Evaluation and comparative analysis of sperm characteristics in men before and after vaccination with Sputnik V (Gam-COVID-Vac)

The study objective is to evaluate reproductive function in men who underwent vaccination with Sputnik V (Gam-COVID-Vac) based on quantitative and qualitative sperm characteristics.Materials and methods. Mean ejaculate characteristics were analyzed in 3 independent groups formed from patients examined at the Laboratory of Genetics of Impaired Reproduction of the Research Center for Medical Genetics in 2021: the comparison group consisted of 759 unvaccinated men; the group of 73 men who were vaccinated with Sputnik V and for whom the time between the full vaccination (2 components of the vaccine) and semen analysis was less than 75 days; and the group of 58 men who underwent vaccination more than 75 days prior to semen analysis.The results of semen analysis of 53 patients before and after full vaccination procedure were compared. In 32 patients, less than 75 days passed since vaccination; in 21 patients, more than 75 days; for 5 patients data prior to 75 days since vaccination and after are available.The study group included patients without history of COVID-19. Standard semen analysis was performed in accordance with the World Health Organization Guidelines. For statistical analysis of the differences between the groups Student's t-test was used with significance level of p <0.05.Results. Comparison of semen analysis of the same patients before and after vaccination procedure showed no statistically significant differences. Small decrease in progressive motility was observed (from 19.0 ± 0.4 to 13.8 ± 1.1 %), as well as decline in sperm morphology (from 4.53 ± 0.12 to 3.55 ± 0.31 %) in the group who underwent vaccination less than 75 days prior to the analysis. In the group who underwent vaccination more than 75 days before semen analysis, sperm characteristics do not differ from the unvaccinated group.Conclusion. There were no statistically significant differences in the ejaculate indices of the same patients before and after vaccination with Sputnik V (Gam-COVID-Vac). In the group of patients examined in a short time after vaccination, there is a decrease in the quality of sperm compared to the comparison group (unvaccinated). In the group of patients examined in a more distant period, there are no significant differences in the quality of sperm from the group of unvaccinated, which indicates the absence of long-term consequences of vaccination for the quality of ejaculate.

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Analysis of the physical aspects of quality of life of kidney recipients

Revista da Escola de Enfermagem da USP ◽

10.1590/s0080-623420150000100010 ◽

2015 ◽

Vol 49 (1) ◽

pp. 76-81 ◽

Cited By ~ 3

Author(s):

Ana Elza Oliveira de Mendonça ◽

Marina de Góes Salvetti ◽

Eulália Maria Chaves Maia ◽

Ana Cristina de Oliveira e Silva ◽

Gilson de Vasconcelos Torres

Keyword(s):

Quality Of Life ◽

Kidney Transplantation ◽

Kidney Transplant ◽

World Health ◽

Need For Treatment ◽

Kidney Recipients ◽

Quality Of Life Scale ◽

Before And After ◽

Health Organization

OBJECTIVE To identify the main factors of the physical domain modified after kidney transplantation and analyze the influence of those aspects in the perception of Overall quality of life (QOL). METHOD Longitudinal study, conducted with 63 chronic kidney patients, evaluated before and after kidney transplant, using the quality of life scale proposed by the World Health Organization. RESULTS We observed significant improvement in the physical aspects of QOL after kidney transplantation. Significant correlations were observed between physical aspects and the Overall QOL. CONCLUSION The kidney transplant generated improvement in all physical aspects of QOL. The factors that showed stronger correlation with the Overall QOL before the transplant were the capacity to work and pain. After the transplant, the perception of need for treatment was the factor that showed stronger correlation with the Overall QOL.

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Changes of Quality of Semen after Swim up Method during Intrauterine Insemination: A Single Centered Experience in Dhaka City

Journal of National Institute of Neurosciences Bangladesh ◽

10.3329/jninb.v4i1.38287 ◽

2018 ◽

Vol 4 (1) ◽

pp. 54-57

Author(s):

Shafeya Khanam ◽

Morium Faruque Shati ◽

Muqsuda Ashraf Shuvro ◽

Sharmin Ahmed ◽

Trifa Obayed ◽

...

Keyword(s):

Intrauterine Insemination ◽

Semen Analysis ◽

Sperm Concentration ◽

Cross Sectional Study ◽

World Health ◽

Dhaka City ◽

Cross Sectional ◽

Before And After ◽

The Mean

Background: Quality of semen is very important during intrauterine insemination.Objectives: The purpose of the present study was to observe the changes of quality of semen after swim up method during intrauterine insemination.Methodology: This analytical type of cross-sectional study was carried out at a private infertility centre (Central Hospital Limited, Dhaka) in Dhaka city of Bangladesh from January 2012 to December 2017 for a period of 6 years. Infertile couples who already had undergone natural cycles of super-ovulation for six months or whose duration of infertility was more than one year were included. Semen samples were collected by the process of masturbation in semen production room after three days of abstinence in sterile, labelled container. After production all samples were placed in an incubator at 37 degrees Celsius for 30 minutes for liquefaction. Routine semen analysis was performed using World Health Organizations’ (WHO) semen analysis criteria. Then the samples were randomly assigned to be processed either with swim-up or density-gradient procedure.Result: A total number of 789 male respondents were recruited for this study. The mean age with SD of the study population was 28.96±5.382 with the range of 19 to 46 years. The mean changes of sperm concentration before and after swim up method was 52.70±42.88 with the 95% confidence of 49.58 to 55.82 (p=0.000). The mean changes of sperm motility before and after swim up method was 29.03±14.849 with the 95% confidence of 30.11 to 27.95 (p=0.000). The mean changes of sperm morphology before and after swim up method was 23.96±11.328 (p=0.000).Conclusion: There is a significant changes of quality of semen after swim up method during intrauterine inseminationJournal of National Institute of Neurosciences Bangladesh, 2018;4(1): 54-57

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Focus Issue on Male Infertility

Advances in Urology ◽

10.1155/2012/823582 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Hideyuki Kobayashi ◽

Koichi Nagao ◽

Koichi Nakajima

Keyword(s):

Male Infertility ◽

Small Volume ◽

Semen Analysis ◽

Reproductive Technology ◽

World Health ◽

Nonobstructive Azoospermia ◽

Successful Pregnancy ◽

The World ◽

Health Organization

Male infertility problems can occur when sperms are limited in number or function. In this paper, we describe the clinical evaluation of male infertility. A detailed history, physical examination, and basic semen analysis are required. In addition, ultrasound, karyotyping, and hormonal studies are needed to determine specific causes of infertility. In addition, the World Health Organization (WHO, 2009) has developed a manual to provide guidance in performing a comprehensive semen analysis. Among the possible reasons for male infertility, nonobstructive azoospermia is the least treatable, because few or no mature sperm may be produced. In many cases, men with nonobstructive azoospermia typically have small-volume testes and elevated FSH. Although treatment may not completely restore the quality of semen from men with subnormal fertility, in some cases a successful pregnancy can still be achieved through assisted reproductive technology.

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Quality Of Life Of Patients With Breast And Gynecological Cancer Faced With Anticancer Chemotherapy

International Archives of Medicine ◽

10.3823/2503 ◽

2017 ◽

Vol 10 ◽

Author(s):

Patrícia Afonso Regino ◽

Thaís Cristina Elias ◽

Caroline Freitas Silveira ◽

Gilberto De Araújo Pereira ◽

Cristina Wide Pissetti ◽

...

Keyword(s):

Quality Of Life ◽

Gynecological Cancer ◽

Statistical Significance ◽

World Health ◽

World Health Organization Quality ◽

Anticancer Chemotherapy ◽

Before And After ◽

Student’S T ◽

Health Organization

Quality of life of patients with breast and gynecological cancer faced with anticancer chemotherapy Backgroud: the evaluation of quality of life in cancer patients is of interest to researchers due to its impact on health policies. The aim of this study was to assess the quality of life of patients with breast and gynecological cancer, undergoing chemotherapy. Methods and Findings: this was a quantitative, descriptive and longitudinal study, conducted in the Clinical Hospital of the Triangulo Mineiro Federal University. To assess the quality of life, the Portuguese brief version of the World Health Organization Quality of Life (WHOQOL-BREF) instrument was applied. The paired Student’s t-test was used for the analysis of the means of/ the scores of the domains. The study included 14 women. The lowest means were observed in the physical domain, 51.78±15.89 and 50.25±15.37, respectively before and after treatment. There was also a compromise of the psychological and environment domains, however, the data analyzed did not show statistical significance. The main limitation of this study is the sample size. Conclusion: quality of life presents itself as an important factor for the measurement of results in clinical studies. Keywords: Quality of Life; Breast Neoplasms; Genital Neoplasms, Females; Chemotherapy.

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The Effect of Doxycycline on Pus Cells and Oxidative Stress in Male Patients with Leukocytospermia

International Journal of Infertility & Fetal Medicine ◽

10.5005/jp-journals-10016-1089 ◽

2014 ◽

Vol 5 (3) ◽

pp. 95-99

Author(s):

Richa Aggarwal

Keyword(s):

Oxidative Stress ◽

Semen Analysis ◽

World Health ◽

Doxycycline Treatment ◽

Study Results ◽

Before And After ◽

Male Patients ◽

The Difference ◽

Health Organization ◽

And Oxidative Stress

ABSTRACT Objective The World Health Organization (WHO) has defined leukocytospermia as > 106 WBC/ml of semen. However, the clinical significance of leukocytospermia is currently a subject of controversy. Evidence from several recent studies indicates that leukocytospermia could significantly contribute to oxidative stress and male infertility. Several clinical trials have investigated the efficacy of antibiotic therapy to treat patients with pyospermia in an attempt to improve fertility. Currently, doxycycline is the most common antibiotic used to treat pyospermia though larger trials are needed to demonstrate its efficacy in treating pyospermia. Materials and methods Hundred male partners with semen analysis showing the presence of significant leukocytospermia (WBC > 1 × 106/ml), sterile semen culture and satisfying the inclusion and exclusion criteria were enrolled in the study and given doxycycline 100 mg bd for 14 days. Semen analysis for pus cells and oxidative stress (ROS) measurement was done before and after the treatment. Results Mean pus cell count before and after treatment with doxycycline was 2.28 ± 1.26 × 106/ml and 1.21 ± 0.58 ×106/mL respectively, the effect being statistically significant (p < 0.05). Resolution of leukocytospermia was seen in 61.4% (54/88) cases after doxycycline treatment. Mean oxidative stress (RLU/ sec/million sperms) before and after doxycycline therapy was 79.72 ± 133.9 and 25.44 ± 47.8, the difference being significant (p < 0.05). Conclusion Study results show that treatment with broad spectrum antibiotic like doxycycline leads to significant decrease in the number of pus cells present in semen thereby significantly decreasing the oxidative stress. How to cite this article Aggarwal R. the Effect of Doxycycline on Pus Cells and Oxidative Stress in Male Patients with Leukocytospermia. Int J Infertil Fetal Med 2014;5(3):95-99.

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Evaluation of Infertility

10.2310/obg.19097 ◽

2018 ◽

Author(s):

Jessica R Zolton ◽

Alan H. DeCherney

Keyword(s):

Semen Analysis ◽

Reproductive Function ◽

Antral Follicle ◽

Antral Follicle Count ◽

World Health ◽

Male Factor ◽

Tubal Patency ◽

Ovulatory Dysfunction ◽

Common Causes ◽

Health Organization

In 2009, the World Health Organization formally recognized infertility as a disease of the reproductive system. This designation serves to ease access to infertility evaluation and treatment. Infertility is a disease of both men and women, and proper evaluation of both partners is necessary. Common causes of infertility are ovulatory dysfunction, tubal and pelvic pathology, unexplained infertility, and male factor. A complete history and physical examination may uncover the underlying etiology, although verification of tubal patency and normal semen analysis is warranted. This period also offers an opportunity to perform preconception testing and optimize women’s health before conception. Treatment for infertility is aimed to restore normal reproductive function and anatomy. In addition, patient education and counseling is indeed a very important aspect of infertility care. This review contains 5 figures, 5 tables and 60 references Key Words: anovulation, Antimullerian hormone, antral follicle count, hysterosalpingogram, infertility, infertility evaluation, ovarian reserve testing, polycystic ovarian syndrome, saline infusion sonohysterography

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PHARMACEAUTICAL CARE IMPROVED THE QUALITY OF LIFE OF PATIENT WITH HEMODIALYSIS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2019v11i6.36341 ◽

2019 ◽

pp. 49-54

Author(s):

ASYRUN ALKHAIRI LUBIS ◽

AZIZAH NASUTION ◽

ROSIDAH

Keyword(s):

Quality Of Life ◽

Pharmaceutical Care ◽

Hemodialysis Patients ◽

Wilcoxon Test ◽

World Health ◽

World Health Organization Quality ◽

Quality Life ◽

Before And After ◽

Health Organization

Objective: Patients undergoing hemodialysis in the long term often experience complications that affect the quality of life (QOL) of the patients. Comprehensive health services are very important for improving the QOL of the patients with chronic renal failure undergoing hemodialysis. The purpose of this study was to prove that the provision of therapy with pharmaceutical care can improve the QOL of hemodialysis patients. Methods: This research was a quasi-experimental study pre and post test design. Samples were recruited applying the purposive sampling method. As many as 50 patients met the inclusion criteria and were asked to fill out the World Health Organization Quality Of Life (WHOQOL) questionnaire to measure their QOLs before and after the provisions of pharmaceutical care. Data obtained before and after pharmaceutical care were tested using paired t test, person correlation test, and Wilcoxon test in the program of SPSS 19. Results: The results showed women more often experience complications when hemodialysis (62%), sex with quality of life (p = 0.907), education with quality of life (p = 0.277), work with quality of life (p = 0.582) length of undergoing hemodialysis with quality life (p = 0.733) no significant effect. Age (p = 0.044) significantly influences quality of life. And the average quality of life before administration of pharmacy and care was 48.12±5.98, while the quality of life after administration of therapy with pharmaceutical care was 50.16±6.22. Based on the Wilcoxon test, this value was significantly different (p = 0.009). Conclusion: The conclusion of this study is the provision of therapy accompanied by pharmaceutical care significantly improves the quality of life of hemodialysis patients.

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Semen analysis: update on clinical value, current needs and future perspectives

Reproduction ◽

10.1530/rep-13-0109 ◽

2013 ◽

Vol 146 (6) ◽

pp. R249-R258 ◽

Cited By ~ 24

Author(s):

Victoria Sánchez ◽

Joachim Wistuba ◽

Con Mallidis

Keyword(s):

Semen Analysis ◽

Reproductive Function ◽

World Health ◽

Semen Parameters ◽

Reference Ranges ◽

Clinical Value ◽

New Era ◽

Analytical Instruments ◽

Male Reproductive Function ◽

Health Organization

At present, evaluation of male reproductive function consists primarily of routine semen analysis, a collection of conventional microscopic assessments ideally performed following the guidelines set by the World Health Organization. While providing some insight into testicular function, these long-performed tests are limited in the information that they impart; more specifically, they are unable to predict true fertility potential. As a consequence, there is a need for the appraisal and consideration of newer semen parameters that may be more indicative of reproductive success. Although various novel assays have been introduced that broaden the scope of information available to both researcher and clinician, the utility of these tests remains limited due to the lack of standardisation of protocols and the absence of clinically established, dependable reference ranges. As such, it is not surprising that most of these parameters and their associated methods remain recommended for ‘research purposes only’. With the burgeoning ‘omics’ revolution, nanotechnology and the development of new analytical instruments, there is now an opportunity for the identification and measurement of previously unknown features that may prove to be more indicative of each sperm's true functional status and capability. Once optimised, simplified, clinically validated and made more readily accessible, these new approaches hold the promise of forming the fulcrum upon which andrological investigations can enter a new era.

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Quality of life in patients with idiopathic pulmonary hypertension: the first experience of trimetazidine

Systemic Hypertension ◽

10.26442/sg29193 ◽

2017 ◽

Vol 14 (2) ◽

pp. 57-64

Author(s):

E G Kuznetsova ◽

S I Glukhova ◽

T V Martynyuk ◽

S N Nakonechnikov ◽

I E Chazova

Keyword(s):

Quality Of Life ◽

Pulmonary Hypertension ◽

Functional Class ◽

World Health ◽

Walking Test ◽

Sf 36 ◽

Before And After ◽

Idiopathic Pulmonary Hypertension ◽

Health Organization

Objective - to estimate the quality of life with therapy of trimetazidine in patients with idiopathic pulmonary hypertension, I-III functional class. Material and methods. In this study we included 29 patients (27 women and 2 men) aged 41.9±10 years. All patients had a common complain of angina-like symptoms. The patients were divided into 2 groups. The first group consisted of 11 patients (1 men and 10 women) who were additionally prescribed trimetazidine 35 mg twice daily for 24 weeks. The second group included 18 patients (1 men and 17 women) who continued to receive standard and specific therapy. At baseline and after 24 weeks all patients were examination, which included: laboratory (general and biochemical blood tests, D-dimer), clinical and instrumental examinations (electrocardiography, echocardiography, chest radiography, scintigraphy, a 6-min walking test, spirometry). We are take into consideration: age, sex, functional class (World Health Organization), complaints, tolerance, a 6-min walking test, Holter electrocardiogram in 12 lead, SF-36 questionnaire. Results. We analyzed the questionnaire SF-36 quality of life compared to before and after treatment trimetazidine: improvement in general health (p

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Homeopathic medicine as health promotion during COVID-19 pandemic period in Niteroi city

International Journal of High Dilution Research - ISSN 1982-6206 ◽

10.51910/ijhdr.v20i1.1086 ◽

2021 ◽

Vol 20 (1) ◽

pp. 15-16

Author(s):

Adriana Passos Oliveira ◽

Maria da Conceição Farias Stern ◽

Cláudia Márcia Osório Xavier Almeida ◽

Fabio de Almeida Bolognani ◽

Carla Holandino ◽

...

Keyword(s):

Health Promotion ◽

Health Professionals ◽

Symptomatic Relief ◽

Signs And Symptoms ◽

World Health ◽

Significance Level ◽

Homeopathic Medicine ◽

Significant Difference ◽

Before And After ◽

Health Organization

Background: According to the World Health Organization, the coronavirus disease 2019 (COVID-19) has 36.835.130 reported cases and 1.068.113 deaths worldwide on October 10, 2020. The city of Niterói has declared a public health emergency due to the COVID-19 pandemic with 13.906 reported cases, 3.03% of lethality, and 445 deaths. In this scenario, it is necessary to search for other forms of treatment such as Integrative Medicine, especially Homeopathy, which was used with excellent results in the great epidemics. Aims: Evaluate the use of the homeopathic medicine composed of Bryonia alba 30CH, China officinalis 30CH, and Metallum album 30CH in the health signs and symptoms of the health professionals of the Dr. Guilherme Taylor March Regional Polyclinic in Niterói. Ethical approval is CAAE 31601020.3.0000.5243. Methodology: The study design was a time series with analysis before and after using homeopathic medicine for eight weeks. Analysis of health signs and symptoms was carried out through a structured questionnaire. Statistical test was used to compare qualitative data paired with a significance level of 5%. Results and discussion: A total of 57 health professionals in face-to-face work used homeopathic medicine. No side effect was observed in all participants. The majority (84.2%) was without any flu-like symptoms before and after treatment. Nine participants (15.8%) had shown initial flu-like symptoms. After using homeopathic medicine, there was an improvement with a significant difference (p <0.05). Among the symptomatic, six participants had a positive result in the covid test with significant improvement (p <0.05) of the symptoms within seven days of using homeopathic medicine. Conclusion: The homeopathic intervention used during the coronavirus pandemic contributed as health promotion and adjunctive measure for symptomatic relief from COVID-19 and a treatment strategy that could be used as an adjunct to all sanitary and therapeutic measures recommended by health authorities.

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