scholarly journals Prevalence of Metabolic Syndrome and Risk Factors for Cardiovascular Disease in Hemophilia Patients Compared to a Control Group in South Khorasan, Iran

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Toba Kazemi ◽  
Masood Ziaee ◽  
Samira Elhamirad
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Healthy Subjects ◽  
Coagulation Factors ◽  
Control Group ◽  
Blood Coagulation Factors ◽  
Significance Level ◽  
Study Results ◽  
Significant Difference

Background: Hemophilia is a rare inherited sex-linked disease caused by the deficiency or lack of some blood coagulation factors. The severity varies depending on the levels of these factors in the blood. Objectives: Therefore, this study aimed at determining the prevalence of metabolic syndrome and risk factors of cardiovascular disease in patients with hemophilia compared to a control group in 2015. Methods: A case-control study was done on all hemophilia patients referring to the Birjand University of Medical Sciences (n = 91). Healthy subjects with no hemophilia were selected using systematic random sampling from healthy individuals in Birjand City, who were matched in terms of age and sex. The data were entered into SPSS19 software. The significance level of less than 0.05 was considered in this study. Results: The mean age was 34.11 ± 14.68 and 33.72 ± 13.46 years in the case and control groups, respectively. The rate of metabolic syndrome was 12.1% in the control group and 4.4% in the hemophilia group. The results of Mann-Whitney U test showed a significant difference between the two groups in terms of TG (P = 0.016) and LDL (P < 0.001), and the waist circumference was significantly higher (P = 0.001) in the control group than in the hemophilia group. Conclusions: In the present study, the prevalence of metabolic syndrome was significantly lower among hemophilia patients than in the control group. The prevalence of diabetes and hypertriglyceridemia was significantly lower in hemophilia patients than in the control group (healthy subjects).

Serum Retinol and β-carotene Levels and Risk Factors for Cardiovascular Disease in Morbid Obesity

2010 ◽  
Vol 80 (3) ◽  
pp. 159-167 ◽  
Author(s):  
Gabriela Villaça Chaves ◽  
Gisele Gonçalves de Souza ◽  
Andréa Cardoso de Matos ◽  
Dra. Wilza Abrantes Peres ◽  
Silvia Elaine Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Morbid Obesity ◽  
Serum Levels ◽  
World Health ◽  
Morbidly Obese ◽  
Serum Retinol ◽  
Significant Difference ◽  
Β Carotene

Objective: To evaluate retinol and β-carotene serum levels and their relationship with risk factors for cardiovascular disease in individuals with morbid obesity, resident in Rio de Janeiro. Methodology: Blood serum concentrations of retinol and β-carotene of 189 morbidly obese individuals were assessed. The metabolic syndrome was identified according to the criteria of the National Cholesterol Education Program (NCEP) and World Health Organization (WHO). Lipid profile, insulin resistance, basal insulin, glycemia, blood pressure, and anthropometry and their correlation with retinol and β-carotene serum levels were evaluated. Results: Metabolic syndrome diagnosis was observed in 49.0% of the sample. Within this percentage the levels of β-carotene were significantly lower when body mass index increased. Serum retinol didn't show this behavior. Serum retinol inadequacy in patients with metabolic syndrome (61.3%), according to WHO criterion, was higher (15.8%) than when the whole sample was considered (12.7%). When metabolic syndrome was diagnosed by NCEP criterion, β-carotene inadequacy was higher (42.8%) when compared to the total sample (37.5%). There was a significant difference between average β-carotene values of patients with and without metabolic syndrome (p=0.048) according to the classification of the NCEP. Lower values were found in patients with metabolic syndrome. Conclusion: Considering the vitamin A contribution in antioxidant protection, especially when risk factors for cardiovascular disease are present, it is suggested that great attention be given to morbidly obese. This could aid in prevention and treatment of cardiovascular disease, which affects a significant part of the population.

scholarly journals Vitamin K2 Supplementation Does Not Affect Vitamin K-Dependent Coagulation Factors Activity in Healthy Subjects: A Pilot Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1843-1843
Author(s):  
Jing Tan ◽  
Ruijun Ren ◽  
Dan Xu
Keyword(s):  
Vitamin K ◽  
Healthy Subjects ◽  
Coagulation Factors ◽  
Vitamin K2 ◽  
Control Group ◽  
Healthy Population ◽  
Thrombin Time ◽  
Healthy Individuals ◽  
Significant Difference ◽  
Healthy Control

Abstract Objectives Vitamin K is generally regarded as a procoagulant drug with physicians, concerns have been raised about its effects on hemostasis in the healthy population. We aimed to investigate whether vitamin K2 affects activities of individual vitamin K dependent coagulation factors in healthy individuals without anticoagulation treatment. Methods Forty healthy volunteers between 25 and 40 years old were recruited. They received 90 μg of vitamin K2 every day for 30 days. Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalized ratio (INR), fibrinogen (FIB) levels and blood coagulation factors II, VII, IX, and X activity levels (F II : C, FⅦ : C, FⅨ : C,FⅩ : C), protein induced by vitamin K absence or antagonist-II (PIVKA-II), which is uncarboxylated prothrombin were measured at day 0, and day 30 after vitamin K2 administration. Plasma diluted 1:10 from vitamin K2 group and healthy control group were assayed for the activity of factors II, VII, IX, and X. Results PT, APTT, TT, and FIB did not show significant difference at day 30 when compared with baseline. The activities of coagulation factors II, VII, IX, and X was not significantly different with baseline (97.28 ± 12.42% vs. 99.96 ± 10.24%, P = 0.24 for F II: C; 76.12 ± 15.82% vs. 76.40 ± 12.33%, P = 0.92 for FⅦ: C; 97.65 ± 13.98% vs. 99.65 ± 13.30%, P = 0.47 for FⅨ: C; 89.18 ± 10.76% vs. 92.01 ± 10.46%, P = 0.1 for FⅩ: C) . PIVKA-II levels were not changed with 30 days vitamin K2 supplementation (21.62 ± 3.21 vs. 23.87 ± 2.65 mAU/ml, P = 0.16). After 30 days vitamin K2 administration, factor II, Ⅶ, Ⅸ, and Ⅹ activity of plasma diluted up to 10 times were proportionally decreased, and did not show significant difference with the healthy control without vitamin K2 exposure (10.32 ± 1.24% vs. 10.97 ± 1.55%, P = 0.38 for F II: C; 9.52 ± 2.94% vs. 9.14 ± 1.79%, P = 0.68 for FⅦ: C; 11.78 ± 2.12% vs.11.65 ± 1.54%, P = 0.87 for FⅨ: C; 8.22 ± 1.28% vs. 8.92 ± 1.13%, P = 0.21 for FⅩ: C). Conclusions Vitamin K2 supplementation at recommended dosage does not affect vitamin K-dependent coagulation factors activity in healthy subjects. Uncarboxylated prothrombin (PIVKA-II) in healthy individuals is not decreased with vitamin K supplementation. Funding Sources None.

scholarly journals Pola makan berhubungan dengan sindrom metabolik pada lanjut usia di Poliklinik Geriatri RSUP Sanglah Denpasar

2010 ◽  
Vol 6 (3) ◽  
pp. 105
Author(s):  
IGA Sagung Kusuma Dewi ◽  
I Dewa Putu Pramantara ◽  
Retno Pangastuti
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Multivariate Analysis ◽  
The Elderly ◽  
Control Group ◽  
Chi Square ◽  
Eating Pattern ◽  
Significant Difference ◽  
And Gender ◽  
Obesity Hypertension

Background: Food intake is a factor determining health status and risk for degenerative diseases including metabolic syndrome. The fundamental function of someone’s nutritional status in the process of the emergence of generative disease and metabolic syndrome can be identified through the effect of food to the prevalence of obesity, hypertension, dyslipidemia or glucose tolerance disorder.Objective: To identify the association between eating pattern and the prevalence of metabolic syndrome among the elderly at Geriatric Polyclinic of Sanglah Hospital Denpasar.Method: The study was analytic observational with matched case control study design using ratio 1:1. There were 80 samples consisting of 40 as control group and 40 as cases matched by age and gender. Eating pattern was identified through food frequency questionnaire and calculated and compared to the need. Statistical analysis used chi square and risk factors were measured using odds ratio (OR). Multivariate analysis used double logistic regression to find out risk factors dominantly affected metabolic syndrome.Result: The result of bivariate statistical test showed significant difference in the prevalence of metabolic syndrome (p < 0.05) for energy intake (OR: 9.1; CI95%: 1.9-43.8), protein (OR: 3.8; CI95%: 1.5-9.7), fat (OR: 3.8; CI95%: 1.1-13.2), carbohydrate (OR:11.4; CI95%: 2.3-54.2). The result of multivariate analysis showed that the variables having dominant risk and significant difference in the prevalence of metabolic syndrome were carbohydrate consumption (OR: 8.1; CI95%: 1.29–50.89), fat consumption (OR: 4.9; CI95%: 1.17-20.61) and protein consumption (OR: 3.9; CI95%: 1.27-12.30).Conclusion: There was difference in eating pattern, i.e. high consumption of carbohydrate, fat and protein which became risk factor for the prevalence of metabolic syndrome among the elderly at Geriatric Polyclinic of Sanglah Hospital Denpasar.

scholarly journals Influence of diabetes mellitus on corneal thickness

2014 ◽  
Vol 142 (9-10) ◽  
pp. 529-534 ◽  
Author(s):  
Ivan Sencanic ◽  
Miroslav Stamenkovic ◽  
Vesna Jovanovic ◽  
Sinisa Babovic ◽  
Vesna Jaksic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Healthy Subjects ◽  
Corneal Thickness ◽  
Ultrastructural Changes ◽  
Control Group ◽  
Diabetic Patients ◽  
Ophthalmological Examination ◽  
Study Results ◽  
Significant Difference

Introduction. Ultrastructural changes in corneas of patients with diabetes mellitus have been previously described. Objective. The aim of this study was to compare central corneal thickness (CDR) values in diabetic patients without retinopathy at the stage of diabetic nonproliferative and proliferative retinopathy and CDR in a control group of healthy subjects. Methods. The study included 121 diabetic patients and 125 healthy subjects matched according to gender and age. Each patient underwent ophthalmological examination involving a dilated fundus examination and CDR measurement using the ultrasound pachymeter. The eyes of diabetic patients were classified according to Early Treatment Diabetic Retinopathy Study into three groups: without diabetic retinopathy (NDR), with nonproliferative diabetic retinopathy (NPDR) and a group with proliferative diabetic retinopathy (PDR). Only one eye of each subject was chosen for the study. Results. The mean CDR value was significantly higher in the diabetic group (570.52?31.81 ?m) compared with the control group (541.42?27.82 ?m). The difference between the two groups was statistically significant (p<0.0001). The highest mean CDR value was recorded in the PDR group (585.97?28.58 ?m), followed by the NPDR group (570.84?30.27 ?m), whereas the lowest mean CDR value was recorded in the NDR group (559.80?31.55 ?m). There was a statistically significant difference in CDR between the NDR and PDR groups, as well as between the NPDR and PDR groups (p<0.001, p<0.05 respectively). No significant difference was recorded between the NDR and NPDR groups (p>0.05). Conclusion. CDR of diabetic patients was higher compared to healthy subjects. The highest mean value of CDR was registered in the PDR group, followed by the NPDR and the NDR groups.

Association of high mobility group box 1 protein with coronary artery disease

2019 ◽  
Vol 27 (4) ◽  
pp. 251-255 ◽  
Author(s):  
Necla Benlier ◽  
Mustafa Bilge Erdoğan ◽  
Serdar Keçioğlu ◽  
Nuri Orhan ◽  
Hülya Çiçek
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Subjects ◽  
High Mobility ◽  
High Mobility Group ◽  
Control Group ◽  
Protein Levels ◽  
Significant Difference ◽  
Artery Disease

Background Recently, the role of inflammation in coronary artery disease and the association of inflammatory biomarkers with adverse outcomes have been investigated in many studies. We investigated the relationship between high serum mobility group box 1 protein levels and established risk factors for coronary artery disease. Methods Fifty-five patients who presented to our Cardiovascular Surgery Clinic and subsequently underwent coronary artery bypass surgery for coronary artery disease and 50 healthy subjects presenting to the cardiology outpatient clinic without any cardiovascular problem were included in the study. The mean age was 61.47 ± 9.38 years for patients and 58.20 ± 10.15 years for controls. Results There was no statistically significant difference between groups with respect to age or sex. Family history of coronary artery disease, aspirin use, hypertension, and type 2 diabetes were significantly more prevalent in the patient group versus the control group. A significant difference was found between patients and healthy controls with respect to high mobility group box 1 protein levels ( p = 0.001). Conclusions Serum high mobility group box 1 protein was significantly increased in patients with coronary artery disease in comparison to healthy subjects. No associations were found between high mobility group box 1 protein level and certain risk factors for coronary artery disease.

scholarly journals Analysis on the effects of folk dance training on players’ spatial expectation levels

2019 ◽  
Vol 23 (5) ◽  
pp. 249-255
Author(s):  
M. Kaya ◽  
A. Yilmaz
Keyword(s):  
Spatial Perception ◽  
Study Groups ◽  
Control Group ◽  
Folk Dance ◽  
Control Groups ◽  
Significance Level ◽  
Dance Training ◽  
Study Results ◽  
Significant Difference ◽  
Folk Dancing

Background and Study Aim: The purpose of this study was to investigate the effects on spatial perception and spatial anticipation levels the effects of control and study groups with 16 week training folk dancing training. Material and Methods: 120 voluntary college students with no folk dancing background, 60 of which is female has participated in the study. The study group had folk dancing training of 16-week whereas control group has not done any training. Brixton Spatial Expectations test was administered to control groups at the first, eighth and sixteenth weeks of the training. Validation of which has previously been done "Prospects Brixton Spatial Test" has been used in the study. A statistical analysis of the data obtained was done with available statistical software (IBM SPSS Statistics 19, SPSS inc., An IBM Co., Somers, NY) and the significance level was taken as 0.05 and 0.01. Similar results were obtained between experimental and control groups in this study. Results: There were not significant differences between groups in terms of measurement time as well as in gender. As a result: Short-term training of folk dancing seems to have no impact on the level of spatial perception. Conclusions: To have a significant effect, a long-term folk dance training is required. In addition, level of spatial perception on folk dance training has no significant difference in terms of gender.

scholarly journals The Effect of Selected Yoga Exercises on Thoracic Spine Alignment and Respiratory Capacity in Children With Asthma

2021 ◽  
pp. 85-92
Author(s):  
Mahbobeh Ahmadi Recabdar ◽  
◽  
Parisa Sedaghati ◽  
Keyword(s):  
Thoracic Spine ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Respiratory Capacity ◽  
Significance Level ◽  
Breathing Exercises ◽  
Study Results ◽  
Significant Difference ◽  
Group 15 ◽  
Children With Asthma

Introduction: People with asthma often have sedentary lifestyles and are less physically, mentally, and cardio-respiratory prepared than their peers. Therefore, the present study aimed to investigate the effect of selected Yoga exercises on thoracic spine alignment and respiratory capacity indices in children with asthma. Methods: The present research is a quasi-experimental study with a pretest-posttest design. For this purpose, 30 children with mild asthma were included in the study purposefully and voluntarily. The subjects were randomly divided into a control group (15 people with mean [SD] age: 11.40 [ 2.13] years) and an experimental group (15 people with mean [SD] age: 10.60 [1.76] years). Written informed consent was obtained from the parents of the children. Flexible ruler and spirometry were used to evaluate the curvature of the thoracic spine and respiratory capacity, respectively. To analyze the results of this study, we used a dependent t test and analysis of covariance at a significance level of P<0.05. Results: The present study results showed a significant difference between the thoracic spine curvature (P = 0.001) and increased respiratory capacity (P = 0.001). Conclusion: Breathing exercises and asanas of Yoga positively influence the extensor muscles of the chest and improve lung function and postural misalignment in children with asthma. Therefore, therapists, coaches, and exercise teachers are recommended to use Yoga exercises to improve the physical, postural, and respiratory indices of children with asthma.

Natural Oestrogen in the Female Climacteric - Influence on Blood Coagulation and Fibrinolysis

1978 ◽  
Vol 40 (02) ◽  
pp. 532-541 ◽  
Author(s):  
Anders Lagrelius ◽  
Nils-Olov Lunell ◽  
Margareta Blombäck
Keyword(s):  
Blood Coagulation ◽  
Antithrombin Iii ◽  
Coagulation Factors ◽  
Control Group ◽  
Blood Coagulation Factors ◽  
Excessive Bleeding ◽  
Oestrone Sulphate ◽  
Menopausal Women ◽  
History Of ◽  
Coagulation And Fibrinolysis

SummaryThe aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. Scopolamine was given to the control group.The women were investigated before and during treatment with regard to factors VIII, VII, X, V, fibrinopeptide A, antithrombin III, plasminogen, rapid antiplasmin and α1-antitrypsin. There was no significant change towards hypercoagulability or decreased fibrinolysis in any group. In the oestrogen group, however, a tendency towards an increased level of plasminogen and a decreased level of antiplasmin was demonstrated. In the scopolamine group there was an unexpected fall in factors X and V and also in plasminogen and α1,-antitrypsin. A low level of some blood coagulation factors in some of the women before treatment is somewhat astonishing; none of them had any history of excessive bleeding.

IDENTIFICATION AND ASSESSMENT OF RISK FACTORS ROLE IN MYOCARDIAL INFARCTION DEVELOPMENT

2019 ◽  
Vol 72 (5) ◽  
pp. 779-783
Author(s):  
Victor A. Ognev ◽  
Anna A. Podpriadova ◽  
Anna V. Lisova
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Disease ◽  
Cardiovascular System ◽  
Control Group ◽  
Biological Factors ◽  
Prevention And Treatment ◽  
High Level ◽  
Social Importance ◽  
The Impact

Introduction:The high level of morbidity and mortality from cardiovascular disease is largely due toinsufficient influence on the main risk factors that contribute to the development of myocardial infarction.Therefore, a detailed study and assessment of risk factors is among the most important problems of medical and social importance. The aim: To study and evaluate the impact of biological, social and hygienic, social and economic, psychological, natural and climatic risk factors on the development of myocardial infarction. Materials and methods: A sociological survey was conducted in 500 people aged 34 to 85. They were divided into two groups. The main group consisted of 310 patients with myocardial infarction. The control group consisted of 190 practically healthy people, identical by age, gender and other parameters, without diseases of the cardiovascular system. Results: It was defined that 30 factors have a significant impact on the development of myocardial infarction.Data analysis revealed that the leading risk factors for myocardial infarction were biological and socio-hygienic. The main biological factors were: hypertension and hypercholesterolemia. The man socio-hygienic factor was smoking. Conclusions: Identification of risk factors provides new opportunities for the development of more effective approaches for the prevention and treatment of myocardial infarction.

Metabolic syndrome and risk factors after hematopoietic stem cell transplantation in children and adolescents

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Gizem Guner Ozenen ◽  
Serap Aksoylar ◽  
Damla Goksen ◽  
Salih Gozmen ◽  
Sukran Darcan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Life Quality ◽  
Control Group ◽  
Hematopoietic Stem

Abstract Objectives The early and late complications after hematopoietic stem cell transplantation (HSCT) determine the patients’ prognosis and life quality. We aim to determine the metabolic syndrome development frequency after HSCT in children to find out the risk factors and compare them with healthy adolescents. Methods Thirty-six children who underwent HSCT at least two years ago were analyzed prospectively and cross-sectionally. Our study included 18 healthy children between the ages of 11 and 17 as a control group. All of the cases were assessed in terms of metabolic syndrome (MS) through the use of Modified WHO Criteria. Results The patients’ median age was 10.6 (5.1–17) years, the median time of follow-up after HCST was 4.1 (2–13.5) years and 70% were male. Two cases were diagnosed with MS (5.6%). When considered in terms of the sub-components of MS, 2 cases (5.6%) were found to have obesity, 17 cases (47%) abnormal glucose tolerance, 11 cases (30.7%) dyslipidemia, and 3 cases (8.6%) hypertension. The MS rate was not different when compared with the 11–17 year-old healthy control group (0 vs. 11%, p=0.48). Myeloablative conditioning regimen (65 vs. 20%) and the increased age at which HSCT was performed were considered to be risk factors in terms of insulin resistance (p=0.025 and 0.002). Conclusions Age and conditioning regimens were found to be the risk factors for insulin resistance development. The long-term follow-up of the cases who had undergone HSCT in childhood in terms of MS and its sub-components is important in order to increase life quality.

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