scholarly journals Anesthetic Agents in Pediatric Patients, A Comprehensive Review of Pharmacological Considerations in Clinical Practice

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
Alan Kaye ◽  
George Jeha ◽  
Jordan Renschler ◽  
Mitchell Fuller ◽  
Alex Pham ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Pediatric Patients ◽  
Comprehensive Review ◽  
Anesthetic Agents

Extensive Extraneural Metastases of Cerebral Glioblastoma in a Pediatric Patient: An Extreme Case Report and Comprehensive Review of the Literature

2021 ◽  
pp. 1-6
Author(s):  
Kadir Oktay ◽  
Dogu Cihan Yildirim ◽  
Arbil Acikalin ◽  
Kerem Mazhar Ozsoy ◽  
Nuri Eralp Cetinalp ◽  
...  
Keyword(s):  
Case Report ◽  
Pediatric Patients ◽  
Extreme Case ◽  
Rare Condition ◽  
Review Of The Literature ◽  
Pertinent Literature ◽  
Cervical Lymph Nodes ◽  
Case Presentation ◽  
Comprehensive Review ◽  
Extraneural Metastases

<b><i>Introduction:</i></b> Extraneural metastases of glioblastoma are very rare clinical entities, especially in pediatric patients. Because of their rarity, they can be confused with other pathological processes. <b><i>Case Presentation:</i></b> We report a case of 16-year-old boy with extensive extraneural metastases of glioblastoma. Lung, liver, cervical lymph nodes, skin, and bone metastases were detected in the patient. <b><i>Conclusion:</i></b> We describe the presentation, evaluation, and diagnosis of this rare condition with regard to pertinent literature.

QTc prolongation induced by targeted biotherapies used in clinical practice and under investigation: a comprehensive review

2014 ◽  
Vol 10 (1) ◽  
pp. 27-43 ◽  
Author(s):  
Marzia Locatelli ◽  
Carmen Criscitiello ◽  
Angela Esposito ◽  
Ida Minchella ◽  
Aron Goldhirsch ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Qtc Prolongation ◽  
Comprehensive Review

scholarly journals Anesteziolosko zbrinjavanje dece sa neurotraumom

2010 ◽  
Vol 57 (2) ◽  
pp. 71-77
Author(s):  
D. Simic ◽  
V. Bumbasirevic ◽  
I. Milojevic ◽  
M. Markovic ◽  
M. Milenovic ◽  
...  
Keyword(s):  
Head Injury ◽  
Pediatric Patients ◽  
Pediatric Trauma ◽  
Childhood Mortality ◽  
Increased Intracranial Pressure ◽  
Injured Child ◽  
Mortality And Morbidity ◽  
Probability Of Survival ◽  
Anesthetic Agents ◽  
Injury Treatment

Neurotrauma is a leading cause of childhood mortality. Physicians are in a continuous search for means to decrease mortality and morbidity caused by head injury. Treatment of these patients requires familiarity with both cerebral pathophysiology and actions of anesthetic agents on brain. Early treatment of hypotension and hypoventilation would cut mortality rate by at least one third. Prevention of increased intracranial pressure is the best treatment for head injury. Anesthetist, neurosurgeon and radiologist should all be members of a team which can secure timely diagnosis and treatment of an injured child. Paying attention to every detail is of huge significance. Treatment of the child in a pediatric trauma center or an accident and emergencies center for adults with both personnel and equipment capable for handling pediatric patients offers greater probability of survival.

scholarly journals Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients

2020 ◽  
Vol 38 (27) ◽  
pp. 3205-3216
Author(s):  
Thomas Lehrnbecher ◽  
Brian T. Fisher ◽  
Bob Phillips ◽  
Melissa Beauchemin ◽  
Fabianne Carlesse ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Clinical Practice ◽  
Clinical Practice Guideline ◽  
Practice Guideline ◽  
Pediatric Patients ◽  
Antifungal Prophylaxis ◽  
Hematopoietic Stem ◽  
Strong Recommendation ◽  
Patients With Cancer

PURPOSE To develop a clinical practice guideline for systemic antifungal prophylaxis in pediatric patients with cancer and hematopoietic stem-cell transplantation (HSCT) recipients. METHODS Recommendations were developed by an international multidisciplinary panel that included a patient advocate. We conducted a systematic review of systemic antifungal prophylaxis in children and adults with cancer and HSCT recipients. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to make strong or weak recommendations and to classify level of evidence as high, moderate, low, or very low. The panel considered directness of the data to pediatric patients. RESULTS There were 68 randomized trials included in the systematic review, of which 6 (9%) were conducted in a solely pediatric population. Strong recommendations were made to administer systemic antifungal prophylaxis to children and adolescents receiving treatment of acute myeloid leukemia, to those undergoing allogeneic HSCT pre-engraftment, and to those receiving systemic immunosuppression for graft-versus-host disease treatment. A strong recommendation was made to administer a mold-active agent with an echinocandin or a mold-active azole when systemic antifungal prophylaxis is warranted. For children younger than 13 years of age, an echinocandin, voriconazole, or itraconazole is suggested. Posaconazole may also be used in those age 13 years or older. A strong recommendation against routine administration of amphotericin as systemic antifungal prophylaxis was made. CONCLUSION We developed a clinical practice guideline for systemic antifungal prophylaxis administration in pediatric patients with cancer and HSCT recipients. Implementation and assessment of guideline-concordant rates and impacts are important future steps.

scholarly journals Dexmedetomidine: What’s New for Pediatrics? A Narrative Review

2020 ◽  
Vol 9 (9) ◽  
pp. 2724 ◽  
Author(s):  
Mohamed Mahmoud ◽  
Egidio Barbi ◽  
Keira P. Mason
Keyword(s):  
Clinical Practice ◽  
Animal Studies ◽  
Neurocognitive Function ◽  
Clinical Applications ◽  
Protective Effects ◽  
Comprehensive Review ◽  
Routes Of Administration ◽  
The Past ◽  
Growing Body ◽  
Alternative Routes

Over the past few years, despite the lack of approved pediatric labelling, dexmedetomidine’s (DEX) use has become more prevalent in pediatric clinical practice as well as in research trials. Its respiratory-sparing effects and bioavailability by various routes are only some of the valued features of DEX. In recent years the potential organ-protective effects of DEX, with the possibility for preserving neurocognitive function, has put it in the forefront of clinical and bench research. This comprehensive review focused on the pediatric literature but presents relevant, supporting adult and animal studies in order to detail the recent growing body of literature around the pharmacology, end-organ effects, organ-protective effects, alternative routes of administration, synergetic effects, and clinical applications, with considerations for the future.

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