scholarly journals Functional rehabilitation of the patient with keratoconus after collagen cross-linking with modified parameters

2016 ◽  
Vol 9 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Sanasar S Papayan ◽  
Inna A Riks ◽  
Sergey A Novikov
Keyword(s):  
Survey Data ◽  
Clinical Case ◽  
Biochemical Properties ◽  
Mechanisms Of Action ◽  
Favorable Outcome ◽  
Dynamic Monitoring ◽  
Cross Linking ◽  
Functional Rehabilitation ◽  
Before And After ◽  
Collagen Cross Linking

This article contains a clinical case of a favorable outcome of treatment of chronic keratoconus by the collagen cross-linking with modified parameters. Possible mechanisms of action of collagen cross-linking on biomechanical and biochemical properties of the cornea are presented as well as survey data and postoperative dynamic monitoring of the patient before and after collagen cross-linking. Reasoning about new ways to perfect standard approaches with the aim of improving the results of the application of this treatment are also given.

Comparison of corneal keratocytes before and after corneal collagen cross-linking in keratoconus patients

2015 ◽  
Vol 35 (6) ◽  
pp. 785-792 ◽  
Author(s):  
Mohammad-Naeim Aminifard ◽  
Hoda Khallaghi ◽  
Mahdi Mohammadi ◽  
Reza Jafarzadeh
Keyword(s):  
Cross Linking ◽  
Before And After ◽  
Corneal Keratocytes ◽  
Collagen Cross Linking ◽  
Corneal Collagen

scholarly journals About a new approach to surgical treatment of corneal endothelial dystrophy

2018 ◽  
Vol 11 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Sergey Yu Astakhov ◽  
Inna A Riks ◽  
Sanasar S Papanyan ◽  
Sergey A Novikov ◽  
Georgiy Z Dzhaliashvili
Keyword(s):  
Visual Acuity ◽  
Surgical Treatment ◽  
Conservative Treatment ◽  
Functional State ◽  
Clinical Case ◽  
Corneal Dystrophy ◽  
Cross Linking ◽  
Common Disease ◽  
New Approach ◽  
Collagen Cross Linking

Primary endothelial dystrophy of the cornea is a fairly common disease in people older than 50 years. Well-developed methods of conservative treatment, as a rule, do not lead to improvement or stabilization of the functional state of the cornea. The choice of tactics of surgical treatment from the existing variety of techniques is complicated. There are isolated reports of the restoration of corneal transparency after descemet membrane removal. The author's method of endothelial corneal dystrophy treatment addressed in this particular clinical case - a combination of isolated descemetorhexis and collagen cross-linking - resulted in impressive increase in visual acuity and significant improvement in objective criteria for the morpho-functional state of the cornea. (For citation: Astakhov SYu, Riks IA, Papayan SS, et al. About a new approach to surgical treatment of corneal endothelial dystrophy. Ophthalmology Journal. 2018;11(1):78-84. doi: 10.17816/OV11178-84).

scholarly journals Post-LASIK Keratoectasia Developing with Sleep Apnea and Floppy Eyelid Syndrome: Case Report and Review of the Literature

2014 ◽  
Vol 3 (1) ◽  
pp. 44-46
Author(s):  
Noa Avni-Zauberman ◽  
David S Rootman
Keyword(s):  
Case Report ◽  
Sleep Apnea ◽  
Sleep Apnea Syndrome ◽  
Careful Examination ◽  
Cross Linking ◽  
Review Of The Literature ◽  
Obstructive Sleep ◽  
Before And After ◽  
Apnea Syndrome ◽  
Collagen Cross Linking

ABSTRACT We report a case of unilateral keratoectasia in a patient who underwent uneventful hyperopic LASIK 8 years prior and was diagnosed with obstructive sleep apnea syndrome (OSAS) and Floppy eyelid syndrome. The before and after LASIK topographies demonstrated clear development of the ectasia after the patient developed OSAS. The patient was treated with collagen cross- linking in the involved eye to stop ectatic progression. Our report emphasizes the importance of inquiring about the patient's sleeping postures and habits (specifically asking about OSAS) and a careful examination of eyelid laxity prior to refractive laser treatment. How to cite this article Zauberman NA, Rootman DS. Post- LASIK Keratoectasia Developing with Sleep Apnea and Floppy Eyelid Syndrome: Case Report and Review of the Literature. Int J Kerat Ect Cor Dis 2014;3(1):44-46.

scholarly journals Corneal collagen cross-linking in mixed etiology keratitis treatment: a case of successful use

2021 ◽  
Vol 13 (3) ◽  
pp. 87-96
Author(s):  
Kirill V. Khripun ◽  
Yulia V. Kobinets ◽  
Pavel A. Danilov ◽  
Elizaveta S. Rozhdestvenskaya ◽  
Yulduz Sh. Nizametdinova
Keyword(s):  
Allergic Reaction ◽  
Effective Treatment ◽  
Clinical Case ◽  
Acanthamoeba Keratitis ◽  
Cross Linking ◽  
High Fluence ◽  
Corneal Inflammation ◽  
Long Time ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Acanthamoeba keratitis with bacterial, fungal superinfection or without it leads to development of an aggressive and long-standing corneal inflammation; up to now, the efficacy of its treatment stays doubtful and demands further investigation. For a long time, there were discussions on the possibility and expediency of corneal collagen cross-linking (PACK-CXL photo activated chromophore for keratitis) in patients with bacterial, fungal and Acanthamoeba keratitis. This article presents a clinical case of effective treatment of mixed etiology keratitis by multiple high fluence accelerated PACK-CXL in a patient with severe local toxico-allergic reaction.

scholarly journals Effect of Riboflavin/UVA Collagen Cross-linking on Central Cornea, Limbus and Intraocular Pressure. Experimental Study in Rabbit Eyes

2016 ◽  
Vol 59 (3) ◽  
pp. 91-96 ◽  
Author(s):  
Vassilios Kozobolis ◽  
Maria Gkika ◽  
Haris Sideroudi ◽  
Efthymia Tsaragli ◽  
Stylliani Lydataki ◽  
...  
Keyword(s):  
Experimental Study ◽  
Intraocular Pressure ◽  
Cross Linking ◽  
Ultraviolet A ◽  
Central Cornea ◽  
Significant Difference ◽  
Before And After ◽  
Animal Experimental Study ◽  
The Right ◽  
Collagen Cross Linking

The Purpose of present study was to investigate the effect of riboflavin/ultraviolet-A-induced collagen cross-linking (CXL) on central cornea, limbus and intraocular pressure (IOP). This was an animal experimental study. The right corneas of 10 rabbits were ultraviolet-A irradiated (3 mW/cm2 for 30 minutes) after de-epithelialization and instillation of 0.1% riboflavin / 20% Dextran drops. Left corneas served as controls. Samples were examined histologically one month postoperatively. Before and after treatment, IOP measurements were recorded bilaterally. At central cornea of eyes underwent CXL keratocyte repopulation, normal arrangement of collagen fibres and a statistically significant change in fibres diameter were detected, compared to controls. At limbus area, there were not any significant histological differences after CXL. There was no statistically significant difference between pre- and postoperative IOP in all eyes.

Lower strength of the human posterior patellar tendon seems unrelated to mature collagen cross-linking and fibril morphology

2010 ◽  
Vol 108 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Philip Hansen ◽  
Bjarki Thor Haraldsson ◽  
Per Aagaard ◽  
Vuokko Kovanen ◽  
Nicholas C. Avery ◽  
...  
Keyword(s):  
Patellar Tendon ◽  
Peak Stress ◽  
Biochemical Properties ◽  
Cross Linking ◽  
Material Strength ◽  
Transmission Electron ◽  
Acl Surgery ◽  
Cross Links ◽  
Fibril Morphology ◽  
Collagen Cross Linking

The human patellar tendon is frequently affected by tendinopathy, but the etiology of the condition is not established, although differential loading of the anterior and posterior tendon may be associated with the condition. We hypothesized that changes in fibril morphology and collagen cross-linking would parallel differences in material strength between the anterior and posterior tendon. Tendon fascicles were obtained from elective ACL surgery patients and tested micromechanically. Transmission electron microscopy was used to assess fibril morphology, and collagen cross-linking was determined by HPLC and calorimetry. Anterior fascicles were markedly stronger (peak stress: 54.3 ± 21.2 vs. 39.7 ± 21.3 MPa; P < 0.05) and stiffer (624 ± 232 vs. 362 ± 170 MPa; P < 0.01) than posterior fascicles. Notably, mature pyridinium type cross-links were less abundant in anterior fascicles (hydroxylysylpyridinoline: 0.859 ± 0.197 vs. 1.416 ± 0.250 mol/mol, P = 0.001; lysylpyridinoline: 0.023 ± 0.006 vs. 0.035 ± 0.006 mol/mol, P < 0.01), whereas pentosidine and pyrrole concentrations showed no regional differences. Fibril diameters tended to be larger in anterior fascicles (7.819 ± 2.168 vs. 4.897 ± 1.434 nm2; P = 0.10). Material properties did not appear closely related to cross-linking or fibril morphology. These findings suggest region-specific differences in mechanical, structural, and biochemical properties of the human patellar tendon.

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