scholarly journals CLINICAL ASPECTS OF SLEEP DISORDERS IN PATIENTS WITH PARKINSON’S DISEASE

2017 ◽  
Vol 8 (2) ◽  
pp. 22-27
Author(s):  
O A Andrienko
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Healthy Volunteers ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Structural Changes ◽  
Paradoxical Sleep ◽  
Sleep Time ◽  
Clinical Aspects ◽  
Time Awake

According to the scientific literature of sleep disturbance in patients with Parkinson’s disease meet from 51 to 85 %. In this study, PD patients with sleep disturbances were found in 50.1% (348 of 694 patients) were included in the registry (it surveyed patients with PD, aged from 21 to 90 years with different stages of BP living in different cities and districts of the Rostov region), noted sleep disorders during the disease, as well as to verify the diagnosis of PD. In the future, EEG-somnography were selected 48 patients with BP stage 2 on the Hoehn-Yahr, aged 52 to 71 years, and 50 healthy volunteers aged 49 to 67 years. It is established that in patients with PD stage of sleep you go faster - less time awake, and time of stage 1 non-REM sleep and the stage of paradoxical sleep (PS) in comparison with healthy volunteers. Chronic dyssomnia may occur due to ingestion of antiparkinson medications. Sleep duration decreases, but the psychological need remains the same. Structural changes are observed in sleep are significantly reduced slow-wave stage of sleep, some to a lesser extent, REM-phase and total sleep time.

scholarly journals Parkinson's Disease and Sleep/Wake Disturbances

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Todd J. Swick
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Treatment Options ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Clinical Aspects ◽  
Nonmotor Symptoms ◽  
Sleep Behavior

Parkinson's disease (PD) has traditionally been characterized by its cardinal motor symptoms of bradykinesia, rigidity, resting tremor, and postural instability. However, PD is increasingly being recognized as a multidimensional disease associated with myriad nonmotor symptoms including autonomic dysfunction, mood disorders, cognitive impairment, pain, gastrointestinal disturbance, impaired olfaction, psychosis, and sleep disorders. Sleep disturbances, which include sleep fragmentation, daytime somnolence, sleep-disordered breathing, restless legs syndrome (RLS), nightmares, and rapid eye movement (REM) sleep behavior disorder (RBD), are estimated to occur in 60% to 98% of patients with PD. For years nonmotor symptoms received little attention from clinicians and researchers, but now these symptoms are known to be significant predictors of morbidity in determining quality of life, costs of disease, and rates of institutionalization. A discussion of the clinical aspects, pathophysiology, evaluation techniques, and treatment options for the sleep disorders that are encountered with PD is presented.

scholarly journals INFLUENCE OF SLEEP DISTURBANCES ON COGNITIVE DECLINE IN PATIENTS WITH PARKINSON’S DISEASE

2020 ◽  
Vol 117 (3) ◽  
pp. 58-67
Author(s):  
Anastasiia Shkodina ◽  
Kateryna Tarianyk ◽  
Dmytro Boiko
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Rating Scale ◽  
Early Stages ◽  
The Impact

The article summarizes the arguments and counter-arguments within the scientific discussion on the impact of sleep disorders on the development of cognitive decline in patients with Parkinson's disease. The main purpose of the study is to study the possibility of predicting the development of cognitive decline by assessing the severity of sleep disorders and their differences in the presence of cognitive impairment. Systematization of literature sources and approaches to solving the problem showed that sleep disorders develop in the early stages of Parkinson's disease and are often accompanied by cognitive impairment. Cognitive decline is manifested throughout Parkinson's disease and ranges from moderate in the early stages to dementia in the late stages. The relevance of the study of the relationship between sleep disorders and cognitive functions lies in the possibility of further improving the prediction of the development of cognitive decline in order to effectively correct it. Treatment of sleep disorders can be accompanied by improved memory and even morphological changes in the brain. Therefore, the question arises about the possibility of correcting cognitive decline by influencing sleep disorders. The methodology of the study included assessment of the overall status of patients on a unified scale of Parkinson's disease, Montreal cognitive rating scale and sleep scale in Parkinson's disease. The duration of the study was 8 months. Patients with Parkinson's disease were selected as the study. The article presents the results of a survey of patients who show that patients with Parkinson's disease and cognitive decline showed a predominance of motor disorders, sleep disorders and the overall score on the sleep scale in Parkinson's disease. In the presence of cognitive decline more pronounced disorders of motor functions in everyday life, which can lead to sleep disorders and its quality. The study empirically confirms and theoretically proves that the assessment of sleep disorders can be used to predict the risk of developing cognitive impairment in patients with Parkinson's disease. The results of this study may be useful for improving the early diagnosis and prevention of cognitive impairment in patients with Parkinson's disease, which, in turn, leads to improved quality of treatment of these patients. Such changes can directly affect the choice of therapeutic tactics and improve the quality of life of patients with Parkinson's disease. The question of the features of various sleep disorders and their prognostic value in relation to cognitive decline in patients with various forms of Parkinson's disease remains open.

scholarly journals The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease

2021 ◽  
Vol 5 (9) ◽  
pp. 856-861
Author(s):  
Ahmad Afdal ◽  
Syarif Indra ◽  
Hendra Permana
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Cross Sectional Study ◽  
Research Subjects ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Relationship ◽  
Dopaminergic Degeneration

Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial. Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows. Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05. Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.

scholarly journals Alvászavarok Parkinson-kórban: megjelenés, kivizsgálás, terápiás lehetőségek

2015 ◽  
Vol 156 (27) ◽  
pp. 1091-1099 ◽  
Author(s):  
Béla Faludi ◽  
József Janszky ◽  
Sámuel Komoly ◽  
Norbert Kovács
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Therapeutic Interventions ◽  
Neurodegenerative Process ◽  
Pubmed Database ◽  
Parkinson's Desease ◽  
Specific Symptoms

Introduction: Parkinson’s disease is a well known representant of the movement disorder group of neurological disorders. The diagnosis of Parkinson’s disease is based on specific symptoms and signs of movement abnormalities. In addition to classic motor symptoms, Parkinson’s disease has characteristic non-motor features, and some of these emerges the classic signs. Aim: The authors discuss characteristics and therapeutic interventions in Parkinson’s disease related sleep disturbances. Method: The authors reviewed and summarised literature data on sleep disorders in Parkinson’s disease published in the PubMed database up to January 2015. Results: Sleep problems are important non-motor complains (insomnia, hypersomnia, REM behaviour disorder, sleep apnea and restless legs syndrome). The neurodegenerative process of the brain-stem, the effect of symptoms of Parkinson’s desease on sleep and concomitant sleep disorders constitute the background of the patient’s complains. Conclusions: Appropriate diagnosis and therapy of the consequential or concomitant sleep disorders in Parkinson’s disease will help to improve the patient’s quality of life. Orv. Hetil., 2015, 156(27), 1091–1099.

scholarly journals New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson’s disease

2019 ◽  
Vol 267 (1) ◽  
pp. 288-294 ◽  
Author(s):  
Lindsay H. M. Keir ◽  
David P. Breen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Disease Process ◽  
Underlying Disease ◽  
Prodromal Phase ◽  
Waste Products ◽  
New Treatment

AbstractThe non-motor features of Parkinson’s disease (PD) are increasingly being recognised. This review deals with the spectrum of sleep disorders associated with PD, which have a multifactorial aetiology and can significantly have an impact on the quality of life of patients and their carers. Some sleep disorders represent a prodromal phase of PD, with REM sleep behaviour disorder (RBD) being of particular interest in this regard, whereas others become more common as the disease advances. Understanding the pathophysiology of these sleep disturbances will hopefully lead to new treatment opportunities in the future. The recent discovery of the glymphatic system for removal of waste products from the brain has also raised the possibility that sleep disruption may cause or accelerate the underlying disease process.

scholarly journals The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease

2021 ◽  
Vol 5 (3) ◽  
pp. 823-828
Author(s):  
Ahmad Afdal ◽  
Syarif Indra ◽  
Hendra Permana
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Cross Sectional Study ◽  
Research Subjects ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Relationship ◽  
Dopaminergic Degeneration

Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial. Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows. Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05. Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.

scholarly journals A Polysomnographic Study of Parkinson’s Disease Sleep Architecture

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Daniel Martinez-Ramirez ◽  
Sol De Jesus ◽  
Roger Walz ◽  
Amin Cervantes-Arriaga ◽  
Zhongxing Peng-Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Rem Sleep ◽  
Sleep Disturbances ◽  
Sleep Stage ◽  
Rem Sleep Behavior Disorder ◽  
Sleep Architecture ◽  
Sleep Stages ◽  
Obstructive Sleep

Sleep disturbance is a common nonmotor phenomenon in Parkinson’s disease (PD) affecting patient’s quality of life. In this study, we examined the association between clinical characteristics with sleep disorders and sleep architecture patterns in a PD cohort. Patients underwent a standardized polysomnography study (PSG) in their “on medication” state. We observed that male gender and disease duration were independently associated with obstructive sleep apnea (OSA). Only lower levodopa equivalent dose (LED) was associated with periodic limb movement disorders (PLMD). REM sleep behavior disorder (RBD) was more common among older patients, with higher MDS-UPDRS III scores, and LED. None of the investigated variables were associated with the awakenings/arousals (A/A). Sleep efficiency was predicted by amantadine usage and age, while sleep stage 1 was predicted by dopamine agonists and Hoehn & Yahr severity. The use of MAO-B inhibitors and MDS-UPDRS part III were predictors of sleep stages 2 and 3. Age was the only predictor of REM sleep stage and gender for total sleep time. We conclude that sleep disorders and architecture are poorly predictable by clinical PD characteristics and other disease related factors must also be contributing to these sleep disturbances.

scholarly journals The mean velocity of posterior cerebral artery and basilar artery in Parkinson's disease with sleep disorders

2021 ◽  
Vol 4 ◽  
pp. 100207
Author(s):  
Muhammad Iqbal Basri ◽  
Ida Farida ◽  
Yudy Goysal ◽  
Jumraini Tammasse ◽  
Muhammad Akbar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Cerebral Artery ◽  
Basilar Artery ◽  
Posterior Cerebral Artery ◽  
Mean Velocity ◽  
The Mean
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