Evans Syndrome Associated with Hematological Malignancies: A Literature Review

Evans syndrome (ES) is a rare disorder in which the immune system produces antibodies that accidentally destroy red blood cells and platelets. The diagnosis of ES is made by the simultaneous presence of autoimmune hemolytic anemia and immune thrombocytopenia. However, the diagnosis of ES associated with hematologic malignancies necessitates a comprehensive evaluation of clinical course, clinical findings, and laboratory test results. Hematological malignancies are the most significant underlying diseases factors impacting ES and the prognosis, but there is no established standard therapy for autoimmune cytopenia associated with hematological malignancies. In ES associated with hematologic malignancies, achieving remission of the underlying disease seems to be the key to long-term remission.

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Predicting Mechanical Ventilation For More Than 7 Days In The Emergency Department

10.21203/rs.3.rs-404559/v2 ◽

2021 ◽

Author(s):

Jin Hui Paik ◽

Jung-Soo Kim ◽

Man-Jong Lee ◽

Mi Hwa Park ◽

Areum Durey ◽

...

Keyword(s):

Emergency Department ◽

Mechanical Ventilation ◽

Underlying Disease ◽

Test Results ◽

C Reactive Protein ◽

Reactive Protein ◽

Factors Influencing ◽

Laboratory Test Results ◽

The Mean ◽

Underlying Diseases

Abstract Background: The duration of mechanical ventilation (MV) required by patients admitted to the emergency department (ED) is difficult to predict. We investigated the duration of MV in ED-admitted patients, as well as their clinical progress.Methods: We investigated the duration of MV in adult patients (aged ≥18 years) who were attached to ventilators in our ED between January and December 2017. The patients were divided into two groups; MV <7 days and MV ≥7 days. The patients’ demographic characteristics, diagnoses, clinical features, and underlying diseases were compared between two groups.Results: The study comprised 282 patients including 142 in the MV <7 days group and 140 in the MV ≥7 days group. The MV ≥7 days group had more patients diagnosed with metabolic disorder, pneumonia, neurological disease, sepsis, and multiple trauma, and also had a greater proportion of patients with dementia or stroke as the underlying disease. The mean C-reactive protein level in the MV ≥7 days group was 6.4 mg/dL, which was higher than that in the MV <7 days group. The risk factors for requiring ≥7 days of MV were identified as a diagnosis of stroke as well as having the underlying diseases of cancer and stroke or dementia. Among the laboratory test results, pH, HCO3- , and albumin <3.5 g/dL were identified as factors influencing the duration of MV.Conclusions: MV for ≥7 days is predicted to be required for patients admitted for a stroke; those with underlying cancer or stroke; and those with adverse pH, HCO3-, and albumin blood test results.

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Predicting Mechanical Ventilation for More Than 7 Days in the Emergency Department

10.21203/rs.3.rs-404559/v1 ◽

2021 ◽

Author(s):

Jin Hui Paik ◽

Jung-Soo Kim ◽

Man-Jong Lee ◽

Mi Hwa Park ◽

Areum Durey ◽

...

Keyword(s):

Emergency Department ◽

Mechanical Ventilation ◽

Underlying Disease ◽

Test Results ◽

C Reactive Protein ◽

Reactive Protein ◽

Factors Influencing ◽

Laboratory Test Results ◽

The Mean ◽

Underlying Diseases

Abstract Background The duration of mechanical ventilation (MV) required by patients admitted to the emergency department (ED) is difficult to predict. We investigated the duration of MV in ED-admitted patients, as well as their clinical progress.Methods We investigated the duration of MV in adult patients (aged ≥18 years) who were attached to ventilators in our ED between January and December 2017. The patients were divided into two groups; MV <7 days and MV ≥7 days. The patients’ demographic characteristics, diagnoses, clinical features, and underlying diseases were compared between two groups.Results The study comprised 282 patients including 142 in the MV <7 days group and 140 in the MV ≥7 days group. The MV ≥7 days group had more patients diagnosed with metabolic disorder, pneumonia, neurological disease, sepsis, and multiple trauma, and also had a greater proportion of patients with dementia or stroke as the underlying disease. The mean C-reactive protein level in the MV ≥7 days group was 6.4 mg/dL, which was higher than that in the MV <7 days group. The risk factors for requiring ≥7 days of MV were identified as a diagnosis of stroke as well as having the underlying diseases of cancer and stroke or dementia. Among the laboratory test results, pH, HCO3- , and albumin <3.5 g/dL were identified as factors influencing the duration of MV.Conclusion MV for ≥7 days is predicted to be required for patients admitted for a stroke; those with underlying cancer or stroke; and those with adverse pH, HCO3-, and albumin blood test results.

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Time-dependent displacement behaviour of model adfreeze and grouted piles in saline frozen soils

Canadian Geotechnical Journal ◽

10.1139/t94-047 ◽

1994 ◽

Vol 31 (3) ◽

pp. 395-406 ◽

Cited By ~ 3

Author(s):

K.W. Biggar ◽

D.C. Sego

Keyword(s):

Field Studies ◽

Frozen Soil ◽

Silty Sand ◽

Time Dependent ◽

Test Results ◽

Model Pile ◽

Laboratory Test Results ◽

Load Carrying ◽

Pile Deformation

The findings of a laboratory study on the time-dependent displacement of model piles in saline frozen soil are reported. The short-term time-dependent pile deformation in ice-poor saline silty sand was best described using a simple power law of time, whereas the long-term time-dependent deformations were best described using a flow law formulation similar to that used to describe the long-term time-dependent deformation of ice or ice-rich permafrost. The use of cementitious grout as a backfill resulted in doubling of the pile load carrying capacity for a given displacement rate. The laboratory test results compare well with other laboratory and field studies. Key words : frozen soil, saline, model pile, time-dependent deformation, sand backfill, grout.

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The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy

Journal of Perinatal Medicine ◽

10.1515/jpm-2015-0089 ◽

2016 ◽

Vol 44 (3) ◽

Author(s):

Jane So ◽

Elizabeth Young ◽

Natalie Crnosija ◽

Joseph Chappelle

Keyword(s):

Severe Disease ◽

Vital Signs ◽

Retrospective Chart Review ◽

Clinical Findings ◽

Bivariate Analysis ◽

Test Results ◽

Quadrant Pain ◽

Laboratory Findings ◽

Abnormal Laboratory ◽

Laboratory Test Results

AbstractPreeclampsia is the 2A retrospective chart review of women who presented for evaluation of hypertension in pregnancy during 2010. Demographic information, medical history, symptoms, vital signs, and laboratory results were collected. Bivariate analysis was used to investigate associations between predictors and the outcome.Of the 481 women in the sample, 22 were identified as having abnormal laboratory test results (4.6%). Women who reported right upper quadrant pain or tenderness had significantly increased likelihood of having laboratory abnormalities compared to those without the complaint.Only a small percentage of women evaluated were determined to have abnormal laboratory findings, predominantly among women with severe preeclampsia. Right upper quadrant pain or tenderness was positively correlated with laboratory abnormalities. The restriction of laboratory analysis in women with clinical evidence of severe disease may be warranted – a broader study should, however, first be used to confirm our findings.

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ESTIMATING LOAD-DISPLACEMENT BEHAVIOR OF SOFT CLAYS

Proceedings of International Structural Engineering and Construction ◽

10.14455/isec.res.2016.165 ◽

2016 ◽

Vol 3 (2) ◽

Author(s):

Murat Tonaroglu ◽

Cem Akguner ◽

Murat E. Selcuk

Keyword(s):

Laboratory Test ◽

Field Measurements ◽

Soil Parameters ◽

Model Parameters ◽

Time Behavior ◽

Test Results ◽

Engineering Structures ◽

Laboratory Test Results ◽

Study Laboratory

Prediction of long term settlement of soft soils below civil engineering structures is an important issue in geotechnical engineering. The data from laboratory consolidation tests are used to estimate the ultimate settlement and problems arise in predicting settlement-time behavior in the field. In order to overcome this difficulty some empirical models or adjustments have been proposed based on field settlement measurements, even if they are available at least for the early stages of loading. In this study, laboratory test results and field settlement measurements obtained for the long term settlement of clayey layers underlying the Alibey Dam in Istanbul, Turkey are used in conjunction with a model proposed by Edil and Mochtar (1984) for peat-like soils. The soil parameters of the proposed model have independently been obtained using both laboratory test data and field measurements, and model predictions are compared with actual recorded settlements. It is observed that the field measurements could be predicted more closely if the model parameters are obtained from field measurements, but predictions based on laboratory consolidation and creep test results also provide satisfactory results following the initial stages of loading.

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Prevalence and Course of SARS-CoV-2 Infection among Immunocompromised Children Hospitalised in the Tertiary Referral Hospital in Poland

Journal of Clinical Medicine ◽

10.3390/jcm10194556 ◽

2021 ◽

Vol 10 (19) ◽

pp. 4556

Author(s):

Karolina Kuczborska ◽

Janusz Książyk

Keyword(s):

Laboratory Test ◽

Clinical Characteristics ◽

Chronic Treatment ◽

Clinical Symptoms ◽

Referral Hospital ◽

Test Results ◽

Tertiary Referral ◽

Tertiary Referral Hospital ◽

Laboratory Test Results ◽

Underlying Diseases

The aim of this retrospective study was the assessment of the prevalence, clinical characteristics, and the comparison of the course of SARS-CoV-2 infection in children with and without immunodeficiency that were admitted to the COVID-19 Subunit of the tertiary referral hospital in Warsaw, Poland. We analysed 313 children hospitalised in the COVID-19 Subunit. The analysis was performed on the total study group and subgroups of children with and without immunodeficiency. In each group, clinical data and laboratory test results were analysed. Of the 68 children with isolated fevers, only seven (11.76%) were diagnosed with COVID-19, whereas among those with the accompanying features of respiratory or gastrointestinal infection, only one (3.23%) and ten (16.95%) patients tested positive, respectively. In both groups, the course of the infection was mainly asymptomatic or mild. The children with immunodeficiencies had lower white blood cell and lymphocyte counts, lower haemoglobin levels, and higher urea levels but did not differ in other biochemical variables. To conclude, the most frequently reported symptoms of COVID-19 indicate that this disease among children is only a small percentage. In both groups, the responses to the infection were comparable in terms of the mild clinical symptoms and the laboratory test results. Therefore, SARS-CoV-2 infection should not alter the chronic treatment of underlying diseases.

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Association of Underlying Diseases and Clinical Characteristics with Mortality in Patients with 2019 Novel Coronavirus in Iran

Archives of Clinical Infectious Diseases ◽

10.5812/archcid.104621 ◽

2020 ◽

Vol 15 (5) ◽

Author(s):

Mohammadhossein Zamanian ◽

Zohre Foroozanfar ◽

Zhila Izadi ◽

Samira Jafari ◽

Hossein Derakhshankhah ◽

...

Keyword(s):

Heart Disease ◽

Clinical Characteristics ◽

Underlying Disease ◽

Test Results ◽

Rt Pcr ◽

Factors Associated ◽

History Of ◽

Novel Coronavirus ◽

Underlying Diseases ◽

Pcr Test

Objectives: The first case of 2019 novel coronavirus disease (COVID-19) was reported in Iran in February 2020. Here, we report the epidemiological and clinical characteristics of patients with COVID-19 and factors associated with mortality in these patients. Methods: A retrospective cohort study was conducted from February 22, 2020, to March 24, 2020, in Golestan Hospital in Kermanshah, Iran. Demographic data including underlying diseases and clinical data including the presenting symptoms, chest computed tomography (CT) scan, reverse transcription polymerase chain reaction (RT-PCR) test results, and outcomes were extracted from electronic medical records. Simple and multiple logistic regression methods were used to explore the factors associated with mortality. Results: Of 245 patients admitted with COVID-19, 155 (63.30%) were male. The mean age of the subjects was 54.68 ± 19.21. Forty-five (18.48%) patients had underlying diseases. Common symptoms were dyspnea (n = 137; 55.9%), cough (n = 93; 38.0%), and fever (n = 78; 31.8%). All patients had pneumonia with abnormal findings on chest CT scan (100%), and RT-PCR test results were positive in 87 (35.50%) patients. Of the total admitted cases, 38 (15.5%) patients died during hospitalization. An old age (OR = 1.09; 95% CI: 1.02 to 1.06), history of heart disease (OR = 5.07; 95% CI: 1.46 to 17.58), hypertension (OR = 5.82; 95% CI: 1.13 to 30.04), smoking (OR = 11.44; 95% CI: 1.01 to 29.53), history of at least one underlying disease (OR = 3.31; 95%CI: 1.54 to 7.09), and symptoms of decreased consciousness at the time of admission (OR = 24.23; 95% CI: 2.62 to 223.39) were associated with mortality. Also, the symptoms of cough (OR = 0.383; 95% CI: 0.17 to 0.88) and fever (OR = 0.278; 95% CI: 0.10 to 0.74) had a negative association with mortality. Conclusions: In the current study, factors including old age, smoking, symptoms of decreased consciousness, and underlying diseases such as heart disease, hypertension, and history of at least one underlying disease were associated with mortality. Factors associated with mortality should be considered so that we can better manage patients with COVID-19.

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Diabetes Insipidus and Concomitant Myocarditis: A Late Sequelae of COVID-19 Infection

Journal of Investigative Medicine High Impact Case Reports ◽

10.1177/2324709621999954 ◽

2021 ◽

Vol 9 ◽

pp. 232470962199995

Author(s):

Abu Baker Sheikh ◽

Nismat Javed ◽

Abdul Ahad Ehsan Sheikh ◽

Shubhra Upadhyay ◽

Rahul Shekhar

Keyword(s):

Diabetes Insipidus ◽

Young Male ◽

Urine Osmolality ◽

High Serum ◽

Test Results ◽

Global Pandemic ◽

Laboratory Test Results ◽

Late Sequela ◽

Endocrine Complications

Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 2019 (COVID-19), which has become a global pandemic. Apart from the mild features of the disease, long-term complications involve many systems including both endocrine and cardiovascular systems. Myocarditis, secondary to COVID-19, has become a well-known complication of the disease. However, endocrine complications are generally not common, particularly isolated pituitary abnormalities. There is one other report of diabetes insipidus developing as a late sequela of COVID-19. In this article, we report a case of a young male who presented with features of myocarditis but developed diabetes insipidus on day 7 of admission as a long-term complication after recovery from COVID-19 infection. His laboratory test results at the time of developing the complication revealed a high serum sodium level and low urine osmolality. The patient recovered on administration of desmopressin and was discharged after 16 days of hospitalization.

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Karantina Sonrası COVID-19 Tanısıyla Takip Edilen Hastaların Değerlendirilmesi

Flora the Journal of Infectious Diseases and Clinical Microbiology ◽

10.5578/flora.70119 ◽

2020 ◽

Vol 25 (4) ◽

pp. 499-505

Author(s):

Onur Ural ◽

Şua Sümer ◽

Nazlım Aktuğ Demir ◽

Emine Yalçınkaya ◽

Elif Uçan ◽

...

Keyword(s):

Underlying Disease ◽

Clinical Findings ◽

Lung Involvement ◽

Shortness Of Breath ◽

Rt Pcr ◽

The World ◽

Underlying Diseases ◽

Time Of Admission ◽

Pcr Test ◽

D Dimer

Introduction: The COVID-19 pandemic continues to affect the world with serious number of cases and deaths. For this reason, knowing the clinical findings and course of the disease is important for early diagnosis and treatment. In this article, COVID-19 cases followed up after quarantine were discussed. Materials and Methods: In this study, the data of 99 patients who were followed up during travel and post-Umrah quarantine between 31 March and 15 April 2020 were retrospectively reviewed. Results: Of the 99 patients included in the study, 66 (66.7%) were females, 33 (33.3%) were males, and mean age was 59.8 ± 11.4 years. SARS-CoV-2 RT-PCR test was positive at the time of admission in 97 (98.0%) of the 99 patients. Thirty-nine (39.4%) of the patients were symptomatic and 25.3% of the patients had cough, 8.1% had fever, and 7.1% had shortness of breath. While SARSCoV-2 RT-PCR test was negative in 2 (3.3%) of the 60 patients without complaints, 58 (96.7%) of them were positive for SARS-CoV-2 RT-PCR test. Leukopenia was detected as 3%, lymphopenia 66.7%, D-dimer height 47.5%, LDH elevation 38.4%, CRP elevation 45.5%. Ground glass opacities were present in 81 (81.8%) of the patients with lung involvement, and consolidation areas were present in 40 patients (40.4%). Underlying disease was present in 38 (38.4%) of the patients. Hypertension and diabetes mellitus were the most common underlying diseases. It was observed that 89 (89.4%) of our cases had negative SARS-CoV-2 RT-PCR test on the 5th day. Conclusion: COVID-19 infection is an infectious disease that can present with many different clinics. In asymptomatic COVID-19 cases, lung involvement findings and disorders in laboratory parameters may be observed. It should be kept in mind that asymptomatic cases pose a risk in terms of transmission.

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