scholarly journals Biomarkers of acute myocardial infarction: diagnostic and prognostic value. Part 1 (literature review)

2020 ◽  
Author(s):  
Aleksey Michailovich Chaulin ◽  
Dmitry Viktorovich Duplyakov
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Growth Factor ◽  
Prognostic Value ◽  
Cd40 Ligand ◽  
Cardiac Biomarkers ◽  
Economic Damage ◽  
Soluble Cd40 Ligand ◽  
Fatty Acid Binding ◽  
Diagnostic And Prognostic Value

Morbidity and mortality rates from acute myocardial infarction (AMI) have been growing rapidly in recent years, causing significant socio-economic damage. Cardiac biomarkers play an important role in the diagnosis and prediction of AMI. In our review article, we will summarize information about the main existing cardiac biomarkers and focus on their diagnostic and prognostic value for patients with AMI. In the first part of the review, we consider the diagnostic and prognostic value of biomarkers of necrosis and myocardial ischemia (aspartate aminotransferase; creatine phosphokinase; cardiac troponins; myoglobin, ischemia-modified albumin, fatty acid binding protein) and neuroendocrine AMI biomarkers (natriuretic peptides, adrenomedullin, catestatin, components of the renin-angiotensin-aldosterone system). In the second part of the review, we discuss the diagnostic and prognostic value of inflammatory AMI biomarkers (C-reactive protein, interleukin-6, tumor necrosis factor, myeloperoxidase, matrix metalloproteinases, soluble CD40 ligand form (sCD40L), procalcitonin, placental growth factor (PGF), procalcitonin) and recently discovered new biomarkers (microRNA, stimulating growth factor, expressed by genome 2 (ST2), growth differentiation factor 15 (GDF-15), galectin-3).

scholarly journals BIOMARKERS OF ACUTE MYOCARDIAL INFARCTION: DIAGNOSTIC AND PROGNOSTIC VALUE. PART 2 (LITERATURE REVIEW)

2021 ◽  
Author(s):  
Aleksey Michailovich Chaulin ◽  
Dmitry Viktorovich Duplyakov
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Growth Factor ◽  
Prognostic Value ◽  
Prognostic Significance ◽  
Cd40 Ligand ◽  
Soluble Form ◽  
Necrosis Factor Alpha ◽  
New Biomarkers ◽  
Diagnostic And Prognostic Value

In the second part of the review, we continue the discussion of biomarkers that have diagnostic and prognostic significance in acute myocardial infarction (AMI). The study of the pathophysiology of AMI through experimental and clinical studies contributes to the discovery of new regulatory molecules and pathogenetic mechanisms underlying AMI. At the same time, many molecules involved in the pathogenesis of AMI can be used as effective biomarkers for the diagnosis and prediction of AMI. This article discusses in detail the diagnostic and prognostic value of inflammatory biomarkers of AMI (C-reactive protein, interleukin-6, tumor necrosis factor-alpha, myeloperoxidase, matrix metalloproteinases, soluble form of CD40 ligand, procalcitonin, placental growth factor) and a number of recently discovered new biomarkers of AMI (microribonucleic acids, galectin-3, stimulating growth factor expressed by gene 2, growth differentiation factor 15, proprotein convertase of subtilisin-kexin type 9).

scholarly journals Diagnostic and prognostic value of biomarkers in acute myocardial infarction

2019 ◽  
Vol 95 (1122) ◽  
pp. 210-216 ◽  
Author(s):  
Yuqi Chen ◽  
Yifei Tao ◽  
Lan Zhang ◽  
Weiting Xu ◽  
Xiang Zhou
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Prognostic Value ◽  
Cardiac Biomarkers ◽  
Cardiac Events ◽  
Reactive Protein ◽  
Diagnosis And Prognosis ◽  
Cardiovascular Prognosis ◽  
Novel Biomarkers ◽  
Diagnostic And Prognostic Value

The incidence of acute myocardial infarction (AMI) has been increasing rapidly in recent years, seriously endangering human health. Cardiac biomarkers play critical roles in the diagnosis and prognosis of AMI. Troponin is a highly sensitive and specific biomarker for AMI diagnosis and can independently predict adverse cardiac events. Other biomarkers such as N-terminal B-type natriuretic peptide and C reactive protein are also valuable predictors of cardiovascular prognosis. Recently, several novel biomarkers have been identified for the diagnosis and risk assessment in patients with AMI. A multibiomarker approach can potentially enhance the diagnostic accuracy and provide more information for the early risk stratification of AMI. In this review, we will summarise the biomarkers discovered in recent years and focus on their diagnostic and prognostic value for patients with AMI.

Diagnostic and prognostic value of heart-type fatty acid-binding protein in the early hours of acute myocardial infarction

2011 ◽  
Vol 66 (3) ◽  
pp. 315-321 ◽  
Author(s):  
Sonsoles Garcia-Valdecasas ◽  
Maria J. Ruiz-Alvarez ◽  
Jaime Garcia De Tena ◽  
Raul De Pablo ◽  
Isabel Huerta ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Prognostic Value ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Diagnostic And Prognostic Value

Soluble CD40 ligand and interleukin-6 in the coronary circulation after acute myocardial infarction

2006 ◽  
Vol 112 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Yoshitaka Ohashi ◽  
Seinosuke Kawashima ◽  
Takao Mori ◽  
Mitsuyasu Terashima ◽  
Shinobu Ichikawa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Interleukin 6 ◽  
Coronary Circulation ◽  
Cd40 Ligand ◽  
Soluble Cd40 Ligand

scholarly journals Plasma concentrations of soluble CD40 ligand in smokers with acute myocardial infarction: a pilot study

2010 ◽  
Vol 26 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Mehmet Kayrak ◽  
Ahmet Bacaksiz ◽  
Mehmet S. Ulgen ◽  
Mehmet Akif Vatankulu ◽  
Kadriye Zengin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Pilot Study ◽  
Plasma Concentrations ◽  
Cd40 Ligand ◽  
Soluble Cd40 Ligand

Detecting plaque rupture? Soluble CD40 ligand for early diagnosis of acute myocardial infarction in the emergency department

2010 ◽  
Vol 27 (Suppl 1) ◽  
pp. A6.2-A6
Author(s):  
Richard Body
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Emergency Department ◽  
Early Diagnosis ◽  
Adverse Events ◽  
Troponin T ◽  
Cd40 Ligand ◽  
Soluble Cd40 Ligand ◽  
Calcium Blockers ◽  
Significant Difference

BackgroundIn recent years there has been growing interest in the identification of novel biomarkers that may enable early exclusion of acute coronary syndromes (ACS) in the Emergency Department (ED). Soluble CD40 ligand (sCD40L) has been identified as a potential marker of coronary plaque destabilisation and platelet activation. We aimed to investigate the value of sCD40L measured at the time of ED presentation for enabling early diagnosis and exclusion of ACS.MethodsWe recruited patients presenting to the ED with suspected cardiac chest pain within the previous 24 h. We measured sCD40L in plasma samples taken at the point of ED presentation. All patients had troponin T measured at least 12 h after symptom onset and were followed up for 6 months for adverse events (death, acute myocardial infarction (AMI) or the need for urgent revascularisation).Results706 patients were recruited to the study. sCD40L levels were significantly lower in smokers, in patients with hyperlipidaemia or prior coronary revascularisation and in patients taking statins, r angiotensin-converting enzyme or calcium blockers. There was no significant difference in sCD40L levels between patients with (median 33.8ng/ml, IQR 18.0–80.5) and without (36.3 ng/ml, IQR 14.2–94.3) AMI (p=0.92) or between patients who did (34.0 ng/ml, 14.2–94.3) and who did not (34.9, 18.2–80.4) develop adverse events (p=0.82). The area under the Receiver Operating Characteristic curve was 0.50 (95% CI 0.45 to 0.56) for AMI and 0.49 (0.44–0.55) for adverse events. There was no trend towards increasing incidence of either outcome with ascending quintiles of sCD40L.ConclusionssCD40L is unhelpful in the ED diagnosis of ACS. Future work in this area should focus on other biomarkers.

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