scholarly journals Diagnosed laryngeal cancer relapse using harpoon biopsy under ultrasound guidance (clinical case)

2019 ◽  
Vol 9 (3) ◽  
pp. 97-101
Author(s):  
А. I. Gafurova ◽  
V. V. Vinogradov ◽  
А. S. Korobkin ◽  
S. S. Reshulsky

The objective is to demonstrate possibilities of a harpoon biopsy under ultrasound guidance for malignant neoplasms early detection using a clinical example.Clinical case. A 65-year-old patient with morphologically verified laryngeal cancer (stage II, T2N0M0) underwent radiation therapy, which resulted in a complete tumor resorption. Subsequent ultrasound detected a neoplasm in the projection of the folding section. Percutaneous harpoon biopsy was performed under ultrasound guidance because standard clinical and instrumental studies were unable to confirm the diagnosis. Histological study of the biopsy material confirmed the “relapse of larynx squamous cell carcinoma”.Conclusion. A transdermal harpoon biopsy under ultrasound guidance followed by morphological biopsy study makes it possible to diagnose the disease and determine therapeutic approach as soon as possible.

Author(s):  
V.N. Gerasimov ◽  
A.M. Karpova ◽  
Ya.S. Abuzova ◽  
M.S. Skripina ◽  
E.V. Slesareva

Malignant tumor is a nosological group that significantly contributes to morbidity, disability and mortality in various age categories. Colon cancer occupies a leading place among the malignant neoplasms of the gastrointestinal tract. Most often they are localized in the rectosigmoid part of the large intestine. However, there is also a casuistic localization of tumors, e.g. vermicular appendix cancer. There are no specific signs of oncologic process in this area, therefore the diagnosis of this nosology causes considerable difficulties. The article presents a clinical case and pathological diagnosis of vermicular appendix primary cancer according to the pathological and anatomical study conducted in Ulyanovsk Regional Clinical Hospital. Primary appendix carcinoma was determined at postmortem autopsy and histological, microscopically - low-grade mucinous (blennogenic) appendix adenocarcinoma with invasion of all wall layers and extensive metastases in the internal organs: lungs, liver, spleen, lymph nodes of thoracic and abdominal cavities and stroma of ovary. Every year, up to 500 vermicular appendices are examined in the pathoanatomical department of Ulyanovsk Regional Clinical Hospital. Over the past 10 years, 3 cases (0.06 %) of appendix primary cancer have been detected in all appendectomies. According to the clinical case, due to late detection of appendix adenocarcinomas, they actively metastasize into lymphogenous and hematogenous pathways. In this regard, for early cancer detection, a mandatory high-quality histological study of the material after appendectomy should be carried out in order to distinguish atypical cells. Keywords: vermicular appendix primary cancer, poorly differentiated mucinous (blennogenic) adenocarcinoma. Злокачественные новообразования – одна из нозологических групп, составляющих значительную часть в структуре заболеваемости, инвалидности и смертности в различных возрастных категориях. Опухоли толстого кишечника занимают ведущее место среди злокачественных новообразований желудочно-кишечного тракта. Наиболее часто они локализуются в ректосигмоидном отделе толстого кишечника. Однако встречается и казуистическое расположение новообразований, такое как рак червеобразного отростка. Специфические признаки онкопроцесса данной области отсутствуют, в связи с чем диагностика этой нозологии вызывает значительные трудности. В статье представлен клинический случай и патоморфологическая диагностика первичного рака червеобразного отростка на основании данных патологоанатомического исследования, проведенного в ГУЗ УОКБ. При патологоанатомическом вскрытии и гистологическом исследовании был выявлен первичный рак червеобразного отростка, микроскопически – низкодифференцированная муцинозная (слизьпродуцирующая) аденокарцинома червеобразного отростка с прорастанием всех слоев стенки и обширными метастазами во внутренние органы: легкие, печень, селезенку, лимфатические узлы грудной и брюшной полости, строму яичников. Ежегодно в патологоанатомическом отделении УОКБ проводится исследование до 500 червеобразных отростков. За последние 10 лет было обнаружено 3 случая (0,06 %) первичного рака червеобразного отростка по всем проведенным аппендэктомиям. Как показывает представленный клинический случай, аденокарциномы червеобразного отростка, вследствие их позднего обнаружения, активно метастазируют по лимфогенным и гематогенным путям. В связи с этим для серьезных профилактических мероприятий по раннему выявлению онкологических заболеваний должно проводиться обязательное более качественное гистологическое исследование материала на наличие атипичных клеток после аппендэктомии. Ключевые слова: первичный рак червеобразного отростка, низкодифференцированная муцинозная (слизьпродуцирующая) аденокарцинома.


Author(s):  
Yaroslav V. Kizim

Topicality: The variety of manifestations of laryngopharyngeal reflux (LPR) in otolaryngological practice has made this problem relevant for the past decades. The development of LPR is associated with impaired function of the upper esophageal sphincter, which allows reflux to enter the larynx, pharynx, nasal cavity and middle ear cavity. In a number of studies, pathological reflux has been identified as one of the factors in the development of cancer of the upper respiratory and digestive tract. Aim of the study: to improve methods fors creening and diagnosis of laryngopharyngeal reflux in patients with laryngeal cancer stage I-II (T1-2N0M0). Materials and methods: The study group included 93 patients with stage I-II laryngeal cancer (T1-2N0M0). The control group was represented by 36 patients with reflux-associated benign neoplasms of the larynx. For preliminary diagnosis and objectification of complaints used the RSI test. To increase the accuracy of interpretation and objectification of laryngoscopic manifestations of LPR, the RFS scale was used. The daily pH-monitoring was carried out using an AG-1pH-M acidogastrograph with an electrode system. The severity of reflux was determined according to DeMeester criteria. According to the results of pH monitoring, clinical groups were formed. Results: When analyzing the results of the examination, the RSI index exceeded “9” in 41 (44.1%) patients. When tested on the RFS scale, the indicator “13 and higher” was recorded in 48 (51.6%) patients. All patients (41) with a positive RSI test received 24-hour pH monitoring. According to 24-hour pH-monitoring, the presence of LPR was verified in 33 (80.1%) patients with a positive RSI test. The study group consisted of 33 (80.1%) patients with squamous cell carcinoma of the larynx T1-2N0M0. After 24-hour pH-monitoring, we obtained the data: mild LPR was observed in 6 (18.2%) patients, moderate severity of LPR in 18 (54.5%) and severe LPR in 9 (27.3%). In patients with laryngeal cancer T1-2N0M0, which is associated with LPR, the DeMeester criterion exceeded 14.72. Conclusions: Comparison of pH-monitoring data and visual-analogue scales reaches 80.1% of compliance in patients with laryngeal cancer T1-2N0M0, which is associated with LPR. According to 24-hour pH-monitoring, the presence of LPR was verified in 33 (35.5%) of the examined patients with squamous cell carcinoma of the larynx. Using the modified The Reflux Symptom Index and The Reflux Finding Score scales is a highly reliable method for screening the diagnosis of laryngopharyngeal reflux in patients with laryngeal cancer.


Author(s):  
Siddharth Sheth ◽  
Douglas R. Farquhar ◽  
Travis P. Schrank ◽  
Wesley Stepp ◽  
Angela Mazul ◽  
...  

2005 ◽  
Vol 17 (1) ◽  
pp. 11-16
Author(s):  
Mioko Matsuo ◽  
Fumihide Rikimaru ◽  
Satoshi Tou ◽  
Yuuichirou Higaki ◽  
Kichinobu Tomita

2013 ◽  
Vol 35 (1) ◽  
pp. 71-73
Author(s):  
PR Pant ◽  
J Sharma ◽  
BL Manandhar ◽  
A Joshi

Squamous cell carcinoma of the vulva is predominantly a disease of postmenopausal women; it accounts for 5% of all female genital malignant neoplasms. Postoperative recovery in two among the five operated patient was late as their vulval wound underwent dehiscence. Other three patients had an uneventful post operative period. Histopathology report showed Squamous cell carcinoma in all the cases. Lymphnodes was negative for malignant cells in all the cases. DOI: http://dx.doi.org/10.2126/joim.v35i1.8902   Journal of Institute of Medicine, April, 2013; 35:71-73


2018 ◽  
Vol 26 (2) ◽  
pp. 150-154
Author(s):  
Kalyan Pal ◽  
Dipanjan Chakraborty ◽  
Sohag Kundu ◽  
Subrata Mukhopadhyay

In our day to day ENT practice we commonly come across diseases involving the larynx, the oral cavity and the paranasal sinuses. These range from inflammatory disorders to benign and malignant neoplasms. Carcinomas involving the head and neck region are most commonly squamous cell carcinoma. However, a small proportion of cases present with other variants of carcinoma or infective pathology uncommon for the site. In this study we present three rare cases encountered in the out-patient department, namely, Primary Malignant Melanoma of the larynx, Neuroendocrine Tumor of the nose and paranasal sinuses and Rhinosporidiosis of cheek.


1980 ◽  
Vol 88 (6) ◽  
pp. 745-748 ◽  
Author(s):  
Milton G. Yoder ◽  
John G. Batsakis

This case report of a 20-year-old white woman is the youngest patient with a documented squamous cell carcinoma in a solitary nonirradiated laryngeal papilloma. It is rare for malignant degeneration of solitary squamous cell papilloma to occur in a patient under the age of 40. This case is also unique in that most solitary laryngeal papilloma with or without neoplasm occur in males. Most reported malignant neoplasms in squamous papilloma have been previously treated with irradiation. Because approximately 2% to 3% of solitary laryngeal papilloma have malignant neoplasms, adequate biopsy of the lesion and thorough histologic examination must always be done.


2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Andrzej Raś ◽  
Iwona Otrocka-Domagała ◽  
Małgorzata Raś-Noryńska

Abstract Background Genital malignant neoplasms in mares are relatively rare. The treatment involve surgical removal of the tumour masses, chemotherapy or both. Case presentation Two elderly warmblood mares, aged 16 and 20 were presented in University Clinic with the lumpy lesions at the region of perineum and left labia. Surgical removals of tumour masses were performed on standing animals. Removed tissues were subjected to histopathological examination which confirmed SCC. Conclusions Clinical and ultrasound examination of reproductive organs in both mares showed no inflammatory or neoplastic changes. Both mares healed within 2 weeks after surgery and showed no signs of tumour recurrence for the following year despite no chemotherapy treatment.


2015 ◽  
Vol 130 (1) ◽  
pp. 100-103 ◽  
Author(s):  
S Lim ◽  
P Sau ◽  
L Cooper ◽  
A McPhaden ◽  
K MacKenzie

AbstractBackground:Over the last decade, we have observed an escalating trend in the number of laryngeal biopsies performed, despite the incidence of laryngeal cancer remaining constant. This study aimed to quantify the rate of laryngeal biopsies and record the indications.Method:A retrospective analysis of laryngeal biopsies performed in North Glasgow, Scotland, UK, between 2001 and 2010, was conducted.Results:From 2001 to 2010, 3902 laryngeal biopsies were carried out in North Glasgow. Histopathological results indicated the following diagnoses: squamous cell carcinoma, in 889 cases (23 per cent); dysplasia, in 986 cases (25 per cent); ‘no tumour’, in 913 cases (23 per cent); and benign pathology, in the remaining 1084 cases (28 per cent). There has been a significant increase in the number of biopsies performed after 2004, with the incidence of squamous cell carcinoma and benign disease remaining relatively static.Conclusion:It is hypothesised that organ preservation strategies, endoscopic resection in early stage laryngeal cancer and chemoradiotherapy in advanced head and neck cancer are responsible for the increase in laryngeal biopsies.


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