Fibronectin of blood plasma in heavy forms of eczema, atopic dermatitis and psoriasis

1993 ◽  
Vol 74 (1) ◽  
pp. 40-44
Author(s):  
I. E. Khazizov ◽  
M. H. Paskhina
Keyword(s):  
Atopic Dermatitis ◽  
Connective Tissue ◽  
Blood Plasma ◽  
Clinical Improvement ◽  
Inflammatory Process ◽  
Integral Characteristics

Fibronectin (Fn) level of blood plasma is studied by the immunofermental method in patients with heavy forms of eczema, psoriasis and atopic dermatitis. An increase of Fn level of blood plasma is revealed in all groups under examination, having no tendency for a decrease in clinical improvement. The results of investigation of the nature and dynamics of Fn characteristics in specific patients allow considering them as the factors, reflecting the integral characteristics of reactivity of the changed connective tissue of derma. The definite types of correlations peculiar to each of dermatoses are determined, relating Fn levels with other characteristics, typical of inflammatory process.

scholarly journals Extraintestinal isosporoid coccidian causing atoxoplasmosis in captive green-winged saltators: clinical and hematological features

2017 ◽  
Vol 37 (11) ◽  
pp. 1327-1330
Author(s):  
Sabrina D.E. Campos ◽  
Camila S.C. Machado ◽  
Tatiana V.T. de Souza ◽  
Renan C. Cevarolli ◽  
Nádia R.P. Almosny
Keyword(s):  
Infectious Diseases ◽  
Clinical Improvement ◽  
Peripheral Blood ◽  
Inflammatory Process ◽  
Blood Smear ◽  
Preventive Measures ◽  
Clinical Signs ◽  
Acute Disease ◽  
Illegal Trade ◽  
Hygienic Conditions

ABSTRACT: Populations of green-winged saltators, Saltator similis, are decreasing especially because of illegal trade and infectious diseases. We describe natural cases of an extraintestinal isosporoid coccidian in caged S. similis, and suggest the need of preventive measures in handling these birds. Nonspecific clinical signs were seen in all of them, however, intracytoplasmic Atoxoplasma sp. was found in peripheral blood, reinforcing the idea of systemic isosporosis. Leukocytosis with high number of heterophils and monocytes suggested that atoxoplasmosis in green-winged saltators can progress as an acute disease. The birds showed clinical improvement after treatment. Handling recommendations were proposed to upgrade hygienic conditions of the facilities. We concluded that nonspecific symptoms and an acute inflammatory process can be associated with atoxoplasmosis in young S. similis. We emphasize the importance of blood smear to detect merozoites.

scholarly journals Method for the prevention of inflammatory processes in the bone part of the external auditory canal accompanied by the growth of connective tissue

2020 ◽  
Vol 19 (4) ◽  
pp. 21-26
Author(s):  
I. A. Anikin ◽  
◽  
S. A. Eremin ◽  
A. E. Shinkareva ◽  
◽  
...  
Keyword(s):  
Hearing Loss ◽  
Connective Tissue ◽  
Granulation Tissue ◽  
Satisfactory Result ◽  
External Auditory Canal ◽  
Inflammatory Process ◽  
Local Therapy ◽  
Scar Tissue ◽  
Inflammatory Processes ◽  
Bone Section

Otosurgery plays an important role in the rehabilitation of patients with hearing loss. Any operation can be accompanied by a long inflammatory process with excessive development of connective tissue, forming atresia or stenosis of the external auditory canal. Formed scars in the external auditory canal reduce the effectiveness of treatment and can lead to reoperation. In the treatment of scars, the use of injections of a suspension of prolonged steroids directly into the developing connective tissue is effective. We have developed a method of injecting drugs into the scar tissue of the bone section of the external auditory canal, which allows the use of such therapy in patients after otosurgery. 12 people were treated with the proposed technique. All patients had an inflammatory process in the external auditory canal with undesirable growth of connective tissue. Previous local therapy did not bring a satisfactory result. Patients received injections of a suspension of steroids into developing scar tissue. The treatment period was 1-8 weeks, for which 1 to 4 sessions of injections were performed. As a result of treatment according to the developed method, in all cases a cessation of the pathological inflammatory process was observed. Timely therapy made it possible to completely eliminate the excess granulation tissue (100%), to stop the growth of the scar, or even to cause a significant decrease (33%). The developed method allows to use of a small dose of a substance (0,1–0,5 ml) for injection to achieve the desired therapeutic effect.

scholarly journals Rapid clinical improvement of atopic dermatitis in an Omalizumab treated patient

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Susanna Bormioli ◽  
Andrea Matucci ◽  
Laura Dies ◽  
Francesca Nencini ◽  
Francesca Grosso ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Improvement ◽  
Treated Patient

CC chemokines as potential immunologic markers correlated with clinical improvement of atopic dermatitis patients by immunotherapy

2010 ◽  
Vol 19 (3) ◽  
pp. 246-251 ◽  
Author(s):  
Yeon Sook Kwon ◽  
Sang Ho Oh ◽  
Wen Hao Wu ◽  
Byung Gi Bae ◽  
Hee Jung Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Improvement ◽  
Immunologic Markers ◽  
Cc Chemokines

Evidence for the presence of rat a α1-acid glycoprotein in granuloma tissue: a fluorescence microscopy study

1980 ◽  
Vol 58 (9) ◽  
pp. 1513-1517 ◽  
Author(s):  
J. C. Jamieson ◽  
B. Turchen ◽  
E. Huebner
Keyword(s):  
Connective Tissue ◽  
Fluorescence Microscopy ◽  
Inflammatory Process ◽  
Microscopy Study ◽  
Acid Glycoprotein ◽  
Inflammatory Site ◽  
Tissue Region ◽  
Granuloma Tissue

Turpentine granulomas were produced in rats and examined histologically and for the presence of rat albumin and α1-acid glycoprotein using fluorescent labelled antibody to these proteins. Examination of granulomas showed the presence of a connective tissue region of granuloma tissue; this region stained strongly with fluorescent anti-α1-acid glycoprotein whereas there was little staining with fluorescent antialbumin. These results suggest that α1-acid glycoprotein is located at the inflammatory site and may be involved in some aspect of the inflammatory process.

scholarly journals Experimental models of dermatological diseases

2019 ◽  
Vol 18 (3) ◽  
pp. 203-213
Author(s):  
O. N. Sergeeva ◽  
M. B. Aksenenko ◽  
Yu. F. Fefelova ◽  
E. Yu. Sergeeva ◽  
T. G. Ruksha
Keyword(s):  
Atopic Dermatitis ◽  
Connective Tissue ◽  
Skin Diseases ◽  
Connective Tissue Diseases ◽  
Cell Types ◽  
Skin Lesions ◽  
Experimental Models ◽  
Skin Symptom ◽  
Mechanisms Of Development ◽  
Antigen Presenting

This review presents analysis of experimental models of atopic dermatitis, psoriasis, skin symptoms of autoimmune systemic connective tissue diseases, and blistering skin diseases. Presented in the review are experimental models of atopic dermatitis which reproduce various stages and types of disease that allows the investigation of disease pathogenesis. Atopic dermatitis can develop spontaneously in Nc/Nga mice. There are atopic dermatitis models initiated by monoclonal IgE injection or epicutant sensitization under dermal barrier disfunction imitation. Genetically modified atopic dermatitis models - transgenic and knockout mice – are convenient for investigation of disease stages, cytokines, antigen-presenting cells and T-cells influence. We show that the psoriasis models created by genetic engineering methods are the most convenient for investigation of the role of particular cell types and specific factors in the disease development. Up-regulation of adhesion molecules, cytokines, transcription factors, inflammation mediators in both keratinocytes and immune cells of transgenic mice reveals their influence on psoriasis pathogenesis. There are descriptions of skin symptom models of autoimmune systemic connective tissue diseases and blistering skin disease models with and without genetic modifications. Each model demonstrates some peculiarities of pathogenesis and disease symptoms, whereas combined use of the models will allow to study the mechanisms of development of atopic dermatitis, psoriasis, blistering skin diseases and skin lesions under autoimmune systemic connective tissue diseases, that will contribute to the development of modern effective methods of treatment.

scholarly journals Phototherapy in Dermatology

Arkus ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 182-185
Author(s):  
Inda Astri Aryani ◽  
Maria Mayfinna Gozali ◽  
Indri Widyasari
Keyword(s):  
Atopic Dermatitis ◽  
Dose Adjustment ◽  
Inflammatory Process ◽  
Therapeutic Procedure ◽  
Minimal Erythema Dose ◽  
Skin Malignancy ◽  
Frequency Of Use ◽  
Narrowband Uvb ◽  
Epidermal Proliferation ◽  
Severity Of The Disease

Phototherapy is a therapeutic procedure in dermatology. Phototherapy uses certain ultraviolet wavelengths classified into 3 types,broadband UVB (BBUVB), narrowband UVB (NBUVB), and psoralen UVA (PUVA). The most widely used is NBUVB for treating psoriasis, atopic dermatitis and vitiligo. The mechanism of action of phototherapy is to reduce epidermal proliferation, suppress the immune system, reduce the inflammatory process, and induce repigmentation. Before starting phototherapy, the dose adjustment depends on skin type and minimal erythema dose (MED). Frequency of use is recommended based on the severity of the disease, continuously administered needed. Besides of this therapeutic effect, some contraindications and side effects that need to be considered in the use of phototherapy such as drug interactions, photoallergic and risk of skin malignancy.

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