scholarly journals Autoimmune Hepatitis: The Third Autoimmune Disease in a Young Female

2018 ◽  
pp. 202-204
Author(s):  
Rasangi Sumudu Clare Suraweera ◽  
Srivickneswaran Ghetheeswaran ◽  
Jansan Jesuthasan
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Hepatitis ◽  
Young Female ◽  
The Third

scholarly journals Biológiai terápia szisztémás alkalmazása a szemészetben

2019 ◽  
Vol 160 (44) ◽  
pp. 1744-1750
Author(s):  
Fruzsina Benyó ◽  
Alexandra Farkas ◽  
Hajnalka Horváth ◽  
Zoltán Zsolt Nagy ◽  
Zsuzsanna Szepessy
Keyword(s):  
Autoimmune Disease ◽  
Biological Treatment ◽  
Biological Therapy ◽  
The Third ◽  
First Case ◽  
Immune Mediated ◽  
Initial Symptoms ◽  
Inactive Period ◽  
Infectious Uveitis ◽  
Inflammatory Bowel

Abstract: We present herewith cases of non-infectious uveitis with biological treatment where the ocular complaints were the initial symptoms indicating a multi-organ autoimmune disease. The first case was a patient with panuveitis and Vogt–Koyanagi–Harada disease, the second case was also a panuveitic patient with sarcoidosis and the third case was a patient with intermediate uveitis and inflammatory bowel disease. In all cases, emerging new, biological therapy (adalimumab) was necessary to achieve permanent inactive period of uveitis and the autoimmune disease. Introducing systemic biological treatment (adalimumab) in ophthalmology is crucial in the therapy of immune-mediated, non-infectious uveitis in order to preserve visual acuity. Orv Hetil. 2019; 160(44): 1744–1750.

scholarly journals Drug-Induced Autoimmune Hepatitis in a Patient Treated with Minocycline: A Rare Adverse Effect

2018 ◽  
Vol 12 (2) ◽  
pp. 447-452 ◽  
Author(s):  
Jamil Shah ◽  
Abul Shahidullah ◽  
Yingxian Liu
Keyword(s):  
Adverse Effect ◽  
Autoimmune Hepatitis ◽  
Antinuclear Antibody ◽  
Acne Vulgaris ◽  
Young Female ◽  
Interesting Case ◽  
Severe Adverse Effect ◽  
Drug Induced ◽  
Smooth Muscle Antibodies

Drug-induced autoimmune hepatitis is an acute and potentially severe adverse effect, which has been reported following the long-term use of minocycline. The condition’s typical biochemical findings include an elevated antinuclear antibody titer, hypergammaglobulinemia with elevated levels of serum immunoglobulin G, and, sometimes, positive anti-smooth muscle antibodies. Characteristically, transaminase levels are very elevated, while markers of cholestasis and bilirubin levels are mildly increased, and histological features are very similar to those observed in sporadic autoimmune hepatitis. Here, we describe an interesting case of a young female who developed drug-induced autoimmune hepatitis after taking minocycline for the treatment of acne vulgaris.

The Excavation of an Oval Burial Mound of the Third Millennium bc at Alfriston, East Sussex, 1974

1975 ◽  
Vol 41 ◽  
pp. 119-152 ◽  
Author(s):  
Peter Drewett ◽  
C. R. Cartwright ◽  
T. P. O'Connor ◽  
C. Green ◽  
K. D. Thomas
Keyword(s):  
Land Use ◽  
Field Survey ◽  
Young Female ◽  
Burial Mound ◽  
The Third ◽  
Third Millennium ◽  
Third Millennium Bc

SummaryThe small oval burial mound at Alfriston, East Sussex, being one of only twelve certain burial structures of the 3rd millennium bc in Sussex, was totally excavated in 1974 prior to its final obliteration by ploughing. The barrow was found to consist of a simple dump mound derived from material out of flanking ditches. It covered a single burial pit containing the crouched skeleton of a young female. Information concerning the post-Neolithic land use of Alfriston Down was obtained from the ditch silts and expanded by an intensive field survey.

Effect of food manipulation on the GnRH-LH-estradiol axis of young female rats

1988 ◽  
Vol 254 (4) ◽  
pp. R616-R621 ◽  
Author(s):  
F. H. Bronson
Keyword(s):  
Food Restriction ◽  
Dark Period ◽  
Pubertal Development ◽  
Young Female ◽  
Female Rats ◽  
The Third ◽  
Feedback Sensitivity ◽  
Effect Of Food ◽  
Ad Libitum ◽  
Ad Libitum Feeding

Female rats were prevented from growing and developing reproductively by restricting their food intake from the time they reached 80-85 g (27-29 days of age) until they were 2 mo old. A return to ad libitum feeding then typically yielded the pubertal ovulation during the third or fourth dark period. Ad libitum feeding for 48 h increased the frequency of luteinizing hormone (LH) pulsing in ovariectomized females. This treatment also depressed the level of circulating estradiol in ovariectomized females implanted with Silastic capsules. It had no effect on the rate at which estradiol was cleared from the blood in a 1-h test, however, nor did it affect the pool of assayable gonadotropin-releasing hormone (GnRH) in the hypothalamus, the pool of assayable LH in the pituitary, the response of the pituitary to GnRH, or the rate at which LH was cleared from the blood. In toto, the present results suggest that food restriction inhibits pubertal development by acting rather specifically on GnRH secretion via an ovarian steroid-independent pathway. The presumed supplemental role for enhanced negative-feedback sensitivity could not be evaluated because of the aberrant results with encapsulated estradiol.

scholarly journals S1144 Prevalence and Risk of Autoimmune Hepatitis in Patients With Autoimmune Disease

2020 ◽  
Vol 115 (1) ◽  
pp. S573-S573
Author(s):  
Erin Walsh ◽  
Kyle Dannemiller ◽  
Aakash Desai ◽  
Patrick Twohig ◽  
Nisheet Waghray
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Hepatitis

scholarly journals Geographic Clusters of Primary Biliary Cirrhosis

2003 ◽  
Vol 10 (2-4) ◽  
pp. 127-131 ◽  
Author(s):  
Saif Abu-Mouch ◽  
Carlo Selmi ◽  
Gordon D. Benson ◽  
Thomas P. Kenny ◽  
Pietro Invernizzi ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Primary Biliary Cirrhosis ◽  
Environmental Factors ◽  
Small Area ◽  
Bile Ducts ◽  
Unknown Etiology ◽  
Biliary Cirrhosis ◽  
The Third ◽  
High Prevalence ◽  
Genetic And Environmental Factors

Genetic and environmental factors have been widely suggested to contribute to the pathogenesis of primary biliary cirrhosis (PBC), an autoimmune disease of unknown etiology leading to destruction of small bile ducts. Interestingly, epidemiologic data indicate a variable prevalence of the disease in different geographical areas. The study of clusters of PBC may provide clues as to possible triggers in the induction of immunopathology. We report herein four such unique PBC clusters that suggest the presence of both genetic and environmental factors in the induction of PBC. The first cluster is represented by a family of ten siblings of Palestinian origin that have an extraordinary frequency of PBC (with 5/8 sisters having the disease). Second, we describe the cases of a husband and wife, both having PBC. A family in which PBC was diagnosed in two genetically unrelated individuals, who lived in the same household, represents the third cluster. Fourth, we report a high prevalence of PBC cases in a very small area in Alaska. Although these data are anedoctal, the study of a large number of such clusters may provide a tool to estimate the roles of genetics and environment in the induction of autoimmunity.

scholarly journals Posaconazole-Vincristine Coadministration Triggers Seizure in a Young Female Adult: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Dalia A. Hamdy ◽  
Hager El-Geed ◽  
Samah El-Salem ◽  
Manal Zaidan
Keyword(s):  
Adverse Effect ◽  
Case Reports ◽  
Lymphoblastic Leukemia ◽  
Young Female ◽  
Induction Phase ◽  
Female Adult ◽  
The Third ◽  
Neurotoxic Effects ◽  
Neurological Exam ◽  
Casual Relationship

Coadministration of azoles and vincristine has been shown to increase vincristine neurotoxic effects due to the inhibition of cytochrome P450 (CYP) isoform 3A4, for which vincristine is a substrate. Despite the absence of any casual relationship between seizure and coadministration of azoles, few case reports of vincristine-induced seizure have been documented after coadministration of fluconazole or posaconazole in children. In this paper we are reporting the first young female adult who experienced generalized seizure after coadministration of posaconazole and vincristine. The 19-year-old female was diagnosed with acute lymphoblastic leukemia. She started induction phase of Berlin Frankfurt Muenster protocol along with posaconazole 200 mg three times daily as prophylactic antifungal therapy. Five days after the third vincristine dose, she developed generalized seizure accompanied by high blood pressure and SIADH. Her neurological exam/CT scan did not show any abnormality. In conclusion, this study reports a novel finding in the sense that all previous case reports pertaining to posaconazole-vincristine-induced seizure in literature involved children. Physicians should be made aware of this rare possible outcome to closely monitor their patients and take appropriate measures to prevent such possible adverse effect.

Wegener's Granulomatosis Presenting as Mastoiditis

1998 ◽  
Vol 107 (7) ◽  
pp. 560-563 ◽  
Author(s):  
Abd El-Mateen Moussa ◽  
Kamal A. Abou-Elhmd
Keyword(s):  
Autoimmune Disease ◽  
Surgical Therapy ◽  
Wegener’S Granulomatosis ◽  
Young Patients ◽  
Wegener's Granulomatosis ◽  
Young Female ◽  
Male Predominance ◽  
Peak Incidence ◽  
Female Patients

Wegener's granulomatosis is an uncommon autoimmune disease. It has a peak incidence in the fifth decade of life, with a slight male predominance. Nasal problems are the predominant presentation, with rare otological manifestations. We report 2 cases of Wegener's granulomatosis presenting as mastoiditis in 2 young female patients. We conclude that young patients presenting with mastoiditis unresponsive to conventional medical and surgical therapy should be investigated for Wegener's granulomatosis.

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