scholarly journals The role of open innovation in biomarker discovery

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Lilla Landeck ◽  
Monika Lessl ◽  
Andreas Busch ◽  
Matthias Gottwald ◽  
Khusru Asadullah

Precision medicine aims to treat diseases with special consideration for the individual biological variability. Novel biomarkers (BM) are needed to predict therapeutic responses and to allow for the selection of suitable patients for treatment with certain drugs. However, the identification and validation of appropriate BMs is challenging. Close col-laboration between different partners seems to be a key success factor. While the importance of partnerships and larger, well-established consortia in BM discovery such as the pharmaceutical industry and academic institutions is well un-derstood and has been investigated in the past, the use of open-innovation models, also known as ‘crowd sourcing for biomarkers’, is still in its infancy. Crowd sourcing comprises of a —usually via internet— request for problem solution to an open group of users in a kind of an ‘open call’. The community (crowd) is asked to provide solutions. Since the application of the crowd sourcing method offers the possibility to collect as many as possible novel ideas from a broad community with different expertise, this approach is particularly promising for BM development. In this article we de-scribe the first examples of open-innovation models, such as the ‘grants for targets’ (G4T) and biomarkers initiative ‘InnoCentive’ (innovation/incentive) platform. They may be a fruitful basis for collaborative BM development in the future.

2019 ◽  
Vol 85 ◽  
pp. 148-175
Author(s):  
Ilma Pranciulytė-Bagdžiūnienė ◽  
Monika Petraitė

Open innovation serves as a principal paradigm for success in diverse and dynamic business environments, as it gives the promise of a better-marked acceptance, a higher level of novelty, and managed innovation risks. However, SMEs face a critical challenge in developing open innovation capabilities and establishing new organizational processes that would empower employees to perform in open innovation regimes. We analyze the mediating role of organizational capabilities for employing and facilitating individual competences for innovation performance improvement as based on a survey of 266 SMEs. This study aimed to identify links between organizational capabilities and individual comp etences in AI for innovation performance in SMEs. The results of our study showed that organizational capabilities in AI at the level of organizations play a role as a mediator between competences for AI at the individual level and the progress of innovations. Considering that organizational skills in AI (organizational culture openness, organizational learning and trust, knowledge management systems, etc.) are strong organizational tools that help to increase the efficiency of AI and individual competences (to enhance employee creativity, enhance interaction with partners) as well as management competences (flexibility, ability to work with various professional communities, strategic thinking, etc.). This study partially refutes the assumptions that SMEs can only achieve innovative progress through individual competences in AI. Organizational capabilities in AI are also very important for AI implementation.


2018 ◽  
Vol 6 (3) ◽  
pp. 8 ◽  
Author(s):  
Carlos Melo Brito

Universities are increasingly acting as promoters of innovation, economic growth and regional development, a trend that has attracted the attention of both policy makers and researchers. The objective of this paper is to contribute to a deeper understanding of the role of higher education institutions as dynamic promoters of growth and development. The University of Porto is used as a case study to explore how universities can act as innovation ecosystems leaders and integrators. The main contributions of the paper are threefold. First, the case puts in evidence a key success factor: the talent to transform the knowledge produced by universities into valuable solutions for companies and other organisations. Second, links between universities and industry must assume a long-term and relational nature rather than an intermittent and transactional character. Finally, the success of university-based ecosystems depends on the integration of a diversity of actors, resources and competences. This means that a sustainable strategy of innovation and knowledge valorisation requires an approach that fosters both internal and external networking.


2018 ◽  
Vol 5 (1) ◽  
pp. 25
Author(s):  
Sri Pajriah

Penelitian ini bertujuan untuk menganalisis peran sumber daya manusia dalam pengembangan pariwisata budaya di Kabupaten Ciamis. Adapun metode yang digunakan dalam penelitian ini adalah metode penelitian sejarah dalam upaya untuk mendapatkan data dan fakta yang ada di lapangan. Berdasarkan hasil penelitian ini bahwa peran sumber daya manusia sebagai faktor kunci keberhasilan dalam mewujudkan pengembangan pariwisata budaya di Kabupaten Ciamis. Peran SDM sebagai motor penggerak industri pariwisata, pencipta produk industri pariwisata, dan sebagai penentu daya saing industri pariwisata. Hal ini dapat diwujudkan melalui pendidikan pariwisata dan pelatihan pemandu wisata yang harus dimiliki bagi masyarakat khususnya berada di daerah wisata untuk mengembangkan pariwisata budaya di wilayah Kabupaten Ciamis, karena melalui kegiatan tersebut akan lebih meningkatkan mutu, kinerja dan hasil yang diperoleh menjadi lebih baik. Maka, peran SDM sangat menunjang keberhasilan bagi pengembangan pariwisata budaya di Kabupaten Ciamis dengan kompetensi yang dimilikinya, sehingga objek wisata budaya yang ada di Kabupaten Ciamis menjadi tujuan wisata yang lebih menarik dan memiliki keunikan yang kaya akan nilai sejarah dan budaya Galuh serta bermanfaat bagi masyarakat yang berada di daerah wisata sebagai sarana memperoleh penghasilan sehingga kesejahteraan masyarakatpun akan lebih meningkat.Abstract This study aims to analyze the role of human resources in the development of cultural tourism in Ciamis Regency. The method used in this study is a historical research method in an effort to obtain data and facts in the field. Based on the results of this study, the role of human resources as a key success factor in realizing the development of cultural tourism in Ciamis Regency. The role of Human Resources as the driving force of the tourism industry, the creator of tourism industry products, and as a determinant of the competitiveness of the tourism industry. This can be realized through tourism education and must-have tour guide training for the community, especially in tourist areas to develop cultural tourism in the Ciamis Regency area, because through these activities the quality, performance and results obtained will be better. So, the role of Human Resources greatly supports the success of the development of cultural tourism in Ciamis Regency with its competencies, so that cultural tourism objects in Ciamis Regency become more attractive and unique tourist destinations that are rich in Galuh's historical and cultural values and beneficial for communities in tourist areas as a means of earning income so that the welfare of the community will increase.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
V. Shela ◽  
T. Ramayah ◽  
Noor Hazlina Ahmad

Purpose This paper aims to highlight the potential role of collective mindfulness as a key success factor for organizational resilience. It also outlines the processes and essential contexts that support the cultivation of collective mindfulness capability in organizations. Design/methodology/approach A review of the relevant articles and current development in the area of organizational resilience and collective mindfulness provided an in-depth understanding and valuable insights into how collective mindfulness can be utilized to engender organizational resilience in the challenging business world. Findings This paper provides a brief overview over the crucial role of collective mindfulness capability in augmenting organizational resilience. Additionally, the processes of collective mindfulness and the essential contexts for developing and sustaining this capability is also unveiled. Originality/value The paper offers practical solutions for the anxiety faced by many organizations around the globe due to the relentless disruptions by highlighting on the potential role of collective mindfulness. It reveals the way that organizations can undertake to wade through the waves imposed by the current volatile environment by leveraging on collective mindfulness capability.


2020 ◽  
Author(s):  
Maximilian Heimstädt ◽  
Georg Reischauer

Public sector organizations increasingly innovate through open innovation practices that originated in the private sector. To explain the use of these innovation practices, extant research has focused on enabling conditions at the individual and organizational level, but has paid little attention to extra-organizational factors such as culture. To address this gap, we adopted a field framing perspective to study the use of open innovation practices in the New York City (NYC) administration. We found that actors in NYC equipped different social positions – insider, outsider, and interstitial – and used different discursive tactics – reflective frame blending and supplemental frame blending – to enhance the cultural resonance of open innovation practices. We further theorize these findings with a framework on the enabling conditions for the cultural resonance of innovation practices. Our study contributes to innovation studies by unpacking the role of culture for the use of innovation practices and to the framing literature by specifying the role of discursive tactics and social positions for the cultural resonance of new practices.


2020 ◽  
pp. 1875-1894
Author(s):  
Harishchander Anandaram

Recent advancements in bio-computing and nano-technology accelerated the discovery of novel biomarkers in the emerging field of personalized medicine. Personalized medicine deals with disease detection and therapy from the molecular profile of each individual. Personalized medicine is also called as predictive medicine that uses genetic/molecular information to predict disease development, progression, and clinical outcome. In this chapter, we discuss the advantages of using nanotechnology to understand biological systems with an example of the biomarker discovery of cancer. Recent developments in bio computing served as the base for the identification of multiplexed probes in a nano particle. Together we have correlated the bio molecular signatures with clinical outcomes and we have also addressed an emerging field called bio-nano-informatics to suggest an individual therapy for cancer and other diseases.


Author(s):  
Mattia Bianchi ◽  
Lorenzo Boscherini ◽  
Davide Chiaroni ◽  
Federico Frattini ◽  
Vittorio Chiesa

The advent of biotechnology in the late ’80s revolutionized the pharmaceutical industry and, in particular, caused a strong division of labour in the innovation process. As a result, the capability to master technological collaborations with external organizations has become a critical success factor for incumbent pharmaceutical firms as well as product biotech firms. This chapter investigates the phenomenon by using a rich and purposively collected empirical basis about the organisational forms (e.g., partnerships, in- and out-licensing, outsourcing, technology purchasing) through which inter-organizational collaborations are put into practice along the phases of the bio-pharmaceutical innovation process, and about the specific role played in these collaborations by platform biotech firms. Results are interpreted by drawing into two relatively novel streams of research in the innovation management literature, dealing with the Open Innovation paradigm and the role of Technical and Scientific Services (TSS).


2018 ◽  
Vol 60 (3) ◽  
pp. 125-132 ◽  
Author(s):  
Reiner Anderl ◽  
Sebastian Haag ◽  
Klaus Schützer ◽  
Eduardo Zancul

Abstract Digital Twin technology is increasingly gaining importance for digitizing industry. Even if digital twin technology still needs fundamental research, its significance for industry has become very visible, as digital twin technology is a key success factor to professionalize Cyber-Physical Systems (CPS) applications. Industrie 4.0 as an initiative to increase industrial added value is based on establishing connectivity between CPS and to enable communication between CPS. The industrial application scenarios for Industrie 4.0 aim at vertical and horizontal lifecycle integration concepts where digital twin technology plays an important role. This contribution explains major concepts of Industrie 4.0 and derives the role of digital twin technology. Furthermore, digital twin approaches are presented and as well as the proposal to use the STEP-technology (Standard for the Exchange of Product Model Data, ISO 10303) as a fundamental basis for a comprehensive digital twin technology.


2017 ◽  
Vol 76 (3) ◽  
pp. 295-302 ◽  
Author(s):  
A. O'Gorman ◽  
L. Brennan

Traditional methods for the assessment of dietary intake are prone to error; in order to improve and enhance these methods increasing interest in the identification of dietary biomarkers has materialised. Metabolomics has emerged as a key tool in the area of dietary biomarker discovery and to date the use of metabolomics has identified a number of putative biomarkers. Applications to identify novel biomarkers of intake have in general taken three approaches: (1) specific acute intervention studies to identify specific biomarkers of intake; (2) searching for biomarkers in cohort studies by correlating to self-reported intake of a specific food/food group(s); (3) analysing dietary patterns in conjunction with metabolomic profiles to identify biomarkers and nutritypes. A number of analytical technologies are employed in metabolomics as currently there is no single technique capable of measuring the entire metabolome. These approaches each have their own advantages and disadvantages. The present review will provide an overview of current technologies and applications of metabolomics in the determination of new dietary biomarkers. In addition, it will address some of the current challenges in the field and future outlooks.


2019 ◽  
Vol 35 (3) ◽  
pp. 172-182 ◽  
Author(s):  
Wael Sha. Mohammed Basri ◽  
Mohammed R.A. Siam

PurposeThe purpose of this paper is to discuss the role of social media and corporate communication as a key success factor of small- and medium-sized enterprises (SMEs) operating in Arab world. This is a conceptual study and has shed light on the notable existing literature on these issues and particularly of Arab context. The social media has emerged as an opportunity for marketing communication, and it is the easiest cheapest way of advertising products and services. Social media provides a platform wherein a company or firm can target a diverse audience and can create an effective communication strategy. The sustainability agenda has emerged as a key as well as a sensitive issue for the global as well as local organizations. The inclusion of corporate social responsibility and incorporation of sustainability initiatives have changed the corporate landscape and merged as key determinants of business success. The social media for many firms has emerged as a major outlet of internal and external corporate communication for sustainability. The uniqueness of social media is that it not only conveys a message, rather it also provides an opportunity for direct feedback from users. This study will be helpful for practitioners, policymakers and researchers in understanding the link between social media, corporate communication and sustainable performance of the SME sector. The paper adds to the literature on the role of social media and corporate communication as a key success factor of SMEs operating in Arab world.Design/methodology/approachThe paper will highlight significant and relevant findings generated from previous scholarly and commercial research on the subject. Thereafter, the discussion will focus on the unique relationship between the social media and the Arab world in social, political, religious or cultural and economic spheres. Thereafter, the paper will progress to the central theme of the discussion, reviewing social media’s impact on the Arabian market in such areas as offering a marketing platform for the new age, being an avenue and forum for increased sales, and as a public relations front line (a benchmark of direct client communication). Ultimately, the paper will provide a succinct conclusion to the discussion.FindingsThe paper affirmed that the social media is influencing/impacting the SMEs in the Arab region in numerous ways. Findings generated from recent empirical studies, strengthened by a resounding theoretical and scholarly literature, helped identify four of the main impacts of social media on SMEs in the Arab world. These four significant impacts, as discussed in the paper, include offering a marketing platform for the Information Age, offering an avenue and forum for increased sales, giving an innovative edge to SMEs in a bid to reduce expenditures/cost and increase profitability and creating a benchmark of direct client communication in modern PR. These fours ways constitute the most significant impact of social media, as demonstrated by SMEs in the Arab world, and in many ways they are congruent with the social media impact beyond the Middle East.Research limitations/implicationsThis paper is very limited in Arab countries, and researchers could not use this study with female.Practical implicationsInformation technology and gender are linked with the usage of social media.Originality/valueThe core focus of the present paper was to provide a brief literature-based review of how the social media affects SME in the Arab world (largely in nations within the Middle East region). Not only is the social media enabling positive “societal and cultural change” in the Arab world.


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