Magnesium and cancer

1935 ◽  
Vol 31 (8-9) ◽  
pp. 1097-1104
Author(s):  
M. S. Znamensky
Keyword(s):  
Magnesium Chloride ◽  
The Body ◽  
Malignant Tumours ◽  
Magnesium Halide ◽  
Magnesium Salts ◽  
Treatment Of Wounds ◽  
Halide Salts ◽  
Interesting Area

In 1915, Prof. Dеlbеt, who was not satisfied with the method of pure asepsis in the treatment of wounds because of its passivity, tried to find a remedy that would actively help the body to fight the infection. In his search, he came across magnesium halide salts (Mg) that met his requirements. But in the process of working with magnesium salts, mainly magnesium chloride, some of their properties were discovered, which attracted Dеlbеt to another, no less interesting area, namely malignant tumours.

Primary Malignant Tumours of the Body Of The Uterus

1975 ◽  
Vol 1 (12) ◽  
pp. 405-406
Author(s):  
G. R. Kurble ◽  
J. J. Campbell
Keyword(s):  
The Body ◽  
Malignant Tumours

Can Serum Thymidine Kinase 1 Detect Small Invisible Malignant Tumours?

2021 ◽  
Author(s):  
Ji Zhou ◽  
Huijun Li ◽  
Cong Fang ◽  
Junye Tan ◽  
Peng Gao ◽  
...  
Keyword(s):  
Thymidine Kinase ◽  
Total Protein ◽  
Magnetic Beads ◽  
Polyclonal Antibodies ◽  
Malignant Tumour ◽  
The Body ◽  
Cell Diameter ◽  
Malignant Tumours ◽  
Thymidine Kinase 1 ◽  
Protein Cell

Abstract Objectives. Early detection of malignant tumour is a prerequisite for a successful treatment. Here we investigate if thymidine kinase 1 is more sensitive than imaging technology to discover small invisible malignant tumours.Material and Methods. The cellular concentration of TK1 was determined by a novel automatic chemiluminescence analyzer of magnetic particle immune sandwich minimum. The primary and secondary antibodies linked to the magnetic beads were chicken anti-human thymidine kinase 1 IgY-polyclonal antibodies (IgY pAb). The minimum number of cells able to be detected by the novel detection technology using an automatic chemiluminescence analyzer were determined based on the cellar TK1 concentration of low and high TK1 cell lines of known cell count.Results. The TK1 concentration of malignant cell was found to be 0.021 pg/cell. Assuming 200 pg of total protein/cell, TK1 corresponds to 0.01 % of the total protein/cell. The concentration of TK1 in human blood serum of malignant patients is in the range of 2-10 pmol/l (pM), corresponding to about 50 x106 growing cells in the body that release TK1 into 5 litre blood. The limit visibility by imaging of a tumour is about 1 mm in diameter, corresponding to about 109cells of a cell diameter of 1µm. Conclusion. TK1 is more sensitive than imaging.

TECHNOLOGICAL INJURIES IN INDUSTRIAL PIG FARMING

2020 ◽  
Vol 1 ◽  
pp. 135-139
Author(s):  
A.A. Stekolnikov ◽  
◽  
M.A. Ladanova ◽  
Keyword(s):  
Local Treatment ◽  
The Body ◽  
The Third ◽  
Closed Type ◽  
Treat Ment ◽  
Industrial Farming ◽  
Industrial Injuries ◽  
Treatment Of Wounds ◽  
Experimental Group ◽  
Infor Mation

Industrial injuries in pig farms of closed type are a very common pathology. Howev-er, nowadays, injury prevention and treat-ment of sick animals in the conditions of industrial pig breeding complex do not bring good results and require improvements. Ac-cording to the literature, there is no infor-mation about the results of the use of oint-ments and immuno- stimulators in the treat-ment of pigs with bitten wounds of the ears, tails and other parts of the body. In this re-gard, we have set a goal to develop therapeu-tic measures for injuries of piglets in a pig breeding complex of a closed type. We ana-lyzed the prevalence of industrial injuries in pigs. During the clinical examination, we studied the specific structures of injuries. The main cause of pigs injuries in industrial farming is cannibalism. In 28 days, 60% of pigs in the second experimental group, showed complete cicatrization of the wound, and 40% of animals showed this process regenerated on 85-95%, meanwhile 2 days they also had complete scarring of the wound. In 28 days, 50% of pigs of the third experimental group had a complete cicatriza-tion of the wound, and for 50% were ob-served scarring of the wound by 75-85%, and only after 4 days they demonstrated the complete scaring of the defect. For the treatment of bitten wounds as a result of developing cannibalism, it is recommended, to use local treatment of wounds with chlor-hexidine solution and argosulfan ointment daily 2 times a day and also to use the im-munostimulator “Ferrovir” in a dose of 1.0 ml/m2 per week. Such scheme of treatment of bitten wounds gives the best therapeutic effect.

scholarly journals Особливості лікування ран, уражених личинками Wohlfahrtia magnifica, у собак

2017 ◽  
Vol 19 (77) ◽  
pp. 67-70
Author(s):  
V. Тkachenko
Keyword(s):  
Effective Treatment ◽  
High Efficiency ◽  
The Body ◽  
Experimental Comparison ◽  
Necessary Condition ◽  
Pathogenic Microorganisms ◽  
Treatment Regimens ◽  
Wohlfahrtia Magnifica ◽  
Treatment Of Wounds ◽  
Dead Tissue

The article presents data of research concerning the characteristics of the treatment of wounds affected by the larvae of the fly Wohlfahrtia magnifica. One of the conditions for effective treatment of such wounds is to remove all larvae, cutting of dead tissue correction of the formed pockets and oppression of pathogenic microorganisms on the surface and in the depth of the wound. The larvae are well adapted to parasitism in animal tissues, have highly developed Piratov hooks and small spines all over the body, which help them to remain in the tissue and gradually penetrate deeper. Larvae wolferton flies much damage tissue and cause the appearance of purulent wounds dolgonosova, this pathology is not only parasitological, and one of the problems of veterinary surgery. A necessary condition for effective treatment is removal of all larvae, cutting of dead tissue correction of the formed pockets and oppression of pathogenic microorganisms on the surface and in the depth of the wound. Experimental comparison of different schemes of treatment of wounds, amazed by the larvae of Wohlfahrtia magnifica, and also proved the high efficiency of complex treatment regimens with the use of solution decasino and ointment levomikol in this pathology.

scholarly journals Histopathological Analysis of Metastatic Tumours of the Oral Cavity with Example of Metastatic Renal Cell Carcinoma to Tongue

2020 ◽  
Vol 24 (1) ◽  
pp. 53-56
Author(s):  
Ljiljana Vučković ◽  
Mirjana Miladinović ◽  
Vladimir Popović ◽  
Nevenka Lukovac Janjić ◽  
Milena Borilović ◽  
...  
Keyword(s):  
Soft Tissues ◽  
Left Kidney ◽  
Tumour Cells ◽  
The Body ◽  
Team Work ◽  
Histopathological Analysis ◽  
Cytokeratin 20 ◽  
Malignant Tumours ◽  
Oral Region ◽  
Attached Gingiva

SummaryBackground/Aim: Metastatic tumours make up only 1-3% of all malignant tumours of the oral region; however, in 25% of the total number of cases, they are the first sign of the disease. Usually, metastases in the oral region are followed by poor prognosis. Metastases are more common in the mandible than in the maxilla; in soft tissues, they most commonly occur in the attached gingiva and tongue. Malignant tumours of the lung, breast, kidney, liver, bone, prostate, thyroid gland, skin, colon and female genital organs most commonly give metastases in this region, usually in patients aged 40 to 70 years.Case Report: We present a patient aged 79 years with a tumour change in the body of the tongue. After histopathological and immunohistochemical analysis (Cytokeratin, Vimentin, CD 10 positive tumour cells, Cytokeratin 7, Cytokeratin 20 negative tumour cells), there was a suspicion of metastasis of clear cell renal carcinoma (CCRC). Due to renal cancer, the patient had left kidney operated seven years before the diagnosis of tongue tumour.Conclusions: Diagnosis of metastatic tumours of the oral region is a great challenge, both for clinicians and for histopathologists. Since it is a heterogeneous group of neoplasms, standard histopathological tissue processing, is not always sufficient to determine the histological type of tumour and its primary origin. In the analysis of metastatic tumours of the oral region, team work is important and careful clinical and histopathological assessment lead to definitive and accurate diagnosis.

scholarly journals THE PARALLEL EFFECTS OF MAGNESIUM ON THE COMPLEMENTARY AND COAGULATIVE ACTIVITIES OF BLOOD SERUM

Blood ◽  
1949 ◽  
Vol 4 (6) ◽  
pp. 728-733 ◽  
Author(s):  
FRANK MALTANER ◽  
JOSÉ O. DE ALMEIDA
Keyword(s):  
Blood Serum ◽  
Magnesium Chloride ◽  
Standardized Test ◽  
Complement Fixation ◽  
Antagonistic Effect ◽  
Ionized Magnesium ◽  
Disodium Phosphate ◽  
Magnesium Salts ◽  
Test Serum

Abstract Magnesium chloride enhances the coagulation and complement activities of blood serum in parallel degree. These enhancing effects are inhibited by inactivated serum or by disodium phosphate. Distortion in the results of complement-fixation tests occurs with the addition of ionized magnesium salts to the system. This is due to the antagonistic effect of the inactivated test serum. In the quantitatively standardized test, however, where the titer is expressed as the ratio of the reaction of serum and antigen to that of serum alone, the findings are the same with or without added magnesium salts.

General and Local Cryotherapy in Treatment of Wounds

2015 ◽  
Vol 22 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Аралова ◽  
M. Aralova ◽  
Глухов ◽  
A. Glukhov
Keyword(s):  
Low Temperatures ◽  
Carbonic Acid ◽  
The Body ◽  
Healthy Human ◽  
Venous Ulcers ◽  
Intracellular Ice ◽  
Healing Wounds ◽  
Local Cryotherapy ◽  
Rate Of Cooling ◽  
Treatment Of Wounds

In recent decades, cryotherapy has gained recognition and dissemination in various fields of medicine, the influence of cold on different systems of the body is studied, the mechanism of human adaptation to the action is revealed. There are new technical possibilities of cold generation and modern crynoidal. Cryotherapy is divided into general and local, with the use of moderately low and low temperatures. Local cryotherapy is divided into hardware and software functional tests. Healthy human body to acute cooling meets a number of standard reactions. Depending on the intensity, duration, dynamics, impact, scientists divide the destructive and regenerative cryotherapy, cryosurgery. Modern cryosurgery is a gentle and economical method of eliminating pathological tissues. The main mechanism of action of low temperatures on biological tissue is the formation of intracellular ice, damaging organelles, membranes. The rate of cooling and thawing are important. At the time of cryotherapy, the boundary of the zone of freezing increases in all directions from the edge of the cryo applicator, and the subsequent reaction of cryodestruction are identical at any location of the hearth. For the treatment of venous ulcers, the authors gave a description of the ways of use the snow of carbonic acid, spraying liquid nitrogen on necrotic tissue. Cryotherapy is well defined in treatment of non-healing wounds.

scholarly journals Application of fibrin in drug technology: Achievements and perspectives

2020 ◽  
Vol 74 ◽  
pp. 322-330
Author(s):  
Jakub Rech ◽  
Justyna Wilińska ◽  
Aleksandra Borecka ◽  
Artur Turek
Keyword(s):  
Drug Delivery ◽  
Water Absorption ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Body ◽  
Solution Casting ◽  
Drug Delivery Carrier ◽  
Drug Substances ◽  
Drug Technology ◽  
Treatment Of Wounds

In recent years, fibrin has been successfully used as a polymer drug delivery carrier. Passive properties of fibrin provide parenteral and local delivery of drug substances in controlled and prolonged manner and also tissue support, gluing and sealing. Fibrin also has hemostatic and proangiogenic effects. Discs, films, gels, beads and nanoparticles are among the most commonly proposed and used fibrin-based formulations. It is routinely obtained from fibrinogen and thrombin. Fibrin formulation methods are solution casting, dual syringe systems and emulsification. All fibrin formulations become gel after administration and water absorption. Biodegradation and biocompatibility are important advantages of fibrin, which make it possible to implant a formulation without the need to remove the carrier from the body after the drug is released. Fibrin-based drug delivery systems are proposed and applied in the treatment of wounds, infections and cancerous diseases.

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