scholarly journals Synthesis, Characterization and Antimicrobial Activity of N’-Benzylidene-5-Bromothiophene-2-Carbohydrazide Derivatives

Author(s):  
Hitesh Makwana ◽  
Yogesh T. Naliapara

Some new N’-benzylidene-5-bromothiophene-2-carbohydrazide derivatives possessing thiophene nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity

Author(s):  
Prakash Mehta ◽  
Prakash Davadra ◽  
Jalpa R. Pandya ◽  
Hitendra S. Joshi

Some new 2-azetidinone derivatives possessing benzimidazole nucleus were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.


2015 ◽  
Vol 10 (3) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Elena Ancheeva ◽  
Georgios Daletos ◽  
Rini Muharini ◽  
Wen Han Lin ◽  
Leonid Teslov ◽  
...  

Stellaria nemorum L. and S. holostea L. (Caryophyllaceae) were investigated for their flavonoids. The new flavonoid 6- C-[(α-arabinopyranosyl)-(1→2)- O-β-xylopyranosyl]apigenin (1) and the four known C-glycosides, 6- C-[(α-arabinopyranosyl)-(1→2)- O-β-glucopyranosyl]apigenin (2), apigenin 6- C-β-galactopyranoside-8- C-β-glucopyranoside (3), apigenin 6- C-β-glucopyranoside-8- C-α-arabinopyranoside (4), and apigenin 6- C-β-glucopyranoside-8- C-β-xylopyranoside (5) were isolated from the aerial parts of S. nemorum for the first time. Furthemore, five known flavonoids, 3,5,7-trihydroxy-3′,5′-dimethoxyflavone (9), diosmetin 6- C-β-glucopyranoside (8), schaftoside (4), isoorientin (6) and orientin (7) were obtained from the aerial parts of S. holostea. Compounds 4, 8 and 9 are reported for the first time from this species. The structures of all isolated compounds were unambiguously elucidated by one- and two- dimensional NMR and mass spectral analysis, by acid hydrolysis, as well as by comparison with literature data. The crude extracts of the investigated species exhibited antimicrobial activity against Staphylococcus aureus, while none of the isolated compounds was found to be active.


Author(s):  
Piyush B. Vekariya ◽  
Jalpa R. Pandya ◽  
Vaishali Goswami ◽  
Hitendra S. Joshi

Some novel 6-fluoro chroman derivatives having 1,2,4-triazolo-[3,4-b]thiadiazole were synthesized and characterized by IR, NMR and mass spectral analysis. All synthesized compounds were screened for antimicrobial activity using broth dilution method. All the compounds showed good antimicrobial activity and compound 5e showed significant antibacterial activity.


2012 ◽  
Vol 9 (2) ◽  
pp. 893-898 ◽  
Author(s):  
B. Prasanna ◽  
B. Srinivas ◽  
Y. Jagannadham ◽  
Sumangala Rao

A series of 3-substitutedphenyl-1-thia-tetrazopentaleno[1,2-b] naphthalene4(a-d)and 2-substitutedphenyl-1-thia-pentazopentaleno[1,2-b] naphthalene5(a-d)were synthesizedvia., the reaction of 2-aminothiazoles2(a-d)and 2-aminothiadiazoles3(a-d)with 2,3-dichloro quinoxaline1in ionic liquid without using any catalyst. This protocol has the advantages of easier workup, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods. The synthesized compounds4(a-d)and5(a-d)tested for their anti-fungal activity and these compounds were characterized by IR, NMR and Mass spectral analysis.


Author(s):  
ALETI RAJAREDDY ◽  
SRINIVAS MURTHY M

Objective: The objective of this study was to synthesize and evaluate the anthelmintic activity (AA) of novel benzothiazole derivatives containing indole moieties (BDIM). Methods: The present works which involve the substituted isatin Schiff bases undergo acetylating and reacting with 2-aminobenzothiazole to give novel BDIM. Results: All the newly synthesized molecules (5a-5o) were characterized by Fourier-transform infrared spectroscopy, H_nuclear magnetic resonance, and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their AA using an Indian earthworm (Pheretima posthuma), and albendazole was used as standard drug. Conclusion: The synthesized compound 5f, 5n, and 5o showed good AA, whereas others exhibited significant activities.


1976 ◽  
Vol 48 (12) ◽  
pp. 1768-1774 ◽  
Author(s):  
T. Fai. Lam ◽  
Charles L. Wilkins ◽  
Thomas R. Brunner ◽  
Leonard J. Soltzberg ◽  
Steven L. Kaberline

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