NEW BIOMARKERS OF HEART FAILURE: DIAGNOSTIC AND PROGNOSTIC VALUE OF NT-proBNP AND INTERLEUKIN RECEPTOR FAMILY MEMBER ST2

Now there is a relevant development of the new biomarkers capable to serve as the instrument of early diagnostics of a disease for the purpose of selection of a pharmacotherapy and further monitoring of its efficiency. Galektin-3 is the atypical representative of the family of galektin. Its participation in fibrosis, remodeling of heart, the immunologic answer and inflammatory reactions are shown. Prognostic value is discussed and diagnostic opportunities of Galektin-3 at CHF are widely studied and take root into clinical practice. Now a great deal of research devoted to the studying of Galektin-3, possibilities of its use as a biomarker at diagnostics, forecasting of outcomes and the choice of therapeutic strategy at other cardiovascular diseases has been conducted.

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Diagnostic and Prognostic Value of Plasma Levels of Cardiac Myosin Binding Protein-C as a Novel Biomarker in Heart Failure

Pediatric Cardiology ◽

10.1007/s00246-016-1532-2 ◽

2016 ◽

Vol 38 (2) ◽

pp. 418-424 ◽

Cited By ~ 3

Author(s):

Doaa El Amrousy ◽

Hossam Hodeib ◽

Ghada Suliman ◽

Nahed Hablas ◽

Eman Ramadan Salama ◽

...

Keyword(s):

Heart Failure ◽

Plasma Levels ◽

Protein C ◽

Prognostic Value ◽

Binding Protein ◽

Cardiac Myosin ◽

Myosin Binding Protein ◽

Myosin Binding Protein C ◽

Myosin Binding ◽

Diagnostic And Prognostic Value

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Diagnostic and prognostic value of serum C-reactive protein in heart failure with preserved ejection fraction: a systematic review and meta-analysis

Heart Failure Reviews ◽

10.1007/s10741-020-09927-x ◽

2020 ◽

Author(s):

Ishan Lakhani ◽

Michelle Vangi Wong ◽

Joshua Kai Fung Hung ◽

Mengqi Gong ◽

Khalid Bin Waleed ◽

...

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Ejection Fraction ◽

Prognostic Value ◽

Meta Analysis ◽

Preserved Ejection Fraction ◽

C Reactive Protein ◽

Reactive Protein ◽

Diagnostic And Prognostic Value

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Connective tissue growth factor (CTGF/CCN2): diagnostic and prognostic value in acute heart failure

Clinical Research in Cardiology ◽

10.1007/s00392-013-0626-6 ◽

2013 ◽

Vol 103 (2) ◽

pp. 107-116 ◽

Cited By ~ 16

Author(s):

Michael Behnes ◽

Martina Brueckmann ◽

Siegfried Lang ◽

Christel Weiß ◽

Parviz Ahmad-Nejad ◽

...

Keyword(s):

Heart Failure ◽

Growth Factor ◽

Connective Tissue ◽

Acute Heart Failure ◽

Connective Tissue Growth Factor ◽

Prognostic Value ◽

Tissue Growth ◽

Diagnostic And Prognostic Value

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The ST2 diagnostic value in selection of patients for heart transplantation and post-transplant period

Modern medical technologies ◽

10.34287/mmt.1(40).2019.1 ◽

2019 ◽

Vol 40 (1) ◽

pp. 4-11

Author(s):

A. S. Nikonenko ◽

O. O. Tanska

Keyword(s):

Heart Failure ◽

Cardiovascular Disease ◽

Cardiovascular Diseases ◽

Chronic Heart Failure ◽

Heart Transplantation ◽

Prognostic Value ◽

Clinical Manifestations ◽

Mechanical Damage ◽

Risk Of Death ◽

Diagnostic And Prognostic Value

Purpose of the study. Study ST2 diagnostic marker in the development and severity of heart failure, evaluation of transplant status and the risk of developing a rejection crisis, as well as the risk of death in patients with cardiovascular disease.Material and methods. There were 41 patients under observation. The cases were conventionally divided into two groups: the first group of patients with chronic heart failure (n = 28), and the control group who performed orthotopic transplantation of the heart (n = 13).Results and discussion. These results suggest that ST2 is a real marker of chronic heart failure or a good predictor of mortality in decompensated patients. Changes in ST2 levels in patients after orthotopic cardiac transplantation may be potentially useful in detecting acute cellular rejection, as well as in controlling rejection therapy. The article is devoted to the analysis of the prognostic role of the ST2 biomarker in the pre and post-transplantation period. ST2 is one of the most promising diagnostic markers for the development and severity of heart failure, as well as the risk of death in patients with cardiovascular disease. ST2 is expressed in cardiomyocytes in response to pathological processes and various mechanical damage in the heart, which allows to diagnose cardiovascular diseases even before clinical manifestations. It is likely that ST2 level measurement of heart transplantation may have a diagnostic and prognostic value when evaluating the graft state and the risk of developing rejection.Conclusions. ST2 is one of the most promising diagnostic markers of development and severity of heart failure, as well as the risk of death in patients with cardiovascular disease. ST2 is expressed in cardiomyocytes in response to pathological processes and various mechanical damage in the heart, which allows to diagnose cardiovascular diseases even before clinical manifestations. Measuring the level of ST2 for heart transplantation may have a diagnostic and prognostic value in evaluating the condition of the graft and the risk of developing rejection. Keywords:heart failure, ST2, heart transplantation, rejection crisis.

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Plasma Levels of Connective Tissue Growth Factor in Children with Congestive Heart Failure

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2020/v32i130358 ◽

2020 ◽

pp. 110-116

Author(s):

Riham Mahmoud Wagieh ◽

Ahmed Hamdy Shabana ◽

Hesham Mohammed Elserogy ◽

Amr Mohamed Zoair

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Growth Factor ◽

Plasma Level ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Prognostic Value ◽

Tissue Growth ◽

Factor Level ◽

Diagnostic And Prognostic Value

Objectives: Assessment of plasma level of connective tissue growth factor in congestive heart failure children, assessment of its diagnostic and prognostic role and correlate its level with clinical and echocardiographic assessment of congestive heart failure. Methods: Connective tissue growth factor level in the plasma was measured in 40 children; 20 of them have congestive heart failure, and 20 are healthy then, correlated with clinical parameters. Results: The diagnostic and prognostic value of it was evaluated. We compared its levels in both patients and healthy children. We found that connective tissue growth factor level was significantly increased in diseased children. Fractional shortening and ejection fraction correlated negatively with the plasma level of connective tissue growth factor. Heart rate, respiratory rate and calibrated integrated backscatter correlated positively with connective tissue growth factor. Connective tissue growth factor was significantly correlated with the class of heart failure according to Ross classification. Conclusions: Plasma connective tissue growth factor has a promising diagnostic and prognostic value as a biomarker for congestive heart failure in children with high sensitivity and specificity.

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