scholarly journals Effect of melatonin on antioxidant state under type II diabetes at rat

2013 ◽  
Vol 59 (4) ◽  
pp. 434-442 ◽  
Author(s):  
A.A. Agarkov ◽  
T.N. Popova ◽  
L.V. Matasova
Keyword(s):  
Diabetes Mellitus ◽  
Superoxide Dismutase ◽  
Free Radical ◽  
Blood Serum ◽  
Enzyme Activities ◽  
Type Ii Diabetes ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Melatonin Administration ◽  
Radical Processes

The effect of melatonin on the intensity of free radical processes and activities of superoxide dismutase (SOD, EC 1.15.1.1.) and catalase (EC 1.11.1.6) has been investigated in liver and blood serum of rats with diabetes mellitus type II. The development of diabetes was accompanied by the increase in biochemiluminescence parameters and the enzyme activities studied. Melatonin administration changed the parameters studied towards control values.

scholarly journals COMPARATIVE ASSESSMENT OF METHODS OF ESTIMATION OF SUPEROXIDE DISMUTASE (SOD) IN TERMS OF SENSITIVITY AND SPECIFICTY IN TYPE-II DIABETES MELLITUS.

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Mr. Pravinkumar Sonawane ◽  
Dr. R.V. KatKam ◽  
Dr. V. S. Shinde ◽  
Dr. S. A. Abhang
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Superoxide Dismutase ◽  
Free Radical ◽  
Type Ii Diabetes ◽  
Microvascular Complications ◽  
Type Ii Diabetes Mellitus ◽  
Comparative Assessment ◽  
Type Ii ◽  
Good Marker

Now a days it is a known fact that the oxidative stress is in the foreground of type-II diabetes mellitus. It is the main cause of macro and microvascular complications in type II diabetes mellitus. Oxidative stress can be served as a good marker of degree of diabetes in addition is HbA1C. Superoxide (O2.- ) is one of the free radical produced during oxidative stress.  Superoxide dismutase (SOD) is an enzyme which quenches superoxide radicals produced due to oxidative stress. Hence it is very obvious that the estimation of SOD should be very sensitive and specific. To attain this aim we compared three different methods. Key words: SOD, Diabetes, Oxidative stress, Superoxide Dismutase.

scholarly journals To Assess the Prevalence of Cognitive Impairment in Type II Diabetes Mellitus: An Observational Study

2021 ◽  
Vol 11 (11) ◽  
pp. 306-312
Author(s):  
Shivani D. Godhasara ◽  
Vaishali Suthar
Keyword(s):  
Diabetes Mellitus ◽  
Cognitive Impairment ◽  
Cognitive Assessment ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Montreal Cognitive Assessment ◽  
Driving Safety ◽  
Age Group ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii

Introduction: Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia that affects various body systems. Elevated blood glucose levels cause brain malfunction, sorbitol which damages blood vessels, and degeneration of the nerves that can lead to dementia or cognitive impairment. Cognitive impairment can result in nonadherence of patients to diabetes treatment, such as medication, diet and exercise. Purpose: The purpose of this study was to assess the prevalence of cognitive impairment in type II diabetes mellitus. Methodology: 50 participants of age group 30 - 60 years, both male and female were included in this study. Cognitive impairment was assessed with the English version of the Montreal Cognitive Assessment (MoCA) tool. The MoCA scoring according to Dementia and Driving Safety: A clinical guideline, Version 3, 2014. Result: Among the 50 patients who were assessed, 24 (48%) were cognitively impaired. 20 (40%) of the subjects were age group of 51-60 years, and males participants 11(22%) outnumbered females 9 (18%). The majority of patients (40%) had diabetes type II for < 2 years. Conclusion: There was strong correlation found between Type II DM and cognitive impairment. Key words: Prevalence, Cognitive impairment, Diabetes mellitus Type II, Montreal Cognitive assessment (MoCA).

scholarly journals Genetic Polymorphism In Individuals With Type II Diabetes Mellitus Using PCR-RAPD In Sidoarjo District

2021 ◽  
Vol 14 (02) ◽  
pp. 153-159
Author(s):  
Miftahul Mushlih ◽  
Fitri Kumala Sari ◽  
Djauharoh A. Hadie ◽  
Syahrul Ardiansyah
Keyword(s):  
Diabetes Mellitus ◽  
Infectious Diseases ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Chi Square ◽  
Cross Sectional ◽  
Diabetes Mellitus Type Ii ◽  
Genetic And Environmental Factors ◽  
Rapd Method

Diabetes Mellitus type II (DMT2) is a metabolic disorder which its number increases from year to year. The Control of DMT2 sufferer’s number is difficult because DMT2 is caused by genetic and environmental factors. DMT2 can worsen infectious diseases for people with other infectious diseases. This study aimed to determine the polymorphism of sufferers and non-sufferers of T2DM using PCR-RAPD method. The sample of this study consisted of 60 samples which 30 positive samples and 30 negative samples taken from several clinics in Sidoarjo district. The primer used is A 18 (5'- AGGTGACCGT-3 '). Data analysis was performed using the SPSS 16.00 program and analyzed with a Cross-sectional Chi-square with a 95% confidence level. The results of this study produced 17 bands with length of 197 bp, 239 bp, 269 bp, 319 bp, 390 bp, 530 bp, 588 bp, 686 bp, 777 bp, 972 bp, 1175 bp, 1676 bp, 2780 bp, 3843 bp, 6563 bp, 11072 bp & 18434 bp. Four of them were monomorphic and two bands showed significantly different results at 319 bp (p: 0.035) and 18434 bp (p: 0.004).there were significant differences in the resulting band at 319 (p: 0.035) bp and 18434 bp (p: 0.004). Further analysis needs to be done to confirm the genes involved.

scholarly journals The effect of combined melatonin therapy on indicators of oxidative status in chronic kidney disease developing in type 2 diabetes mellitus

2021 ◽  
Vol 99 (2) ◽  
pp. 121-127
Author(s):  
S. S. Popov ◽  
E. I. Anufrieva ◽  
E. D. Krylskiy ◽  
K. K. Shulgin ◽  
A. N. Verevkin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Free Radical ◽  
Kidney Disease ◽  
Type Ii Diabetes ◽  
Biochemical Parameters ◽  
Oxidative Status ◽  
Type Ii ◽  
Basic Treatment

Chronic kidney disease (CKD) is the main cause of end-stage renal failure and is a complication of diabetes mellitus (DM). Oxidative stress plays the key role in its pathogenesis. In this regard, the use of drugs with antioxidant effect in DN therapy seems to be reasonable.Objective. In the course of this work, the effect of combination melatonin therapy on the biochemical parameters of the pathology development, concentration of pigment epithelial factor (PEDF) and the oxidative status of patients with CKD developing in type II diabetes was assessed.Material and methods. The study involved 60 people with CKD developing in type II diabetes. The patients were divided into 2 groups; each group included 30 people. The first group of patients underwent basic treatment; the second group of participants was given 2 mg of melatonin in addition to the basic therapy. The control group consisted of 65 apparently healthy individuals with normal indicators of general and biochemical blood tests. In the course of the work, the analysis of biochemical indicators of the pathology development, level of PEDF by enzyme immunoassay, the activity of free radical oxidation by the method of iron-induced biochemiluminescence (BCL) and the concentration of reduced glutathione (GSH) in the study participants was carried out.Results. The addition of melatonin to basic treatment led to a more signifi cant decrease in the intensity of free radical-induced oxidation and the level of PEDF, as well as an increase in the GSH content and general antioxidant eff ect in patients with CKD. The observed changes were accompanied by shifts in the indicators of proteinuria, hyperglycemia and urea concentration close to the ones detected in healthy volunteers group.Conclusion. The results obtained were, apparently, due to a more signifi cant decrease in the level of oxidative stress in patients who additionally received melatonin, which is characterized by the presence of antioxidant activity. An improvement in the oxidative status in patients of the second group was linked with the degree of changes in the clinical and biochemical parameters of pathology.

scholarly journals STUDY OF NIDANA PANCHAKA OF CONTEMPORARY MADHUMEHA PATIENT vis. a. vis. TYPE II DIABETES MELLITUS

2020 ◽  
Vol 8 (9) ◽  
pp. 4358-4362
Author(s):  
Lokhande Abhijeet Sahebrao ◽  
Joshi Dnyanesh Sudhakarrao ◽  
Gawai Abhijeet Ashokrao
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Junk Food ◽  
Type Ii ◽  
Cross Sectional ◽  
Standard Case ◽  
Diabetes Mellitus Type Ii ◽  
Treat Ment ◽  
History Of

Junk food and lavish lifestyle is a status statement of today era which is responsible for various type of diseases. Diabetes Mellitus is one of the predominant diseases causing this lifestyle. Diabetes Mellitus re-sembling with Madhumeha which is one type of Vataj Prameha explained by Acharya Charaka. The ayurvedic protocol of management is very beneficial for prophylaxis and treatment of Madhumeha (Dia-betes Mellitus). Madhumeha can be treated more accurately according to the Ayurvedic method of treat-ment only if its Nidan Panchaka (Etiopathogenesis) is well established. Aim: To study Nidana Panchaka of contemporary Madhumeha patient vis. a. vis. type II diabetes mellitus. Material & Method: In this study, already diagnosed 30 patients of diabetes mellitus type II were selected and the history of those patients was taken according to standard case proforma. Present study is Analyti-cal, Retrospective, Observational, and Cross-sectional type. Observation: An analyzed data indicated that lavish lifestyle, unhealthy food, and junk food are also the reasons behind disease along with Hetus (Etiological factor) mentioned in the Samhitas (Ayurveda Litera-ture). Conclusion: It can be concluded that it is possible to establish the Nidan Panchak of Madhumeha vyadhi with the help of Ayurvedic basic principles.

Sign in / Sign up

Export Citation Format

Share Document