Effect of Yiqi Huoxue Huatan Tongluo Method on Intestinal Flora Expression in Patients with Acute Cerebral Infarction

Objective: To evaluate the clinical effect of Yiqi Huoxue Huatan Recipe (recipient for invigorating qi, activating blood and resolving phlegm) on ischemic stroke patients and its effect on intestinal flora expression through clinical study of Yiqi Huoxue Huatan Recipe, and to explore its possible mechanism and provide clinical basis for its further application. Methods: 60 patients with acute cerebral infarction were divided into treatment group (30 cases, combined Chinese traditional and Western medicine) and control group (30 cases, pure Western medicine). Fecal samples were collected at 24 hours and 14 days after the onset of the disease, and 16SrDNA high-throughput sequencing was used to observe the status of the faecal samples and the changes of intestinal flora abundance. To compare whether there was a difference between the two groups at 24 hours and 14 days after the onset of the disease. To compare whether there is a difference in microbiological status between the two groups during the same time period. To compare the difference ofTCM syndrome integral between the two groups. Results: Before and after treatment of the patients with cerebral infarction in the two groups, those ranked the top six at the level of intestinal flora are: Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Tenericutes and Cyanophyta. After treatment, the abundance of Bacteroides was up-regulated, while the abundance of Firmicutes and Proteobacteria was down-regulated. However, the adjustment range of treatment group with combined Chinese medicine and western medicine was larger and there was significant difference between the two groups (P<0.05). The improvement ofTCM syndrome in the treatment group was more significant than that in the control group (P<0.05). Conclusion: Intestinal flora disturbance may be a potential causative factor of cerebral ischemic diseases. Yiqi Huoxue Huatan Recipe has a certain effect on the abundance of intestinal flora, and the symptom of the patients in the treatment group is improved more obviously. By regulating the intestinal flora, the patients’ internal environment is improved and the constitution is improved, which may be one of the effective mechanisms of Yiqi Huoxue Huatan Recipe.

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Effect of Yiqi Tongnao Decoction on Acute Cerebral Infarction of Qi Deficiency and Blood Stasis

E3S Web of Conferences ◽

10.1051/e3sconf/202018503015 ◽

2020 ◽

Vol 185 ◽

pp. 03015

Author(s):

Shenghua Zhou ◽

Rui-Cong Ding ◽

Hua He

Keyword(s):

Cerebral Infarction ◽

Research Group ◽

Western Medicine ◽

Research Work ◽

Blood Stasis ◽

Blood Lipid ◽

Acute Cerebral Infarction ◽

Control Group ◽

Significant Difference ◽

The Difference

Objective: To explore the method and clinical effect of applying Yiqi Tongnao Decoction in the treatment of patients with acute cerebral infarction of Qi deficiency and blood stasis. Methods: To carry out research work in our hospital, a total of 70 patients with acute cerebral infarction of Qi deficiency and blood stasis who were treated in our hospital from March 2018 to March 2019 were randomly divided into two groups, one of which was given Western Medicine as the control group, and the other group was given Yiqi Tongnao Decoction combined with Western medicine, as the research group, the treatment status of the two groups of patients was compared and observed. Results: When comparing, the research group with skewed mouth and eyes, white greasy tongue coating, shortness of breath and fatigue, and pulse fineness scores were lower than those of the control group. The data difference between the groups was shown as P <0.05. The difference between the research group and the control group is quite large. Before treatment, the NIHSS score of the two groups of patients did not change significantly, P> 0.50. After the treatment intervention, the score of the research group was (5.10 ± 1.24), which was lower than that of the control group, and the difference between the groups was P <0.05. Before receiving treatment, there was no significant difference in blood lipid levels between the two groups of patients, P> 0.05. After treatment, the blood lipid level of the two groups of patients both changed, but in contrast, the degree of change in the research group was significantly greater than that of the control group, P <0.05, in general, the treatment effect of the research group was better. Conclusion: In the treatment of patients with acute cerebral infarction of qi deficiency and blood stasis, Yiqi Tongnao Decoction has significant effects, which can effectively improve the patients' adverse symptoms and has positive significance for clinical development.

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Effect of Argatroban Injection on Clinical Efficacy in Patients with Acute Cerebral Infarction: Preliminary Findings

European Neurology ◽

10.1159/000512813 ◽

2021 ◽

pp. 1-5

Author(s):

Pan Huang ◽

Xiao-ying He ◽

Min Xu

Keyword(s):

Treatment Group ◽

Cerebral Infarction ◽

Clinical Efficacy ◽

Adverse Reactions ◽

National Institutes Of Health ◽

Acute Cerebral Infarction ◽

Control Group ◽

Scale Scores ◽

The Difference ◽

And Control

Objective: The aim is to observe the effects of argatroban injection and butylphthalide injection on blood flow rheology, clinical efficacy, and safety in patients with acute cerebral infarction. Methods: 344 patients with acute cerebral infarction within 48 h after admission were divided into treatment group and control group, with 172 cases in each group. The control group received routine treatment. The treatment group received argatroban injection 60 mg on the basis of the control group, intravenously guttae (ivgtt) was used for 2 days and then changed to argatroban injection 10 mg, ivgtt bid for 5 days, and the total course of treatment was 7 days. The neurological changes, activities of daily living, and the rheology indicators (fibrinogen [Fib], platelet aggregation rate [Pag], whole blood high shear viscosity [Whsv], hematocrit [Hct]) were compared between the 2 groups, clinical efficacy and adverse drug reactions. Results: After treatment, the total effective rates of the treatment group and the control group were 90.70% (156 /172 cases) and 74.41% (128 and 172 cases), respectively, and the difference was statistically significant (p < 0.05). After treatment, the National Institutes of Health Stroke Scale scores of the treatment group and the control group were (7.05 ± 1.97) and (8.30 ± 1.79), respectively, and the Barthel index was (68.02 ± 11.07) and (62.32 ± 11.46), respectively. The difference was statistically significant (p < 0.05). After treatment, the treatment group and the control group were (2.66 ± 0.22) g/L and (3.50 ± 0.22) g/L, respectively, and Pag were (0.68 ± 0.06)% and (0.81 ± 0.09)%, respectively, and Whsv was (6.44 ± 0.76) mPs/s and (6.87 ± 0.91) mPs/s, Hct were (8.19 ± 1.21)% and (10.44 ± 1.04)%, respectively, and the differences were statistically significant (p < 0.05). The incidence of adverse reactions in the treatment group and the control group was 6.97 and 5.81%, respectively, and the difference was not statistically significant (p > 0.05). Conclusion: Argatroban injection is effective in the treatment of acute cerebral infarction, which can significantly improve the hemorheology of patients with good safety.

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OHIS Differences on Primary School Students in Relation to Little Dentist Training

10.31219/osf.io/uxbks ◽

2021 ◽

Author(s):

Asep Arifin Senjaya ◽

Ni Made Sirat ◽

I Nyoman Wirata ◽

Ni Ketut Ratmini

Keyword(s):

Treatment Group ◽

Primary School ◽

Oral Hygiene ◽

Dental Health ◽

Control Group ◽

Primary School Students ◽

School Students ◽

Significant Difference ◽

Before And After ◽

The Difference

Dental healthcare is very important since dental and oral hygiene should be maintained. Statistics showed that more than 80% of children in developed and developing countries suffer from dental disease. This study aimed to see the safety of OHIS (Oral Hygiene Index Simplified) in primary school students who got and did not get little dentist cadre training in Bangli Regency in 2019. The study was done in an experimental design: pre and post-test with control design, which was conducted in August-September 2019. The sample in this study is 366 students. The difference in OHIS scores before and after treatment in the control group and treatment group was carried out by the bivariate Mann Whitney U Test. The results of the study showed that before dental health training was conducted, there were 54.3% of primary school students in the treatment group with good OHIS score criteria, and after the training was carried out as many as 98.4% of the students in the treatment group had a good OHIS. Additionally, prior to the training, 57.5% of the control group had fair OHIS criteria score. Then, after the training was carried out, 73.7% of the control group had good OHIS score. Hence, the study concluded that there was a significant difference in the OHIS of primary school students who got little doctor training prior to and after the training. Also, there was a significant difference in the OHIS of the students who did not get such treatment before and after the training.

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Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.36.4.1831 ◽

2020 ◽

Vol 36 (4) ◽

Author(s):

Xuewen Wo ◽

Jinyan Han ◽

Jiajia Wang ◽

Xinmin Wang ◽

Xiaoying Liu ◽

...

Keyword(s):

Plasma Level ◽

Cerebral Infarction ◽

Antiplatelet Therapy ◽

Adverse Reactions ◽

Dual Antiplatelet Therapy ◽

Acute Cerebral Infarction ◽

Control Group ◽

Observation Group ◽

Significant Difference ◽

Better Than

Objective: To observe the clinical efficacy of sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of elderly patients with acute cerebral infarction (ACI). Methods: One hundred and twenty-two elderly patients with ACI who were admitted to the department of neurology of our hospital at May 2016-August 2018 were selected grouped into a control group and an observation group by random number table method, 61 in each group. On the basis of conventional treatment, the patients in the control group were given dual antiplatelet therapy (aspirin enteric-coated tablets + clopidogrel bisulfate tablets), while the patients in the observation group were given sequential butylphthalide therapy on the basis of the control group. The clinical effects of the two groups were compared after four weeks of treatment, and the changes of National Institutes of Health Stroke Scale (NIHSS), ADL score, plasma 3-mercaptopyruvate sulphurtransferase (3-MST) and Amyloid β42 (Aβ42) levels and the occurrence of adverse reactions during treatment were recorded. Results: The clinical efficacy of the observation group was better than that of the control group (P<0.05). There was no significant difference in NIHSS and ADL scores between the two groups before treatment (P>0.05). After treatment, the NIHSS and ADL scores of the observation group were better than those of the control group (P<0.05). There was no significant difference in plasma levels of 3-MST and AB42 between the two groups before treatment (P>0.05). The level of plasma 3-MST in the observation group was higher than that in the control group, and the level of plasma Aβ42 was lower than that in the control group (P<0.05). No serious adverse reactions occurred during the treatment period in both groups. Conclusion: Butylphthalide sequential therapy combined with dual antiplatelet therapy is effective in the treatment of elderly ACI. It can effectively improve the plasma level of 3-MST and decrease the plasma level of Aβ42, which is conducive to improving the living ability and neurological function of patients and has high safety. doi: https://doi.org/10.12669/pjms.36.4.1831 How to cite this:Wo X, Han J, Wang J, Wang X, Liu X, Wang Z. Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1831 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparative study on the efficacy and safety of alteplase and urokinase in the treatment of acute cerebral infarction

Technology and Health Care ◽

10.3233/thc-202382 ◽

2020 ◽

pp. 1-6

Author(s):

Hua Bao ◽

Hao-Ran Gao ◽

Min-Lu Pan ◽

Lei Zhao ◽

Hai-Bin Sun

Keyword(s):

Treatment Group ◽

Cerebral Infarction ◽

Early Stage ◽

Intravenous Thrombolysis ◽

Acute Cerebral Infarction ◽

Neurological Injury ◽

Control Group ◽

Efficacy And Safety ◽

Time Period ◽

And Control

BACKGROUND: Acute cerebral infarction (ACI) is a common cerebrovascular disease in clinical practice. OBJECTIVE: The present study aims to investigate the efficacy and safety of alteplase and urokinase in treating ACI. METHODS: A total of 96 patients with ACI, who were treated with alteplase and urokinase, were selected as the main subjects. Among these patients, 45 patients with ultra-early acute cerebral infarction, who received intravenous thrombolysis with RT-PA (alteplase), were included in the treatment group, while 51 patients with acute cerebral infarction, who were treated with urokinase in the same time period, were included in the control group. RESULTS: The National Institute of Health Stroke Scale (NIHSS) scores were significantly lower in the treatment group and control group (P< 0.05) at two hours, seven days and 14 days after thrombolysis, when compared to those before thrombolysis. The bleeding rate was significantly lower in the control group, when compared to the treatment group (P< 0.05). CONCLUSION: The intravenous thrombolysis with urokinase or alteplase in the ultra-early stage of acute cerebral infarction can reduce the neurological injury symptoms and effectively improve the prognosis of patients with stroke. Urokinase is lower in risk of bleeding, but better in safety, when compared to alteplase.

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Effects of care transitions intervention mode on the beneﬁt-ﬁnding in caregivers for patients with acute cerebral infarction

10.22514/sv.2021.224 ◽

2021 ◽

Keyword(s):

Quality Of Life ◽

Cerebral Infarction ◽

Care Transitions ◽

Family Relationship ◽

Intervention Group ◽

Acute Cerebral Infarction ◽

Benefit Finding ◽

Control Group ◽

Significant Difference

To explore the effect of care transitions intervention (CTI) on the sense of benefit-finding of caregivers for patients with acute cerebral infarction (ACI). Ninety caregivers for patients with ACI were divided into two groups according to the random number table method (n = 45 in each group). The control group was given regular health guidance, and the intervention group was given care transitions intervention on the basis of the guidance used in the control group. The changes in the sense of benefit-finding and quality of life between the two groups were compared before and after the intervention. There was no statistically significant difference in caregivers between the two groups in gender, age, educational level, occupational status, gender and age of the patients, activities of daily living (ADL) scores before discharge, and the relationships between the caregiver and the patient. Before CTI, there was no statistically significant difference in the caregivers’ sense of benefit-finding (including sense of benefit, family relationship, personal growth, social relationship and healthy behavior) and quality of life (including benefit-finding of care, stress of care, choice of care, support to care and money issue) between the two groups. While after CTI, the scores of each dimension of the caregivers’ sense of benefit-finding and quality of life in the intervention group were significantly higher than those in the control group (p < 0.05). The CTI can help improve the sense of benefit-finding and quality of life of caregivers for patients with ACI.

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Nao-Xue-ShuOral Liquid Protects and Improves Secondary Brain Insults of Hypertensive Cerebral Hemorrhage

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/9121843 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Hongning Jiang ◽

Ying Qin ◽

Te Liu ◽

Liang Zhang ◽

Mingzhe Wang ◽

...

Keyword(s):

Treatment Group ◽

Cerebral Hemorrhage ◽

Clinical Medicine ◽

Control Group ◽

Clinical Effects ◽

Favorable Prognosis ◽

Significant Difference ◽

Oral Liquid ◽

The Difference ◽

Brain Insults

Aim.To determine one traditional Chinese medicine (TCM)Nao-Xue-Shuoral liquid which protects and improves secondary brain insults (SBI) in hypertensive cerebral hemorrhage (HCH).Methods.158 patients with HCH were divided into routine clinical medicine plusNao-Xue-Shuoral liquid (n=78) as treatment group, and routine clinical medicine (n=80) only served as the control group. The incidence of SBI and the classification of a favorable prognosis and a bad prognosis using the Glasgow outcome scale (GOS) were assessed to evaluate the clinical effects. The changes of IL-6 and TNF-αlevels were determined to study the mechanism of the effects for the TCM.Results.The incidence of SBI at the end of week 2 was 8.97% in the treatment group and 23.75% in the control group, and the difference was significant (P<0.001). The incidence of a favorable prognosis was 48.72% in the treatment group and 32.72% in the control group, and the difference was significant (P<0.01) at the end of week 2. These findings indicate clear differences for IL-6 and TNF-αat the end of week 1 and week 2 compared with before treatment for the treatment group and a marked difference at the end of week 2 between the two groups. It also shows a significant difference between the end of week 2 and before treatment for IL-6 and TNF-αfor the control group, although the difference was much smaller than the treatment group.Conclusion. Nao-Xue-Shuoral liquid could protect against the occurrence of SBI and improve HCH and SBI patients. It may also decrease the damage and the mass effects of the hematoma by reducing IL-6 and TNF-αto obtain the effects, and thus it is a potentially suitable drug for HCH and SBI.

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A Retrospective Cohort Study of Risk of Gallbladder Disease in Acute Cerebral Infarction Patients

Journal of the Korean Neurological Association ◽

10.17340/jkna.2020.1.3 ◽

2020 ◽

Vol 38 (1) ◽

pp. 16-24

Author(s):

Suk-Hee Lee ◽

Seongheon Kim ◽

Jae-Won Jang ◽

Seung-Hwan Lee ◽

Young-Ju Kim

Keyword(s):

Cerebral Infarction ◽

Liver Diseases ◽

Cox Regression ◽

Gallbladder Disease ◽

Population Based ◽

Exposed Group ◽

Acute Cerebral Infarction ◽

Control Group ◽

Mortality And Morbidity ◽

The Difference

Background: Gallbladder diseases after acute cerebral infarction are relatively rare, but could have a serious impact on mortality and morbidity of patients. The purpose of this study was to investigate the risk of gallbladder disease in patients with acute cerebral infarction.Methods: This study analyzed a population-based matched cohort constructed using National Health Insurance Service-Senior cohort dataset in South Korea. Subjects after acute cerebral infarction during 2002-2015 were identified as the exposed group, and up to four individual matched for age, sex, and index years were as the controls. The difference of the risk of gallbladder disease between the exposed and control group was evaluated using Cox regression adjusting for hypertension, diabetes, liver diseases, and the modified Charlson Comorbidity Index (mCCI). The risk of gallbladder disease of the exposed group was evaluated using Cox regression analyses to identify the risk factors.Results: The occurrence of the gallbladder disease was significantly associated with the acute cerebral infarction (p<0.0001). The presence of acute cerebral infarction was associated with a higher risk of gallbladder disease (adjusted hazard ratio=1.44, 95% confidence interval=1.26-1.66). The subjects with higher CCI showed higher risk of gallbladder disease. Among acute cerebral infarction patients, the oldest group, subjects having liver diseases, or subjects with the mCCI higher than two were found significant on the risk of gallbladder disease.Conclusions: Our study showed that the acute cerebral infarction has a significant association with gallbladder disease. These results suggested that the possibility of developing of gallbladder disease in patients with acute cerebral infarction should be considered.

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Butyphthalide in the treatment of massive Cerebral Infarction

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.1.320 ◽

2019 ◽

Vol 35 (1) ◽

Author(s):

Xinmin Wang ◽

Yingjun Sun ◽

Shugang Dong ◽

Xiaoying Liu ◽

Jinming Ji

Keyword(s):

Treatment Group ◽

Cerebral Infarction ◽

Daily Living ◽

Statistical Significance ◽

Response Rates ◽

Control Group ◽

Activity Of Daily Living ◽

Nihss Score ◽

Before And After ◽

The Difference

Objective: To evaluate the effect of butyphthalide in the treatment of massive cerebral infarction. Methods: One hundred and twenty patients with massive cerebral infarction who were admitted to the hospital between January 2017 and December 2017 were selected and divided into a treatment group (n = 60) and a control group (n = 60) using random number table, 80 each group. Patients in the control group were given conventional cerebral infarction therapy, while patients in the treatment group were given butyphthalide injection besides the conventional treatment. The National Institutes of Health Stroke Scale (NIHSS) score, score of activity of daily living (ADL), lipoprotein-associated phospholipase A2 (LP-PLA2) and prognosis were recorded and compared between the two groups. The response rates of the two groups were recorded. Results: The total response rates of the control group and treatment group were 73.85% and 93.85% respectively at the postoperative 21st day, and the difference had statistical significance (P<0.05). The NIHSS score of the two groups obviously decreased, and the ADL score significantly increased after treatment; the differences of NIHSS score and ADL score before and after treatment in the same group had statistical significance (P<0.05). The improvement of the indexes of the treatment group was obviously superior to that of the control group, and the differences between the two groups had statistical significance (P<0.05). The level of LP-PLA2 of both groups significantly decreased at the postoperative 21st day, and the difference before and after treatment in the same group was statistically significant (P<0.05); the treatment group had a significantly lower level of LP-PLA2 than the control group, and the difference had statistical significance (P<0.05). The treatment group had significantly higher positive outcome rate and lower mortality rate than the control group at the postoperative 90th day, and the differences had statistical significance (P<0.05). The incidence of adverse events of the treatment group and control group was 8.3% (5/60) and 5.0% (3/60) respectively, suggesting no significant difference (P>0.05). Conclusion: Butyphthalide has a favourable effect in treating massive cerebral infarction. It can repair neurologic impairment, improve activity of daily living, and adjust the level of LP-PLA2, suggesting favourable application values. How to cite this:Wang X, Sun Y, Dong S, Liu X, Ji J. Butyphthalide in the treatment of massive Cerebral Infarction. Pak J Med Sci. 2019;35(1):---------. doi: https://doi.org/10.12669/pjms.35.1.320 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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POTENSI PEMBERIAN EKSTRAK BUAH DELIMA (Punica granatum L) TERHADAP KUALITAS SPERMATOZOA TIKUS PUTIH (Rattus norvegicus) YANG TERPAPAR PANAS

Ovozoa Journal of Animal Reproduction ◽

10.20473/ovz.v8i1.2019.5-9 ◽

2020 ◽

Vol 8 (1) ◽

pp. 5

Author(s):

Nucifera Fadhillah Santoso ◽

Budi Utomo ◽

Mirni Lamid

Keyword(s):

Treatment Group ◽

Rattus Norvegicus ◽

Membrane Integrity ◽

Punica Granatum ◽

Control Treatment ◽

Control Group ◽

White Rats ◽

Significant Difference ◽

The Difference

The purpose of this research was to determine the effect of pomegranate (Punica granatul l) fruit extract for spermatozoa quality including the motility, viability and membrane integrity of spermatozoa. The researchused 20 male white rats (Rattus norvegicus) with 200-300 gram average body weight. P0 as control was given with CMC Na 0.5%. P1 used 75 mg/kg BW dose of extract, P2used 150 mg/kg BW dose of extract, P3 used 300 mg/kg BW dose of extract. The treatment was given perorally for 14 days. The experiment was used completely random design (CRD). The result of this study was analyzed with ANOVA followed by Tukey Test (p<0.05). The result showed that there was significant effect from therapy on the quality of rats spermatozoa. The difference of spermatozoa’s concentration between first treatment group P1 and control treatment group is not significant, while the treatment other result showed between the second treatment group and the control group P0. A significant difference occurs in the percentage of motility, viability and membrane integrity. The treatment from P2 group showed the best result in maintaining the quality of rats spermatozoa.

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