scholarly journals Effect of intravenous infusion of magnesium sulphate on postoperative analgesia in patients undergoing arthroscopic knee surgeries under spinal anaesthesia

2017 ◽  
Vol 6 (2) ◽  
pp. 291
Author(s):  
Revi N ◽  
Mithun Raju P ◽  
Mohsin Mohammed Ali
Keyword(s):  
Postoperative Pain ◽  
Spinal Anaesthesia ◽  
Magnesium Sulphate ◽  
Intravenous Infusion ◽  
Study Cohort ◽  
Control Cohort ◽  
Analgesic Effects ◽  
Analgesic Consumption ◽  
Pain Scores ◽  
Arthroscopic Knee

Background: Magnesium sulphate is being used for postoperative pain relief intravenously, intrathecally and epidurally. Currently, it is also gaining popularity as an adjuvant in blocks. The objective of the study was aimed at the postoperative analgesic effects of magnesium sulphate when given as intravenous infusion in patients undergoing arthroscopic knee surgeries under spinal anaesthesia and to compare the postoperative analgesic effects of magnesium sulphate infusion in a study cohort who received magnesium sulphate with the control cohort who were not given magnesium sulphate and underwent arthroscopic knee surgeries under spinal anaesthesia.Methods: After obtaining ethical committee clearance and consent from the patients, 31 patients each were placed in study cohort and control cohort. Spinal anaesthesia was administered in the lateral decubitus position through the L3–4 or L4–5 interspace. Hyperbaric bupivacaine 0.5% solution with fentanyl 20 μg was injected intrathecally. After spinal anaesthesia, patients received magnesium sulphate 50 mg/kg for 15 min and then 15 mg/kg/hr by continuous intravenous infusion until the end of surgery. The other group did not receive magnesium sulphate infusion. Postoperative pain scores and postoperative analgesic consumption were the primary end points.Results: The results of the study reveal the efficacy of perioperative intravenous infusion of magnesium sulphate in prolonging the spinal block as well as reducing the postoperative pain scores without hemodynamic variability or side effects.Conclusions: Post-operative pain and analgesic consumption was reduced with the use of intravenous magnesium following spinal anaesthesia.

scholarly journals Impact of dexamethasone added to intra-articular morphine and bupivacaine for postoperative analgesia after knee arthroscopy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Heba Fouad Toulan ◽  
Raafat Abdel-Azim Hammad ◽  
Amr Mohammed Talaat ◽  
Ahmed Abd El-Daeem Abd El-Haq
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Postoperative Analgesia ◽  
Knee Arthroscopy ◽  
Control Group ◽  
Study Group ◽  
Early Recovery ◽  
Analgesic Consumption ◽  
Pain Scores ◽  
Arthroscopic Knee

Abstract Background Pain relief after knee arthroscopy is very important for early recovery and rehabilitation. The study was conducted to evaluate the effects of adding dexamethasone (8 mg) to intra-articular morphine (10 mg) and bupivacaine (25 mg) combination on postoperative pain after knee arthroscopy. Results We enrolled 40 patients, 18–65 years-old of both sexes, ASA I and II scheduled for minor arthroscopic knee surgeries. The study group showed a lower visual analog score at rest and movement, prolonged postoperative analgesia, and decreased total analgesic consumption compared with the control group (P value < 0.05). Conclusions Adding dexamethasone to intra-articular combination of morphine and bupivacaine after knee arthroscopy prolongs the duration of analgesia, lowers pain scores, and decreases total analgesic consumption with no detected adverse effects.

scholarly journals Perioperative pregabalin for reducing pain, analgesic consumption, and anxiety and enhancing sleep quality in elective neurosurgical patients: a prospective, randomized, double-blind, and controlled clinical study

2016 ◽  
Vol 125 (6) ◽  
pp. 1513-1522 ◽  
Author(s):  
Nir Shimony ◽  
Uri Amit ◽  
Bella Minz ◽  
Rachel Grossman ◽  
Marc A. Dany ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Sleep Quality ◽  
Rating Scale ◽  
Preoperative Anxiety ◽  
Controlled Study ◽  
Double Blind ◽  
Analgesic Consumption ◽  
Pain Scores ◽  
Neurosurgical Patients ◽  
Duration Of Surgery

OBJECTIVE The aim of this study was to assess in-hospital (immediate) postoperative pain scores and analgesic consumption (primary goals) and preoperative anxiety and sleep quality (secondary goals) in patients who underwent craniotomy and were treated with pregabalin (PGL). Whenever possible, out-of-hospital pain scores and analgesics usage data were obtained as well. METHODS This prospective, randomized, double-blind and controlled study was conducted in consenting patients who underwent elective craniotomy for brain tumor resection at Tel Aviv Medical Center between 2012 and 2014. Patients received either 150 mg PGL (n = 50) or 500 mg starch (placebo; n = 50) on the evening before surgery, 1.5 hours before surgery, and twice daily for 72 hours following surgery. All patients spent the night before surgery in the hospital, and no other premedication was administered. Opioids and nonsteroidal antiinflammatory drugs were used for pain, which was self-rated by means of a numerical rating scale (score range 0–10). RESULTS Eighty-eight patients completed the study. Data on the American Society of Anesthesiologists class, age, body weight, duration of surgery, and intraoperative drugs were similar for both groups. The pain scores during postoperative Days 0 to 2 were significantly lower in the PGL group than in the placebo group (p < 0.01). Analgesic consumption was also lower in the PGL group, both immediately and 1 month after surgery. There were fewer requests for antiemetics in the PGL group, and the rate of postoperative nausea and vomiting was lower. The preoperative anxiety level and the quality of sleep were significantly better in the PGL group (p < 0.01). There were no PGL-associated major adverse events. CONCLUSIONS Perioperative use of twice-daily 150 mg pregabalin attenuates preoperative anxiety, improves sleep quality, and reduces postoperative pain scores and analgesic usage without increasing the rate of adverse effects. Clinical trial registration no.: NCT01612832 (clinicaltrials.gov)

scholarly journals Postoperative Analgesic Effects of Laserpuncture and Meloxicam in Bitches Submitted to Ovariohysterectomy

2020 ◽  
Vol 7 (3) ◽  
pp. 94
Author(s):  
Rubia M. Tomacheuski ◽  
Marilda O. Taffarel ◽  
Guilherme S. Cardoso ◽  
Ana A. P. Derussi ◽  
Marcos Ferrante ◽  
...  
Keyword(s):  
Pain Management ◽  
Postoperative Pain ◽  
Area Under The Curve ◽  
Postoperative Pain Management ◽  
Pain Scale ◽  
Rescue Analgesia ◽  
Analgesic Effects ◽  
Pain Scores ◽  
Chi Squared ◽  
Perioperative Pain Management

Background: This prospective, randomised and blind study investigated the efficacy of laserpuncture for postoperative pain management in dogs. Method: Sixteen bitches were sedated with acepromazine and randomly treated before ovariohysterectomy with meloxicam 0.2 mg·kg−1 intramuscular or laserpuncture (wavelength 904 mm, frequency 124 Hz, potency 10 Joules, 100 s in each acupoint). Anaesthesia was performed with propofol, isoflurane/O2, and fentanyl. The Glasgow Composite Measure Pain Scale (GCMPS) and Dynamic Interactive Visual Analog Scale (DIVAS) were used to evaluate postoperative pain before and for 24 h after surgery. Morphine was administrated as rescue analgesia when pain scores were ≥3.33 (GCMPS). Differences between treatments, time points, and amount of rescue analgesia between groups were investigated by the Mann–Whitney test and the area under the curve (AUC) for GCMPS, Friedman, and Chi-squared tests, respectively (p < 0.05). Results: Dogs treated with laserpuncture presented lower GCMPS AUC for 24 h and lower GCMPS scores at 2 and 4 h postoperatively (p = 0.04). Three dogs treated with meloxicam required postoperatively rescue analgesia against none treated with laserpuncture. Conclusions: In this preliminary study, laserpuncture mitigated postoperative pain in dogs following ovariohysterectomy, and the technique is a promising adjunct to perioperative pain management in dogs undergoing soft tissue surgery.

Effects of spinal anaesthesia versus epidural anaesthesia for caesarean section on postoperative analgesic consumption and postoperative pain

2009 ◽  
Vol 26 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Jens-Christian Schewe ◽  
Adam Komusin ◽  
Joerg Zinserling ◽  
Joachim Nadstawek ◽  
Andreas Hoeft ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Caesarean Section ◽  
Spinal Anaesthesia ◽  
Epidural Anaesthesia ◽  
Analgesic Consumption

scholarly journals Intercostal Nerve Block and Peritubal Infiltration with Bupivacaine for Postoperative Analgesia after Percutaneous Nephrolithotomy: A Randomised Clinical Study

2021 ◽  
Author(s):  
Karunakaran Binil ◽  
Kaniyil Suvarna ◽  
Kannammadathy Poulose Biji
Keyword(s):  
Postoperative Pain ◽  
Nerve Block ◽  
Percutaneous Nephrolithotomy ◽  
Postoperative Analgesia ◽  
Intercostal Nerve ◽  
Categorical Variables ◽  
P Value ◽  
Intercostal Nerve Block ◽  
Analgesic Consumption ◽  
Pain Scores

Introduction: Percutaneous Nephrolithotomy (PCNL), a common endourologic procedure for removal of renal stones is associated with significant pain. Regional blocks are being used for postoperative analgesia after PCNL. Aim: To compare the analgesic efficacy of intercostal nerve block and fluoroscopic guided peritubal infiltration in terms of duration of analgesia, postoperative pain scores and total analgesic consumption in first 24 hours. Materials and Methods: This was a randomised clinical trial conducted from May 2018 to October 2018 on total of eighty patients, randomly allocated to two groups of 40 each. Group IC received intercostal nerve block and group IF received fluoroscopy guided peritubal infiltration with 0.25% bupivacaine. Duration of analgesia was assessed from postoperative pain scores (Numerical Rating Scale (NRS) during rest and coughing). Total analgesic consumption for 24 hours was also noted. Data was analysed using Chi-square test for categorical variables and independent Student’s t-test for quantitative variables. Results: The duration of analgesia was 702.00±140.022 minutes in Group IC and 346.50±129.566 minutes in group IF which was significant statistically with a p-value of <0.001. Resting and dynamic NRS were lower upto 12 hours postoperatively in group IC (p-value less than 0.05). Both tramadol (50.00±11.32 mg vs 82.50±24.15 mg) and paracetamol (100±303.82mg vs 850±622.23mg) requirements were lower in group IC as compared to group IF with p-values less than 0.001. Total consumption of first rescue analgesic tramadol as well as second analgesic Paracetamol both were significantly lesser(p-value<0.001) in group IC than group IF. Conclusion: Intercostal Nerve Block (INB) provided superior analgesia compared to fluoroscopic guided peritubal infiltration after PCNL.

scholarly journals Interpleural Bupivacaine Infusion Compared with Intravenous Pethidine Infusion after Cholecystectomy

1991 ◽  
Vol 19 (4) ◽  
pp. 539-545 ◽  
Author(s):  
H. Kastrissios ◽  
G. A. G. Mogg ◽  
E. J. Triggs ◽  
J. W. Higbie
Keyword(s):  
Side Effects ◽  
Postoperative Pain ◽  
Postoperative Period ◽  
Intravenous Infusion ◽  
Blood Gases ◽  
Arterial Blood Gases ◽  
Pain Scores ◽  
Arterial Blood ◽  
Vas Scores ◽  
Group B

Twenty-six cholecystectomy patients received either an interpleural infusion of bupivacaine (Group B, n = 12) or an intravenous infusion of pethidine (Group P, n = 14) for management of postoperative pain over a three-day period. Patients in Group P experienced a significantly (P < 0.05) greater incidence of total side-effects (146) than patients in Group B (66). Pain scores (VAS) and responses to a pain questionnaire were similar for both groups; however, within Group B improvement in mean VAS scores at rest with time were more sustained. Similar reductions in FEV, and FVC from preoperative values occurred for both groups, while for Group P there were significant (P < 0.05) changes in arterial blood gases (increase in Pco2, decrease in Po2) over two days postoperatively. Patients in Group P recorded longer times to passing flatus and unaided mobilisation (P < 0.05), and required a significantly greater number of additional medications (anti-emetics and analgesics) over the postoperative period (41 vs 29, P < 0.05).

scholarly journals Application of magnesium sulphate as a " multimodal general anesthesia" protocol in patients undergoing hysteroscopy: a randomized controlled study

2020 ◽  
Author(s):  
Peng-fei Gao ◽  
Jing-yan Lin ◽  
Shun Wang ◽  
Yun-feng Zhang ◽  
Guo-qiang Wang ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
General Anesthesia ◽  
Magnesium Sulphate ◽  
Intravenous Infusion ◽  
Rating Scale ◽  
Serum Magnesium ◽  
Isotonic Saline ◽  
Magnesium Concentration ◽  
Controlled Study ◽  
Control Group

Abstract Background: The purpose of the study was to applicate magnesium sulphate as a " multimodal general anesthesia" protocol to reduce perioperative opioids requirements in patients undergoing hysteroscopy.Methods: 70 patients scheduled for hysteroscopy were randomly divided into 2 groups. Patients in Group M received intravenous magnesium sulfate 50 mg/kg in 100 ml of isotonic saline over 15 min before fentanyl injection and then 15 mg/kg per hour by continuous intravenous infusion. Patients in the control group received an equal volume of normal saline as placebo. All patients were anesthetized under a BIS guided monitored anesthesia care with propofol and fentanyl. Intraoperative hemodynamic variables were recorded and postoperative pain scores were assessed with verbal numerical rating scale (VNRS) 1 min, 15 min, 30 min, 1 hour, and 4 hours after recovery of consciousness. The primary outcome of our study was total amount of intraoperative and postoperative analgesics administered.Results: Postoperative serum magnesium concentrations in Group C were significantly decreased than preoperative levels (0.86 ± 0.06 to 0.80 ± 0.08 mmol/L, P=0.001) while there was no statistical change in Group M (0.86 ± 0.07 to 0.89 ± 0.07 mmol/L, P=0.129). Bradycardia did not occur in either group and the incidence of hypotension was comparable between the two groups. Total dose of fentanyl given to patients in Group M was less than the one administered to Group C [100 (75-150) vs 145 (75-175) μg, median (range); P < 0.001]. Fewer patients in Group M required additional analgesics postoperatively. In addition, patients receiving magnesium displayed lower VNRS scores at 15 min, 30 min, 1 hour, and 4 hours postoperatively. Conclusions: Intravenous infusion of magnesium sulphate significantly reduces postoperative pain and perioperative opioid requirements without increasing the risk of cardiovascular side effects. Meanwhile, it was beneficial to maintain a stable serum magnesium concentration after the procedure.Trial registration: www.chictr.org.cn ChiCTR1900024596 date of registration: July 18th 2019.

Assessment of postoperative analgesic effect of rectus sheath block for patients who had emergency midline laparatomy, in University of Gondar Compressive Specialized Hospital, Northwest Ethiopia: an observational prospective cohort study.

2019 ◽  
Author(s):  
Wubie Birlie Chekol ◽  
Hailu Yimer Tawuye ◽  
zewuditu abdissa denu ◽  
Abatneh Feleke agegnehu
Keyword(s):  
Cohort Study ◽  
Postoperative Pain ◽  
Prospective Cohort Study ◽  
Analgesic Effect ◽  
Prospective Cohort ◽  
Rectus Sheath ◽  
Exposed Group ◽  
Analgesic Consumption ◽  
Pain Scores ◽  
Rectus Sheath Block

Abstract Background : Postoperative pain is a major concern after midline abdominal surgeries. Rectus sheath block (RSB) has been indicated after midline laparatomy ; however, the analgesic effect of landmark technique on postoperative pain was not well investigated. Objectives: we tested the hypothesis that RSB reduces pain scores, decreased total analgesic consumption and prolong first analgesic request time after emergency midline laparatomy . Methods : Prospective cohort study was done from February 1 to May 10, 2018. Eighty eight patients were observed in this study, 44 in the RSB group and 44 in the non exposed group. Pain severity was assessed in first 24 hours postoperative period in terms of total analgesic consumption, first analgesic request time and visual analogue scale (VAS) score at 1 hour , 2 hours , 4 hours , 6 hours , 8 hours , 10 hours, 12 hours and 24 hours. Results : The RSB group had significantly reduced VAS score at rest and on movement at (1, 2, 4, 6 and 8 hours), but not at (10, 12 and 24 hours) point assessed. Patients in RSB group had reduced tramadol requirement compared to non exposed group in 24 hours (255.68±80.13) VS (314.77±97.40), P=0.003). The 24 hours diclofenac consumption was significantly lowered in RSB group (75 ( 75-150) than non exposed group (150 ( 75-150), P=0.031.Mean time to first analgesic request was significantly longer in RSB group (372.95±131.41) than non exposed group (50.34±14.12), p≤0 . 001). Conclusions : The RSB group resulted in less pain scores, reduced total analgesic utilization and stayed for longer time for first analgesic request. Therefore we recommend RSB as part of multimodal analgesia after emergency midline laparatomy. Keywords: midline abdominal surgery, rectus sheath block, abdominal field block

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