Retina photosensitivity indexes as an objective indicator of expression of psychostimulating effect

2021 ◽  
Vol 19 (3) ◽  
pp. 313-326
Author(s):  
Karen B. Ovanesov ◽  
Petr D. Shabanov
Keyword(s):  
Emotional Disorders ◽  
Mental Activity ◽  
Psychotropic Substances ◽  
Pathological Conditions ◽  
Color Sensitivity ◽  
The Central Nervous System ◽  
Visual Motor ◽  
The One ◽  
Relationship Of ◽  
The Relationship

BACKGROUND: The variety of neurotransmitter systems providing photoreceptor capabilities of the retina is a prerequisite for studying the retinotropic properties of some psychotropic drugs, taking into account their ability to interfere with the work of synapses. MATERIALS AND METHODS: Given this circumstance, a set of studies was carried out with the participation of volunteers to assess the effect of psychotropic substances with a stimulating (caffeine, piracetam, Bilobil) type of action on the functional state of the retina, recorded by the campimetric method. In the course of the research, the photosensitivity of the retina, its ability to distinguish colors and the speed of the visual-motor reaction were assessed. Such an approach can not only demonstrate the interest of retinal cellular elements in the action of substances, but also broaden the question of the participation of the visual system in the psychopharmacological effect. RESULTS: The function of the retina was studied both in healthy volunteers and in individuals with organic lesions of the central nervous system, which were often accompanied by emotional disorders, which were identified using special questionnaire tests. It was found that these pathological conditions are accompanied by a limitation of the photosensitivity of the retina of varying severity. These facts can be interpreted in different ways. On the one hand, violations of visual functions can lead to psychoemotional disorders and be a pathogenetic link in their development, and on the other hand, primary disorders of retinal light and color sensitivity can provoke the development of psychopathology. However, regardless of the pharmacological characteristics of the studied drugs that stimulate mental activity, the relationship of their effect with changes in visual function seems obvious, which makes it possible to raise the question of the advisability of taking into account the light and color sensitivity of the retina for a comprehensive assessment of both the mental state and the pharmacodynamics of the drugs, stimulating mental activity. CONCLUSION: Thus, it is legitimate to conclude that taking into account the light and color sensitivity of the retina can be one of the quantitative criteria for the severity and effectiveness of psychopharmacotherapy.

Assessment of retinal photosensitivity as an objective indicator of expression psychodense effect

2021 ◽  
Vol 19 (2) ◽  
pp. 211-220
Author(s):  
Karen B. Ovanesov ◽  
Petr D. Shabanov
Keyword(s):  
Emotional Disorders ◽  
Field Of View ◽  
Emotional Status ◽  
Retinal Activity ◽  
Objective Indicator ◽  
Psychotropic Substances ◽  
Wide Range ◽  
Color Sensitivity ◽  
The One ◽  
Visual Apparatus

BACKGROUND: The retina of the eye, with its wide range of neurotransmitter systems, can be the point of application in the action of the psychotropic drugs, given their synaptotropic properties. MATERIALS AND METHODS: In this regard, a complex of studies was carried out with the participation of volunteers to assess the effect of psychotropic substances with a depressing (melatonin, grandaxin, motherwort tincture) type of action on the functional state of the retina, registered by the campimetric method. In the course of the research, the photosensitivity of the retina and its ability to distinguish colors were evaluated. Moreover, the capabilities of the technique made it possible to assess retinal activity in the field of view from 0 to 21. Such an approach can not only demonstrate the interest of retinal cellular elements in the action of substances, but also raise the question of the participation of the visual system in the psychopharmacological effect more broadly. RESULTS: The work of the visual apparatus was studied both in healthy volunteers of different ages and in persons with emotional disorders, which were identified using special questionnaire tests. It was found that violations of the emotional status are often accompanied by a limitation of the photosensitivity of the retina of varying severity. These facts can be interpreted in different ways. On the one hand, violations of visual functions can lead to psychoemotional disorders and be a pathogenetic link in their development, and on the other hand, primary disorders of retinal light and color sensitivity can provoke the development of psychopathology. However, regardless of the pharmacological characteristics of the studied drugs with psychodeprimating activity, the connection between their anti-anxiety effect and changes in visual function seems to be obvious, which allows us to raise the question of the advisability of taking into account the photosensitivity of the retina for a comprehensive assessment of both the mental state of emotionally labile subjects and the pharmacodynamics of psychodemitting drugs. CONCLUSIONS: Thus, it is legitimate to conclude that taking into account the light and color sensitivity of the retina can be one of the quantitative criteria for the severity and effectiveness of psychopharmacotherapy.

Pensare Dio. Spunti di riflessione in dialogo con Anca Vasiliu

Elenchos ◽  
2020 ◽  
Vol 41 (1) ◽  
pp. 181-194
Author(s):  
Angela Longo
Keyword(s):  
Late Antiquity ◽  
Human Being ◽  
Common Thread ◽  
Critical Issues ◽  
Relevant Topic ◽  
The Common ◽  
The One ◽  
Relationship Of ◽  
The Relationship ◽  
The Trinity

AbstractThe following work features elements to ponder and an in-depth explanation taken on the Anca Vasiliu’s study about the possibilities and ways of thinking of God by a rational entity, such as the human being. This is an ever relevant topic that, however, takes place in relation to Platonic authors and texts, especially in Late Antiquity. The common thread is that the human being is a God’s creature who resembles him and who is image of. Nevertheless, this also applies within the Christian Trinity according to which, not without problems, the Son is the image of the Father. Lastly, also the relationship of the Spirit with the Father and the Son, always within the Trinity, can be considered as a relationship of similarity, but again not without critical issues between the similarity of attributes, on the one hand, and the identity of nature, on the other.

scholarly journals Socio-legal studies and the humanities – law, interdisciplinarity and integrity

2009 ◽  
Vol 5 (3) ◽  
pp. 243-261 ◽  
Author(s):  
Melanie L. Williams
Keyword(s):  
Human Experience ◽  
Normative Values ◽  
Moral Sensibility ◽  
Hard Data ◽  
Legal Studies ◽  
Psychological Significance ◽  
The One ◽  
Relationship Of ◽  
The Relationship

This paper was delivered as a plenary lecture, designed to respond to the one-day special conference focus upon links between socio-legal studies and the humanities.1 The paper focuses in particular upon the relationship between law and the humanities. It may be argued that the role of empirically sourced socio-legal research is well accepted, given its tangible utility in terms of producing hard data which can inform and transform policy perspectives. However, scholarly speculation about the relationship between law and the humanities ranges from the indulgent to the hostile. In particular, legal scholars aligning themselves as ‘black letter’ commentators express strong opinions about such links, suggesting that scholarship purporting to establish links between the two fields is essentially spurious, bearing in mind the purposive role of law as a problem-solving mechanism. The paper sets out to challenge such assertions, indicating the natural connections between the two fields and the philosophical necessity of continued interaction, given the fact that certain aspects of human experience and nature cannot be plumbed by doctrine or empiricism or even by combinations of the two. Law must be understood to stand at the nexus of human experience, in a relationship of integrity, where the word is understood to mean both morally principled and culturally integrated. In particular, the development of human qualities, of character and moral sensibility informing normative values – and, ultimately, engagement with the world of law – is a process of subtle cultural as well as psychological significance, and may benefit from interrogation deriving from the wider fields of human discourse.

On humoral factors in nervous activity

1935 ◽  
Vol 31 (6) ◽  
pp. 777-787
Author(s):  
D. S. Vorontsov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nervous Activity ◽  
Active Part ◽  
Humoral Factors ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship

Not only in the peripheral working organs, irritating substances are formed, which, as we can see, take an active part in their regulation, but also in the central nervous system, in the relationship of its individual elements, such substances apparently play an important role.

Intake of Anti-Epileptic Drugs and their Influences on Sexual Dysfunctions

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Roheela Yasmeen ◽  
Nida Mobeen ◽  
Muhammad Amjad Khan ◽  
Irfan Aslam ◽  
Samia Chaudhry
Keyword(s):  
Quality Of Life ◽  
Sexual Dysfunction ◽  
Neurological Disorders ◽  
Penile Erection ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain ◽  
Psychiatric Problems

Epilepsy which is also called seizures disorder is an uncontrolled action of the central nervous system. Itis not a single disease but a set of neurological disorders. Actually in this situation, the brain does notreceive a precise signal and as a result an abnormal condition is produced that is usually involuntary inaction. In this review, we aimed to focus on the relationship of anti-epileptic drugs with sexual dysfunctionand adaptation of better remedies that improve a patient’s family life. Sexual dysfunction is a commoncomorbidity in people with epilepsy which badly affects their quality of life. Sexual dysfunction is causedby different factors like psychiatric problems, anti-epileptic drugs (AEDs) and social factors etc. Sexualdysfunctions include ejaculatory failure, lessen libido, penile erection in men and irregular menstrual cyclein women. Common drugs such as Topiramate, Gabapentin (GBP), Valproate (VA), Carbamazepine (CBZ),Olanzapine (OL) and Risperidone (RTG) that are in practice to treat epilepsy usually produced adverseeffect on sexual dysfunction. Even though a lot of studies have been carried out to control sexualdysfunction in epilepsy’s patient, but still research is going on. Medicine such as Cyproheptadine,Mianserin, Buspirone, Yohimbine were found better to treat epilepsy with minimum side effects of sexualdysfunction. Moreover, it is also seen that certain vasodilators, folate , and vitamin supplements areeffective in improving the quality of life.

Effect of voluntary vs. artificial activation on the relationship of muscle torque to speed

1990 ◽  
Vol 69 (6) ◽  
pp. 2215-2221 ◽  
Author(s):  
G. A. Dudley ◽  
R. T. Harris ◽  
M. R. Duvoisin ◽  
B. M. Hather ◽  
P. Buchanan
Keyword(s):  
Knee Extensor ◽  
Voluntary Activation ◽  
Knee Extensors ◽  
Angular Velocities ◽  
The Central Nervous System ◽  
The Right ◽  
Artificial Activation ◽  
Relationship Of ◽  
The Relationship ◽  
Eccentric Actions

The speed-torque relationship of the right knee extensor muscle group was investigated in eight untrained subjects (28 +/- 2 yr old). Torque was measured at a specific knee angle during isokinetic concentric or eccentric actions at nine angular velocities (0.17-3.66 rad/s) and during isometric actions. Activation was by "maximal" voluntary effort or by transcutaneous tetanic electrical stimulation that induced an isometric torque equal to 60% (STIM 1) or 45% (STIM 2) of the voluntary isometric value. Torque increased (P less than 0.05) to 1.4 times isometric as the speed of eccentric actions increased to 1.57 rad/s for STIM 1 and STIM 2. Thereafter, increases in eccentric speed did not further increase torque. Torque did not increase (P greater than 0.05) above isometric for voluntary eccentric actions. As the speed of concentric actions increased from 0.00 to 3.66 rad/s, torque decreased (P less than 0.05) more (P less than 0.05) for both STIM 1 and STIM 2 (two-thirds) than for voluntary activation (one-half). As a result of these responses, torque changed three times as much (P less than 0.05) across speeds of concentric and eccentric actions with artificial (3.4-fold) than voluntary (1.1-fold) activation. The results indicate that with artificial activation the normalized speed-torque relationship of the knee extensors in situ is remarkably similar to that of isolated muscle. The relationship for voluntary activation, in contrast, suggests that the ability of the central nervous system to activate the knee extensors during maximal efforts depends on the speed and type of muscle action performed.

scholarly journals The Perspective of Overcoming Nihilism in Heidegger’s Dialogue with Jünger

2019 ◽  
Vol 30 (1) ◽  
Author(s):  
Tautvydas Vėželis
Keyword(s):  
Point Of View ◽  
The Other ◽  
Dialectical Thinking ◽  
Other Hand ◽  
History Of ◽  
Metaphysical Tradition ◽  
The One ◽  
Relationship Of ◽  
The Relationship ◽  
European Civilization

This article examines the problem of overcoming nihilism in Heidegger’s dialogue with Jünger. It is suggested that nihilism is manifested in various forms and is the deep logic of the whole history of European civilization. One of the main aims of this paper is to outline the relationship of nihilism and Nothing in Heidegger’s dispute with Jünger, viewing how Heidegger distinguishes his approach from Jünger’s point of view. Heidegger, on the one hand, treats nihilism as consummation of the Western metaphysical tradition, on the other hand, identifies Nothing itself as the shadow of Being, which cannot be overcome in the traditional dialectical thinking manner.

scholarly journals Kändisförfattarens varumärke i Finland

2012 ◽  
Vol 40 (114) ◽  
pp. 143-158
Author(s):  
Tarja-Lisa Hypén
Keyword(s):  
21St Century ◽  
Home Country ◽  
The Other ◽  
Modern Times ◽  
American Research ◽  
Anglo American ◽  
The One ◽  
Relationship Of ◽  
The Relationship

THE BRAND OF THE CELEBRITY AUTHOR IN FINLAND | In the 21st century, the celebrity author has begun to interest researchers not only as a marketing phenomenon, but also as the literary institution’s own phenomenon. In my article, I explore the relationship of the celebrity author to the so-called acclaimed authors of modern times. In Anglo-American research, the celebrity author and the bestselling author are distinguished as separate author types, but in the case of Finnish Jari Tervo, these types combine. For almost 20 years, Jari Tervo has been amongboth the most sold and the most visible celebrity authors in his home country. I examine how the publicity and brand of the Finnish celebrity author are formed. I consider how the brand affects the author’s works on the one hand, and the reception of the works on the other. I point out the limiting effects of the brand, but I also examine how, in combining the high and the low, it affords mobility in the literary fields while it also offers an opportunity to influence society.

scholarly journals Association of Beverage Consumption with Obesity in Healthy Adults

2017 ◽  
Vol 1 (1) ◽  
pp. 37
Author(s):  
Sirine Maher Zahran
Keyword(s):  
Abdominal Obesity ◽  
Weight Status ◽  
Intervention Group ◽  
Overweight And Obesity ◽  
Abu Dhabi ◽  
Major Health ◽  
Sweetened Beverages ◽  
The One ◽  
Relationship Of ◽  
The Relationship

Background: The increased consumption of sugar-sweetened beverages (SSBs) has been found to be an important contributor of calories in the diet. Whether there is an association between the increased consumption of SSBs and the high rates of overweight and obesity is still questionable. The objective of this study was to examine the relationship of weight status and beverages consumed of adults in a residential compound in Abu Dhabi.Methods: Forty nine out of 65 residents form Al Reef Villas in Abu Dhabi agreed to participate in the study. Initial assessments including beverages frequency questionnaire and anthropometry measurements were completed for all participants. Participants who were identified as high beverages consumers were invited to a one-month intervention aiming to limit their beverages consumption. A final assessment was completed for all high consumers of beverages at the end of the one-month intervention.Results: 55% of the subjects were overweight or obese, and 51% had abdominal obesity. 73% consumed 100% fruit juices with no added sugar, 65% consumed soft drinks, and 60 % consumed plain milk and milk products. The majority (69%) consumed tea beverages rather than coffee beverages. There was no association between weight & beverages consumption. The mean energy percentage from beverages was 14.2 (± 11.1) among all participants. 53% were considered high consumers of beverages and 47% (n=23) were considered low consumers of beverages. The one-month intervention showed a significant decrease in % of calories from beverages and weight in the overweight & obese intervention group (p<0.001 and p<0.05) respectively.Conclusion: This study highlighted major health problems in Abu Dhabi including high rates of overweight, obesity, and abdominal obesity. The one-month intervention was effective in reducing the energy percentage from beverages and weight of the overweight and obese participants, but no association was found in this sample between beverages consumption and overweight and obesity.

Sign in / Sign up

Export Citation Format

Share Document