Physical Activity in Pediatric Multiple Sclerosis—Can Lifestyle Factors Affect Disease Outcomes?

US Neurology ◽  
2015 ◽  
Vol 11 (01) ◽  
pp. 19
Author(s):  
E Ann Yeh ◽  
Robert Motl ◽  
◽  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Disease Activity ◽  
Pediatric Population ◽  
Complex Relationship ◽  
Pediatric Multiple Sclerosis ◽  
Symptoms Of Depression ◽  
Disease Outcomes ◽  
Modifiable Factors ◽  
Clear Information

Currently, little to no information is available about interventions that can ameliorate symptoms such as depression and fatigue in children and adolescents with multiple sclerosis (MS), nor is there clear information on modifiable factors that can provide neuroprotection in this population. However, physical activity (PA) may have significant effects on disease activity, future disability, cognition, and symptoms of depression and fatigue in pediatric MS. The extent of this effect is unknown. In this paper, after providing an overview of definitions of and outcomes in pediatric MS, we provide a review of existing literature relating PA to outcomes in MS, and then turn to a review of the complex relationship between PA, neuroinflammation, and outcomes in the pediatric population.

Matrix Metalloproteinase-7, Matrix Metalloproteinase-9, and Disease Activity in Pediatric Multiple Sclerosis

2013 ◽  
Vol 48 (3) ◽  
pp. 255-256
Author(s):  
Ünsal Yılmaz ◽  
Kıvılcım Gücüyener ◽  
Esra Gürkaş ◽  
Ercan Demir ◽  
Ayşe Serdaroğlu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Matrix Metalloproteinase ◽  
Disease Activity ◽  
Matrix Metalloproteinase 9 ◽  
Pediatric Multiple Sclerosis ◽  
Matrix Metalloproteinase 7 ◽  
Metalloproteinase 9

scholarly journals Among Persons With Multiple Sclerosis (MS), Objective Sleep, Psychological Functioning, and Higher Physical Activity Scores Remained Stable Over 2 Years—Results From a Small Study Under Naturalistic Conditions

2020 ◽  
Vol 11 ◽  
Author(s):  
Dena Sadeghi Bahmani ◽  
Roman Gonzenbach ◽  
Jürg Kesselring ◽  
Jens Bansi ◽  
Robert W. Motl ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Psychological Functioning ◽  
Activity Levels ◽  
Rehabilitation Center ◽  
Sleep Patterns ◽  
Subjective Sleep ◽  
Symptoms Of Depression ◽  
Physical Activity Levels ◽  
Activity Indices

Background: Persons with multiple sclerosis (PwMS) are at increased risk to report poor sleep patterns and lower physical activity indices. To date, data on longitudinal objectively sleep assessment is missing. In the present study, we investigated the pattern of objective sleep and subjective physical activity indices over a period of 13.5 months, under naturalistic conditions.Method: 13.5 months after their first assessment, a total of 16 PwMS (mean age = 49.13 median EDSS score: 5; 11 females) were reassessed on their objective sleep via portable sleep-electroencephalogram (EEG-) devices, along with their subjective sleep patterns (symptoms of insomnia, restless legs syndrome (RLS), and sleep-disordered breathing), physical activity indices, psychological functioning (symptoms of depression, fatigue, daytime sleepiness), and MS-related information (fatigue, EDSS; disease-modifying treatments). While the baseline assessment was performed in a rehabilitation center, the follow-up assessment took place at participants' naturalistic and familiar setting.Results: Statistically, symptoms of depression and fatigue, subjective sleep, and physical activity levels did neither increase, nor decrease over time, although descriptively, both moderate and vigorous physical activity levels decreased, and fatigue and subjective insomnia increased. Time awake after sleep onset statistically significantly decreased, while light sleep duration increased by trend.Conclusions: Among a smaller sample of PwMS, objective sleep in their naturalistic setting remained fairly stable over a mean time lapse of 13.5 months after clinic discharge. Physical activity levels descriptively decreased. The present results are of clinical and practical importance for treatment counseling: PwMS can be reassured that their sleep quality does not deteriorate, once they have left a rehabilitation center. Further, they should be encouraged to keeping their physical activity levels as stable as possible.

Potentially Modifiable Factors Associated With Physical Activity in Individuals With Multiple Sclerosis

2017 ◽  
Vol 40 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Nadia Reider ◽  
Amber R. Salter ◽  
Gary R. Cutter ◽  
Tuula Tyry ◽  
Ruth Ann Marrie
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Factors Associated ◽  
Modifiable Factors

scholarly journals Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis

Neurology ◽  
2015 ◽  
Vol 85 (19) ◽  
pp. 1663-1669 ◽  
Author(s):  
Stephanie A. Grover ◽  
Berengere Aubert-Broche ◽  
Dumitru Fetco ◽  
D. Louis Collins ◽  
Douglas L. Arnold ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Disease Burden ◽  
Pediatric Multiple Sclerosis ◽  
Lower Physical Activity

scholarly journals Physical Activity and Sedentary Behavior Patterns Across Weekdays and Weekend Days in Youth with Multiple Sclerosis and Controls

2021 ◽  
Author(s):  
E. Morghen Sikes ◽  
Renisha Iruthayanathan ◽  
Stephanie A. Grover ◽  
Effie Viguiliouk ◽  
Zehra Kamani ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Sedentary Behavior ◽  
Analysis Of Variance ◽  
Physically Active ◽  
Activity Monitors ◽  
Pediatric Multiple Sclerosis ◽  
Physical Activity Interventions ◽  
Behavior Change Interventions ◽  
Within Subjects

Abstract Background: This study quantified and compared weekday and weekend patterns of device-measured physical activity (PA) and sedentary behavior between youth with pediatric multiple sclerosis (MS) and controls for the purpose of informing future PA behavior change interventions. Methods: Participant data were obtained from three ongoing observational studies, and the sample included 40 participants with pediatric MS and 41 controls. Light PA (LPA), moderate-to-vigorous PA (MVPA), and sedentary behavior data were collected using activity monitors (ActiGraph LLC) over 1 week. The main analysis involved a two-way mixed factor analysis of variance with group as a between-subjects factor (pediatric MS vs control) and day as a within-subjects factor (weekday vs weekend day). Results: There was no group × day interaction from the analysis of variance for percentage of activity monitor wear time spent in LPA, MVPA, or sedentary behavior. There was no effect of group for LPA, MVPA, or sedentary behavior. There was an effect of day of week on percentage of day spent in LPA, MVPA, and sedentary behavior. Conclusions: These results suggest that youth with pediatric MS and controls were less physically active and more sedentary on weekends than on weekdays, but there were no differences between groups in PA and sedentary behavior overall or by day of the week. Physical activity interventions may be more successful by initially targeting weekend day activity.

scholarly journals Multiple Sclerosis: Associations Between Physical Disability and Depression Are Not Mediated by Self-Reported Physical Activity

2017 ◽  
Vol 124 (5) ◽  
pp. 974-991 ◽  
Author(s):  
Helene Merkt ◽  
Dena Sadeghi Bahmani ◽  
Pasquale Calabrese ◽  
Yvonne Naegelin ◽  
Markus Gerber ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
Physical Disability ◽  
Rating Scales ◽  
Activity Levels ◽  
Expanded Disability Status Scale ◽  
Symptoms Of Depression ◽  
Disability Status ◽  
Physical Activity Levels

This study investigated the interrelatedness of physical disability, physical activity, and depression among patients with multiple sclerosis (MS). We hypothesized that self-reported physical activity would mediate the effect of disability on depressive symptoms. Twenty-seven patients with MS (mean age: 49 years; 44.5% females) completed self-rating scales covering sociodemographic variables, intake of antidepressants, physical activity, and symptoms of depression; disability was measured by the Expanded Disability Status Scale. We found a higher level of disability to be significantly associated with more symptoms of depression. While higher reported physical activity was descriptively associated with lower depression scores and unrelated to Expanded Disability Status Scale, physical activity levels did not mediate the effect of disability on depressive symptoms.

Youth with multiple sclerosis have low levels of fitness

2020 ◽  
pp. 135245852097436
Author(s):  
Samantha Stephens ◽  
Tara Berenbaum ◽  
Marcia Finlayson ◽  
Robert W Motl ◽  
E Ann Yeh
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Physical Fitness ◽  
Disease Activity ◽  
Vigorous Physical Activity ◽  
Walk Test ◽  
Improved Outcomes ◽  
Low Levels ◽  
Lower Disease Activity ◽  
Minute Walk

Background: Moderate and vigorous physical activity is associated with improved outcomes in youth with multiple sclerosis (MS). Physical fitness may also influence disease and health outcomes in this population. Objectives: To determine if there were differences in physical fitness between youth with MS and healthy controls (HC). To examine relationships between physical fitness, physical activity (PA) level, fatigue, depression and disease activity in youth with MS and HC. Methods: Youth with MS ( n = 19) and HC ( n = 21) completed tests establishing cardiorespiratory-fitness (VO2peak), endurance via 2-minute walk test, and musculoskeletal strength via grip strength (GS). Questionnaires determined fatigue, depression, and PA levels. Weekly PA level was determined by accelerometry. Tests of differences and correlational analyses were used to evaluate physical fitness. Results: Youth with MS had lower VO2peak ( U = 279, p < 0.0001), endurance ( t = 2.6, p = 0.02), and higher body mass index (BMI) ( t = -5.9, p = 0.001) than HC. Higher VO2peak was associated with higher moderate to vigorous PAaccelerometer in HC (Spearman-Rho = 0.5, p = 0.03), but not in youth with MS (Spearman-Rho = 0.5, p = 0.06). Lower VO2peak and GS were associated with higher disability (Spearman-Rho = -0.6, p = 0.03) and relapses in MS (Spearman-Rho = -0.52, p = 0.04). Conclusions: Youth with MS have lower levels of fitness, compared with HC. Higher levels of fitness were associated with lower disease activity and disability in youth with MS.

Physical activity and pediatric multiple sclerosis: Developing a research agenda

2015 ◽  
Vol 21 (13) ◽  
pp. 1618-1625 ◽  
Author(s):  
E Ann Yeh ◽  
Dominique Kinnett-Hopkins ◽  
Stephanie A Grover ◽  
Robert W Motl
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Disease Burden ◽  
Physical Activity Behavior ◽  
Future Research ◽  
Pediatric Multiple Sclerosis ◽  
Pediatric Populations ◽  
Activity Behavior ◽  
Behavioral Methods ◽  
Neurocognitive Decline

Three-quarters of children with multiple sclerosis (MS) experience fatigue or depression, and progressive neurocognitive decline may be seen as early as two years after MS diagnosis. Furthermore, a higher magnetic resonance imaging disease burden is seen in pediatric-onset MS compared with adult-onset MS. To date, limited knowledge exists regarding behavioral methods for managing symptoms and disease progression in pediatric MS. To that end, this paper builds an evidence-based argument for the possible symptomatic and disease-modifying effects of exercise and physical activity in pediatric MS. This will be accomplished through: (a) a review of pediatric MS and its consequences; (b) a brief overview of physical activity and its consequences in children and adults with MS; and (c) a selective review of research on the neurological benefits of physical activity in pediatric populations. This topical review concludes with a list of 10 questions to guide future research on physical activity and pediatric MS. The objective of this paper is the provision of a research interest, focus and agenda involving pediatric MS and its lifelong management though exercise and physical activity behavior. Such an agenda is critical as the effects and maintenance of physical activity and exercise track across the lifespan, particularly when developed in the early stages of life.

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