scholarly journals Assessing the role of stimulus cues in promoting discriminated responding in abbreviated functional analysis

2012 ◽  
Author(s):  
Monica L. Frisbee
Keyword(s):  
Functional Analysis ◽  
Stimulus Cues

scholarly journals Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport

2017 ◽  
Vol 101 (4) ◽  
pp. 489-502 ◽  
Author(s):  
Hye In Kim ◽  
Johannes Raffler ◽  
Wenyun Lu ◽  
Jung-Jin Lee ◽  
Deepti Abbey ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Fine Mapping

Functional analysis of the SUMOylation pathway in Drosophila

2008 ◽  
Vol 36 (5) ◽  
pp. 868-873 ◽  
Author(s):  
Ana Talamillo ◽  
Jonatan Sánchez ◽  
Rosa Barrio
Keyword(s):  
Functional Analysis ◽  
Fine Tuning ◽  
Model Systems ◽  
Post Translational Modification ◽  
Reversible Process ◽  
Cellular Processes ◽  
Tuning Mechanism ◽  
Sumo Conjugation

SUMOylation, a reversible process used as a ‘fine-tuning’ mechanism to regulate the role of multiple proteins, is conserved throughout evolution. This post-translational modification affects several cellular processes by the modulation of subcellular localization, activity or stability of a variety of substrates. A growing number of proteins have been identified as targets for SUMOylation, although, for many of them, the role of SUMO conjugation on their function is unknown. The use of model systems might facilitate the study of SUMOylation implications in vivo. In the present paper, we have compiled what is known about SUMOylation in Drosophila melanogaster, where the use of genetics provides new insights on SUMOylation's biological roles.

scholarly journals Genetic Analysis of Neuroligin 4Y Gene in Autism Population of India

2021 ◽  
Author(s):  
Rajat Hegde ◽  
Smita Hegde ◽  
Suyamindra S. Kulkarni ◽  
Aditya Pandurangi ◽  
Pramod B. Gai ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Genetic Analysis ◽  
Missense Mutation ◽  
Mentally Ill ◽  
Large Population ◽  
Original Structure ◽  
Male Predominance ◽  
Local Configuration ◽  
Autistic Population

Abstract Background Autism is one of the most complex, heterogeneous neurological disorders. It is characterized mainly by abnormal communication, impaired social interaction, and restricted behaviors. Prevalence of autism is not clear in Indian population. Aim The present study hypothesizes that Y chromosome plays role in sex bias of autism in Indian autistic population. To investigate our hypothesis, we underwent genetic analysis of neuroligin 4Y [NLGN4Y] gene by sequencing 85 male autistic children after screening large population of 1,870 mentally ill children from North Karnataka region of India. Result Detailed sequencing of the single targeted gene revealed nine variants including, one novel missense mutation and eight synonymous variants; this accounts for 88.9% of synonymous variants. A single novel missense mutation is predicted to be nonpathogenic on the functions of neuroligin4Y protein but it slightly affects the local configuration by altering the original structure of a protein by changing charge and size of amino acid. Conclusion Probably NLGN4Y gene may not be the risk factor for autism in male children in Indian autistic population. Functional analysis was an important limitation of our study. Therefore, detailed functional analysis is necessary to determine the exact role of novel missense mutation of neuroligin 4Y [NLGN4Y] gene especially in the male predominance of autism in Indian autistic population.

Structural and functional analysis of reconnaissance and fire system and decomposition of its functions and subsystems

2021 ◽  
pp. 38-48
Author(s):  
O. Maistrenko ◽  
O. Karavanov ◽  
A. Shcherba
Keyword(s):  
Functional Analysis ◽  
Fire Damage ◽  
Expert Group ◽  
Expert Evaluation ◽  
Military Conflicts ◽  
Main Factors ◽  
The Stability ◽  
The Impact

It is established that the role of reconnaissance and fire systems in the implementation of enemy fire damage in military conflicts occurring at the beginning of the XXI century. Increased  to 75%. However, it was found that the effectiveness of these systems depends on the quality of their equipment. The main factors that are often not taken into account in the acquisition are the possibility, interoperability, stability of each element, the impact of elements on the stability of each other and the functioning of the RVS as a whole. The analysis of recent research and publications has shown that as of today, the approaches to determining the composition of reconnaissance fire systems taking into account these factors are not justified. Given the above, it was decided to conduct a structural and functional analysis of the reconnaissance fire system and the decomposition of its functions and subsystems. To this end, based on the method of cluster analysis, an algorithm for combining a set of tasks performed by reconnaissance and fire systems into groups has been developed and substantiated. The method of expert evaluation was used to obtain substantiated data on the implementation of such a merger. According to the proposed algorithm, the main tasks were first identified, which involve reconnaissance and fire systems. Subsequently, an expert group was formed and the coefficient of relative competence of each member of the expert group was determined. The experts were then asked to combine the identified tasks according to their characteristics into an arbitrary number of groups. After processing the opinions of experts, 10 characteristic groups were identified. Finally, the experts were asked to combine the obtained groups in such a way that each association consisted of similar objects and the objects of different associations differed significantly. The results of the work revealed the functional interconnectedness of the tasks, processes and subsystems of the reconnaissance and fire system. It is also established that a typical reconnaissance fire system will consist of three subsystems (control, reconnaissance and fire influence), which perform specific functions for each of them.

scholarly journals Structure–functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication

Virology ◽  
2004 ◽  
Vol 328 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Dineshkumar Thotala ◽  
Elizabeth A. Schafer ◽  
Biswanath Majumder ◽  
Michelle L. Janket ◽  
Marc Wagner ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Human Immunodeficiency Virus ◽  
Virus Replication ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus ◽  
Hiv 1

scholarly journals Identification and functional analysis of a novel PRKAG2 mutation responsible for Chinese PRKAG2 cardiac syndrome reveal an important role of non-CBS domains in regulating the AMPK pathway

2013 ◽  
Vol 62 (4) ◽  
pp. 241-248 ◽  
Author(s):  
Bi-li Zhang ◽  
Rong-liang Xu ◽  
Jing Zhang ◽  
Xian-xian Zhao ◽  
Hong Wu ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Ampk Pathway ◽  
Cardiac Syndrome ◽  
Cbs Domains

Functional Analysis of a Thermal Spring Ecosystem, with an Evaluation of the Role of Consumers

Ecology ◽  
1976 ◽  
Vol 57 (6) ◽  
pp. 1221-1232 ◽  
Author(s):  
Nicholas C. Collins ◽  
Rodger Mitchell ◽  
Richard G. Wiegert
Keyword(s):  
Functional Analysis ◽  
Thermal Spring

scholarly journals In Vitro Action of Meconium on Bronochomotor Tonus of Newborns with Meconium Aspiration Syndrome

2018 ◽  
Vol 6 (6) ◽  
pp. 992-996 ◽  
Author(s):  
Arsim Haliti ◽  
Lirim Mustafa ◽  
Sadi Bexheti ◽  
Drita Islami ◽  
Adnan Bozalija ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Respiratory System ◽  
Meconium Aspiration Syndrome ◽  
Control Group ◽  
Meconium Aspiration ◽  
Smooth Musculature ◽  
Inflammatory Processes ◽  
Tracheobronchial System

AIM: Here we studied the role of meconium in the respiratory system on live and exited newborns (weight 250-3000 g). Throughout this study is followed the response of tracheal rings in acetylcholine and histamine in different molar concentrations (10-1, 10-2, 10-3, 10-4 mol/dm3).METHODS: To study the smooth tracheal musculature we used 23 tracheal preparations obtained from the newborns exited from meconium aspiration.RESULTS: Based on the functional analysis of the tracheal specimen we have concluded that the meconium aspiration did not change the smooth musculature response on acetylcholine and histamine when compared to control group, exited from lung inflammatory processes (e.g., pneumonia, bronchopneumonia, atelectasis, cerebral hemorrhage), where tracheal smooth musculature response is significant (P for other causes is not significant (P > 0.01).CONCLUSION: The conclusions suggest that meconium did not potentiate the constrictor action of acetylcholine and histamine in the tracheobronchial system and did not cause modulation of bronchomotor tonus in case of his aspiration. Meconium causes mild relaxation of smooth tracheal musculature with a mechanism which is not mediated by cyclooxygenase products, from tracheal epithelium or proteins. Also, direct activity in the smooth musculature of several tested acids seems to have no significant impact in increasing the tonus of respiratory airway of smooth tracheal musculature.

Functional analysis of cauliflower mosaic virus 35S promoter: re-evaluation of the role of subdomains B5, B4 and B2 in promoter activity

2007 ◽  
Vol 5 (6) ◽  
pp. 696-708 ◽  
Author(s):  
Simran Bhullar ◽  
Sudipta Datta ◽  
Sonia Advani ◽  
Suma Chakravarthy ◽  
Taru Gautam ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Mosaic Virus ◽  
Promoter Activity ◽  
Cauliflower Mosaic Virus ◽  
35S Promoter ◽  
Cauliflower Mosaic Virus 35S
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