scholarly journals Efficacy of Autologous Growth Factors Application in Musculo-Skeletal System Injuries and Diseases

2014 ◽  
Vol 21 (1) ◽  
pp. 86-93
Author(s):  
S. P Mironov ◽  
A. A Ochkurenko ◽  
G. A Kesyan ◽  
S. N Savel’ev ◽  
A. A Arkad’ev ◽  
...  
Keyword(s):  
Growth Factors ◽  
Side Effects ◽  
Literature Review ◽  
Secretory Proteins ◽  
Skeletal System ◽  
Randomized Controlled ◽  
Randomized Controlled Studies ◽  
Start Up ◽  
To Receive

Literature review on the assessment of the efficacy of platelet rich autoplasma for the treatment of various musculo-skeletal system diseases - tendinopathy, osteoarthrosis, injuries of ligaments, tendons, muscles and bones is presented. Platelet rich autoplasma contains growth factors and secretory proteins that can start up remodeling and restorative processes in pathologic tissues. The method showed itself to be effective, safe, free from side effects and complications. Most of the research workers consider it reasonable to conduct randomized controlled studies in order to receive reliably data on this methods efficacy.

scholarly journals Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern Sweden

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Karin Holm ◽  
Maria N. Lundgren ◽  
Jens Kjeldsen-Kragh ◽  
Oskar Ljungquist ◽  
Blenda Böttiger ◽  
...  
Keyword(s):  
Plasma Treatment ◽  
Viral Infections ◽  
Standard Of Care ◽  
Hospitalized Patients ◽  
Care Group ◽  
Open Label ◽  
Randomized Controlled ◽  
Oxygen Treatment ◽  
Randomized Controlled Studies ◽  
To Receive

Abstract Objective Convalescent plasma has been tried as therapy for various viral infections. Early observational studies of convalescent plasma treatment for hospitalized COVID-19 patients were promising, but randomized controlled studies were lacking at the time. The objective of this study was to investigate if convalescent plasma is beneficial to hospitalized patients with COVID-19. Results Hospitalized patients with confirmed COVID-19 and an oxygen saturation below 94% were randomized 1:1 to receive convalescent plasma in addition to standard of care or standard of care only. The primary outcome was number of days of oxygen treatment to keep saturation above 93% within 28 days from inclusion. The study was prematurely terminated when thirty-one of 100 intended patients had been included. The median time of oxygen treatment among survivors was 11 days (IQR 6–15) for the convalescent plasma group and 7 days (IQR 5–9) for the standard of care group (p = 0.4, median difference -4). Two patients in the convalescent plasma group and three patients in the standard of care group died (p = 0.64, OR 0.49, 95% CI 0.08–2.79). Thus no significant differences were observed between the groups. Trial registration ClinicalTrials NCT04600440, retrospectively registered Oct 23, 2020.

scholarly journals BABY-LED WEANING, AN OVERVIEW OF THE NEW APPROACH TO FOOD INTRODUCTION: INTEGRATIVE LITERATURE REVIEW

2020 ◽  
Vol 38 ◽  
Author(s):  
Melisa Sofia Gomez ◽  
Ana Paula Toneto Novaes ◽  
Janaina Paulino da Silva ◽  
Luciane Miranda Guerra ◽  
Rosana de Fátima Possobon
Keyword(s):  
Literature Review ◽  
Latin American ◽  
Caribbean Literature ◽  
National Library ◽  
Letters To The Editor ◽  
New Approach ◽  
Randomized Controlled ◽  
Randomized Controlled Studies ◽  
Data Source ◽  
The Subject

ABSTRACT Objective: To analyze the scientific literature on Baby-Led Weaning with an integrative literature review to identify risks and benefits. Data source: The databases used were: National Library of Medicine (MEDLINE), Latin American and Caribbean Literature in Health Sciences (LILACS – Literatura Latino-Americana e do Caribe em Ciências da Saúde), US National Library of Medicine (PubMed), and Virtual Health Library (BVS – Biblioteca Virtual em Saúde) in December 2017. The inclusion criteria established were publications in English with the descriptor “baby-led weaning” in the heading, abstract, or keywords, classified as original articles, of primary nature, and available online and in full. We excluded review articles, editorials, letters to the editor, critical commentaries, and books on the subject, as well as articles not available in full and duplicates. Data summary: We identified 106 articles, of which 17 met the selection criteria. The Baby-Led Weaning method was significantly associated with the baby’s satiety, the start of complementary feeding, and adequacy of weight gain. On the other hand, choking and the intake of micronutrients were negatively associated, however with no statistical differences. Conclusions: Despite the benefits found, the risks still deserve attention and should be investigated with longitudinal randomized controlled studies to ensure the safety of the method when practiced exclusively.

scholarly journals Iron Supplementation in Twin Pregnancy — The Benefit of Doubling the Iron Dose in Iron Deficient Pregnant Women: A Randomized Controlled Trial

2017 ◽  
Vol 20 (5) ◽  
pp. 419-424 ◽  
Author(s):  
Shiri Shinar ◽  
Avital Skornick-Rapaport ◽  
Sharon Maslovitz
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Iron Deficient ◽  
Gastrointestinal Side Effects ◽  
Secondary Outcomes ◽  
Group B ◽  
To Receive ◽  
Twin Pregnancies

Objective: To assess the efficacy of doubling the daily dose of iron supplement in iron-deficient women with twin pregnancies. Study design: Using a prospective randomized controlled trial, iron-deficient women with twin gestations were randomized to receive a single or a double dose of daily iron from 16 weeks of gestation until 6 weeks postpartum. The primary outcome was hemoglobin at 32 weeks. Secondary outcomes included ferritin at 32 weeks, hemoglobin during pregnancy and postpartum, birth weights, preterm birth rate, gastrointestinal side effects, intravenous iron administration, and compliance with treatment. Results: Eighty-five and 87 women were randomized to receive one capsule (group A) or two capsules (group B) of 34 mg of ferrous sulfate, respectively. Mean hemoglobin (9.6 g/dL and 9.7 g/dL) and ferritin (8.6 ng/ml and 8.5 ng/ml) were similar in both groups A and B, respectively, at allocation. Hemoglobin in group B was significantly higher from 32 weeks onward, until 6 weeks postpartum. There were no significant differences in any of the secondary outcomes examined. Conclusions: In twin pregnancies complicated by iron deficiency anemia, doubling the dose of iron increases hemoglobin and ferritin without worsening gastrointestinal side effects.

scholarly journals Phenobarbitone versus levetiracetam in neonatal seizures

2020 ◽  
Vol 7 (8) ◽  
pp. 1701
Author(s):  
Ravindra Kumar Jain ◽  
Hemant Kumar
Keyword(s):  
Adverse Effect ◽  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Good Alternative ◽  
Preterm Neonates ◽  
Neonatal Seizures ◽  
Medical College ◽  
Randomized Controlled ◽  
To Receive

Background: There is increasing evidence that neonatal seizures have an adverse effect on neurodevelopmental progression and it may predispose to cognitive, behavioral or epileptic complications later in life. The objective of this study was to compare the efficacy of phenobarbitone and levetiracetam for the treatment of neonatal seizures in term and late preterm neonates. The study was aimed to know the efficacy of phenobarbitone (PB) in comparison with levetiracetam (LEV) in controlling neonatal seizures.Methods: This was a randomized controlled trial where data of the babies with seizures weighing more than 2 kg who were admitted in NICU of Muzaffarnagar Medical College was collected and analysed for intervention to either phenobarbitone or levetiracetam.Results: Clinically apparent seizures were controlled in only 65.38% neonates assigned to receive levetiracetam as compared to 76.92% neonates assigned to receive phenobarbitone.Conclusions: LEV although lesser effective than PB with very fewer side effects is found to be a good alternative in controlling neonatal seizures.

Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial

2001 ◽  
Vol 26 (1) ◽  
pp. 67-71 ◽  
Author(s):  
S. A. Ahmadi-Abhari ◽  
S. Akhondzadeh ◽  
S. M. Assadi ◽  
O. L. Shabestari ◽  
Z. M. Farzanehgan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled

Relationship between total plasma homocysteine and the risk of aneurysms – a meta-analysis

VASA ◽  
2020 ◽  
pp. 1-6
Author(s):  
Hanji Zhang ◽  
Dexin Yin ◽  
Yue Zhao ◽  
Yezhou Li ◽  
Dejiang Yao ◽  
...  
Keyword(s):  
Large Scale ◽  
Meta Analysis ◽  
Single Species ◽  
Total Plasma ◽  
Control Groups ◽  
Randomized Controlled ◽  
Randomized Controlled Studies ◽  
The Difference ◽  
The Relationship ◽  
Healthy Participants

Summary: Our meta-analysis focused on the relationship between homocysteine (Hcy) level and the incidence of aneurysms and looked at the relationship between smoking, hypertension and aneurysms. A systematic literature search of Pubmed, Web of Science, and Embase databases (up to March 31, 2020) resulted in the identification of 19 studies, including 2,629 aneurysm patients and 6,497 healthy participants. Combined analysis of the included studies showed that number of smoking, hypertension and hyperhomocysteinemia (HHcy) in aneurysm patients was higher than that in the control groups, and the total plasma Hcy level in aneurysm patients was also higher. These findings suggest that smoking, hypertension and HHcy may be risk factors for the development and progression of aneurysms. Although the heterogeneity of meta-analysis was significant, it was found that the heterogeneity might come from the difference between race and disease species through subgroup analysis. Large-scale randomized controlled studies of single species and single disease species are needed in the future to supplement the accuracy of the results.

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