scholarly journals Psychological Continuum of Elderly Patients Suffering from Arterial Hypertension with Metabolic Syndrome, Against the Background of Chronotherapy with a Fixed Combination of Amlodipine, Lisinopril and Rosuvastatin

Kardiologiia ◽  
2021 ◽  
Vol 61 (3) ◽  
pp. 36-41
Author(s):  
N. M. Agarkov ◽  
O. I. Okhotnikov ◽  
S. I. Korneeva ◽  
E. O. Moskaleva ◽  
A. A. Moskalev ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Depressive Disorders ◽  
Fixed Combination ◽  
Anxiety Score ◽  
Control Group ◽  
Traditional Treatment ◽  
Psychological Continuum ◽  
Study Results

Aim        To study the psychological continuum in elderly patients with arterial hypertension associated with metabolic syndrome during the chronotherapy with a fixed combination (FC) of amlodipine, lisinopril, and rosuvastatin.Material and methods        In the inpatient conditions, 63 patients aged 60–74 years with arterial hypertension associated with metabolic syndrome were treated with chronotherapy with a FC of amlodipine, lisinopril, and rosuvastatin (5 / 10 / 10 mg/day in the evening). These patients composed the main group. The control group (58 patients aged 60–74 years with arterial hypertension associated with metabolic syndrome) was treated with the FC of amlodipine, lisinopril, and rosuvastatin at the same dose of 5 / 10 / 10 mg/day in the morning.Results   At one year, the disorders of psychological continuum were significantly decreased with the chronotherapy (evening dosing) with the antihypertensive FC of amlodipine, lisinopril, and rosuvastatin compared to the traditional treatment (morning dosing) at the same dose of 5 / 10 / 10 mg/day in both groups. With the chronotherapeutic approach, the dynamic of cognitive disorders in patients aged 60–74 years with arterial hypertension associated with metabolic syndrome was characterized by a significant increase in the Mini-Mental-State-Examination scale score from 17.8±0.3 at baseline to 23.5±0.4 with the evening dosing (р<0.001) vs. the increase from 16.9±0.3 to 20.4±0.4 (р<0.001) with the morning dosing. The situational anxiety score decreased from 40.0±2.2 to 30.6±1.8 (р<0.05) and from 40.8±2.5 to 33.5±1.9  (р<0.05), and the trait anxiety score decreased from 48.8±2.0 to 26.4±1.9 (р<0.001) and from 44.9±1.9 to 30.7±1.7  (р<0.01) with the evening and morning dosing, respectively. Depressive disorders slightly decreased with the chronotherapy by 14.1 % vs. 7.7 % with the traditional regimen; nevertheless, they were consistent with depressive spectrum disorders in both groups.Conclusion            The study results showed a higher effectiveness of the chronotherapeutic treatment compared to the traditional treatment with FC of amlodipine, lisinopril, and rosuvastatin in arterial hypertension with metabolic syndrome.

scholarly journals Pleiotropic effect of chronotherapy with a fixed combination of amlodipine, lisinopril and rosuvastatin on the psychological state in elderly hypertensive patients with metabolic syndrome

2021 ◽  
Vol 27 (5) ◽  
pp. 536-545
Author(s):  
N. M. Agarkov ◽  
O. I. Okhotnikov ◽  
S. I. Korneeva ◽  
E. O. Moskaleva ◽  
A. A. Moskalev ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Depressive Disorders ◽  
Fixed Combination ◽  
Controlled Trial ◽  
Cognitive Disorders ◽  
Anxiety Score ◽  
Psychological State ◽  
Control Group ◽  
Traditional Use ◽  
Double Blind

Background. Hypertension (HTN) in metabolic syndrome (MS) in the elderly contributes to the formation of cognitive disorders and anxiety-depressive disorders. Objective. To study the psychological state of elderly patients with HTN and MS treated by evening versus morning dosing of a fixed combination (FC) of amlodipine, lisinopril and rosuvastatin. Design and methods. In a randomized, double-blind, controlled trial 63 patients aged 60–74 years with HTN and MS received a FC of amlodipine, liiznopril and rosuvastatin at a dose of 5/10/10 mg in the evening (after 20:00 hours) (study group) And 58 patients aged 60–74 years with HTN and MS took the drug in the morning (control group). Cognitive dysfunction was assessed by Mini-Mental State Examination (MMSE), anxiety and depressive disorders were assessed by State-Trait Anxiety Inventory adapted by Yu. Khanin and scale of the Center for Epidemiologic Studies-Depression (CES-D). Results. In evening dosing group, MMSE result increased from 17,8 ± of 0,3 to 23,5 ± 0,4 points (р = 0,13) vs. 16,9 ± of 0,3 to 20,4 ± 0,4 points (р = 0,148) in morning dosing. Situational anxiety score decreased from 40,0 ± 2,2 to 30,6 ± 1,8 points (р = 0,009) vs. from 40,8 ± of 2,5 to 33,5 ± 1,9 points (р = 0,011), and personal anxiety score from 48,8 ± 2,0 to 26,4 ± of 1,9 points (р = 0,003) and from 44,9 ± of 1,9 to 30,7 ± of 1,7 points (р = 0,008) in evening and morning dosing, respectively. Depressive disorders decreased similarly and slightly in both groups (14,1% versus 7,7% in evening and morning dosing, respectibely, p = 0,214). Conclusions. The results indicate that chronotherapy is more effective than the traditional use of a FC of amlodipine, lisinopril and rosuvastatin in HTN associated with MS.

scholarly journals Psychological continuum of elderly hypertensive patients with metabolic syndrome receiving chronotherapy with a fixed-dose combination of amlodipine, lisinopril and rosuvastatin

2021 ◽  
Vol 26 (2) ◽  
pp. 4312
Author(s):  
N. M. Agarkov ◽  
O. I. Okhotnikov ◽  
S. I. Korneeva ◽  
E. O. Moskaleva ◽  
A. A. Moskalev ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Depressive Disorders ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Control Group ◽  
Hypertensive Patients ◽  
Psychological Continuum ◽  
Dose Combination ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients

Aim. To study the psychological continuum of elderly hypertensive patients with metabolic syndrome (MS) receiving chronotherapy with a fixed-dose combination of amlodipine, lisinopril and rosuvastatin.Material and  methods. In a  clinical setting, 63 hypertensive  patients with MS aged 60-74 years (experimental group) received chronotherapy with fixed-dose combination of amlodipine, lisinopril and rosuvastatin (Ekvamer®) at a dose of 5/10/10 mg in the evening (8 pm). The control group of hypertensive patients with MS aged 60-74 years old (n=58) received Ekvamer® in the morning (conventional therapy) at the same dosage.Results. With fixed-dose combination of amlodipine, lisinopril and rosuvastatin, the severity of psychological continuum abnormalities significantly decreases after 1 year in the chronotherapy regimen (evening intake) than with morning intake with an equivalent dosage of 5/10/10 mg per day in both cases. The dynamics of cognitive impairments in hypertensive patients aged 60-74 years with MS using chronotherapy regimen is characterized by a significant increase  in  the  mean MMSE score from the initial 17,8±0,3 to 23,5±0,4 points (p±0,001) vs 16,9±0,3 to 20,4±0,4 points (p<0,001) when taking the drug in the morning. Situational anxiety decreased from 40,0±2,2 to 30,6±1,8 points (p<0,05) vs 40,8±2,5 to 33,5±1,9 points (p<0,05), personal anxiety from 48,8±2,0 to 26,4±1,9 (p<0,001) vs from 44,9±1,9 to 30,7±1,7 (p<0,01) points, respectively. Depressive disorders slightly decreased with chronotherapy (14,1%) vs 7,7% than with the conventional scheme, but despite this, they corresponded to depressive spectrum disorders in both groups.Conclusion. The results obtained indicate a greater efficiency of chronotherapy than the conventional use of fixed-dose combination of amlodipine, lisinopril and rosuvastatin in hypertensive patients with MS.

Psychological status of elderly patients suffering arterial hypertension in metabolic syndrome against the background of chronotherapy

2021 ◽  
Vol 23 (2) ◽  
pp. 59-66
Author(s):  
Nikolai M. Agarkov ◽  
Oleg I. Okhotnikov ◽  
Snezhana I. Korneeva ◽  
Ekaterina O. Moskaleva ◽  
Alexander A. Moskalev ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Depressive Disorders ◽  
Fixed Combination ◽  
Cognitive Disorders ◽  
The Elderly ◽  
Psychological Status ◽  
Average Score ◽  
Traditional Use ◽  
The Metabolic Syndrome

Arterial hypertension in the metabolic syndrome in the elderly contributes to the formation of cognitive disorders and anxiety-depressive disorders. It is shown that the severity of these deviations of the psychological continuum significantly decreases after 1 year, under the influence of an antihypertensive fixed combination of amlodipine, mesinopril and rosuvastatin in the chronotherapy mode (evening reception), than in the traditional application (morning reception in the equivalent dosage of 5/10/10 mg per day in both cases. The dynamics of cognitive impairment in chronotherapeutical approach in patients 6074 flights from arterial hypertension with metabolic syndrome is characterized by a significant increase in the average score on a scale MMSE, f source 17.8 0.3 to 23.5 0.4 points (р 0.001), against 16.9 0.3 to 20.4 0.4 points (р 0.001) in the morning taking the drug. Situational anxiety decreased from 40.8 2.2 to 30.6 1.8 points (р 0.05) and from 40.0 2.5 to 32.1 2.0 points (р 0.05), personal anxiety from 48.8 2.0 to 25.4 1.9 (р 0.001) and from 44.9 1.9 to 30.7 1.7 (р 0.01) points in the evening and morning the reception, respectively. Depressive disorders decreased slightly more significantly in chronotherapy (14.1% vs. 7.7%) than in the traditional scheme, but despite this, both cases with (groups) corresponded to depressive spectrum disorders. The results obtained indicate that chronotherapy is more effective than the traditional use of a fixed combination of amlodipine, lisinopril and rosuvastatin in arterial hypertension with metabolic syndrome.

Age-associated features of the development of fibrosis and inflamaging in patients with arterial hypertension and ischemic stroke

2022 ◽  
pp. 879-884
Author(s):  
О.А. Осипова ◽  
Е.В. Гостева ◽  
О.Н. Белоусова ◽  
Н.И. Жернакова ◽  
Н.И. Клюшников ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Old Age ◽  
Control Group ◽  
Cerebral Stroke ◽  
Middle Aged ◽  
Aged Patients ◽  
Tnf Α ◽  
Immune Inflammation

В статье рассмотрены вопросы развития фиброза и иммунного воспаления у больных артериальной гипертензией (АГ) с острым ишемическим инсультом (ИИ) в пожилом возрасте. Цель исследования - изучение возраст-ассоциированных особенностей концентрации маркеров фиброза (металлопротеиназы-9, тканевого ингибитора матриксных металлопротеиназ-1, их соотношения ММП-9/ТИМП-1), иммунного воспаления (TNF-α, IL-1β, INF-γ) у больных АГ с ИИ. В исследование были включены 86 больных АГ II степени, из которых 42 человека - среднего возраста (53±5 лет) и 44 - пожилого (66±5 лет), контрольную группу составили 22 пациента пожилого возраста с АГ без ИИ в анамнезе. Критерии включения - пациенты с АГ, поступившие в стационар в остром периоде первого церебрального инсульта. Установлено, что у пожилых больных АГ с ИИ показатели инфламэйджинга и маркеры фиброза были достоверно выше, чем у лиц среднего возраста. Уровень IL-1β был выше на 31,7 % (р<0,01), TNF-α - на 55,7 % (р<0,001), INF-γ - на 36,6 % (р<0,01), уровень ММП-9 - на 46,4 % (р<0,01), ТИМП-1 - на 21,2 % (р<0,01), ММП-9/ТИМП-1 - на 19,6 % (р<0,01) в пожилом возрасте по сравнению с больными среднего возраста с АГ и острым ИИ. Таким образом, установлено, что больные АГ с ИИ имеют нарушения процессов инфламейджинга, синтеза и деградации внеклеточного матрикса, особенно выраженные в пожилом возрасте. The article deals with the development of fibrosis and immune inflammation in patients with arterial hypertension and acute ischemic stroke in old age. The aim of the study was to study age-associated features of the concentration of fibrosis markers (metalloproteinase-9, tissue inhibitor of matrix metalloproteinases-1, their ratio MMP-9/TIMP-1), immune inflammation (TNF-α, IL-1β, INF-γ) in patients with arterial hypertension and ischemic stroke (AI). The study included 86 patients with arterial hypertension (AH) of the 2nd degree, of which 42 were middle-aged (53±5 years) and 44 elderly (66±5 years). The control group consisted of 22 elderly patients with AH without a history of AI. The criteria for inclusion in the study are patients with hypertension who were admitted to the hospital in the acute period of the first cerebral stroke. It was found that in elderly patients with hypertension with AI, the indicators of inflamaging and fibrosis markers were significantly higher than in middle-aged people. The level of IL-1β was 31,7 % higher (p<0,01), TNF-α by 55,7 % (p<0,001), INF-γ by 36,6 % (p<0,01), the level of MMP-9 was 46,4 % higher (p<0,01), TIMP-1 by 21,2 % (p<0,01), MMP-9/TIMP-1 by 19,6 % (p<0,01) in the elderly compared to middle-aged patients with hypertension and acute AI. Thus, it was found that patients with arterial hypertension and ischemic stroke have violations of the processes of inflamaging, synthesis and degradation of the extracellular matrix, especially pronounced in old age.

scholarly journals Effects of Flaxseed Oil Consumption on Anthropometric Parameters in the Patients with Metabolic Syndrome: A Randomized Clinical Trial

2017 ◽  
Vol 6 (1) ◽  
pp. 44-51
Author(s):  
Atefeh Akrami ◽  
Farzad Nikaein ◽  
Siavash Babajafari ◽  
Shiva Faghih ◽  
Mohammad Javad Zibaeenejad
Keyword(s):  
Metabolic Syndrome ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Sunflower Oil ◽  
Flaxseed Oil ◽  
Control Group ◽  
Alpha Linolenic Acid ◽  
Anthropometric Parameters ◽  
Anthropometric Measures ◽  
Study Results

Background: Flaxseed oil, as the main source of Alpha linolenic acid (ALA), decreases the production of Arachidonic acid (AA) from linoleic acid (LA) that plays an important role in the development of metabolic syndrome (MS). The aim of the present study was to compare the effects of flaxseed oil and sunflower oil on anthropometric parameters in patients suffering from MS. Materials and Methods: In this randomized clinical trial, 60 participants aged 30-60 years who suffered from MS were selected according to ATP III definition and were divided into two even groups receiving flaxseed oil and sunflower oil. Each group received 25 ml of the specified oil on a daily basis for 7 weeks. The anthropometric measures were evaluated on the first and last days of the study. Results: No significant differences were observed between the two groups regarding weight. However, waist circumference reduced significantly in the flaxseed oil group compared to the control group (P=0.001). Conclusions: The ALA might prevent the increase in adipose tissues. Therefore, it seems that flaxseed oil has beneficial effects on MS. [GMJ.2017;6(1):44-51]

scholarly journals Outpatient COVID-19 Pneumonia In Elderly Patients In Kazakhstan

2021 ◽  
Author(s):  
Essetova G. U. ◽  
Idrissova L.R ◽  
Muminov T.A
Keyword(s):  
Elderly Patients ◽  
Arterial Hypertension ◽  
Clinical Features ◽  
Disseminated Intravascular Coagulation ◽  
Blood Platelets ◽  
Community Acquired Pneumonia ◽  
Control Group ◽  
Saturation Indices ◽  
Complex Therapy ◽  
Ct Data

Abstract COVID pneumonia is difficult to manage in elderly patients over 65 years of age.The aim of the study was to determine the clinical features of the course of COVID pneumonia in a cohort of patients over 65 years old.Materials and methods: We observed patients with community-acquired pneumonia, of whom PCR positive for COVID were 33 patients, mean age 67.6 ± 12 years, men – 11, women – 22; 16 patients had no confirmed virus (COVID PCR negative), mean age 65.5 ± 8.2 years, 7 women and 9 men.Examination results: in the group of COVID patients, the disease more often proceeded according to the type of bilateral polysegmental pneumonia according to CT data, with severe monocytosis, с thrombocytosis and transient increase in creatinine, which required the appointment of intensive anticoagulant therapy. Arterial hypertension was observed in the majority of people. In the control group (PCR -), pneumonia proceeded predominantly as bronchopneumonia, saturation indices were approximately the same in both groups. COVID patients had significantly higher levels of monocytes, blood platelets, CRP, creatinine levels, including arterial hypertension was more common.Conclusion: COVID pneumonia in elderly patients proceeds as multisegmented bilateral pneumonia with moderate disseminated intravascular coagulation syndrome, which is well controlled due to complex therapy with anticoagulants and antibiotics.

scholarly journals Informative significance of serum cytokines and their importance for development of metabolic syndrome with arterial hypertension in elderly persons

2021 ◽  
Vol 23 (2) ◽  
pp. 303-310
Author(s):  
N. M. Agarkov ◽  
V. I. Kolomiets ◽  
S. I. Korneeva ◽  
E. O. Moskaleva ◽  
K. F. Makkonen
Keyword(s):  
Metabolic Syndrome ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Proinflammatory Cytokines ◽  
Research Society ◽  
Malignant Neoplasms ◽  
Elderly Persons ◽  
Public Health Challenges ◽  
Anti Inflammatory ◽  
Reliable Differentiation

Metabolic syndrome (MS) is among the main public health challenges worldwide, leading to significant labor losses, increased costs for treatment and rehabilitation of the patients. The aim of the present study was to identify the informative serum interleukins, by determining the odds ratio in elderly patients with MS and hypertension. The main group of 86 patients with MS and arterial hypertension (AH) aged 60-75 years was examined under clinical conditions. The inclusion criteria were as follows: age of 60-75 years, presence of MS, primary hypertension (grade II-III), absence of acute myocardial infarction, malignant neoplasms, disorders of cerebral circulation, kidney failure over last 6 months. Diagnostics of MS and hypertension was carried out in accordance with Expert Guidelines from the Russian Research Society of Cardiology on the MS Diagnosis and Treatment. Our first study of a large range of serum interleukins in elderly patients with MS and hypertension allowed us to reveal the inversely directed changes in pro- and anti-inflammatory cytokine contents. Combined AH/MS in elderly persons is accomplished by sufficient increase of the most proinflammatory cytokines, and vice versa, by significant decrease in anti-inflammatory cytokines in blood serum. This finding clearly points to importance of immunological regulatory systems for initiation of AH with MS at older age. Pro- and anti-inflammatory serum interleukins are actively involved into the AH/MS development in elderly accompanied by their pronounced imbalance. The mentioned immune reactions could underlie the MS/AH condition. High risk of this disorder is connected with changed production of proinflammatory cytokines (IL-8, IL-1β), like as anti-inflammatory serum interleukins (IL-4, IL-10), with predominance of the former. The above interleukins should be considered dominant diagnostic markers of AH/MS in elderly persons. Measurement of serum interleukins and discriminant-based approach allows highly reliable differentiation of elderly patients with AH/MS from similar individuals without this disorder. 

scholarly journals The influence of antyhypertensive therapy of valsartan and fixed combination with hydrochlorothiazide use on pulse-wave velocity and central arterial pressure in patients with arterial hypertension of 1-2 grades in international VICTORY clinical trial

2018 ◽  
Vol 15 (2) ◽  
pp. 6-13 ◽  
Author(s):  
I E Chazova ◽  
T V Martynyuk ◽  
R Accetto ◽  
Yu N Sirenko ◽  
J Vincelj ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Arterial Pressure ◽  
Pulse Wave Velocity ◽  
Arterial Hypertension ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Fixed Combination ◽  
Randomized Clinical Study ◽  
Study Results ◽  
The Impact

Objective - to explore influence of valsartan monotherapy use and its use in combination with hydrochlorothiazide (HCTZ) on pulse-wave velocity (PWV) and central arterial pressure (CAP) in patients with arterial hypertension (AH) of 1-2 grades in international VICTORY clinical trial. Materials and methods. The international multicenter prospective randomized clinical study VICTORY that lasted for 16 weeks included patients with 1-2 grades AH. In patients who previously received antihypertensive therapy a 7 days washout period was carried out. All patients started their therapy with 80 mg valsartan (Valsacor®, KRKA, Slovenia); in Russia the starter dose of Valsacor®, KRKA was 160 mg in previously treated patients that did not influence the study results. If after 4 weeks of treatment BP was more than 140/90 mm hg (more than 130/80 mm hg in high risk patients or in diabetes mellitus patients) the dose of valsartan was increased to 160 mg (320 mg in Russia) or diuretic in fixed combination with valsartan was added (160 mg valsartan/12.5 mg HCTZ): Valsacor® H 160 (KRKA, Slovenia). If target BP after 8 weeks of treatment was not reached valsartan dose was increased to 320 mg or fixed combination of valsartan and diuretic (160 mg/12.5 mg) was used. If target BP after 12 weeks of treatment was not reached - valsartan and diuretic 320 mg/12.5 mg were used. PWV and CAP (SphygmoCor®, AtCorMedical) were assessed at baseline and after 16 weeks of treatment. The primary endpoints were assessment of the impact of studied medications on aortic stiffness, aortic augmentation index and comparison of absolute medians of reached central and peripheral BP reduction with baseline value. Results. Of 365 patients included in the study 74 were included in PWV and CAP study subgroup. Valsartan and its combination with HCTZ were effective in CBP reduction. The mean absolute reduction of central systolic and diastolic BP after 16 weeks of treatment was 19.7±12.9 mm hg and 13.9±8.5 mm hg, respectively (р

Blood pressure time load formation in patients with arterial hypertension without metabolic syndrome

2021 ◽  
Vol 25 (4) ◽  
pp. 282-289
Author(s):  
Tatjana Yu. Zotova ◽  
Anastasiya A. Lukanina ◽  
Mikhail L. Blagonravov
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Pressure Profile ◽  
Control Group ◽  
Double Product ◽  
Nocturnal Blood Pressure ◽  
Blood Pressure Profile ◽  
Pressure Time ◽  
Structural Point

Relevance . The study of the daily dynamics of blood pressure in arterial hypertension both on the basis of the daily index and on the basis of the time load is a relevant task, since, these indicators are associated in the literature with stable changes in the neurohumoral regulation of the cardiovascular system in arterial hypertension . The aim of the study was to compare data of the time load in patients with arterial hypertension , depending on the nocturnal blood pressure profile, with integrative indicators of the activity of the cardiovascular system in the form of a Circadian index, a structural point of blood pressure, double product. Materials and Methods. The study included 72 patients who were treated at the City Clinical Hospital No 13 in Moscow and signed a voluntary consent to participate in the research and the processing of personal data. Inclusion criteria: arterial hypertension. Exclusion criteria: metabolic syndrome, secondary forms of arterial hypertension and concomitant pathology. Depending on the daily index (DI10% and DI10%) patients were divided into 2 groups: 1 group (N= 32): patients with arterial hypertension without nocturnal decrease in blood pressure (non-dippers and night-pickers100%); Group 2 (N = 40): patients with arterial hypertension who had a nocturnal decrease in blood pressure (dippers and over dippers 100%). All patients and members of the control group (N=15) underwent daily monitoring of blood pressure (24-hour Arterial Blood Pressure Monitoring). The data were statistically processed to determine the 5% level of significance of differences (p0.05) (Students test). In the comparative analysis of integrative indicators at day and at night, a variance analysis was applied. Results and Discussion . As a result of the study, it was found that the values of Circadian Index for blood pressure vary depending on the type of night decrease in blood pressure and the blood pressure time load, while daily index and structural point of blood pressure remain on the same level as a reflection of the hemodynamic allostasis existing in both groups. Conclusion. Reflection of the allostatic load on hemodynamics is change of values of double product and of the structural point of blood pressure compared with the control group. These changes are not associated with the peculiarities of the nocturnal blood pressure profile in patients with hypertension without metabolic syndrome.

scholarly journals Prevalence of Metabolic Syndrome and Risk Factors for Cardiovascular Disease in Hemophilia Patients Compared to a Control Group in South Khorasan, Iran

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Toba Kazemi ◽  
Masood Ziaee ◽  
Samira Elhamirad
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Healthy Subjects ◽  
Coagulation Factors ◽  
Control Group ◽  
Blood Coagulation Factors ◽  
Significance Level ◽  
Study Results ◽  
Significant Difference

Background: Hemophilia is a rare inherited sex-linked disease caused by the deficiency or lack of some blood coagulation factors. The severity varies depending on the levels of these factors in the blood. Objectives: Therefore, this study aimed at determining the prevalence of metabolic syndrome and risk factors of cardiovascular disease in patients with hemophilia compared to a control group in 2015. Methods: A case-control study was done on all hemophilia patients referring to the Birjand University of Medical Sciences (n = 91). Healthy subjects with no hemophilia were selected using systematic random sampling from healthy individuals in Birjand City, who were matched in terms of age and sex. The data were entered into SPSS19 software. The significance level of less than 0.05 was considered in this study. Results: The mean age was 34.11 ± 14.68 and 33.72 ± 13.46 years in the case and control groups, respectively. The rate of metabolic syndrome was 12.1% in the control group and 4.4% in the hemophilia group. The results of Mann-Whitney U test showed a significant difference between the two groups in terms of TG (P = 0.016) and LDL (P < 0.001), and the waist circumference was significantly higher (P = 0.001) in the control group than in the hemophilia group. Conclusions: In the present study, the prevalence of metabolic syndrome was significantly lower among hemophilia patients than in the control group. The prevalence of diabetes and hypertriglyceridemia was significantly lower in hemophilia patients than in the control group (healthy subjects).

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