Correlation analysis of some functional and anatomical parameters of the visual analyzer in nystagmus and amblyopia of various origins

Aim: To conduct a correlation analysis of the parameters of visual fixation, light sensitivity of the retina in the central region, and the thickness of the central region of the retina and choroid with the best corrected visual acuity (BCVA), refraction (SER), and axial length of the eye (AL) in nystagmus and amblyopia of various origins. Material and methods: The study included 45 patients aged 544 years (mean 11.26.14 years). All patients were divided into six groups depending on the type of amblyopia and associated conditions (with nystagmus). The retinal photosensitivity and fixation parameters were studied using an MP-3 Nidek microperimeter (Japan). Chorioretinal parameters were studied using an RS-3000 Advance 2 spectral optical coherence tomograph (Nidek, Japan). The axial length of the eye was measured using a Galilei G6 Scheimpflug analyzer. Correlation analysis was performed using the linear Pearson correlation coefficient (r). Results: In nystagmus, refractive and dysbinocular amblyopia, a strong direct correlation was found between the indicators of BCVA and the characteristics of fixation. In the groups associated with congenital myopia, relationships were found between BCVA, retinal thickness, and light sensitivity of the retina in the central region. There was no relationship between the subfoveal choroidal thickness and functional parameters of the eyes. Conclusions: In nystagmus and amblyopia associated with strabismus and hyperopic refraction, the primary amblyogenic factor is a decrease in the density and amplitude of fixation. In relative amblyopia due to congenital myopia, the decrease in visual acuity correlates with the photosensitivity of the retina and does not correlate with fixation parameters, which indicates the partially organic nature of relative amblyopia. No relationship was found between the choroidae thikness and the degree of amblyopia, which does not cofine its participation in the pathogenesis of the disease.

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Examining the effect and safety of orthokeratology in controlling the development of myopia: Based on fluorosilicone acrylic breathable material

Materials Express ◽

10.1166/mex.2020.1690 ◽

2020 ◽

Vol 10 (5) ◽

pp. 740-747

Author(s):

Yanxia Song ◽

Haixia Tian ◽

Suling Yang ◽

Feifan Du ◽

Huihui Sun ◽

...

Keyword(s):

Visual Acuity ◽

Intraocular Pressure ◽

Axial Length ◽

Corneal Endothelium ◽

Clinical Effect ◽

Naked Eye ◽

Corrected Visual Acuity ◽

Significant Difference ◽

Before And After

We aimed to evaluate the clinical effect and safety of orthokeratology in controlling the development of myopia. We assessed the changes in visual acuity, diopter change, axial length, corneal endothelium count, intraocular pressure, and corneal Q value in 30 adolescents with 60 years of wearing an orthokeratology lens. In this study, no significant difference was observed between the naked eye vision and corrected visual acuity before wearing the lens (t = –0.23, P = 0.59); furthermore, no significant difference was observed in diopter, axial length, corneal endothelium count, and intraocular pressure 1 year before and after wearing the lens (t = 1.24, P = 0.45; t = –0.89, P = 0.25; t = –0.43, P = 0.57; t = 1.43, P = 0.61); by contrast, there was a significant difference in the corneal Q value before and after wearing the lens (t = –8.37, P = 0.001). These results suggest that the fluorosilicone acrylic breathable material corneal orthopedic lens is safe and effective in controlling myopia, and has little effect on the physiology of the eye.

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Performing corneal tunnel incision with keratotomy scars intersection in patients after radial keratotomy during phacoemulsification

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-5-94-98 ◽

2021 ◽

pp. 94-98

Author(s):

H.P. Takhchidi ◽

◽

E.N. Panteleev ◽

A.S. Semakina ◽

I.V. Afanasova ◽

...

Keyword(s):

Visual Acuity ◽

Clinical Study ◽

Anterior Chamber ◽

Corneal Tissue ◽

Optical Coherence ◽

Radial Keratotomy ◽

Corrected Visual Acuity ◽

The Difference ◽

Optical Coherence Tomograph ◽

Best Corrected Visual Acuity

Purpose. A clinical study of safety and changes of refraction during intersection of a keratotomy scar while performing the corneal tunnel incision in phacoemulsification with IOL implantation. Material and methods. The clinical study included 11 patients (19 eyes) suffering from cataract and patients with previously performed anterior radial keratotomy. A tunnel incision 2.2 mm wide was performed with the location of the scar in its center. In case of insufficient area of the corneal tissue between the scars to involve only one keratotomy scar into the tunnel incision, the adjacent scar was transected at the final stage of tunnel formation when entering the anterior chamber. The other stages of phacoemulsification were carried out in a standard way. During the operation, the state of the keratotomy scar was assessed. A day, a week and a month later after the operation, the patients underwent biomicroscopy, autorefractokeratometry, visometry with an assessment of the values of subjective and objective cylindrical correction. In order to assess the postoperative state of the keratotomy scar and the incision zone, OCT of the cornea was performed using an RTVue 100 optical coherence tomograph (Optovue, Inc, USA) in Line, Crossline, 3D cornea modes. Results. In all cases, during the operation and also the next day, biomicroscopically the cornea was transparent, there was no keratotomy scar dehiscence. There is a dynamic of the best corrected visual acuity value by 1 month after surgery and the difference between the value for subjective and objective cylinder correction as well. The next day after the operation, in all cases the keratotomy scar on the OCT scans is uniform, comparable in width, the architectonics of the tunnel incision does not differ from that of standard phacoemulsification. Conclusion. Performing a corneal tunnel incision with the beginning of the formation outside the zone of the keratotomy scar and with further intersection of the scar with the plane of the blade so that most of it is in the projection of the center of the tunnel incision, as well as the intersection of the adjacent keratotomy scar at the end of the formation of the tunnel incision when entering the anterior chamber in case of insufficient the area of the corneal tissue between the incisions is safe at all stages of phacoemulsification and in the postoperative period. Changes in the values of best corrected visual acuity over time and the difference between the values of subjective and objective cylinder correction require further study on a larger sample and using various keratometry methods. Key words: radial keratotomy, phacoemulsification, tunnel incision, intersection of the keratotomy scar, cornea optical coherence tomography.

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Chronological changes of the anterior chamber structure, axial length, and refraction in patients with Vogt–Koyanagi–Harada disease

European Journal of Ophthalmology ◽

10.1177/1120672120902037 ◽

2020 ◽

pp. 112067212090203

Author(s):

Tetsuya Muto ◽

Shigeki Machida

Keyword(s):

Visual Acuity ◽

Anterior Chamber ◽

Axial Length ◽

Anterior Chamber Depth ◽

Pulse Treatment ◽

Spherical Equivalent ◽

Foveal Thickness ◽

Steroid Pulse ◽

Corrected Visual Acuity ◽

Best Corrected Visual Acuity

Purpose: To clarify the chronological changes in the anterior chamber structure and identify the spherical equivalent and axial length to assess the effects of steroid pulse treatment in patients with Vogt–Koyanagi–Harada disease with active uveitis. Methods: The anterior chamber condition, including anterior chamber volume, central anterior chamber depth, peripheral anterior chamber depth, anterior chamber angle, and pupil diameter, was measured using Pentacam, and axial length was measured using IOLMaster in patients with Vogt–Koyanagi–Harada disease between June 2015 and February 2018. Furthermore, the best-corrected visual acuity, spherical equivalent, and retinal foveola thickness were also analyzed. All patients were treated with steroid pulse. All these factors were compared before and at 1 and 6 months of treatment. Results: Significant changes were observed in the anterior chamber volume, central anterior chamber depth, peripheral anterior chamber depth, anterior chamber angle, axial length, best-corrected visual acuity, spherical equivalent, and retinal foveal thickness before and at 1 and 6 months of steroid pulse treatment ( P < 0.001, P < 0.001, P < 0.001, P = 0.0015, P = 0.027, P < 0.001, P = 0.0043, and P < 0.001, respectively). No significant difference was observed in the pupil diameter before and at 1 month and 6 months of steroid pulse treatment ( P = 0.11). Conclusion: The anterior chamber structure, axial length, best-corrected visual acuity, spherical equivalent, and retinal foveal thickness were dramatically changed by steroid pulse treatment in patients with Vogt–Koyanagi–Harada disease who develop active uveitis. These changes were completed within 1 month.

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Lens coloboma secondary to neglected buphthalmos

Journal of Clinical Images and Medical Case Reports ◽

10.52768/2766-7820/1370 ◽

2021 ◽

Vol 2 (5) ◽

Author(s):

Mousumi Banerjee ◽

Keyword(s):

Visual Acuity ◽

Intraocular Pressure ◽

Optic Nerve ◽

Axial Length ◽

Congenital Glaucoma ◽

Slit Lamp ◽

Posterior Subcapsular Cataract ◽

Slit Lamp Examination ◽

Corrected Visual Acuity ◽

Best Corrected Visual Acuity

A 36-year-old male presented with progressive diminution of vision OS for 3 months. He was a known case of bilateral congenital glaucoma who underwent trabeculectomy at 6 months and 5 years of age OD and OS respectively. Best corrected visual acuity was 6/24 OD and 1/60 OS. Slit lamp examination revealed bilateral Haab striae (Figure 1a) with lens subluxation OS evident by the scalloped border of the lens with broken zonules in the superonasal quadrant and lens coloboma in the inferonasal quadrant with the absence of zonules (Figure 1b,c,d). A posterior subcapsular cataract was also noted OS. Advanced glaucomatous optic nerve cupping was noted OU. An intraocular pressure of 10 mm Hg OD and 16 mm Hg OS was noted. Biometry documented an axial length of 26.30 mm OD and 28.75 mm OS with a keratometry of 42.50D/46.50D @20˚/110˚OD and 37.75D/40.00D @ 45˚/135˚OS. Ultrasound bio-microscopy depicted increased sphericity of the lens with broken zonules OS (Figure 1e).

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The effectiveness and safety of modified posterior scleral reinforcement in Chinese children with high myopia

10.21203/rs.3.rs-255754/v1 ◽

2021 ◽

Author(s):

Qianru Ouyang ◽

Zequn Miao ◽

Xin Xu ◽

Lili Guo ◽

Qingyu Meng ◽

...

Keyword(s):

Visual Acuity ◽

Refractive Error ◽

Axial Length ◽

High Myopia ◽

Upward Trend ◽

Short Term ◽

Reference Information ◽

Corrected Visual Acuity ◽

Posterior Scleral Reinforcement ◽

Best Corrected Visual Acuity

Abstract Background To evaluate the effectiveness and safety of modified posterior scleral reinforcement in controlling the progression of myopia in patients with high myopia and provide reference information on surgical treatment for these patients.Methods The study included 32 patients (55 eyes) with high myopia who were treated with modified posterior scleral reinforcement and were followed up at 3 months, 6 months, 1 year and 2 years after the operation.The axial length, refractive error, best corrected visual acuity (BCVA) and fundus colour photographs after the operation were compared with those before the operation, and whether there were any complications was recorded.Results The axial length of the eye increased by 0.07 mm, 0.12 mm, 0.31 mm and 0.19 mm at 3 months, 6 months, 1 year and 2 years after the operation, respectively. The refractive error increased by 0.05 D, 0.28 D, 0.53 D and 0.50 D at 3 months, 6 months, 1 year and 2 years after the operation, respectively, and the differences were not significant (P > 0.05). There were no statistically significant changes in BCVA, but there was an upward trend. No severe complications occurred.Conclusion Modified posterior scleral reinforcement can effectively delay the worsening of the ocular axis and refractive error, without severe complications in the short term.

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Posterior Scleral Reinforcement for The Treatment of Myopic Foveoschisis

10.21203/rs.3.rs-966882/v1 ◽

2021 ◽

Author(s):

Qing He ◽

Xiu Wang ◽

Caiyuan Xie ◽

Anquan Xue ◽

Ruihua Wei

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Refractive Error ◽

Axial Length ◽

Spherical Equivalent ◽

Myopic Foveoschisis ◽

Corrected Visual Acuity ◽

Posterior Scleral Reinforcement ◽

Best Corrected Visual Acuity

Abstract Background: This study aimed to investigate the clinical effectiveness of posterior scleral reinforcement for the treatment of myopic foveoschisis.Methods: This was a prospective study of 32 eyes from 20 patients with myopic foveoschisis treated with posterior scleral reinforcement using genipin-cross-linked donor sclerae . The length of the scleral strip used for the surgery was designed to be 1.5-times the axial length of the eye, whereas its width was 0.4-times the axial length of the eye. The optical coherence tomography images, spherical equivalent of refractive error, axial length, best corrected visual acuity, electroretinogram findings, and intraocular pressure of the patients were assessed postoperatively. Results: The mean duration of follow-up was 17.80 ± 8.74 months. The differences between the spherical equivalent of refractive error, best corrected visual acuity, axial length, and electroretinogram findings recorded preoperatively and those measured postoperatively were statistically significant (p＜0.05). The final reduction in axial length was 1.64 ± 0.85 mm. At the end of the follow-up, optical coherence tomography showed essential foveal reattachment in 30 eyes (93.75%), partial reattachment in two eyes (6.25%), and closure of macular holes in seven eyes (77.78%). No retinal detachment, vitreous haemorrhage, or other serious complications occurred following the surgery. Conclusions: Posterior scleral reinforcement with genipin-cross-linked sclera showed safe and effective outcomes for the treatment of myopic foveoschisis during a follow-up period of at least one yearTrial registration:ChiCTR1800020012

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INFLUÊNCIA DAS VARIÁVEIS AMBIENTAIS NA ESTRUTURA DE CINCO POPULAÇÕES ARBÓREAS DO CERRADO NA REGIÃO CENTRAL DE MINAS GERAIS

Nativa ◽

10.31413/nativa.v7i4.6852 ◽

2019 ◽

Vol 7 (4) ◽

pp. 460

Author(s):

Mateus De Souza Ferreira ◽

Bárbara Costa Diniz Barros ◽

Anne Priscila Dias Gonzaga ◽

Evandro Luiz Mendonça Machado ◽

Thiago José Ornelas Otoni

Keyword(s):

Correlation Analysis ◽

Central Region ◽

Environmental Variables ◽

Environmental Influence ◽

Pearson Correlation ◽

Sensu Stricto ◽

Minas Gerais ◽

Soil Samples ◽

Pearson Correlation Analysis ◽

Edaphic Variables

Neste trabalho, verificou-se a influência de fatores edáficos na estrutura populacional de cinco espécies arbóreas em duas fitofisionomias do bioma Cerrado na Fazenda Experimental do Moura em Curvelo – MG. Na área de estudo, em 2010, foram alocamos 25 parcelas de 20 x 50 metros, separadas entre si por 100m, sendo 15 parcelas no Cerrado sensu stricto e 10 no Cerradão. Foram identificados e medidos todos os indivíduos arbóreos vivos com diâmetro altura do solo (DAS) ≥ 5,0 cm, e coletadas amostras de solo em todas parcelas amostradas, para realização de análises química e granulométrica. Foram selecionadas as cinco espécies mais abundantes na área de estudo, e utilizou-se análises de correlação de Pearson para verificar as relações solo-vegetação destas populações. Os resultados mostraram correlações significativas (positivas e negativas) entre as variáveis: P, M.O., pH, K, SB, m, K, Areia, Silte e Argila e as espécies amostradas, além de diferenças entre ambientes. Considerando-se as relações existente entre as espécies e as variáveis ambientais, pode-se concluir que as populações investigadas, apresentaram variações na densidade ao longo das duas fitofisionomias. Tal informação reforça a ideia de que embora as fitofisionomias pertençam ao mesmo bioma e que apresentam espécies em comum, as populações precisam se adaptar às condições microambientais existentes em cada fitofisionomia.Palavras-chave: variáveis edáficas; relação solo-vegetação; densidade. ENVIRONMENTAL INFLUENCE IN THE STRUCTURE OF POPULATIONS OF CERRADO IN THE CENTRAL REGION OF MINAS GERAIS ABSTRACT: The present study aimed to generate information on the ecology of important populations in two Cerrado biome Phytophysiognomies in the Experimental Farm of Moura in Curvelo - MG. An inventory was carried out in 2010, with 25 parcels being systematically allocated with dimensions of 20 x 50 meters, separated from each other by 100m. All living arboreal individuals with soil height diameter (DAS) ≥ 5.0 cm were identified and measured. In all plots of each phytophysiognomy soil samples were collected to determine the chemical and granulometric analyzes to be used in Pearson correlation analysis (vegetation and environment) in order to understand the possible relationships. The results of the analyzes showed that there were significant correlations between the variables P, M.O., pH, K, SB, m, K, Sand, Silt and Clay. Considering the diametric structure and the relationships between the species and the environmental variables, it can be concluded that the populations investigated showed variations in density along the two phytophysiognomies. This information reinforces the idea that although the phytophysiognomies belong to the same biome and that they have species in common, the populations need to adapt to the environmental conditions of each phytophysiognomy.Keywords: edaphic variables; soil-vegetation ratio; density.

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Correlation analysis of epicardial adipose tissue thickness, C-reactive protein, interleukin-6, visfatin, juxtaposed with another zinc finger protein 1, and type 2 diabetic macroangiopathy

Lipids in Health and Disease ◽

10.1186/s12944-021-01451-7 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Yuan-Yuan Gong ◽

Hai-Ying Peng

Keyword(s):

Correlation Analysis ◽

Zinc Finger Protein ◽

Pearson Correlation ◽

Statistical Significance ◽

Healthy Control Group ◽

Control Group ◽

Diabetes Group ◽

Reactive Protein ◽

Healthy Control

Abstract Background To investigate the correlation between the thickness of epicardial adipose tissue (EAT), C-reactive protein (CRP), interleukin (IL) -6, visfatin, juxtaposed with another zinc finger protein 1 (JAZF1) and type 2 diabetic mellitus (T2DM) macroangiopathy. Methods The study enrolled 82 patients with T2DM with macroangiopathy (the Complication Group), and 85 patients with T2DM (the Diabetes Group) who were admitted to Shandong Provincial Third Hospital from February 2018 to February 2020. In addition, 90 healthy people who underwent physical examination at the same hospital during the same period were enrolled (the Healthy Control Group). Age, gender, height, weight, waist circumference (WC), hip circumference (HC), diabetic course and therapeutic drugs, waist hip ratio (WHR), and body mass index (BMI) were recorded and calculated. Results The baseline characteristics of the three groups were comparable, and the diabetic course of the Complication Group and the Diabetes Group was not significantly different (P > 0.05). The WHR of the Complication Group was higher than that of the Diabetes Group and the Healthy Control Group, with statistical significance (P < 0.05). The FPG, 2hPG, HbA1C, CRP, IL-6, Visfatin, JAZF1, HOMA-IR, EAT thickness, and baPWV of the Complication Group were all higher than those of the Diabetes Group and the Healthy Control Group (P < 0.05, respectively). The JAZF1 and FIns of the Complication Group and Diabetes Group were lower than those of the Healthy Control Group, and JAZF1 of the Complication Group was lower than the Diabetes Group with statistical significance (P<0.05, respectively). Pearson correlation analysis showed that the EAT thickness was positively correlated with CRP, IL-6, visfatin, and JAZF1 (r = 0.387, 0.451, 0.283, 0.301, respectively, all P<0.001). Pearson correlation analysis showed that baPWV was positively correlated with EAT thickness, CRP, IL-6, visfatin, and JAZF1 (r = 0.293, 0.382, 0.473, 0.286, respectively, all P < 0.001). Multivariate stepwise regression analysis showed that FPG, 2hPG, HbA1C, CRP, IL-6, visfatin, JAZF1, and EAT thickness were independent risk factors that affected T2DM macroangiopathy. Conclusions Clinical monitoring and treatment of T2DM macroangiopathy can use CRP, IL-6, Visfatin, JAZF1, and EAT thickness as new targets to delay the progression of the disease. Further research on the relationship between the above factors and the pathogenesis of T2DM macroangiopathy may be helpful provide new treatment strategies.

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Descemet membrane suturing to manage recurrent graft detachment in a patient with Descemet membrane endothelial keratoplasty on failed penetrating keratoplasty

Therapeutic Advances in Ophthalmology ◽

10.1177/25158414211027705 ◽

2021 ◽

Vol 13 ◽

pp. 251584142110277

Author(s):

Zahra Ashena ◽

Thomas Hickman-Casey ◽

Mayank A. Nanavaty

Keyword(s):

Visual Acuity ◽

Penetrating Keratoplasty ◽

Anterior Segment ◽

Endothelial Keratoplasty ◽

Descemet Membrane Endothelial Keratoplasty ◽

Descemet Membrane ◽

Ocular Coherence Tomography ◽

Corrected Visual Acuity ◽

Intracameral Injection ◽

History Of

A 65-year-old patient with history of keratoconus, mild cataract and penetrating keratoplasty over 30 years ago developed corneal oedema subsequent of graft failure with best corrected visual acuity (BCVA) of counting fingers. He underwent a successful cataract surgery combined with a 7.25 mm Descemet’s Membrane Endothelial Keratoplasty (DMEK) with Sodium Hexafluoride (SF6) gas. His cornea remained oedematous inferiorly at 4 weeks, despite two subsequent re-bubbling due to persistent DMEK detachment inferiorly. This was managed by three radial full thickness 10-0 nylon sutures placed in the inferior cornea along with intracameral injection of air. Following this, his anterior segment ocular coherence tomography (OCT) confirmed complete attachment of the graft, and the sutures were removed 4 weeks later. Unaided visual acuity was 20/63 and BCVA was 20/32 after 8 months. DMEK suturing can be helpful in persistent DMEK detachments, which is refractory to repeated re-bubbling due to uneven posterior surface of previous PK.

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Comparison of the Effectiveness of Intravitreal Ranibizumab for Diabetic Macular Edema in Vitrectomized and Nonvitrectomized Eyes

Ophthalmologica ◽

10.1159/000446992 ◽

2016 ◽

Vol 236 (2) ◽

pp. 67-73 ◽

Cited By ~ 5

Author(s):

Yoshito Koyanagi ◽

Shigeo Yoshida ◽

Yoshiyuki Kobayashi ◽

Yuki Kubo ◽

Muneo Yamaguchi ◽

...

Keyword(s):

Visual Acuity ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Treatment Option ◽

Central Macular Thickness ◽

Intravitreal Ranibizumab ◽

Corrected Visual Acuity ◽

The Mean ◽

The Difference ◽

Best Corrected Visual Acuity

Purpose: To compare the effectiveness of intravitreal ranibizumab (IVR) for diabetic macular edema (DME) between eyes with and without previous vitrectomy. Procedures: We prospectively assessed the best-corrected visual acuity (BCVA) and central macular thickness (CMT) after IVR for 6 months. Results: There were no significant differences in the baseline BCVA and CMT between both groups. In the nonvitrectomized group (n = 15), the mean changes of BCVA and CMT from baseline to month 6 were significant (p < 0.01). In the vitrectomized group (n = 10), the improvement appeared to be slower, and the mean BCVA improvement was not significant (p = 0.5), although the mean CMT decrease was significant (p < 0.05). There were no significant differences in the mean changes of BCVA and CMT between both groups at 6 months. Conclusions: The difference in the effectiveness of IVR between both groups was not significant. IVR can be a treatment option even for vitrectomized DME eyes.

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