scholarly journals Identification and Treatment of Primary Cervical Gestational Trophoblastic Neoplasia: a Retrospective Study of 13 Patients and Literature Review

2021 ◽  
Author(s):  
Xiaoyu Wang ◽  
Junjun Yang ◽  
Xirun Wan ◽  
Fengzhi Feng ◽  
Jun Zhao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Vaginal Bleeding ◽  
English Language ◽  
Case Reports ◽  
Massive Bleeding ◽  
Common Symptom ◽  
College Hospital ◽  
Medical College ◽  
Abnormal Vaginal Bleeding ◽  
Beijing China

Abstract Background: Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies.Results: Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%).Conclusions: Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.

scholarly journals Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiaoyu Wang ◽  
Junjun Yang ◽  
Xirun Wan ◽  
Fengzhi Feng ◽  
Jun Zhao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Vaginal Bleeding ◽  
English Language ◽  
Case Reports ◽  
Massive Bleeding ◽  
Common Symptom ◽  
College Hospital ◽  
Medical College ◽  
Abnormal Vaginal Bleeding ◽  
Beijing China

Abstract Background Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies. Results Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%). Conclusions Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.

scholarly journals HISTOMORPHOLOGICAL SPECTRUM OF LESIONS OF HYSTERECTOMY SPECIMENS IN GCS MEDICAL COLLEGE, HOSPITALAND RESEARCH CENTER, AHMEDABAD : A STUDY OF 100 CASES

2020 ◽  
pp. 80-82
Author(s):  
Shweta Shah ◽  
S.K. Suri ◽  
Ami Shah
Keyword(s):  
Retrospective Study ◽  
Age Groups ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Medical College Hospital ◽  
Research Centre ◽  
Age Group ◽  
Gynaecological Surgery ◽  
College Hospital ◽  
Medical College

Background: Most frequently performed gynaecological surgery is hysterectomy. The prevalence of hysterectomy varies within different regions. There are mainly two types of hysterectomies according to which part of uterus is removed. The main types of hysterectomy are total and subtotal or partial hysterectomy. The hysterectomy can be performed by three routes abdominal, laproscopic and vaginal hysterectomy. The main objective of our study is to know most common pathology and different age groups of the patients underwent hysterectomy. Materials and Methods: In this retrospective study was carried during period 6 months, at GCS medical college, hospital and research centre, Ahmedabad. Total 100 hysterectomy specimens were analyzed for histopathological lesions. We had taken the clinical and histopathological findings of these cases from the records of department of pathology, GCS medical college , hospital and research centre. Results: In our study of 100 cases, most common age group underwent hysterectomy was 40-49 years and least common age group was 20-29 years. Type of hysterectomy performed most commonly in this study was total abdominal hysterectomy with bilateral salpingoophorectomy. Most of lesions were seen in the myometrium 42 cases (42%), Endometrium 32 cases (32%), Cervix 16 cases (16%) and Ovary 10 cases (10%). Hysterectomy remains the widely used treatment modality.

A Clinicopathological Review of Adnexal Masses in a Tertiary Care Centre of Rural Haryana - A Retrospective Study

2021 ◽  
Vol 8 (30) ◽  
pp. 2719-2723
Author(s):  
Shivani Khandelwal ◽  
Lakra Pinkey ◽  
Sangwan Vijayata ◽  
Mahendru Rajiv ◽  
Siwach Sunita ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Tertiary Care ◽  
Serous Cystadenoma ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
Adnexal Masses ◽  
Sexually Transmitted ◽  
Medical College ◽  
Wide Range ◽  
Ectopic Pregnancies

BACKGROUND There is a wide range of adnexal masses ranging from functional cyst to infection and even malignancy. Epithelial ovarian tumours are the most common benign ovarian lesion. The purpose of this study was to study the pattern of adnexal masses in rural area and plan the preventive steps according to the pattern. METHODS It was a retrospective study of patients who presented with adnexal masses in Bhagat Phool Singh Medical College (Women), Khanpur, Sonepat, Haryana, India over a period of 5.5 years from September 2012 to August 2018. The file records of the patients who underwent surgery for adnexal masse were evaluated to identify the risk factors, presenting complaints, examination findings, serological markers and radiological findings. The histopathological reports were reviewed. The cases excluded were ectopic pregnancies. Frequency distribution tables were used and data was analyzed using percentages. RESULTS Out of total 180 adnexal masses, 167 (92.77 %) cases were of ovarian origin. Out of these, 150 (83.33 %) cases were benign and 17 (9.44 %) were malignant. Among the benign lesions, serous cystadenoma was the most common lesion counting for 54 cases i.e., 30 %. In our study, most common symptom was vague abdominal pain- 63.88 %. Maximum adnexal masses were in the age group of 41 - 50 years i.e., 53 (29.44 %). Different types of surgeries were done. Maximum were bilateral oophorectomies with transabdominal hysterctomy 88 (48.88 %). CONCLUSIONS By proper education about personal and perineal hygiene, use of contraceptives, we can at least prevent some sexually transmitted diseases causing pelvic inflammatory disease (PID) and adnexal masses. KEYWORDS Adnexal Mass, Benign, Malignant, Serous Cystadenoma

scholarly journals Clinical features of a Chinese female nongestational choriocarcinoma cohort: a retrospective study of 37 patients

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Yuming Shao ◽  
Yang Xiang ◽  
Fang Jiang ◽  
Boju Pan ◽  
Xirun Wan ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Clinical Laboratory ◽  
Age Of Onset ◽  
Survival Rates ◽  
Malignant Neoplasm ◽  
Complete Response ◽  
College Hospital ◽  
Medical College ◽  
Gestational Choriocarcinoma ◽  
Therapeutic Outcomes

Abstract Background Choriocarcinoma is a rare malignant neoplasm, which is classified as either gestational choriocarcinoma or nongestational choriocarcinoma. The purpose of this study was to examine the clinical characteristics of Chinese female nongestational choriocarcinoma patients and discuss our experience in treating this rare disease. Results We conducted a single-center retrospective study on a sample of 37 nongestational choriocarcinoma patients who were diagnosed and treated at Peking Union Medical College Hospital from March 1982 to March 2020. Their demographic, clinical, laboratory, and therapeutic data were collected. Detailed information was available for all 37 individuals in our sample. The primary lesions included 34 in the ovaries, 2 in the pituitary and 1 in the stomach. The median age of onset was 22 years, and the median follow-up period spanned 41 months. The lungs (40.5%) were the most commonly observed metastatic site. All subjects were treated with surgery and multidrug chemotherapies, and a median of 4.0 courses was required to achieve complete remission. The overall complete response rate, relapse rate, and 3-year and 5-year survival rates were 81.1%, 16.7%, 80.0%, and 75.5%, respectively. Conclusions Nongestational choriocarcinoma can be managed well using surgery and multidrug chemotherapies, but the overall outcome of nongestational choriocarcinoma is still worse than that of gestational choriocarcinoma. Mixed nongestational choriocarcinoma seems to have similar therapeutic outcomes as pure tumors.

scholarly journals Study on specific species of malaria in relation to haematological changes

2021 ◽  
Vol 7 (1) ◽  
pp. 1-8
Author(s):  
Dr. Binita Kanaujia ◽  
◽  
Dr. Anand AS ◽  
Dr. Sagar Mhetre ◽  
◽  
...  
Keyword(s):  
Malaria Diagnosis ◽  
Medical Emergency ◽  
Common Symptom ◽  
College Hospital ◽  
Medical College ◽  
Duration Of Illness ◽  
Haematological Profile ◽  
Red Cell Indices ◽  
Haematological Changes ◽  
Specific Species

Background: As malaria is a potential medical emergency, prompt and accurate diagnosis is criticalfor its effective management. Conventional microscopic examination of peripheral thick and thinblood smear examination remains the “gold standard” for malaria diagnosis. Material: A 2 yearprospective study from 2011 to 2013 was conducted at Navodaya Medical College Hospital andResearch Centre, Raichur. The study comprised of a total number of 150 cases positive for Malaria,collected from above mentioned centre and those referred from peripheral referral centres. Clinicalhistory regarding age, sex, nature and duration of illness were elicited. Blood sample forhaematological study was taken before starting anti-malarial drugs in all these cases. Result: Out oftotal cases, P. vivax infected cases (62%) were common than P. falciparum (34%) and mixedinfection cases [PV & PF] (4%). Most common presenting symptom of cases affected by PV, PF andmixed infection were fever and chills & rigors and least common symptom was cough. Mostimportant haematological changes observed were anaemia and thrombocytopenia (77.3% each) andleucopenia (31.3%). All the above mentioned changes in haematological parameters were speciesspecific and statistically significant, except for red cell indices, DLC and ESR. Conclusions: Inconclusion, changes in haematological profile can help in early diagnosis of specific species ofmalaria for timely and appropriate treatment that can reduce the severity and prevention ofadditional consequences.

scholarly journals Abruptio placenta: a retrospective study on maternal and perinatal outcome

2017 ◽  
Vol 6 (10) ◽  
pp. 4389
Author(s):  
Subha Sivagami Sengodan ◽  
Mohana Dhanapal
Keyword(s):  
Retrospective Study ◽  
Fetal Outcome ◽  
Age Group ◽  
Third Trimester ◽  
College Hospital ◽  
Maternal Deaths ◽  
Mortality And Morbidity ◽  
Medical College ◽  
Maternal Mortality And Morbidity ◽  
Abruptio Placenta

Background: Abruptio placenta is separation of a normally situated placenta after 20 weeks of gestation and prior to the birth of the fetus. It is an important cause of antepartum haemorrhage and presents as an acute abdomen in the third trimester of pregnancy. Obstetrical haemorrhage is one of the triad (Haemorrhage hypertension and infection) of causes of maternal deaths in both developed and underdeveloped countries.Methods: This is a retrospective study of Abruptio Placenta cases carried out between January 2015 and December 2015 at Government Mohan Kumaramangalam Medical College Hospital, Salem and about its perinatal and maternal outcome.Results: Incidence of Abruptio placenta is 0.5%. It is most common in the women of age group 26-30yrs. 67% of cases were associated with severe pre-eclampsia. Live births were 69.8% while stillbirths were 30.2%. PPH occurred in 19.6% of cases. DIC accounts for 16.7% of the complication.Conclusions: Abruptio placenta is associated with poor maternal and fetal outcome. Hence early diagnosis and prompt resuscitative measures would prevent both perinatal and maternal mortality and morbidity.

A case of alpha-fetoprotein–producing adenocarcinoma of the endometrium with a hepatoid component as a potential source for alpha-fetoprotein in a postmenopausal woman

2006 ◽  
Vol 16 (3) ◽  
pp. 1442-1445
Author(s):  
K. Takeuchi ◽  
S. Kitazawa ◽  
S. Hamanishi ◽  
M. Inagaki ◽  
K. Murata
Keyword(s):  
Postmenopausal Woman ◽  
Vaginal Bleeding ◽  
Pap Smear ◽  
Case Reports ◽  
Unknown Origin ◽  
Serum Levels ◽  
Alpha Fetoprotein ◽  
Endometrioid Adenocarcinoma ◽  
Eosinophilic Cytoplasm ◽  
Abnormal Vaginal Bleeding

Although case reports of alpha-fetoprotein (AFP)–producing adenocarcinoma other than hepatocellular carcinoma have gradually increased in number, AFP-producing adenocarcinoma of the endometrium is very rare. The patients universally complain of abnormal vaginal bleeding. The patient presented with complaints of epigastric discomfort. No vaginal bleeding was observed. Serum AFP concentration was 453 ng/mL, and lens culinaris agglutinin–reactive AFP percentage of total AFP was increased to 67%. Radiologic imaging and endoscopy did not provide evidence of any primary carcinoma in the liver and gastrointestinal tract. To investigate the unknown origin of high AFP, Pap smear of the endometrium followed by fractional curettage was performed and revealed adenocarcinoma of the endometrium. Radical hysterectomy with pelvic lymph node dissection and partial omentectomy was performed. Histologic study showed a mixture of major AFP-negative endometrioid adenocarcinoma and minor medullary proliferation of the AFP-positive hepatoid adenocarcinoma cells with eosinophilic cytoplasm and hyaline globules. After the surgery followed by four courses of weekly carboplatin and paclitaxel administration, serum levels of AFP dropped into normal range. The possible existence of AFP-producing adenocarcinoma of the endometrium should be considered in a postmenopausal woman even if there is no vaginal bleeding, when AFP-producing tumor is clinically suspected and the imaging studies fail to confirm the diagnosis.

scholarly journals Evaluation of molar pregnancy in Rajshahi Medical College Hospital

KYAMC Journal ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 24-27
Author(s):  
Mosammat Nargis Shamima ◽  
Rubayet Zereen ◽  
Mohd Alamgir Hossain ◽  
Nargis Zahan ◽  
Nurjahan Akter ◽  
...  
Keyword(s):  
Low Socioeconomic Status ◽  
Hydatidiform Mole ◽  
Treatment Protocol ◽  
Medical College Hospital ◽  
Molar Pregnancy ◽  
College Hospital ◽  
Low Socioeconomic ◽  
Medical College ◽  
One Year ◽  
Abnormal Vaginal Bleeding

Background: A molar pregnancy is also known as hydatidiform mole which is a benign tumour that develops in the uterus. It begins when an egg is fertilized but normal viable pregnancy not occurs, rather than the placenta develops into an abnormal mass of cyst. In all cases of molar pregnancy observation is essential to detect the reawakening of chorionic activity.Objectives: The aim of the study was to explore the incidence, clinical presentation, management and outcome of the molar pregnancy in our hospital.Materials & Methods: This prospective study was conducted in Rajshahi Medical College Hospital, Rajshahi, Bangladesh over a period of one year from July 2016 to June 2017. All pregnant women who were diagnosed as molar pregnancy were included in the study.Results: In this study the incidence of molar pregnancy was 5.3 per 1,000 deliveries that was 1 in 188 deliveries. Among the patients 54.7% were between (23 - 27 years) age group, 81.2% cases were multiparous and 58.4% patients belonged to low socioeconomic status. The prevalent blood group was A and constitute 56.6%. About 62.2% patient presented with amenorrhoea and abnormal vaginal bleeding. 45.3% admitted between (12-16) weeks of gestation. Most of the patients 58.4% were managed by suction and evacuation. Among all the cases 92.4% were complete mole and only 16.9% came for follow up.Conclusion: Results from this study showed that a small portion of patient of molar pregnancy came for routine follow up. To achieve high cure rate and low chemotherapy rate an effective registration programme and treatment protocol should be established.KYAMC Journal Vol. 9, No.-1, April 2018, Page 24-27

scholarly journals A Five Years Retrospective Study on Etiology and Clinical Analysis of Meningitis in St. Paul’s Hospital Millennium Medical College Pediatric Ward from 2012-2016

2019 ◽  
pp. 1-13
Author(s):  
Ermias Getaneh Ayele ◽  
Zebenay Workneh Bitew ◽  
Kibir Temesgen Assefa ◽  
Teshome Gishu Tura ◽  
Rahel Mezemir
Keyword(s):  
Retrospective Study ◽  
Clinical Analysis ◽  
Dry Season ◽  
Common Symptom ◽  
Inclusion Criteria ◽  
High Grade Fever ◽  
Female Ratio ◽  
Medical College ◽  
Significant Seasonal Variation ◽  
Study Population

Meningitis is the sever CNS pyogenic infections which primarily affects infants and children. Ethiopia is one of the countries where meningitis is endemic and frequent episodes of meningococcal epidemics are very common in the dry season (December to June). The main purpose of this study was to identify determinants and clinical analysis of meningitis in pediatrics ward admitted to St.Paul’s hospital millennium medical college pediatrics wards from 2012-2016. A retrospective study on etiology and clinical analysis of meningitis was conducted at the pediatric unit. The study population was all pediatric patients admitted with meningitis that were presented in ward during the study period. Those fulfilling the mentioned inclusion criteria were included. The data were collected using a structured format in September /2016. From the study population 95 cases fulfilled the inclusion criteria and 64 & 31 of them were males and females, respectively making a male to female ratio of 2:1. The most significant seasonal variation was observed for N. meningitidis having high incidence in the 2nd quarter (April to June). In the dry season 18 cases were diagnosed using the culture results. Culture findings also revealed that S. pneumonia was one of the commonest causes of bacterial meningitis. The most common symptom was fever with high grade fever (>38oC) recorded in 84 (88.4%) of cases. Most (65.5 %). of clients were recovered from meningitis at the end of the treatment where as death was the second outcome with 17(20.2 %) cases ended up with death. Neurological or other complications  were seen  in 9(10.7 %) cases.

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