scholarly journals BIOMARKERS, NEOANGIOGENESIS AND GROWTH FACTORS IN PANCREATIC CANCER

2019 ◽  
Vol 6 (3) ◽  
pp. 51-64
Author(s):  
E. M. Frantsiyants ◽  
O. I. Kit ◽  
V. I. Aleynov ◽  
I. A. Goroshinskaya
Keyword(s):  
Pancreatic Cancer ◽  
Growth Factors ◽  
Growth Factor ◽  
Rapid Progression ◽  
Therapeutic Effects ◽  
Intracellular Signals ◽  
Igf I ◽  
Key Factor ◽  
Endothelial Growth Factor

Pancreatic cancer (PC) is a lethal malignant tumor characterized by a rapid progression, invasiveness and resistance to radiochemotherapy. The development of biomarkers for the early diagnosis of the disease is relevant. Angiogenesis has been identified as a key factor in a number of pathological conditions, including cancer. The proangiogenic signaling molecule – vascular endothelial growth factor (VEGF) and its receptors play a central role in tumor angiogenesis. In this review, we also highlight the dual role of growth factor-β (TGF-β) and touch upon the prospects for therapeutic effects on targets associated with TGF-β signaling in pancreatic cancer. A growing interest is attracted to the role of insulin-like growth factors IGF-I and IGF-II in cancer diseases. IGF-I and its receptor are highly expressed on the surface of pancreatic cancer cell lines that initiate the transduction of intracellular signals associated with the proliferation, invasion and expression of angiogenesis mediators. And so, the study of markers and growth factors may be a new, viable option for the diagnosis and treatment of pancreatic cancer.

scholarly journals Effect of PDGF-BB, IGF-I Growth Factors and their Combination Carried by Liposomes in Tooth Socket Healing

2013 ◽  
Vol 24 (4) ◽  
pp. 299-307 ◽  
Author(s):  
Fernando Antonio Mauad de Abreu ◽  
Cynthia Lopes Ferreira ◽  
Gerluza Aparecida Borges Silva ◽  
Camila de Oliveira Paulo ◽  
Melissa Nunes Miziara ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Blood Vessels ◽  
Bone Repair ◽  
Blood Clot ◽  
Healing Process ◽  
Igf I ◽  
Bone Trabeculae ◽  
The Right ◽  
Endothelial Growth Factor

This work evaluated the bone-forming potential of the platelet-derived growth factor isoform BB (PDGF-BB), insulin-like growth factor I (IGF-I), and mixed PDGF-BB/IGF-I delivered in liposomes compared with phosphate buffered saline (PBS), in the healing process of rat tooth sockets. One hundred and twelve Wistar rats were randomized into 7 groups of 16 animals each and were evaluated at 3, 7, 14 and 21 days after extraction of the maxillary second molars. The left sockets were treated with PBS (P), empty liposome (L), IGF-I in PBS (IP), IGF-I in liposome (IL), PDGF-BB in PBS (PDP), PDGF-BB in liposome (PDL) and both growth factors (GFs) together within liposomes (PDIL). The right sockets were filled with blood clot (BC). Histological and histomorphometric analyses were used to evaluate the formation of new bone and blood vessels. Immunohistochemistry was performed to evaluate the expression of osteocalcin and vascular endothelial growth factor (VEGF) during bone repair. Data were tested statistically using a Tukey's test according to a Dunn's analysis and Mann-Whitney U test followed by Kruskal-Wallis one-way analysis. Results were considered significant when p<0.05. A significantly higher percentage of bone trabeculae and a higher number of blood vessels were observed in the IL, PDL and PDIL groups (p<0.05). However, these GF-liposome groups had statistically similar results. Immunohistochemical assays first detected osteocalcin and VEGF expression at 3 days followed by a peak at 7 days. Lower immunoreactivity levels were observed in the BC, L, P, IP and PDP groups compared with the IL, PDL and PDIL groups (p<0.05). The results suggest that GFs carried by liposomes, either in isolated or mixed forms, enhanced the healing process in rat tooth sockets. The differential expression of the osteogenic markers VEGF and osteocalcin in the early phases of bone healing support these findings.

Growth Factors and Their Corresponding Receptors as Targets for Ovarian Cancer Therapy

2018 ◽  
Author(s):  
Anca Maria Cimpean ◽  
Andreea Adriana Jitariu ◽  
Marius Raica
Keyword(s):  
Ovarian Cancer ◽  
Growth Factors ◽  
Growth Factor ◽  
Disease Free Survival ◽  
Endocrine Gland ◽  
Vascular Endothelial ◽  
Free Survival ◽  
Ovarian Carcinogenesis ◽  
Endothelial Growth Factor

Ovarian cancer remains one of the most aggressive and difficult to manage malignancies regarding evaluation and therapeutic options. The high mortality persists despite extensive research in the field. Current conventional chemotherapy does not improve disease-free survival and does not decrease recurrences amongst patients. This calls for a stringent reconsideration of the drugs selection, focused on the most targeted strategies and personalization of the therapy. Targeted agents against growth factors and their corresponding receptors are already approved as first- or second-line neoadjuvant therapy with controversial results. This chapter critically discusses the role of growth factors as vascular endothelial growth factor, fibroblast growth factors, or platelet-derived growth factors and their corresponding receptors in the pathogenesis, progression, and selection of therapeutic strategies. Other growth factors, such as nerve growth factor or endocrine gland derived growth factor, seem to have a strong involvement in ovarian carcinogenesis but their actual impact is not fully understood.

scholarly journals Growth Factors in Human Pancreatic Cancer: Update on the Role of the Epidermal Growth Factor Receptor

1994 ◽  
Vol 11 (3-6) ◽  
pp. 147-149 ◽  
Author(s):  
Murray Korc ◽  
Helmut Friess ◽  
Michael S. Kobrin ◽  
Matthias Ebert ◽  
Markus W. Büchler
Keyword(s):  
Pancreatic Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factors ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Human Pancreatic Cancer ◽  
Epidermal Growth

scholarly journals Growth factors and kinases in glioblastoma growth

2016 ◽  
Vol 2 (5) ◽  
pp. 248 ◽  
Author(s):  
Miguel Ángel Peña-Ortiz ◽  
Liliana Germán-Castelán ◽  
Aliesha González-Arenas
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Signaling Pathways ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Glycogen Synthase ◽  
Vascular Endothelial ◽  
Growth Factor Beta ◽  
Endothelial Growth Factor

<p>Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, having the highest invasion, migration, proliferation, and angiogenesis rates. Several signaling pathways are involved in the regulation of these processes including growth factors and their tyrosine kinase receptors, such as vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFβ), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and insulin-like growth factor–I (IGF–I). Different kinases and regulators also participate in signaling pathways initiated by growth factors, such as mitogen-activated kinases (MAPK), protein kinases C (PKC), phosphatidylinositol-3 kinases (PI3K), protein kinase B (PKB or Akt), glycogen synthase kinase 3β (GSK3β), the mTOR complex, and Bcl-2. In this review, we will focus on the role of these proteins as possible therapeutic targets in GBM.</p>

scholarly journals Vascular endothelial growth factor role in predicting vascular disorders in pregnant with fetal growth restriction syndrome

2015 ◽  
Vol 96 (2) ◽  
pp. 220-223 ◽  
Author(s):  
E V Ul’yanina ◽  
I F Fatkullin
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factors ◽  
Growth Factor ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Blood Circulation ◽  
Growth Restriction ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

The review covers the up-to-date data of vascular endothelial growth factor role in forming of placental blood circulation in non-complicated pregnancy and in fetal growth retardation syndrome. It is shown that the normal trophoblast invasion to the spiral arteries wall in the myometrium and adequate remodeling of spiral arteries are essential for the normal fetal growth and development. The processes of blood vessels formation - vasculogenesis and angiogenesis - are described in detail. The process of angiogenesis regulation by growth factors and their receptors is reviewed. The importance of angiogenic and antiangiogenic factors coordinated action for the adequate placental microvasculature formation and normal fetal development is described. The growth factor complexes and their receptors formation processes and competition for receptor binding, as well as the role of placental growth factor in uteroplacental complex angiogenesis are analyzed. It is shown that the serum growth factors represent the mechanisms of pathologic reactions in placental insufficiency and fetal growth restriction syndrome. Special attention is given to the family of vascular endothelial growth factor as for the most important angiogenesis regulator. To determine the physiological role of vascular endothelial growth factor and to assess the its influence on angiogenesis and adequate uteroplacental and fetoplacental blood circulation formation, the features of vascular endothelial growth factor chemical structure are described. Determining the vascular endothelial growth factor in blood may be used to assess the mother-placenta-fetus system formation. The need for developing the criteria for choosing the optimal delivery term in pregnant with fetal growth restriction syndrome is discussed.

The Emerging Role of the Insulin-like Growth Factors in Oral Biology

2004 ◽  
Vol 83 (11) ◽  
pp. 832-836 ◽  
Author(s):  
H. Werner ◽  
J. Katz
Keyword(s):  
Growth Factors ◽  
Igf System ◽  
Pathological Conditions ◽  
Tissue Healing ◽  
System Components ◽  
Igf I ◽  
Key Factor ◽  
Oral Malignancies ◽  
Insulin Like Growth Factors

The insulin-like growth factors (IGF) are a family of growth factors, receptors and binding proteins that are involved in numerous growth and differentiation processes, as well as in various pathological conditions. The aim of this review is to summarize data that has been accumulating in recent years linking the IGF system to a number of physiological and pathological oral processes. The IGF system fulfills an important role in growth and development of teeth, mandible, maxillae, and tongue. It has been postulated that IGF-I may be of great value in the treatment of periodontal defects and in tissue healing. Furthermore, IGF-II has been shown to be overexpressed in salivary gland adenomas, suggesting that aberrant IGF signaling may be a key factor in the etiology of oral malignancies. Understanding the role and regulation of IGF system components in salivary glands and other oral structures will be of significant basic and clinical relevance.

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