 (80.00%) patients were alive Moderate disability existed in 12(25.00%) cases. Again, severe disability and persistent vegetative cases observed in 14(29.16%), 9(18.75%) cases. Glasgow Outcome Scale at 3 months follow up of my study patients, it was observed that total died patients 16 (26.66%). Conclusion: According to my study, majority of the study patients survived following EVD in spontaneous ICH with ventricular extension but most cases was unfavorable outcome which was statistically

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Clinical Presentation and Risk Factors of Stroke-A Study of 100 Hospitalized Stroke Patients in Bangladesh

Faridpur Medical College Journal ◽

10.3329/fmcj.v11i1.30875 ◽

2016 ◽

Vol 11 (1) ◽

pp. 23-25 ◽

Cited By ~ 1

Author(s):

Radheshyam Saha ◽

MM Shahin Ul Islam ◽

Ahmed Manadir Hossain ◽

Mohammad Rafiqul Kabir ◽

Abdullah Al Mamun ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Haemorrhagic Stroke ◽

Medical Emergency ◽

Stroke Patients ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Male Female Ratio ◽

History Of

Stroke is one of the most common medical emergency. A total number of 100 randomly selected clinically and CT proven acute stroke patients were studied at medicine and neurology ward of Faridpur Medical College Hospital (FMCH), Faridpur from January to July, 2014 with a view to study the clinical features and risk factors of Stroke. Among 100 patients, stroke was found most commonly in 59-70 years age group. Ischaemic stroke was 56%, haemorrhagic stroke was 39% and haemorrhagic infarct was 5%. Most of the patients were male with male-female ratio was 1.6:1. The commonest risk factor was hypertension found in 60%, diabetes mellitus found in 17%, smoking was present in 54% patients and dyslipidaemia was present in 22% cases. History of heart disease (Myocardial infarction was present in 2% patients, valvular heart disease was present in 4% patients) was present in 6% patients. The commonest presentation in both ischaemic and haemorrhagic stroke was hemiplegia (61%). Headache (14%) and vomiting (10%) were found to be more common accompaniment in haemorrhagic stroke. Loss of consciousness was present in 34% patients. Alcohol intake was not found in any patient.Faridpur Med. Coll. J. Jan 2016;11(1): 23-25

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Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-021-02111-w ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Xiaoyu Wang ◽

Junjun Yang ◽

Xirun Wan ◽

Fengzhi Feng ◽

Jun Zhao ◽

...

Keyword(s):

Retrospective Study ◽

Vaginal Bleeding ◽

English Language ◽

Case Reports ◽

Massive Bleeding ◽

Common Symptom ◽

College Hospital ◽

Medical College ◽

Abnormal Vaginal Bleeding ◽

Beijing China

Abstract Background Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies. Results Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%). Conclusions Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.

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Clinical Pattern of Intra-cranial space occupying lesion in Tertiary Level Hospital

Journal of Dhaka Medical College ◽

10.3329/jdmc.v28i1.45751 ◽

2020 ◽

Vol 28 (1) ◽

pp. 17-22

Author(s):

Ponkaj Kanti Datta ◽

Satya Ranjan Sutradhar ◽

Md Nur A alam Khan ◽

Mohammad Zaid Hossain ◽

Sultan Mahamud Sumon ◽

...

Keyword(s):

Rural Areas ◽

Common Symptom ◽

Age Group ◽

College Hospital ◽

Clinical Pattern ◽

Medical College ◽

Neoplastic Lesion ◽

Intracranial Lesions ◽

Symptoms And Signs ◽

Space Occupying Lesion

Background : The term “Intra-cranial space occupying lesion” (ICSOL) is defined as any neoplasm, benign or malignant, primary or secondary, as well as any inflammatory or parasitic mass lying within the cranial cavity. Advances in intracranial imaging have made the detection of intracranial lesions relatively accurate and enabling us to focus on the etiology of these space-occupying lesions. Many reports suggested that both incidence and pattern of intracranial space occupying lesions are subject to considerable geographic and racial variations. Knowledge of the regional peculiarities of these lesions will help in identifications of possible risk factors. Materials and Methods: This observational study was done in the department of medicine of Mymensingh medical college hospital, Bangladesh from November, 2011 to April, 2012 to evaluate the clinical pattern of ICSOL among the 75 adult admitted patients. Patient aged more than 15 years of either sex with symptoms and signs of ICSOL and at least one CT or MRI evidence in favour of diagnosis were included. Results: The highest participation (22.7%) was observed from 55-64 years age group. Mean age of the participants was 54.35±18.68 years. Neoplastic tumor was (25.8%) in 15-24 years age group and non neoplastic lesion was (31.8%) in 55-64 years age group, among participants (76.0%) came from rural areas and 24% from urban. Population regarding the occupation 30.7% were housewives, 21.3% were service holders and 20.0% are farmers. Headache was the most common symptom noted in 93.33% of patients. Nausea/ vomiting, difficulty in limb movement and imbalance were the other most common three symptoms. In this series intracerebral hemorrhage was found in 53.3% of patients, Astrocytoma was the second most common (20.0%). Meningioma was found in 8% of the participants and another 8% had metastatic lesions in their brain. There were two cases of schwanoma while tuberculoma was diagnosed in another two participants (2.7%). Conclusion: Patients with symptoms and signs of ICSOL should be dealt with great care and CT or MRI helps to evaluate them for early diagnosis and proper management. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 17-22

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Identification and Treatment of Primary Cervical Gestational Trophoblastic Neoplasia: a Retrospective Study of 13 Patients and Literature Review

10.21203/rs.3.rs-789541/v1 ◽

2021 ◽

Author(s):

Xiaoyu Wang ◽

Junjun Yang ◽

Xirun Wan ◽

Fengzhi Feng ◽

Jun Zhao ◽

...

Keyword(s):

Retrospective Study ◽

Vaginal Bleeding ◽

English Language ◽

Case Reports ◽

Massive Bleeding ◽

Common Symptom ◽

College Hospital ◽

Medical College ◽

Abnormal Vaginal Bleeding ◽

Beijing China

Abstract Background: Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies.Results: Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%).Conclusions: Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.

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