scholarly journals Method for the prevention of inflammatory processes in the bone part of the external auditory canal accompanied by the growth of connective tissue

2020 ◽  
Vol 19 (4) ◽  
pp. 21-26
Author(s):  
I. A. Anikin ◽  
◽  
S. A. Eremin ◽  
A. E. Shinkareva ◽  
◽  
...  
Keyword(s):  
Hearing Loss ◽  
Connective Tissue ◽  
Granulation Tissue ◽  
Satisfactory Result ◽  
External Auditory Canal ◽  
Inflammatory Process ◽  
Local Therapy ◽  
Scar Tissue ◽  
Inflammatory Processes ◽  
Bone Section

Otosurgery plays an important role in the rehabilitation of patients with hearing loss. Any operation can be accompanied by a long inflammatory process with excessive development of connective tissue, forming atresia or stenosis of the external auditory canal. Formed scars in the external auditory canal reduce the effectiveness of treatment and can lead to reoperation. In the treatment of scars, the use of injections of a suspension of prolonged steroids directly into the developing connective tissue is effective. We have developed a method of injecting drugs into the scar tissue of the bone section of the external auditory canal, which allows the use of such therapy in patients after otosurgery. 12 people were treated with the proposed technique. All patients had an inflammatory process in the external auditory canal with undesirable growth of connective tissue. Previous local therapy did not bring a satisfactory result. Patients received injections of a suspension of steroids into developing scar tissue. The treatment period was 1-8 weeks, for which 1 to 4 sessions of injections were performed. As a result of treatment according to the developed method, in all cases a cessation of the pathological inflammatory process was observed. Timely therapy made it possible to completely eliminate the excess granulation tissue (100%), to stop the growth of the scar, or even to cause a significant decrease (33%). The developed method allows to use of a small dose of a substance (0,1–0,5 ml) for injection to achieve the desired therapeutic effect.

scholarly journals Mechanisms of benzydamine action against local inflammatory process

2019 ◽  
pp. 78-86 ◽  
Author(s):  
G. V. Poryadin ◽  
J. M. Salmasi ◽  
A. N. Kazimirsky
Keyword(s):  
Immune System ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Local Therapy ◽  
Mechanisms Of Action ◽  
Pharmacological Effects ◽  
Inflammatory Processes ◽  
Antimicrobic Activity ◽  
Acute And Chronic Inflammation ◽  
Inflammatory Action

Local inflammatory diseases caused by various infections are one of the most common pathologies in medical practice. For example, tonsillopharyngitis. This disease is extremely frequent for a physician’s practice. There is a fair amount of drugs, which supposed to be helpful against tonsillopharyngitis, but different drugs are also not the same in their pharmacological effects. In gynecological practice, frequent diseases are specific and non-specific vulvovaginitis, which have inflammatory and infectious components. For administrating local pharmacotherapy in gynecology against inflammation, a large number of drugs with different mechanisms of action are proposed. In this study, we focused on key pathological mechanisms associated with acute and chronic inflammation, for which these drugs should be exposed by their pharmacokinetic and pharmacodynamic properties. The best combination of these properties is available for benzydamine hydrochloride. Benzydamine hydrochloride has a wide antimicrobic activity against bacteria and Candida spices both albicans and non-albicans strains and allows to influence on etiologic cause of the disease. Also benzydamine hydrochloride associated with «cytokine» mechanism of anti-inflammatory action, which means that he does not affect COX enzymes and it allows to avoid gastrotoxic adverse events. Also, in this work showed and discussed aspects of the interaction of benzydamine with local immune system and justification of useful usage the benzydamine for local therapy of acute and chronic inflammatory processes caused by various infections.

scholarly journals Isolated Myxoma of the External Auditory Canal: A Case Report and Literature Review

2020 ◽  
pp. 014556132092791
Author(s):  
Mehdi Hasnaoui ◽  
Mohamed Masmoudi ◽  
Takwa Belaid ◽  
Khalifa Mighri
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Connective Tissue ◽  
Literature Review ◽  
Histological Examination ◽  
External Auditory Canal ◽  
Postoperative Course ◽  
Myxoid Tumor ◽  
Carney Syndrome

Myxoma is a benign myxoid tumor of connective tissue that develops primarily in the heart. At the level of the external auditory canal, it is extremely rare. It can be isolated or associated with Carney syndrome. Only 5 cases of isolated myxoma of the external auditory canal have been reported in the literature. We present the case of a 53-year-old patient who consulted for a hearing loss that has been evolving for 3 years. Otoscopy revealed a mass filling the external auditory canal. The scan showed a total filling of the external auditory canal with a homogenous sessile neoformation of 20 × 10 mm. This mass was completely resected and the histological examination showed spindle-shaped and star-shaped cells against an abundant myxoid background, which was consistent with myxoma. All the tests, done to eliminate Carney syndrome, did not reveal any abnormalities. The postoperative course was favorable, and no complications were noted. The patient was under follow-up. There was no recurrence 1 year after surgery.

IMMUNOLOGICAL CHARACTERISTICS OF THE INFLAMMATORY PROCESS IN THE PULP

2021 ◽  
Vol 2 (1) ◽  
pp. 11-14
Author(s):  
Gilyazeva V.V.
Keyword(s):  
Connective Tissue ◽  
Basement Membrane ◽  
Inflammatory Process ◽  
Pathological Process ◽  
Tooth Pulp ◽  
Pulp Inflammation ◽  
Inflammatory Processes ◽  
Cd 68 ◽  
Main Component

The paper presents the immunological characteristics of the pathological process of the tooth pulp of an inflammatory nature. The content of key markers of inflammatory processes was studied: CD-68, which plays a role in the phagocytic activity of tissue macrophages and type 4 collagen - the main component of the basement membrane of epithelial cells, found in the wall of arterial vessels and the intrinsic substance of connective tissue. An increase in the number of macrophages and a significant increase in the expression of type 4 collagen in pulp inflammation were found. It has been shown that the inflammatory reaction in the pulp is characterized by a sufficient immunological potential for the involvement of a complex of periapical and periradicular tissues in the pathological process and its subsequent long-term completion.

scholarly journals Cochlear Implantation Following Explorative Tympanotomy in Patients With Sudden Sensorineural Hearing Loss: Surgical Features and Audiological Outcomes

2021 ◽  
pp. 014556132110091
Author(s):  
Robin Rupp ◽  
Joachim Hornung ◽  
Matthias Balk ◽  
Matti Sievert ◽  
Sarina Müller ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Connective Tissue ◽  
Sensorineural Hearing Loss ◽  
Cochlear Implantation ◽  
Round Window ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Round Window Membrane ◽  
Hearing Results ◽  
Round Window Niche

Objective: To investigate the anatomical status of the round window niche and hearing outcome of cochlear implantation (CI) after explorative tympanotomy (ExT) with sealing of the round window membrane in patients with sudden sensorineural hearing loss at a tertiary referral medical center. Methods: Between January 1, 2007, and July 30, 2020, 1602 patients underwent CI at our department. Out of these, all patients previously treated by ExT with sealing of the round window membrane because of unilateral sudden hearing loss were included in the study. A retrospective chart review was conducted concerning method of round window membrane sealing, intraoperative findings during CI, postoperative imaging, and hearing results. Results: Twenty one patients (9 females; 8 right ears; 54.3 years [± 12.9 years]) underwent ExT with sealing of the round window membrane with subsequent CI after 26.6 months (± 32.9 mo) on average. During CI, in 76% of cases (n = 16), the round window niche was blocked by connective tissue due to the previous intervention but could be removed completely in all cases. The connective tissue itself and its removal had no detrimental effects on the round window membrane. Postoperative computed tomography scan showed no electrode dislocation. Mean postoperative word recognition score after 3 months was 57.4% (± 17.2%) and improved significantly to 73.1% (± 16.4%, P = .005) after 2 years. Conclusion: Performing CI after preceding ExT, connective tissue has to be expected blocking the round window niche. Remaining tissue can be removed safely and does not alter the round window membrane allowing for a proper electrode insertion. Short- and long-term hearing results are satisfactory. Consequently, ExT with sealing of the round window membrane in patients with sudden sensorineural hearing loss does not impede subsequent CI that can still be performed safely.

scholarly journals Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nádia Marielly Gomes Batista ◽  
Antonia Taiane Lopes de Moraes ◽  
Karolyny Martins Balbinot ◽  
Osvaldo Rodrigues de Souza Neto ◽  
Juliana Melo da Silva Brandão ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Immunohistochemical Analysis ◽  
Dental Follicle ◽  
Radicular Cyst ◽  
Periapical Lesions ◽  
Periapical Granuloma ◽  
Inflammatory Processes

Abstract Background ADAMTS expression can be associated with several inflammatory processes, and has been correlated with tumorigenesis of some neoplasms, but its participation in the development of periapical lesions has not been investigated. Therefore, our objective was to verify the expression of ADAMTS-1, versican and pEGFR in Periapical Granuloma (PG) and in the Radicular Cyst (RC) since they are the most common lesions of the periapex. Methods 25 samples of RC and 10 of PG were used. As a control, 10 samples of inflammatory fibrous hyperplasia (IFH) and 10 of dental follicle (DF) were used. The expression of these proteins was investigated using immunohistochemistry. Results In the epithelium of RC, IFH and DF, the expression of ADAMTS-1 was greater in DF than in RC (p < .001). Versicano showed greater expression in IFH than in RC, DF than in RC (p < .001). pEGFR showed greater expression in IFH and RC than in DF (p < .01 and p < .05, respectively). In connective tissue, ADAMTS-1 expression was greater in PG and RC than in IFH and DF (p < .001). Versicano showed greater expression in PG, RC and IFH compared to DF (p < .001). In pEGFR there was a higher expression in PG when compared to RC, IFH and DF (p < .001). Greater immunostaining occurred in the RC than in the DF (p < .001). Conclusions Our results suggest that the studied proteins may participate in the pathogenesis of PG and RC, through the interaction of these proteins, in the remodeling of the ECM (versican) by ADAMTS-1, producing bioactive fragments, which could activate EGFR, contributing to the formation, growth and maintenance of injuries.

Biologics in Microangiopathic Wounds

2018 ◽  
Vol 17 (4) ◽  
pp. 205-213
Author(s):  
Massimo Papi ◽  
Claudia Papi
Keyword(s):  
Inflammatory Diseases ◽  
Platelet Rich Plasma ◽  
Connective Tissue Diseases ◽  
Local Therapy ◽  
Biologic Agents ◽  
Biologic Drugs ◽  
New Class ◽  
Skin Ulcers ◽  
Inflammatory Processes ◽  
Inflammatory Molecules

In the last decades the possibility to diagnose a skin ulcer has greatly improved. We learnt that a consistent percentage of nonhealing ulcers may be caused by a microangiopathic disorder that has not been properly investigated and cured. Pathogenetically, we can distinguish 2 main groups: (1) ulcers due to inflammatory microangiopathy, mainly including cutaneous small and medium vessel vasculitis, pyoderma gangrenosum, and connective tissue diseases, and (2) ulcers due to occlusive microangiopathy. The group of microangiopathic occlusive ulcers is more heterogeneous and includes different disorders ranging from livedo vasculopathy to calciphylaxis, hydroxyurea-induced ulcers, antiphospholipid antibodies ulcers, and various other types. These conditions can induce thromboses or anatomo-functional occlusion of cutaneous microvessels. Despite different physiopathologic mechanisms, the ulcer resulting from a primitive microangiopathy may receive basic treatments that are in the complex similar to other pathogenetically different wounds, including MOIST-based local therapy and elastic compression when it is not contraindicated. Persistent inflammatory processes are increasingly demonstrated as responsible for the chronicity of many skin ulcers. New data concerning the biological phases of wound healing and the molecules that play crucial roles in this process suggested the use of new specific therapies. Some of them such as growth factors and platelet-rich plasma are prevalently used as topical biologic agents with variable benefits. In recent years, a new class of systemic anti-inflammatory molecules, better known as biologic drugs, have been introduced in the cure of chronic inflammatory diseases that can induce microangiopathic injuries and ulcerative complication. They enlarged the therapeutic options in case of nonresponder microangiopathic ulcers and could represent a future model of “pathogenetically based” therapy of skin ulcers.

Successful Placement of a BAHA Implant in a Patient With Epidermolysis Bullosa: A Case Report and Review of the Literature

2017 ◽  
Vol 126 (11) ◽  
pp. 778-780 ◽  
Author(s):  
Jason R. Brown ◽  
D. Micah Milgraum ◽  
Farhaad R. Riyaz ◽  
Marla N. Jahnke ◽  
Prasad John Thottam
Keyword(s):  
Hearing Loss ◽  
Epidermolysis Bullosa ◽  
Hearing Aids ◽  
External Auditory Canal ◽  
Skin Irritation ◽  
Minor Trauma ◽  
Mixed Hearing Loss ◽  
Osseointegrated Implant ◽  
Bone Anchored Hearing Aid ◽  
Conductive Hearing

Introduction: Epidermolysis bullosa (EB) is a spectrum of mechanobullous disorders characterized by blistering following minor trauma or traction to the skin. Hearing loss in this population is poorly described in the otolaryngology literature, and its treatment oftentimes results in external auditory canal skin irritation. Case Presentation: We present the case of a 26-year-old female with EB and mixed hearing loss unable to wear conventional hearing aids due to sequelae of the external auditory canals. An osseointegrated implant was used as other hearing aids were deemed to be too destructive of the external auditory canal skin. Management and Outcome: Our patient underwent placement of a right bone-anchored hearing aid with minimal disruption of the surrounding skin using a minimally invasive punch technique. Over 1 year of follow-up, her course was complicated by 1 simple cellulitic infection at the surgical site treated successfully with oral antibiotics. Discussion: The literature regarding the otolaryngologic manifestations of EB is sparse. The otologic sequelae are particularly overlooked in the workup and management. Based on the results of this case study, it appears that an osseointegrated implant can be safely utilized to treat significant mixed or conductive hearing loss in patients with EB.

scholarly journals Lipogranulomas of the mammary glands: diagnosis and treatment

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Natalia Cara ◽  
◽  
Veronica Svet ◽  
Ion Mereuta ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Mammary Gland ◽  
Inflammatory Process ◽  
Pathological Condition ◽  
Scar Tissue ◽  
Mammary Glands ◽  
Diagnosis And Treatment ◽  
Breast Lesions ◽  
Fat Necrosis

Steatonecrosis of the mammary gland is necrosis of its adipose tissue, followed by replacement with scar tissue. Lipogranuloma is known as a benign inflammatory process, necrosis of breast fat occurs due to iatrogenic breast trauma. Most often, fatty necrosis is seen in women with large breasts – in women with small breasts, it develops much less often. It is important to diagnose lipogranulomas because it can often mimic breast cancer. Fat necrosis of the breast is a common pathological condition, with a wide variety of presentations on mammography, ultrasound and MRI. The incidence of fatty necrosis of the breast is estimated at 0.6%, representing 2.75% of all breast lesions.

scholarly journals Melanocytic Nevus in the External Auditory Canal with Keratin Accumulation

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Junhui Jeong ◽  
Kyuin Lee ◽  
Hyun Seung Choi
Keyword(s):  
Hearing Loss ◽  
Malignant Transformation ◽  
External Auditory Canal ◽  
Melanocytic Nevus ◽  
Common Type ◽  
Skin Tumor ◽  
Microscopic Surgery

Nevus is a benign melanocytic neoplasm and the most common type of skin tumor. It may occur anywhere on the skin, but it is rare in the external auditory canal (EAC). We present a case of melanocytic nevus in the EAC with keratin accumulation. In microscopic surgery, the mass was excised completely, and the wax and keratin material medial portion of the EAC behind the mass was removed. In this patient, a melanocytic nevus in the EAC caused symptoms of hearing loss and wax and keratin buildup. For melanocytic nevus in the EAC, excision and pathologic confirmation should be performed if there are symptoms or when malignant transformation is suspected.

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