scholarly journals Differences in adrenal steroid hormones production in pubertal rats exposed to low doses of endocrine disruptor DDT during prenatal and postnatal development

2017 ◽  
Vol 63 (4) ◽  
pp. 306-311 ◽  
Author(s):  
N.V. Yaglova ◽  
D.A. Tsomartova ◽  
V.V. Yaglov
Keyword(s):  
Postnatal Development ◽  
Steroid Hormones ◽  
Endocrine Disruptor ◽  
Wistar Rats ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Adrenal Steroid ◽  
Steroid Profile ◽  
Male Wistar Rats ◽  
Circulatory Disorders

Production of adrenal steroid hormones in pubertal male Wistar rats exposed to low doses of DDT during both prenatal and postnatal and only postnatal development was evaluated. Altered production of all types of steroid hormones and serum steroid profile with opposite changes in rats exposed prenatally and postnatally, and only postnatally was found. The study showed that daily exposure to low doses of DDT enhanced conversion of progesterone to 17OH-progesterone and did not exert selective antiandrogenic or proestrogenic action unlike effect of toxic and subtoxic doses. Impaired morphogenesis of the adrenal cortex and circulatory disorders in zona glomerulosa contributed to reduced aldosterone and sex steroid hormones production.

scholarly journals The action of prolyl-leucyl-glycinamide (PLG) on the nigrostriatal pathway of the rat

1990 ◽  
Vol 48 (2) ◽  
pp. 156-160
Author(s):  
João S. Pereira ◽  
Luiz Augusto F. Andrade ◽  
Paulo H. F. Bertolucci ◽  
J. Geraldo Camargo Lima ◽  
Henrique B. Ferraz
Keyword(s):  
Wistar Rats ◽  
Electrolytic Lesion ◽  
Behavior Model ◽  
Low Doses ◽  
Nigrostriatal Pathway ◽  
Rem Sleep Deprivation ◽  
Hypothalamic Region ◽  
Male Wistar Rats ◽  
6 Hydroxydopamine ◽  
Higher Doses

In order to study the nigrostriatal pathway, we obtained the rotatory behavior model in male Wistar rats by electrolytic lesion of the left lateral hypothalamic region. Animals thus lesioned displayed rotations toward the same side of lesion when apomorphine was administered, a result in disagreement with what has been obtained in the model with 6-hydroxydopamine lesion. The administration of PLG alone was not followed by rotatory behavior but when the compound was administered in low doses (0.25 to 1mg/kg) simultaneously with apomorphine to animals previously submitted to REM sleep deprivation, a significant increase in the number of rotations was observed in comparison with controls and groups receiving higher doses of PLG. These results indicate that PLG may act as, a modulator on dopamine receptors in the striatum.

scholarly journals Early postnatal development of the lumbar vertebrae in male Wistar rats: double staining and digital radiological studies

2016 ◽  
Vol 75 (1) ◽  
pp. 1-13 ◽  
Author(s):  
F. Burdan ◽  
M. Błaszczak-Szalak ◽  
I. Różyło-Kalinowska ◽  
R. Klepacz ◽  
W. Dworzański ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Wistar Rats ◽  
Lumbar Vertebrae ◽  
Double Staining ◽  
Early Postnatal Development ◽  
Male Wistar Rats ◽  
Radiological Studies

scholarly journals Secretion of adrenal zona glomerulosa cells in rats exposed to low doses of dichlorodiphenyltrichloroethane during prenatal and postnatal development

2018 ◽  
Vol 7 (3) ◽  
pp. e0302
Author(s):  
Dibakhan A. Tsomartova ◽  
Natalia V. Yaglova ◽  
Sergey S. Obernikhin ◽  
Svetlana V. Nazimova ◽  
Valentin V. Yaglov
Keyword(s):  
Postnatal Development ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Glomerulosa Cells ◽  
Prenatal And Postnatal Development ◽  
Zona Glomerulosa Cells

CHANGES IN ADRENAL ZONA GLOMERULOSA CELLS OF RATS EXPOSED TO LOW DOSES OF DDT DURING POSTNATAL DEVELOPMENT

2018 ◽  
Vol 26 (2) ◽  
pp. 25-30
Author(s):  
D.A. Tsomartova ◽  
◽  
N.V. Yaglova ◽  
S.S. Obernikhin ◽  
S.V. Nazimova ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Glomerulosa Cells ◽  
Zona Glomerulosa Cells

Further analysis of behavioral and endocrine consequences of chronic exposure of male Wistar rats to subtoxic doses of endocrine disruptor chlorobenzenes

2011 ◽  
Vol 103 (5) ◽  
pp. 421-430 ◽  
Author(s):  
Z. Valkusz ◽  
G. Nagyéri ◽  
M. Radács ◽  
T. Ocskó ◽  
P. Hausinger ◽  
...  
Keyword(s):  
Chronic Exposure ◽  
Endocrine Disruptor ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression

2021 ◽  
Vol 22 (12) ◽  
pp. 6324
Author(s):  
Nataliya V. Yaglova ◽  
Sergey S. Obernikhin ◽  
Dibakhan A. Tsomartova ◽  
Svetlana V. Nazimova ◽  
Valentin V. Yaglov ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Low Dose ◽  
Organic Pollutant ◽  
Endocrine Disrupting Chemicals ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Hormone Production ◽  
Functional Changes ◽  
And Function ◽  
The Impact

Dichlorodiphenyltrichloroethane (DDT) is a persistent organic pollutant and one of the most widespread endocrine disrupting chemicals. The impact of low-dose exposure to DDT on the morphogenesis of the adrenal gland is still poorly understood. The development and function of zona glomerulosa in rats has been found to be associated with changes in the expression of the transcription factor Oct4 (Octamer 4), which is the most important player in cell pluripotency. The aim of the study was to investigate the morphogenesis and function of rat adrenal zona glomerulosa in rats exposed to low doses of DDT during prenatal and postnatal development and to determine the possible role of Oct4 in DDT-mediated structural and functional changes. The DDT-exposed rats demonstrated slower development and lower functional activity of the zona glomerulosa during the pubertal period associated with higher expression of Oct4. Further, accelerated growth and restoration of hormone production was associated with, firstly, a decrease in Oct4 expressing cells and secondly, the loss of the inverse relationship between basal aldosterone levels and the number of Oct4 expressing cells. Thus, the transcriptional factor Oct4 exhibited an altered pattern of expression in the DDT-exposed rats during postnatal development. The results of the study uncover a novel putative mechanism by which low doses of DDT disrupt the development of adrenal zona glomerulosa.

scholarly journals Developmental and Reproductive Outcomes in Male Rats Exposed to Triclosan: Two-Generation Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Bruno Garcia Montagnini ◽  
Simone Forcato ◽  
Karine Vandressa Pernoncine ◽  
Mariana Cunha Monteiro ◽  
Marina Rangel Ferro Pereira ◽  
...  
Keyword(s):  
Endocrine Disruptor ◽  
Wistar Rats ◽  
Corn Oil ◽  
Sperm Quality ◽  
Male Rats ◽  
Control Group ◽  
Sperm Viability ◽  
Male Wistar Rats ◽  
Reproduction Toxicity ◽  
Environmental Compartments

Triclosan (TCS) is a phenolic compound with broad-spectrum antimicrobial action that has been incorporated into a variety of personal care products and other industry segments such as toys, textiles, and plastics. Due to its widespread use, TCS and its derivatives have been detected in several environmental compartments, with potential bioaccumulation and persistence. Indeed, some studies have demonstrated that TCS may act as a potential endocrine disruptor for the reproductive system. In the current study, we are reporting on the results obtained for male rats after a two-generation reproduction toxicity study conducted with TCS. Female and male Wistar rats were treated daily by gavage with TCS at doses of 0.8, 2.4, and 8.0 mg/kg/day or corn oil (control group) over 10 weeks (F0) and over 14 weeks (F1) before mating and then throughout mating, until weaning F2 generations, respectively. TCS exposure decreased sperm viability and motility of F1 rats at the dose of 2.4 mg/kg. The effects of TCS on sperm quality may be related to the exposure window, which includes the programming of reproductive cells that occurs during fetal/neonatal development.

scholarly journals Cellular mechanisms of impaired mineralocorticoid and glucocorticoid production by endocrine disruptor DDT

2021 ◽  
pp. 12-19
Author(s):  
Nataliya V. Yaglova ◽  
Sergey S. Obernikhin ◽  
Valentin V. Yaglov ◽  
Svetlana V. Nazimova ◽  
Ekaterina P. Timokhina
Keyword(s):  
Electron Microscopy ◽  
Endocrine Disruptor ◽  
Zona Glomerulosa ◽  
Enzyme Linked Immunosorbent Assay ◽  
Zona Fasciculata ◽  
Low Doses ◽  
Postnatal Exposure ◽  
Morphological Examination ◽  
Adult Rats ◽  
Glucocorticoid Production

Developmental exposure to persistent endocrine disruptors is of a great concern. Affection of adrenal hormones production by low-dose exposure to dichlorodiphenyltrichloroethane (DDT) has been revealed recently. Objective of the research – investigation of ultrastructural mechanisms of impaired mineralocorticoid and glucocorticoid production after prenatal and postnatal exposure to endocrine disruptor DDT. Male Wistar rats exposed to low doses of DDT during prenatal and postnatal development were studied. Aldosterone and corticosterone levels in serum were measured by enzyme-linked immunosorbent assay, histological examination and electron microscopy of the adrenals were performed. Pubertal rats, developmentally exposed to low doses of DDT, demonstrated lowered aldosterone and elevated corticosterone serum levels. After puberty the rats showed tendency to normalization of hormones’ production. Morphological examination of the adrenals revealed less developed zona glomerulosa in pubertal period and its relative hyperplasia after puberty. Microcirculatory disorders and focal cell death were observed in outer zona fasciculata. Electron microscopy of glomerulosa cells found signs of suppressed secretory activity in pubertal period and no significant reduction of mitochondria size in adult rats. Total number of mitochondria in 1 µm2 of cytoplasm and percent of mitochondria with swollen matrix were diminished compared to the control. Cells of inner zona fasciculata demonstrated increased functional activity. Age-dependent changes in fine structure of fasciculata cells were similar to the control, but were more pronounced. In this way, cellular mechanism of impaired mineralocorticoid production in rats prenatally and postnatally exposed to low doses of endocrine disruptor DDT, are insufficient mitochondrion function and impaired reorganization of mitochondrial apparatus, which occurs during pubertal period. Mechanisms of elevated glucocorticoid secretion are attributed to enhanced function of mitochondria in fasciculata cells.

TRANSCRIPTIONAL REGULATION OF RAT ADRENAL ZONA GLOMERULOSA POSTNATAL DEVELOPMENT EXPOSED TO LOW DOSES OF DDT

2020 ◽  
Author(s):  
Sergey Stanislavovich Obernikhin ◽  
Nataliya Valentinovna Yaglova ◽  
Valentin Vasilyevich Yaglov ◽  
Svetlana Vladimirovna Nazimova
Keyword(s):  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Wnt Signaling ◽  
Endocrine Disruptor ◽  
Adrenal Glands ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Postnatal Exposure ◽  
Canonical Wnt

The role of the transcription factor Oct4 and canonical Wnt signaling in the postnatal morphogenesis of the glomerular zone of the adrenal glands of rats under the conditions of pre- and postnatal exposure to low doses of DDT endocrine disruptor was determined.

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